公开(公告)号：US20110217459A1

公开(公告)日：2011-09-08

申请号：US11974970

申请日：2007-10-16

Applicant: Basil I. Swanson ,  Clifford J. Unkefer ,  Jurgen G. Schmidt ,  Scott M. Reed ,  John E. Shively ,  Lin Li

Inventor： Basil I. Swanson ,  Clifford J. Unkefer ,  Jurgen G. Schmidt ,  Scott M. Reed ,  John E. Shively ,  Lin Li

IPC: B05D5/06

CPC classification number: G01N33/5432

Abstract: A process is provided of conjugating a recognition element such as a biomolecule to a hydrophobic multifunctional linker molecule by incorporating a multifunctional linker molecule including one or more anchoring groups, a reporter group and a reactive site thereon into a membrane, and, reacting the membrane including the incorporated multifunctional linker molecule with a pre-selected recognition element to form a covalently bound recognition element-multifunctional linker molecule-membrane assembly. Also, a chemical assembly suitable for subsequent covalent attachment of a recognition element is provided such assembly including a multifunctional linker molecule including one or more anchoring groups, a reporter group, and a hydrophilic spacer terminated by a reactive group capable of subsequent covalent bonding, the one or more anchoring groups incorporated in a membrane.

Abstract translation: 提供了通过将包括一个或多个锚定基团，报道基团和反应位点的多官能连接分子掺入到膜中，使识别元件例如生物分子与疏水多功能连接分子结合的方法， 所引入的多功能连接分子具有预选的识别元件以形成共价结合的识别元件 - 多功能连接子分子 - 膜组件。 此外，提供适于随后共价连接识别元件的化学组合物，其包括包含一个或多个锚定基团的多官能连接分子，报道基团和由能够随后共价键合的反应性基团封端的亲水性间隔基 一个或多个结合在膜中的锚定基团。

公开(公告)号：US07903242B2

公开(公告)日：2011-03-08

申请号：US12889823

申请日：2010-09-24

Applicant: Richard Karl Fenrich ,  Lin Li

Inventor： Richard Karl Fenrich ,  Lin Li

IPC: G06K9/74

CPC classification number: G06K9/00046

Abstract: A fingerprint imaging system configured to capture an image of a friction ridge pattern of a subject (e.g., a fingerprint, a palm print, a hand print, a footprint, etc.). The system may include one or more components that reduce the impact of ambient light on the performance of the system. In some implementations, the system may reduce the impact of ambient light without requiring additional power (e.g., to generate an increased amount of radiation) and without including “external” hoods and/or covers designed to block ambient light prior to the ambient light entering system. Instead, the system may reduce the impact of ambient light on performance by blocking ambient light internally within the system along an optical path of radiation used to electronically capture an image of the friction ridge pattern.

公开(公告)号：US20110013174A1

公开(公告)日：2011-01-20

申请号：US12889823

申请日：2010-09-24

Applicant: Richard Karl FENRICH ,  Lin Li

Inventor： Richard Karl FENRICH ,  Lin Li

IPC: G06K9/74

CPC classification number: G06K9/00046

Abstract: A fingerprint imaging system configured to capture an image of a friction ridge pattern of a subject (e.g., a fingerprint, a palm print, a hand print, a footprint, etc.). The system may include one or more components that reduce the impact of ambient light on the performance of the system. In some implementations, the system may reduce the impact of ambient light without requiring additional power (e.g., to generate an increased amount of radiation) and without including “external” hoods and/or covers designed to block ambient light prior to the ambient light entering system. Instead, the system may reduce the impact of ambient light on performance by blocking ambient light internally within the system along an optical path of radiation used to electronically capture an image of the friction ridge pattern.

