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1.发明授权Method of treatment with combinations of statin and aryl-substituted propanolamine derivatives 有权用他汀类药物和芳基取代的丙醇胺衍生物联合治疗的方法公开(公告)号：US06897198B2
公开(公告)日：2005-05-24
申请号：US10351317
申请日：2003-01-27
IPC分类号： C07D213/74 , A61K31/44 , A61K31/4402 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/675 , A61K31/7028 , A61K31/706 , A61K38/00 , A61P3/00 , A61P3/06 , A61P9/10 , C07D413/14 , C07D417/14 , C07H5/06 , C07H15/18 , C07H15/26 , C07K4/00 , A61K31/70
CPC分类号： C07H15/18
摘要： Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described.Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
摘要翻译： 描述了取代的丙醇胺衍生物，其药学上可耐受的盐及其生理功能衍生物。 还描述了其中基团具有上述含义的式I化合物及其生理上耐受的盐，生理功能衍生物及其制备方法。 该化合物适合作为例如降血脂药。
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2.发明授权Combinations with statin and aryl-substituted propanolamine derivatives, their preparation pharmaceuticals comprising them, and their use 有权与他汀类和芳基取代的丙醇胺衍生物的组合，它们的制备，包含它们的药物及其用途公开(公告)号：US06569835B2
公开(公告)日：2003-05-27
申请号：US09985149
申请日：2001-11-01
IPC分类号： A61K3170
CPC分类号： C07H15/18
摘要： Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
摘要翻译： 描述了取代的丙醇胺衍生物，其药学上可耐受的盐及其生理功能衍生物。 还描述了具有上述含义的基团的式Iin化合物及其生理学耐受的盐，生理功能衍生物及其制备方法。 该化合物适合作为例如降血脂药。
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3.发明授权Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use 有权芳基取代的丙醇胺衍生物，其制备方法，包含它们的药物及其应用公开(公告)号：US06566340B2
公开(公告)日：2003-05-20
申请号：US09833676
申请日：2001-04-13
IPC分类号： A61K3170
CPC分类号： C07H15/18
摘要： Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
摘要翻译： 描述了取代的丙醇胺衍生物，其药学上可耐受的盐和生理功能衍生物。还描述了具有上述含义的基团的式Iin化合物及其生理学耐受的盐，生理学功能衍生物及其制备方法。 该化合物适合作为例如降血脂药。
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4.发明授权Aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use 有权芳基取代的丙醇胺衍生物，其制备方法，包含它们的药物及其应用公开(公告)号：US06245744B1
公开(公告)日：2001-06-12
申请号：US09410084
申请日：1999-10-01
IPC分类号： A61K3170
CPC分类号： C07H15/18
摘要： Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
摘要翻译： 描述了取代的丙醇胺衍生物，其药学上可耐受的盐和生理功能衍生物。还描述了具有上述含义的基团的式Iin化合物及其生理学耐受的盐，生理学功能衍生物及其制备方法。 该化合物适合作为例如降血脂药。
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5.发明授权Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use 有权二苯基氮杂环丁酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07674773B2
公开(公告)日：2010-03-09
申请号：US11155109
申请日：2005-06-17
申请人： Heiner Glombik , Werner Kramer , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
发明人： Heiner Glombik , Werner Kramer , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
CPC分类号： C07D205/08 , C07F7/1804
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
摘要翻译： 其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义的式I化合物及其生理上可接受的盐。 该化合物适合用作例如降血脂药。
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6.发明申请NOVEL DIPHENYLAZETIDINONES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS AND THEIR USE 审中-公开新型二苯乙酮，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20100160282A1
公开(公告)日：2010-06-24
申请号：US12646023
申请日：2009-12-23
申请人： Heiner Glombik , Werner Kramer , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
发明人： Heiner Glombik , Werner Kramer , Stefanie Flohr , Wendelin Frick , Hubert Heuer , Gerhard Jaehne , Andreas Lindenschmidt , Hans-Ludwig Schäfer
IPC分类号： A61K31/397 , A61P9/10
CPC分类号： C07D205/08 , C07F7/1804
摘要： Compounds of the formula I, in which R1, R2, R3, R4, R5, and R6 have the meanings given in the description, and their physiologically acceptable salts. The compounds are suitable for use, for example, as hypolipidemics.
