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41.发明授权Benzo(b)thiepine-1,1-dioxide derivatives, a method for the production thereof, medicaments containing these compounds, and their use 有权苯并（b）硫嘌呤-1,1-二氧化物衍生物，其制备方法，含有这些化合物的药物及其用途公开(公告)号：US06387944B1
公开(公告)日：2002-05-14
申请号：US09719047
申请日：2000-12-07
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07D337/08 , A61K38/00 , C07K5/06086 , C08G65/329 , Y02P20/55
摘要： The invention relates to substituted benzo(b)thiepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention relates to compounds of formula (I), wherein R1, R2, R3, R4, R5 and Z have the cited descriptions, to the physiologically compatible salts, to physiologically functional derivatives, and to a method for the production thereof. The compounds are suited, for example, as hypolipidemic agents.
摘要翻译： 本发明涉及取代的苯并（b）硫脲-1,1-二氧化物衍生物及其酸加成盐。 本发明涉及式（I）化合物，其中R 1，R 2，R 3，R 4，R 5和Z具有生理上相容的盐，生理功能衍生物，以及其生产方法。 该化合物适合于例如降血脂药。
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42.发明授权公开(公告)号：US07576200B2
公开(公告)日：2009-08-18
申请号：US12219196
申请日：2008-07-17
申请人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
发明人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
IPC分类号： C07D205/08 , C07D263/20 , A61K31/397 , A61K31/70 , C07H17/02
CPC分类号： C07D205/08 , C07F7/1804
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
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43.发明申请Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use 有权新型二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20070208179A1
公开(公告)日：2007-09-06
申请号：US11797720
申请日：2007-05-07
申请人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schafer
发明人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schafer
IPC分类号： C07D263/20 , C07D205/08
CPC分类号： C07D205/08 , C07F7/1804
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
摘要翻译： 其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义的式I化合物及其生理上可接受的盐。 该化合物适合用作例如降血脂药。
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44.发明授权公开(公告)号：US06992067B2
公开(公告)日：2006-01-31
申请号：US10021502
申请日：2001-12-19
申请人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
发明人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
IPC分类号： A61K31/70 , A61K31/397 , C07H17/02
CPC分类号： C07D205/08 , C07F7/1804
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
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45.发明授权1,4-benzothiazepine-1,1-dioxide derivatives substituted by sugar residues, process for their preparation, pharmaceuticals comprising these compounds, and their use 有权被糖残基取代的1,4-苯并硫氮杂-1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06277831B1
公开(公告)日：2001-08-21
申请号：US09545456
申请日：2000-04-07
IPC分类号： A61K317028
CPC分类号： C07D281/10 , A61K31/554 , Y02P20/55
摘要： The invention relates to substituted 1,4-benzothiazepine-1,1-dioxide derivatives and their acid addition salts. 1,4-Benzothiazepine-1,1-dioxide derivatives of formula 1, wherein R1, R2, R3, and Z have the meanings indicated in the specification, physiologically tolerable salts, and physiologically functional derivatives thereof, and also processes for their preparation, are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 本发明涉及取代的1,4-苯并硫氮杂-1,1-二氧化物衍生物及其酸加成盐.1。式1的苯并硫氮杂-1,1-二氧化物衍生物，其中R1，R2，R3和Z具有 描述了本说明书中指出的含义，生理上可耐受的盐及其生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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46.发明授权Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06221897B1
公开(公告)日：2001-04-24
申请号：US09398315
申请日：1999-09-20
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 描述式I的取代苯并噻吩1,1-二氧化物衍生物：其中R1，R2，R3，R4，R5和Z具有所示含义，并描述了其生理上可耐受的盐和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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47.发明申请Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use 有权新型二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20080281092A1
公开(公告)日：2008-11-13
申请号：US12219196
申请日：2008-07-17
申请人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schafer
发明人： Heiner Glombik , Werner Krame , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schafer
IPC分类号： C07D205/04
CPC分类号： C07D205/08 , C07F7/1804
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义的式I化合物及其生理上可接受的盐。 该化合物适合用作例如降血脂药。
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48.发明授权Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US06441022B1
公开(公告)日：2002-08-27
申请号：US09773772
申请日：2001-02-02
申请人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K3138
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 描述式I的取代苯并噻吩1,1-二氧化物衍生物：其中R1，R2，R3，R4，R5和Z具有所示含义，并描述了其生理上可耐受的盐和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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49.发明授权Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use 有权芳基取代的丙醇胺衍生物，其制备方法，包含它们的药物及其应用公开(公告)号：US06566340B2
公开(公告)日：2003-05-20
申请号：US09833676
申请日：2001-04-13
IPC分类号： A61K3170
CPC分类号： C07H15/18
摘要： Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
摘要翻译： 描述了取代的丙醇胺衍生物，其药学上可耐受的盐和生理功能衍生物。还描述了具有上述含义的基团的式Iin化合物及其生理学耐受的盐，生理学功能衍生物及其制备方法。 该化合物适合作为例如降血脂药。
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50.发明授权Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use 有权芳基取代的丙醇胺衍生物，其制备方法，包含它们的药物及其应用公开(公告)号：US06245744B1
公开(公告)日：2001-06-12
申请号：US09410084
申请日：1999-10-01
IPC分类号： A61K3170
CPC分类号： C07H15/18
摘要： Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
摘要翻译： 描述了取代的丙醇胺衍生物，其药学上可耐受的盐和生理功能衍生物。还描述了具有上述含义的基团的式Iin化合物及其生理学耐受的盐，生理学功能衍生物及其制备方法。 该化合物适合作为例如降血脂药。
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