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41.发明授权
公开(公告)号：US4335114A
公开(公告)日：1982-06-15
申请号：US161527
申请日：1980-06-20
IPC分类号： A23K20/195 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/236
摘要： The invention relates to sisomicin derivatives defined below in Formula (I) and a process for the preparation of said derivatives. Also included in the invention are compositions containing said derivatives and methods for using said derivatives and compositions. ##STR1##
摘要翻译： 本发明涉及式（I）中定义的西索米星衍生物及其制备方法。 本发明还包括含有所述衍生物的组合物和使用所述衍生物和组合物的方法。 （一）
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42.发明授权1-N-4,6-di-O-(Aminoglycosyl)-1,3-diamino-cyclitol derivatives, processes for their preparation and their use 失效1-N-4,6-di-O-（氨基糖基）-1,3-二氨基 - 环烷醇衍生物，其制备及其用途
公开(公告)号：US4234572A
公开(公告)日：1980-11-18
申请号：US960205
申请日：1978-11-13
申请人： Uwe Petersen , Eckart Voss , Karl G. Metzger , Peter Stadler
发明人： Uwe Petersen , Eckart Voss , Karl G. Metzger , Peter Stadler
IPC分类号： C07H15/23 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07D207/48 , C07D211/46 , C07D333/48 , C07H13/12 , C07H15/234 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07D333/48 , C07D207/48 , C07D211/46 , C07H13/12 , C07H15/234
摘要： The invention relates to 1-N-4,6-di-O-(aminoglycosyl)-1,3-diamino-cyclitol derivatives useful as antimicrobial agents. Also included in the invention are methods for preparing said derivatives, the provision of pharmaceutical compositions containing said derivatives and methods for the use of said derivatives and compositions.
摘要翻译： 本发明涉及可用作抗微生物剂的1-N-4,6-di-O-（氨基糖基）-1,3-二氨基 - 环状醇衍生物。 本发明还包括制备所述衍生物的方法，提供含有所述衍生物的药物组合物和使用所述衍生物和组合物的方法。
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43.发明授权6,7-disubstituted 1-cycloproply-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids 失效6,7-二取代的1-环丙-1,4-二氢-4-氧代-1,8-二氮杂萘-3-羧酸
公开(公告)号：US4840954A
公开(公告)日：1989-06-20
申请号：US815440
申请日：1985-12-31
IPC分类号： A61K31/33 , A61K31/435 , A61K31/495 , A61P31/04 , C07D20060101 , C07D213/61 , C07D213/77 , C07D213/78 , C07D213/80 , C07D471/04
CPC分类号： C07D213/78 , C07D213/61 , C07D213/77 , C07D213/80 , C07D471/04
摘要： New 6,7-disubstituted-1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxy lic acids of the formula (I) ##STR1## in which X represents halogen or nitro and A represents ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are defined hereinbelow are disclosed as well as their usefulness as antibacterial agents.
摘要翻译： 式（I）的新的6,7-二取代-1-环丙基-1,4-二氢-4-氧代-1,8-二氮杂萘-3-羧酸，其中X表示卤素或硝基，A 表示其中R1，R2，R3和R4如下文定义的
以及它们作为抗菌剂的用途。 -
44.发明授权7-Amino-1-cyclopropyl-6,8-difluoro-1,4-di hydro-4-oxo-quinoline-3-carboxylic acids and antibacterial agents containing these compounds 失效7-氨基-1-环丙基-6,8-二氟-1,4-二氢-4-氧代喹啉-3-羧酸和含有这些化合物的抗菌剂
公开(公告)号：US4556658A
公开(公告)日：1985-12-03
申请号：US603480
申请日：1984-04-24
IPC分类号： A01N43/42 , A23K1/16 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61P31/04 , C07D211/00 , C07D215/00 , C07D215/56 , C07D241/00 , C07D401/02 , C07D401/04 , C07D403/04 , C07D413/04
CPC分类号： C07D215/56 , C07D401/04 , C07D413/04
摘要： The invention relates to 7-amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acids, processes for their preparation and compositions containing them as antibacterial agents. Also included in the invention are methods for treating bacterial infection using the compounds and compositions of the invention.
摘要翻译： 本发明涉及7-氨基-1-环丙基-6,8-二氟-1,4-二氢-4-氧代 - 喹啉-3-甲酸甲酯，其制备方法和含有它们作为抗菌剂的组合物。 本发明还包括使用本发明的化合物和组合物治疗细菌感染的方法。
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45.发明授权1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(oxo-alkyl)-1-piperazinyl ]quinoline-3-carboxylic acids and their derivatives, and antibacterial agents containing them 失效1-环丙基-6-氟-1,4-二氢-4-氧代-7- [4-（氧代 - 烷基）-1-哌嗪基]喹啉-3-羧酸及其衍生物和含有它们的抗菌剂
公开(公告)号：US4547503A
公开(公告)日：1985-10-15
申请号：US560026
申请日：1983-12-09
IPC分类号： C07D401/00 , A61K31/495 , A61P31/04 , C07D215/56 , C07D401/04 , C07D405/12
CPC分类号： C07D215/56 , C07D405/12
摘要： The invention relates to 1-cyclopropyl-6-fluoro-1,4 dihydro-4-oxo-7-[4-(oxo-(alkyl)-1-piperazinyl]-quinoline-3-carboxylic acids of Formula (I), processes for their manufacture, compositions containing them and use of said compounds and compositions as antibacterial and/or feedstuff additives.