公开(公告)号：US07864416B2

公开(公告)日：2011-01-04

申请号：US12072348

申请日：2008-02-26

Applicant: Jianguo Huang ,  Lin Li ,  Jiandong Yang ,  Weimin Ma

Inventor： Jianguo Huang ,  Lin Li ,  Jiandong Yang ,  Weimin Ma

IPC: G02B23/00

CPC classification number: G02B23/06 ,  F16M11/10 ,  F16M11/22 ,  F16M11/28 ,  F16M11/34 ,  F16M2200/027

Abstract: A portable astronomical telescope includes the cylinder body, on which three telescopic legs are hinged through a joint to form a tripod stand. The bottom of aforementioned cylinder body is fixed by means of connection element and mounted with part box. On the bottom end of this part box, a bottom cover is insert-mounted. On the upper end of the part box, limit connection elements of the connected telescopic leg are hinged. Within the aforementioned cylinder body, a guide bush is fixed and installed, inside of which telescope base is mounted. On the side of this telescope base, a guide pin is established. On the side of the guide sleeve, an L-shaped feed-through slot is established to accommodate the guide sleeve. On the tail end of the above feed-through slot, one guide pin residence slot is connected. The aforementioned telescope base is activated by the lug and mounted with bellows. This product can be used without need for separate assembly, and eliminates the need for a separate package. With small volume and light-weight features, it can hide the bellows within the cylinder body, in order to provide protection, which facilitates the product carrying and movement, particularly suitable for astronomy enthusiasts at the time of outdoor observation activities.

Abstract translation: 便携式天文望远镜包括气缸体，三个伸缩腿通过接头铰接在其上，形成三脚架。 上述缸体的底部通过连接元件固定，并安装有零件箱。 在该部件盒的底端，底盖是插入式安装的。 在零件盒的上端，连接的伸缩腿的限位连接元件铰接。 在上述筒体内，固定安装导向衬套，其内安装有望远镜底座。 在这个望远镜底座的一侧，建立了一个导销。 在引导套筒的一侧，建立一个L形馈通槽以容纳引导套筒。 在上述馈通槽的尾端连接有一个导销固定槽。 上述望远镜基座由凸耳激活并安装有波纹管。 本产品无需单独组装即可使用，无需单独包装。 具有体积小，重量轻的特点，可以隐藏气缸体内的波纹管，以提供保护，便于产品携带和移动，特别适合于户外观察活动时的天文爱好者。

公开(公告)号：US07816538B2

公开(公告)日：2010-10-19

申请号：US12509190

申请日：2009-07-24

Applicant: Patrick G. Harran ,  Xiaodong Wang ,  Jef K. De Brabander ,  Lin Li ,  Ranny Mathew Thomas ,  Hidetaka Suzuki

Inventor： Patrick G. Harran ,  Xiaodong Wang ,  Jef K. De Brabander ,  Lin Li ,  Ranny Mathew Thomas ,  Hidetaka Suzuki

IPC: C07D249/04 ,  C07D257/04 ,  A61K31/41 ,  A61K31/42

CPC classification number: C07D413/14 ,  A61K31/41 ,  A61K31/422 ,  C07D207/08 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D409/10 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D495/04 ,  C07K5/06026 ,  C07K5/06034

Abstract: Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

Abstract translation: 使用通式M1-L-M2的活性二聚体Smac肽模拟物促进胱天蛋白酶活性和凋亡，其中部分M1和M2是单体Smac模拟物，L是共价连接体。 靶向癌性或炎性细胞与有效量的活性二聚体Smac模拟物接触，并且检测到靶细胞凋亡的最终增加。 接触步骤可以通过给予包含治疗有效量的复合模拟物的药物组合物来实现，其中个体可以同时或先前放射或化疗用于治疗新生血管病变。

公开(公告)号：US20100008969A1

公开(公告)日：2010-01-14

申请号：US12216718

申请日：2008-07-10

Applicant: Yi Li ,  Jiashen Li ,  Junyan Hu ,  Lin Li

Inventor： Yi Li ,  Jiashen Li ,  Junyan Hu ,  Lin Li

IPC: A61F2/00 ,  A61K38/17

CPC classification number: A61L27/227 ,  A61L27/18 ,  A61L27/56 ,  C08L67/04

Abstract: The present invention relates to methods for preparing porous natural or synthetic material scaffolds with keratin for improving cell affinity.

