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    Once daily pharmaceutical tablet having a unitary core
    41.
    发明授权
    Once daily pharmaceutical tablet having a unitary core 失效
    每日一次药片具有单一核心

    公开(公告)号：US5837379A

    公开(公告)日：1998-11-17

    申请号：US791999

    申请日：1997-01-31

    申请人： Chih-Ming Chen ,  Joseph C. H. Chou

    发明人： Chih-Ming Chen ,  Joseph C. H. Chou

    IPC分类号： A61K9/00 ,  A61K9/32 ,  A61K9/20

    CPC分类号： A61K9/0004

    摘要： A controlled release nifedipine tablet which comprises: (a) a homogeneous compressed core which comprises: (i) a medicament; (ii) a water soluble osmotic compound (iii) one or more osmotic polymers; and (b) a membrane coating which completely covers said core tablet which comprises a mixture of: (i) a water insoluble pharmaceutically acceptable polymer; and (ii) an enteric polymer.

    摘要翻译： 一种控释硝苯地平片剂，其包含：（a）均质压缩核心，其包含：（i）药物; （ii）水溶性渗透化合物（iii）一种或多种渗透性聚合物; 和（b）完全覆盖所述芯片的膜包衣，其包含以下混合物：（i）水不溶性药学上可接受的聚合物; 和（ii）肠溶性聚合物。

    Controlled release formulation for water insoluble drugs in which a passageway is formed in situ
    42.
    发明授权
    Controlled release formulation for water insoluble drugs in which a passageway is formed in situ 失效
    水不溶性药物的控制释放制剂，其中通道原位形成

    公开(公告)号：US5736159A

    公开(公告)日：1998-04-07

    申请号：US430356

    申请日：1995-04-28

    申请人： Chih-Ming Chen ,  Der-Yang Lee ,  Jianbo Xie

    发明人： Chih-Ming Chen ,  Der-Yang Lee ,  Jianbo Xie

    IPC分类号： A61K9/00 ,  A61K9/28 ,  A61K9/36

    CPC分类号： A61K9/0004 ,  A61K9/282 ,  A61K9/2866

    摘要： A controlled release pharmaceutical tablet is disclosed which is based on: (a) a compressed core which contains: (i) a medicament; (ii) at least 23% to 55% by weight, based on the total weight of the core, of a water soluble osmotic agent; (iii) a water soluble pharmaceutically acceptable polymeric binder; (iv) a water-swellable pharmaceutically acceptable polymer; (v) a conventional pharmaceutical excipient; and (b) a membrane coating around said core tablet which consists essentially of: (i) a modified water insoluble pharmaceutically acceptable polymer; and (ii) a pharmaceutically acceptable water soluble polymer.

    摘要翻译： 公开了一种控释药物片剂，其基于：（a）压缩核心，其包含：（i）药物; （ii）基于芯的总重量的至少23重量％至55重量％的水溶性渗透剂; （iii）水溶性药学上可接受的聚合物粘合剂; （iv）水溶胀性药学上可接受的聚合物; （v）常规药物赋形剂; 和（b）围绕所述芯片的膜包衣，其基本上由以下组成：（i）改性的水不溶性药学上可接受的聚合物; 和（ii）药学上可接受的水溶性聚合物。

    Pulsatile particles drug delivery system
    44.
    发明授权
    Pulsatile particles drug delivery system 失效
    脉动颗粒药物输送系统