摘要翻译： 其中R1，R2，R3，R4，R5和R6具有说明书中给出的含义的式I化合物及其生理上可接受的盐。 该化合物适合用作例如降血脂药。
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7.发明授权1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof 有权被苄基取代的1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US07956085B2
公开(公告)日：2011-06-07
申请号：US12465911
申请日：2009-05-14
申请人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： A61K31/38 , C07D409/08
CPC分类号： C07H5/06 , A61K31/38 , A61K31/7028 , A61K45/06 , C07D409/12 , C07H5/04 , C07H7/02 , C07H7/027 , C07H13/12 , C07H15/26 , A61K2300/00
摘要： This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof.
摘要翻译： 本发明涉及由苄基取代的新型1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途。
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8.发明申请NOVEL DIPHENYLAZETIDINONE WITH IMPROVED PHYSIOLOGICAL PROPERTIES, PROCESS FOR ITS PREPARATION, MEDICAMENTS COMPRISING THIS COMPOUND, AND ITS USE 失效具有改善的生理特性的新型二氢噻吩酮，其制备方法，包含该化合物的药物及其用途公开(公告)号：US20070197498A1
公开(公告)日：2007-08-23
申请号：US11690993
申请日：2007-03-26
申请人： Gerhard JAEHNE , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
发明人： Gerhard JAEHNE , Wendelin Frick , Andreas Lindenschmidt , Stefanie Flohr , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer , Eric Galia , Heiner Glombik
IPC分类号： A61K31/397 , C07D205/02
CPC分类号： C07C233/18 , C07D205/08
摘要： Novel diphenylazetidinone, process for its preparation, medicaments comprising this compound and their use The invention relates to the compound of the formula 1 and to its physiologically acceptable salts. The compound is suitable, for example, as a hypolipidemic.
摘要翻译： 新型二苯基氮杂环丁酮，其制备方法，包含该化合物的药物及其用途本发明涉及式1的化合物及其生理上可接受的盐。 该化合物例如可用作降血脂药物。
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公开(公告)号：US20070043017A1
公开(公告)日：2007-02-22
申请号：US11544718
申请日：2006-10-10
申请人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
发明人： Gerhard Jaehne , Wendelin Frick , Stefanie Flohr , Andreas Lindenschmidt , Heiner Glombik , Werner Kramer , Hubert Heuer , Hans-Ludwig Schaefer
IPC分类号： A61K31/397 , C07D205/02 , C07D403/02
CPC分类号： C07D403/12 , C07D205/08 , C07D453/02 , C07D487/08 , Y10S930/28
摘要： One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.
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10.发明授权Combination product of a 1,4-benzothiepine 1,1-dioxide compound with at least one other active ingredient and the use of the product 有权1,4-苯并噻吩1,1-二氧化物化合物与至少一种其它活性成分的组合产物和产物的用途公开(公告)号：US07179792B2
公开(公告)日：2007-02-20
申请号：US10699967
申请日：2003-11-03
CPC分类号： A61K45/06 , A61K31/395 , A61K31/55 , A61K2300/00
摘要： The present invention is directed to a 1,4-benzothiepine 1,1-dioxide compound of formula I in which the radicals have the meanings defined herein, or a pharmaceutically acceptable salt or physiologically functional derivative thereof, with at least one other active ingredient, or a pharmaceutically acceptable salt or physiologically functional derivative thereof. The invention is also directed to the use of the combination product, pharmaceutical composition comprising the combination product and method for preparing the pharmaceutical composition.
摘要翻译： 本发明涉及其中基团具有本文定义的含义，或其药学上可接受的盐或生理功能衍生物的式I的1,4-苯并硫代1,1-二氧化物化合物与至少一种其它活性成分， 或其药学上可接受的盐或生理功能衍生物。 本发明还涉及组合产品，包含组合产品和方法的药物组合物用于制备药物组合物的用途。
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