Abstract translation: 本发明涉及用于改善细胞亲和力的用于制备具有角蛋白的多孔天然或合成材料支架的方法。

公开(公告)号：US20090281155A1

公开(公告)日：2009-11-12

申请号：US12509218

申请日：2009-07-24

Applicant: Patrick G. Harran ,  Xiaodong Wang ,  Jef K. De Brabander ,  Lin Li ,  Ranny Mathew Thomas ,  Hidetaka Suzuki

Inventor： Patrick G. Harran ,  Xiaodong Wang ,  Jef K. De Brabander ,  Lin Li ,  Ranny Mathew Thomas ,  Hidetaka Suzuki

IPC: A61K31/421 ,  C07D257/04 ,  A61K31/41 ,  C07D263/08 ,  C12Q1/02 ,  A61P35/00 ,  A61P37/06

CPC classification number: C07D413/14 ,  A61K31/41 ,  A61K31/422 ,  C07D207/08 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C07D405/10 ,  C07D409/10 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D417/04 ,  C07D417/10 ,  C07D417/14 ,  C07D495/04 ,  C07K5/06026 ,  C07K5/06034

Abstract: Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an effective amount of an active, dimeric Smac mimetic, and a resultant increase in apoptosis of the target cells is detected. The contacting step may be effected by administering to a pharmaceutical composition comprising a therapeutically effective amount of The compoundic mimetic, wherein the individual may be subject to concurrent or antecedent radiation or chemotherapy for treatment of a neoproliferative pathology.

公开(公告)号：US07541196B2

公开(公告)日：2009-06-02

申请号：US11172244

申请日：2005-06-29

Applicant: Jennifer S. Martinez ,  Basil I. Swanson ,  John E. Shively ,  Lin Li

Inventor： Jennifer S. Martinez ,  Basil I. Swanson ,  John E. Shively ,  Lin Li

IPC: G01N33/551

CPC classification number: B82Y30/00 ,  B82Y15/00 ,  G01N33/57473 ,  G01N2610/00 ,  Y10S436/805

Abstract: An assay element is described including recognition ligands adapted for binding to carcinoembryonic antigen (CEA) bound to a film on a single mode planar optical waveguide, the film from the group of a membrane, a polymerized bilayer membrane, and a self-assembled monolayer containing polyethylene glycol or polypropylene glycol groups therein and an assay process for detecting the presence of CEA is described including injecting a possible CEA-containing sample into a sensor cell including the assay element, maintaining the sample within the sensor cell for time sufficient for binding to occur between CEA present within the sample and the recognition ligands, injecting a solution including a reporter ligand into the sensor cell; and, interrogating the sample within the sensor cell with excitation light from the waveguide, the excitation light provided by an evanescent field of the single mode penetrating into the biological target-containing sample to a distance of less than about 200 nanometers from the waveguide thereby exciting any bound reporter ligand within a distance of less than about 200 nanometers from the waveguide and resulting in a detectable signal.

Abstract translation: 描述了一种测定元件，其包括适于结合到单模平面光波导上与膜结合的癌胚抗原（CEA）的识别配体，来自膜组的膜，聚合双层膜和含有 描述了其中的聚乙二醇或聚丙二醇基团，并且描述了用于检测CEA存在的测定方法，包括将可能的含CEA的样品注入到包含测定元件的传感器单元中，将样品保持在传感器单元内足以结合发生的时间 在样品中存在的CEA和识别配体之间，将包含报道分子配体的溶液注入到传感器单元中; 并且使用来自波导的激发光来询问传感器单元内的样本，由单一模式的消逝场提供的激发光穿透到含生物靶标的样品中，距离波导的距离小于约200纳米，由此令人兴奋 距离波导小于约200纳米的范围内的任何结合的报道配体，并产生可检测的信号。