摘要翻译： 本发明涉及式（I）的1-环丙基-6-氟-1,4-二氢-4-氧代-7- [4-（氧代（烷基）-1-哌嗪基] - 喹啉-3-羧酸， 其制造方法，含有它们的组合物和所述化合物和组合物作为抗菌和/或饲料添加剂的用途。
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公开(公告)号：US4224315A
公开(公告)日：1980-09-23
申请号：US931708
申请日：1978-08-07
申请人： Peter Stadler , Karl G. Metzger , Uwe Petersen , Eckart Voss
发明人： Peter Stadler , Karl G. Metzger , Uwe Petersen , Eckart Voss
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/234 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234
摘要： The invention includes, as novel compounds, aminoglycoside antibiotics of the 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols which are 3-N"-substituted. Also included in the invention are compositions containing said novel compounds and methods for the use of said compounds and compositions.
摘要翻译： 本发明包括作为3-N“取代的4,6-二-O-（氨基糖基）-1,3-二氨基二醇的氨基糖苷类抗生素作为新化合物。 本发明还包括含有所述新化合物的组合物和使用所述化合物和组合物的方法。
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47.发明授权8-chloro-1-cyclopropyl-6,7-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof 失效8-氯-1-环丙基-6,7-二氟-1,4-二氢-4-氧代-3-喹啉羧酸及其烷基酯
公开(公告)号：US5468861A
公开(公告)日：1995-11-21
申请号：US316314
申请日：1994-09-30
IPC分类号： C07D215/56 , C07D401/04 , C07D409/12 , C07D413/04
CPC分类号： C07D215/56 , C07D401/04 , C07D409/12 , C07D413/04
摘要： The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.
摘要翻译： 本发明涉及式（I）的化合物（I）的7-氨基-1-环丙基-6,8-二卤代-1,4-二氢-4-氧代-3-喹啉 - 汽车壳酸酯，其中 X1，X2，R1和R2具有以下说明书中指出的含义。 此外，本发明涉及制备式（I）化合物的方法和含有它们的抗菌剂。
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公开(公告)号：US4820716A
公开(公告)日：1989-04-11
申请号：US13744
申请日：1987-02-12
IPC分类号： A23K1/17 , A23K1/16 , A61K31/435 , A61K31/47 , A61P31/04 , C07D215/56 , C07D401/04 , C07D405/14 , C07D471/04
CPC分类号： C07D215/56 , C07D401/04 , C07D471/04
摘要： 7-(1-Pyrrolidinyl)-3-quinolonecarboxylic acid derivatives of the formula ##STR1## in which A is CH, CCl, CF or N,R.sup.1 is hydroxyl, hydroxymethyl or mercapto andR.sup.2 is hydrogen, alkyl, having 1 to 4 carbon atoms or (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl,with the proviso that, when R.sup.1 is hydroxy, A is not CF or N, or pharmaceutically acceptable hydrates, or salts thereof, are useful as antibacterials and animal feed utilization promoters.
摘要翻译： 其中A是CH，CCl，CF或N的式（IMA）的7-（1-吡咯烷基）-3-喹啉酮羧酸衍生物，R1是羟基，羟甲基或巯基，R2是氢，具有1-4个碳原子的烷基 原子或（5-甲基-2-氧代-1,3-二氧杂环戊烯-4-基）甲基，条件是当R 1是羟基时，A不是CF或N，或其药学上可接受的水合物或其盐 用作抗菌剂和动物饲料利用促进剂。
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49.发明授权1-Cyclopropyl-6-fluoro-1,4-dih ydro-4-oxo-7-(alkyl-1-piperazinyl)quinoline-3-carboxylic acids, processes for their preparation and antibacterial agents containing them 失效1-环丙基-6-氟-1,4-二氢-4-氧代-7-（烷基-1-哌嗪基）喹啉-3-羧酸的制备方法和含有它们的抗菌剂
公开(公告)号：US4544658A
公开(公告)日：1985-10-01
申请号：US560027
申请日：1983-12-09
IPC分类号： C07D401/04 , A61K31/495 , A61P31/04 , C07D215/56 , C07D401/00 , A61K31/47
CPC分类号： C07D215/56
摘要： The invention relates to 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-piperazinyl)quinoline-3-carboxylic acids of Formula (I), processes for their manufacture, compositions containing them and use of said compounds and compositions as antibacterial and/or feedstuff additives.
摘要翻译： 本发明涉及式（I）的1-环丙基-6-氟-1,4-二氢-4-氧代-7-（烷基-1-哌嗪基）喹啉-3-烯酸，其制备方法，组合物 含有它们并使用所述化合物和组合物作为抗菌和/或饲料添加剂。
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50.发明授权
公开(公告)号：US4312859A
公开(公告)日：1982-01-26
申请号：US147908
申请日：1980-05-08
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/236
摘要： The invention relates to sesomycin derivatives of Formula I, infra as well as processes for preparing said sisomycin derivatives. Also included in the invention are compositions containing said sisomycin derivatives and methods for the use of said compounds and compositions. The sisomycon derivatives are useful as antibacterial agents of broad activity and reduced side effects.
摘要翻译： 本发明涉及式I的芝霉素衍生物，以及制备所述西沙星霉素衍生物的方法。 本发明还包括含有所述顺式霉素衍生物的组合物和使用所述化合物和组合物的方法。 sisomycon衍生物可用作具有广泛活性和减少副作用的抗菌剂。
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