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公开(公告)号：US4224315A
公开(公告)日：1980-09-23
申请号：US931708
申请日：1978-08-07
申请人： Peter Stadler , Karl G. Metzger , Uwe Petersen , Eckart Voss
发明人： Peter Stadler , Karl G. Metzger , Uwe Petersen , Eckart Voss
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/234 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234
摘要： The invention includes, as novel compounds, aminoglycoside antibiotics of the 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols which are 3-N"-substituted. Also included in the invention are compositions containing said novel compounds and methods for the use of said compounds and compositions.
摘要翻译： 本发明包括作为3-N“取代的4,6-二-O-（氨基糖基）-1,3-二氨基二醇的氨基糖苷类抗生素作为新化合物。 本发明还包括含有所述新化合物的组合物和使用所述化合物和组合物的方法。
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2.发明授权1-N(Aminopolyhydroxyalkyl)aminoglycoside antibiotics and method of use 失效1-N（氨基多羟基烷基）氨基糖苷类抗生素及其使用方法
公开(公告)号：US4393051A
公开(公告)日：1983-07-12
申请号：US155896
申请日：1980-06-02
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/234 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234
摘要： The invention relates to pseudotrisaccharides of Formula (I) as defined above, methods for preparing them, compositions containing them and methods for the use of said compounds and compositions.
摘要翻译： 本发明涉及如上定义的式（I）的假三糖，其制备方法，含有它们的组合物和使用所述化合物和组合物的方法。
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3.发明授权
公开(公告)号：US4312859A
公开(公告)日：1982-01-26
申请号：US147908
申请日：1980-05-08
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/236
摘要： The invention relates to sesomycin derivatives of Formula I, infra as well as processes for preparing said sisomycin derivatives. Also included in the invention are compositions containing said sisomycin derivatives and methods for the use of said compounds and compositions. The sisomycon derivatives are useful as antibacterial agents of broad activity and reduced side effects.
摘要翻译： 本发明涉及式I的芝霉素衍生物，以及制备所述西沙星霉素衍生物的方法。 本发明还包括含有所述顺式霉素衍生物的组合物和使用所述化合物和组合物的方法。 sisomycon衍生物可用作具有广泛活性和减少副作用的抗菌剂。
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4.发明授权4,6-Di-O-(aminoglycosyl)-1,3-diaminocyclitols, process for their production and their use 失效4,6-二-O-（氨基糖基）-1,3-二氨基二醇，其制备及其用途
公开(公告)号：US4190722A
公开(公告)日：1980-02-26
申请号：US913135
申请日：1978-06-06
IPC分类号： C07H15/234 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/236
摘要： The invention includes selectively acylated or sulphenylated 4,6-O-(aminoglycosyl)-1,3-diaminocyclitols (and methods for their preparation). Also included in the invention are 1-N-acylated-derivatives, such as 1-N-formyl-sisomicin, useful because of the anti-bacterial effects (and methods for their procurement). The invention includes, furthermore, methods for the procurement of said 1-N-acylated or sulphenylated derivatives, compositions containing them and methods for their use.
摘要翻译： 本发明包括选择性酰化或磺基化的4,6-O-（氨基糖基）-1,3-二氨基二醇（及其制备方法）。 本发明还包括1-N-酰化衍生物，例如1-N-甲酰基西索米星，因为其具有抗菌作用（及其采购方法）。 此外，本发明还包括采购所述1-N-酰化或磺化衍生物的方法，含有它们的组合物及其使用方法。
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5.再颁专利Pseudotrissaccharides, a process for their production and their use as medicaments 失效伪三糖，其生产过程及其作为药物的用途
公开(公告)号：USRE31512E
公开(公告)日：1984-01-31
申请号：US260853
申请日：1981-05-06
申请人： Peter Stadler , Karl G. Metzger , Eckart Voss , Uwe Petersen , Hans-Joachim Zeiler , Hans-Joachim Kabbe
发明人： Peter Stadler , Karl G. Metzger , Eckart Voss , Uwe Petersen , Hans-Joachim Zeiler , Hans-Joachim Kabbe
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07D317/72 , C07H15/236
CPC分类号： C07D317/72 , C07H15/236
摘要： Pseudotrisaccharides of the sisomycin type are provided which are effective an antibacterial agents, particularly against gram-negative microorganisms. The invention also includes methods for the manufacture of the pseudotrisaccharides, compositions containing said pseudotrisaccharides and methods for the treatment of warm-blooded animals using said compounds and compositions.
