公开(公告)号：US11434301B2

公开(公告)日：2022-09-06

申请号：US16348135

申请日：2017-11-10

申请人： The Regents of the University of California

发明人： Bin Liu ,  Daniel W. Sherbenou ,  Blake T. Aftab ,  Yang Su ,  Christopher R. Behrens

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/6886 ,  C07K16/00 ,  G01N33/574 ,  A61K39/00

摘要： Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

公开(公告)号：US20190276553A1

公开(公告)日：2019-09-12

申请号：US16348135

申请日：2017-11-10

申请人： The Regents of the University of California

发明人： Bin Liu ,  Daniel W. Sherbenou ,  Blake T. Aftab ,  Yang Su ,  Christopher R. Behrens

IPC分类号： C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/6886 ,  A61K47/68

摘要： Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

公开(公告)号：US10342869B2

公开(公告)日：2019-07-09

申请号：US14098710

申请日：2013-12-06

申请人： SANOFI ,  The Regents of the University of California

发明人： Byron C. Hann ,  Blake Tomkinson ,  Thomas G. Martin, III ,  Blake T. Aftab

IPC分类号： A61K39/395 ,  A61K31/45 ,  A61K45/06 ,  A61K31/37 ,  A61K31/454 ,  A61K31/573 ,  A61K31/616 ,  A61K31/727

摘要： Disclosed herein are compositions and kits which comprise anti-CD38 antibodies and lenalidomide compounds. Also disclosed are methods for treating cancers, such as multiple myeloma, in subjects with the compositions and kits.

公开(公告)号：US20230383005A1

公开(公告)日：2023-11-30

申请号：US17815514

申请日：2022-07-27

申请人： The Regents of the University of California

发明人： Bin Liu ,  Daniel W. Sherbenou ,  Blake T. Aftab ,  Yang Su ,  Christopher R. Behrens

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00 ,  C07K16/30 ,  C12Q1/6886 ,  C07K16/00 ,  G01N33/574

CPC分类号： C07K16/2896 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6813 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/3069 ,  C12Q1/6886 ,  A61K47/6803 ,  C07K16/00 ,  G01N33/57492 ,  A61K2039/55

摘要： Disclosed herein are methods of treating a subject having a cancer characterized by a modification at biomarker 1q21, which comprises administering to the subject a therapeutically effective amount of an anti-CD46 antibody.

公开(公告)号：US20140161819A1

公开(公告)日：2014-06-12

申请号：US14098710

申请日：2013-12-06

申请人： The Regents of the University of California ,  SANOFI

发明人： Byron C. Hann ,  Blake Tomkinson ,  Thomas G. Martin, III ,  Blake T. Aftab

IPC分类号： A61K39/395 ,  A61K31/45 ,  A61K45/06

CPC分类号： A61K39/39558 ,  A61K31/37 ,  A61K31/45 ,  A61K31/454 ,  A61K31/573 ,  A61K31/616 ,  A61K31/727 ,  A61K45/06 ,  A61K31/00 ,  A61K2300/00

摘要： Disclosed herein are compositions and kits which comprise anti-CD38 antibodies and lenalidomide compounds. Also disclosed are methods for treating cancers, such as multiple myeloma, in subjects with the compositions and kits.

摘要翻译： 本文公开了包含抗CD38抗体和来那度胺化合物的组合物和试剂盒。 还公开了在具有组合物和试剂盒的受试者中治疗癌症如多发性骨髓瘤的方法。