公开(公告)号：US20080246952A1

公开(公告)日：2008-10-09

申请号：US11733080

申请日：2007-04-09

Applicant: Richard Karl Fenrich ,  Lin Li

Inventor： Richard Karl Fenrich ,  Lin Li

IPC: G06K9/74

CPC classification number: G06K9/00046

Abstract: A fingerprint imaging system configured to capture an image of a friction ridge pattern of a subject (e.g., a fingerprint, a palm print, a hand print, a footprint, etc.). The system may include one or more components that reduce the impact of ambient light on the performance of the system. In some implementations, the system may reduce the impact of ambient light without requiring additional power (e.g., to generate an increased amount of radiation) and without including “external” hoods and/or covers designed to block ambient light prior to the ambient light entering system. Instead, the system may reduce the impact of ambient light on performance by blocking ambient light internally within the system along an optical path of radiation used to electronically capture an image of the friction ridge pattern.

Abstract translation: 一种被配置为捕获被摄体的摩擦脊图案（例如，指纹，手掌印刷，手印，印记等）的图像的指纹成像系统。 该系统可以包括减少环境光对系统性能的影响的一个或多个组件。 在一些实施方案中，系统可以减少环境光的影响，而不需要额外的功率（例如，产生增加的辐射量），并且不包括设计成在环境光进入之前阻挡环境光的“外部”罩和/或盖 系统。 相反，系统可以通过沿着用于电子捕获摩擦脊图案的图像的辐射光路阻挡系统内的环境光来减小环境光对性能的影响。

公开(公告)号：US20080108668A1

公开(公告)日：2008-05-08

申请号：US10598033

申请日：2005-02-17

Applicant: Changling Liu ,  Miao Li ,  Hong Zhang ,  Lin Li ,  Mingxing Zhang ,  Aiying Guan ,  Chunqing Hou ,  Zhinian Li ,  Yonggang Jia

Inventor： Changling Liu ,  Miao Li ,  Hong Zhang ,  Lin Li ,  Mingxing Zhang ,  Aiying Guan ,  Chunqing Hou ,  Zhinian Li ,  Yonggang Jia

IPC: A61K31/4439 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC classification number: A01N43/56 ,  A01N43/80 ,  C07D231/20 ,  C07D261/12 ,  C07D261/18 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04

Abstract: The invention relates to fungicide and insecticide, especifically to the substituted azole compounds and its preparation method and use thereof. The azole compounds of the invention having general formula (I): The compounds of present invention, having broad spectrum fungicidal activity, applied for controlling various disease in plants. For example they have good activity against the diseases such as cucumber downy mildew, cucumber grey mold, cucumber powdery mildew, tomato early blight, tomato late blight, phytophthora blight of pepper, grape downy mildew, grape white rot, apple ring rot, apple alternaria leaf spot, rice sheath blight, rice blast, wheat leaf rust, wheat leaf blotch, wheat powdery mildew, rapesclerotiniose, corn southern leaf blight. Some compounds have good insecticidal or acaricidal activity and can be used to control insects and acacids of various crops. For example they are used to control army worm, diamond backmoth and aphid, and culex mosquito.

Abstract translation: 本发明涉及杀真菌剂和杀虫剂，特别涉及取代的唑化合物及其制备方法和用途。 具有通式（I）的本发明唑类化合物：具有广谱杀真菌活性的本发明化合物被用于控制植物中的各种疾病。 例如，它们对黄瓜霜霉病，黄瓜灰霉病，黄瓜白粉病，番茄早疫病，番茄晚疫病，胡椒疫霉病，葡萄霜霉病，葡萄白腐病，苹果腐烂，苹果轮虫 叶斑病，水稻纹枯病，稻瘟病，小麦叶锈病，小麦叶斑病，小麦白粉病，rapesclerotiniose，玉米南叶枯病。 一些化合物具有良好的杀虫或杀螨活性，可用于控制各种作物的昆虫和螨类。 例如，它们用于控制军队蠕虫，钻石背蛾和蚜虫，以及库蚊。