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6.发明授权
公开(公告)号：US4335114A
公开(公告)日：1982-06-15
申请号：US161527
申请日：1980-06-20
IPC分类号： A23K20/195 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/236
摘要： The invention relates to sisomicin derivatives defined below in Formula (I) and a process for the preparation of said derivatives. Also included in the invention are compositions containing said derivatives and methods for using said derivatives and compositions. ##STR1##
摘要翻译： 本发明涉及式（I）中定义的西索米星衍生物及其制备方法。 本发明还包括含有所述衍生物的组合物和使用所述衍生物和组合物的方法。 （一）
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7.发明授权1-N-4,6-di-O-(Aminoglycosyl)-1,3-diamino-cyclitol derivatives, processes for their preparation and their use 失效1-N-4,6-di-O-（氨基糖基）-1,3-二氨基 - 环烷醇衍生物，其制备及其用途
公开(公告)号：US4234572A
公开(公告)日：1980-11-18
申请号：US960205
申请日：1978-11-13
申请人： Uwe Petersen , Eckart Voss , Karl G. Metzger , Peter Stadler
发明人： Uwe Petersen , Eckart Voss , Karl G. Metzger , Peter Stadler
IPC分类号： C07H15/23 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07D207/48 , C07D211/46 , C07D333/48 , C07H13/12 , C07H15/234 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07D333/48 , C07D207/48 , C07D211/46 , C07H13/12 , C07H15/234
摘要： The invention relates to 1-N-4,6-di-O-(aminoglycosyl)-1,3-diamino-cyclitol derivatives useful as antimicrobial agents. Also included in the invention are methods for preparing said derivatives, the provision of pharmaceutical compositions containing said derivatives and methods for the use of said derivatives and compositions.
摘要翻译： 本发明涉及可用作抗微生物剂的1-N-4,6-di-O-（氨基糖基）-1,3-二氨基 - 环状醇衍生物。 本发明还包括制备所述衍生物的方法，提供含有所述衍生物的药物组合物和使用所述衍生物和组合物的方法。
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8.发明授权Selectively protected 1-N-(.omega.-aminoalkoxycarbonyl)-sisomicin derivatives 失效选择性保护的1-N-（ω-氨基烷氧基羰基） - 拟微生物衍生物
公开(公告)号：US4336369A
公开(公告)日：1982-06-22
申请号：US149384
申请日：1980-05-13
申请人： Uwe Petersen , Eckart Voss , Peter Stadler
发明人： Uwe Petersen , Eckart Voss , Peter Stadler
IPC分类号： C07H15/236 , C07H15/22 , A61K31/71
CPC分类号： C07H15/236
摘要： The invention relates to selectively protected 1-N-(.omega.-aminoalkoxycarbonyl)-sisomicin derivatives and methods for their procurement. Said derivatives are useful as intermediates for the procurement of highly active antibacterial agents of low toxicity.
摘要翻译： 本发明涉及选择性保护的1-N-（ω-氨基烷氧基羰基） - 亚氨基蛋白衍生物及其采购方法。 所述衍生物可用作购买低活性的高活性抗菌剂的中间体。
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9.发明授权Pseudotrissaccharides, a process for their production and their use as medicaments 失效伪三糖，其生产过程及其作为药物的用途
公开(公告)号：US4235888A
公开(公告)日：1980-11-25
申请号：US52871
申请日：1979-06-28
申请人： Peter Stadler , Karl-Georg Metzger , Eckart Voss , Uwe Petersen , Hans-Joachim Zeiler , Hans-Joachim Kabbe
发明人： Peter Stadler , Karl-Georg Metzger , Eckart Voss , Uwe Petersen , Hans-Joachim Zeiler , Hans-Joachim Kabbe
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07D317/72 , C07H15/236 , C07H17/08
CPC分类号： C07D317/72 , C07H15/236
摘要： Pseudotrisaccharides of the sisomycin type are provided which are effective an antibacterial agents, particularly against gram-negative microorganisms. The invention also includes methods for the manufacture of the pseudotrisaccharides, compositions containing said pseudotrisaccharides and methods for the treatment of warm-blooded animals using said compounds and compositions.
摘要翻译： 提供了具有抗菌剂，特别是抗革兰氏阴性微生物的抗生素，具有抗生素的类型。 本发明还包括制备假三糖的方法，含有所述假三糖的组合物和使用所述化合物和组合物治疗温血动物的方法。
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10.发明授权Selectively protected 4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols and their production 失效选择性保护的4,6-二-O-（氨基糖基）-1,3-二氨基二醇和它们的生产
公开(公告)号：US4294959A
公开(公告)日：1981-10-13
申请号：US74047
申请日：1979-09-10
申请人： Eckart Voss , Uwe Petersen , Peter Stadler
发明人： Eckart Voss , Uwe Petersen , Peter Stadler
IPC分类号： C07H15/236 , C07H23/00 , C07H17/00 , C07H15/22
CPC分类号： C07H23/00 , C07H15/236
摘要： The invention relates to selectively protected 4,6-di-O-(aminoglycosyl)-1,3-diamino cyclitols (and methods for their preparation) useful as intermediates for the synthesis of antibiotics, such as those of the sisomycin type.
摘要翻译： 本发明涉及可用作抗生素合成中间体的选择性保护的4,6-二-O-（氨基糖基）-1,3-二氨基环状醇（及其制备方法），该等抗生素如顺式霉素类型。
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