    公开(公告)号：US5472708A

    公开(公告)日：1995-12-05

    申请号：US290815

    申请日：1994-08-16

    申请人： Chih-Ming Chen

    发明人： Chih-Ming Chen

    IPC分类号： A61K9/48 ,  A61K9/00 ,  A61K9/20 ,  A61K9/50 ,  A61K9/56

    CPC分类号： A61K9/0004 ,  A61K9/2081 ,  A61K9/5084

    摘要： Unit dosage form for delivering drugs into the body in a series of sequential, pulsatile releasing events employs conventional pharmaceutical equipment and processes for optimum economy, reliability, and bioavailability. The system can be used with drugs which cannot be released by diffusion through a porous coating, such as water insoluble drugs. A plurality of populations of pellets is provided within a unit dosage form such as a capsule (8) or tablet. The pellets are composed of a core containing the drug (3) and a swelling agent (4) which expands in volume when exposed to water. The core is enclosed within a membrane or coating which is permeable to water. The membrane is composed of a water insoluble and permeable film forming polymer, a water soluble film forming polymer (11) and a permeability reducing agent (14). When the unit dose releases the pellets into the digestive tract, water diffuses through the coating and into the core. As water is taken up by the swelling agent, the core expands, exerting force on the coating until it bursts, releasing the drug. The permeability reducing agent reduces the rate at which water reaches the swelling agent, thereby delaying release time. The water soluble polymer dissolves, weakening the coating so that it bursts sooner. By varying the proportions of the three coating ingredients and/or coating thickness from one pellet population to another, the release timing of the pellets can be very effectively controlled.

    摘要翻译： PCT No.PCT / US93 / 10643 Sec。 371日期：1994年8月16日 102（e）日期1994年8月16日PCT提交1993年11月2日PCT公布。 出版物WO94 / 12160 日期：1994年6月9日。用于以一系列顺序，脉动释放事件将药物输送到体内的单剂剂型采用常规药物设备和方法，以获得最佳的经济性，可靠性和生物利用度。 该系统可以与通过多孔涂层（例如水不溶性药物）扩散而不能释放的药物一起使用。 在单位剂型例如胶囊（8）或片剂中提供多个颗粒群。 颗粒由含有药物（3）的核心和暴露于水时体积膨胀的溶胀剂（4）组成。 核心封闭在可透水的膜或涂层中。 膜由水不溶性且可渗透的成膜聚合物，水溶性成膜聚合物（11）和渗透性还原剂（14）组成。 当单位剂量将丸粒释放到消化道中时，水通过涂层扩散并进入核心。 当水被溶胀剂吸收时，芯膨胀，对涂层施加力，直到爆裂，释放药物。 渗透性降低剂降低水到达溶胀剂的速度，从而延缓释放时间。 水溶性聚合物溶解，削弱涂层，使其更快爆裂。 通过将三种涂层成分的比例和/或涂层厚度从一个粒料群改变到另一个，粒料的释放时间可以被非常有效地控制。

    Audio processing system for restoring bass frequencies
    46.
    发明授权
    Audio processing system for restoring bass frequencies 失效
    用于恢复低音频率的音频处理系统

    公开(公告)号：US4698842A

    公开(公告)日：1987-10-06

    申请号：US754518

    申请日：1985-07-11

    申请人： Gregory C. Mackie ,  Stephen E. Satra ,  Chih-Ming Chen

    发明人： Gregory C. Mackie ,  Stephen E. Satra ,  Chih-Ming Chen

    IPC分类号： G11B5/035 ,  G11B20/02 ,  H03G5/18 ,  H03G9/02 ,  H04R5/00 ,  G10H1/02

    CPC分类号： G11B20/02 ,  G11B5/035 ,  H03G5/18 ,  H03G9/025 ,  Y10S84/09

    摘要： An audio processing system for injecting left and right channel audio signals with a signal having a fundamental frequency component that is half the frequency of the highest amplitude low frequency component in the left and right channel audio signals. The left and right channel audio signals are combined to form a monaural signal that is low pass filtered and applied to a demodulator circuit. The demodulator circuit generates a control signal having a frequency that is half the frequency of the highest amplitude frequency component in the signal at the output of the band pass filter. The control signal varies the phase of the signal at the output of the band pass filter according to the polarity of the control signal. The resulting signal is selectively added to the left and right input signals. In order to prevent the audio processing circuit from producing annoying artifact when the audio signals are vocally generated, a voice detector determines that the input signals are from a vocal source and then disables the audio processing circuit. The voice detector operates by comparing the monaural (left plus right) signal to a differential signal (left minus right). Vocal source material has a relatively higher monaural signal while a musical source has a relatively higher differential signal.

    摘要翻译： 一种音频处理系统，用于使用具有在左右声道音频信号中的最高幅度低频分量的频率的一半的基频分量的信号来注入左声道和右声道音频信号。 左声道和右声道音频信号被组合以形成低通滤波并应用于解调器电路的单声道信号。 解调器电路产生具有在带通滤波器的输出处的信号中的最高幅度频率分量的频率的一半的频率的控制信号。 控制信号根据控制信号的极性改变带通滤波器的输出处的信号的相位。 所得到的信号被选择性地添加到左和右输入信号。 为了防止音频处理电路在声音产生时产生烦人的假象，语音检测器确定输入信号来自声源，然后禁用音频处理电路。 语音检测器通过将单声道（左加右）信号与差分信号（左减右）进行比较来进行操作。 声源材料具有相对较高的单声道信号，而音源具有相对较高的差分信号。

    Magnetic tunnel junction (MTJ) structure in magnetic random access memory
    48.
    发明授权
    Magnetic tunnel junction (MTJ) structure in magnetic random access memory 有权
    磁性随机存取存储器中的磁隧道结（MTJ）结构

    公开(公告)号：US09343656B2

    公开(公告)日：2016-05-17

    申请号：US13410714

    申请日：2012-03-02

    申请人： Kai-Wen Cheng ,  Chwen Yu ,  Chih-Ming Chen

    发明人： Kai-Wen Cheng ,  Chwen Yu ,  Chih-Ming Chen

    IPC分类号： H01L29/82 ,  H01L43/08

    CPC分类号： H01L43/08

    摘要： Methods and apparatuses for a magnetic tunnel junction (MTJ) which can be used in as a magnetic random access memory cell are disclosed. The MTJ comprises a free layer and an insulator layer. The MTJ further comprises a pinned layer with a first region, a second region, and a third region. The second region is of a first length and of a first thickness, and the first region and the third region are of a second length and of a second thickness. A ratio of the first thickness to the second thickness may be larger than 1.2. A ratio of the second length to the first length is larger than 0.5. The first thickness may be larger than a spin diffusion length of a material for the pinned layer. So formed MTJ results in increased tunneling magnetic resistance ratio and reduced critical switch current of the MTJ.

    摘要翻译： 公开了可用作磁性随机存取存储器单元的磁性隧道结（MTJ）的方法和装置。 MTJ包括自由层和绝缘体层。 MTJ还包括具有第一区域，第二区域和第三区域的钉扎层。 第二区域具有第一长度和第一厚度，并且第一区域和第三区域具有第二长度和第二厚度。 第一厚度与第二厚度之比可以大于1.2。 第二长度与第一长度的比率大于0.5。 第一厚度可以大于用于钉扎层的材料的自旋扩散长度。 所形成的MTJ导致隧道磁阻比提高，MTJ的关键开关电流降低。

    Computer with force sensing resistor
    49.
    发明授权
    Computer with force sensing resistor 有权
    具有力感测电阻的电脑

    公开(公告)号：US09268380B2

    公开(公告)日：2016-02-23

    申请号：US13664630

    申请日：2012-10-31

    申请人： Chih-Ming Chen

    发明人： Chih-Ming Chen

    IPC分类号： H01H35/00 ,  G06F1/26 ,  H03K17/96

    CPC分类号： G06F1/26 ,  H03K17/9625

    摘要： A computer includes a motherboard with a signal receiving port and a switch circuit. The switch circuit includes a force sensing module and a transistor. The transistor includes a first terminal connected to the force sensing module, a second terminal connected to a power source, and a third terminal connected to the signal receiving port. When there is a pressure applied to the force sensing module, the force sensing module outputs a first driving signal to turn on the transistor and enables the computer to maintain its current power on or off state. When there is no pressure applied to the force sensing module, the force sensing module outputs a second driving signal to turn off the transistor and switches on or off the computer.

    摘要翻译： 计算机包括具有信号接收端口和开关电路的主板。 开关电路包括力感测模块和晶体管。 晶体管包括连接到力感测模块的第一端子，连接到电源的第二端子和连接到信号接收端口的第三端子。 当施加到力感测模块上的压力时，力感测模块输出第一驱动信号以接通晶体管，并使得计算机能够保持其当前功率的打开或关闭状态。 当没有压力施加到力感测模块时，力感测模块输出第二驱动信号以关闭晶体管并打开或关闭计算机。