公开(公告)号：US20080312221A1

公开(公告)日：2008-12-18

申请号：US12175361

申请日：2008-07-17

申请人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

发明人： Yasunari Fujiwara ,  Terufumi Senga ,  Tsuyoshi Nishitoba ,  Tatsushi Osawa ,  Atsushi Miwa ,  Kazuhide Nakamura

IPC分类号： A61K31/47 ,  C07D215/233 ,  C07D413/12 ,  A61K31/541 ,  A61P35/00 ,  A61K31/5377 ,  C07D417/12

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  C07D215/40 ,  C07D239/88 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12

摘要： An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X=CH or N; Z=O or S; L=O or S; M=CR10R11, wherein R10 and R11=H, alkyl, or alkoxy, NR12 wherein R12=H or alkyl; R1, R2, and R3=H or optionally substituted alkoxy; R4=H; R5-8=H, halogen, alkoxy or the like; and R9=alkyl optionally substituted by —R14, -T-R15, or —NR16R17 wherein T=O, S, or NH; R14=an optionally substituted carbocyclic or heterocyclic ring; and R15-17=alkyl or an optionally substituted carbocyclic or heterocyclic ring, or —NR18R19 wherein R18 and R19=H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.

摘要翻译： 本发明的目的是提供具有有效抗肿瘤活性的化合物。 本发明的化合物由式（I）表示或其药学上可接受的盐或溶剂化物：其中X = CH或N; Z = O或S; L = O或S; M = CR10R11，其中R10和R11 = H，烷基或烷氧基，NR12，其中R12 = H或烷基; R1，R2和R3 = H或任选取代的烷氧基; R4 = H; R5-8 = H，卤素，烷氧基等; 并且R 9 =任选被-R 14，-T-R 15或-NR 16 R 17取代的烷基，其中T = O，S或NH; R14 =任选取代的碳环或杂环; 和R 15-17 =烷基或任选取代的碳环或杂环，或-NR 18 R 19，其中R 18和R 19 = H，任选取代的烷基，或任选取代的碳环或杂环，或任选取代的碳环或杂环。

公开(公告)号：US20080207617A1

公开(公告)日：2008-08-28

申请号：US10533081

申请日：2003-10-29

申请人： Atsushi Miwa ,  Tetsuya Yoshino ,  Mineo Kurokawa ,  Hisamaru Hirai ,  Naoko Hirai

发明人： Atsushi Miwa ,  Tetsuya Yoshino ,  Mineo Kurokawa ,  Hisamaru Hirai ,  Naoko Hirai

IPC分类号： A61K31/4709 ,  C07D215/233 ,  C07D401/12 ,  C07D413/12 ,  A61P35/02 ,  A61P35/00 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/47

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/55 ,  C07D215/22 ,  C07D401/12

摘要： An objective of the present invention is to provide compounds and pharmaceuticals useful for the treatment of disease where the inhibition of autophosphorylation of FMS-like tyrosine kinase 3(Flt3) is therapeutically effective. The present invention relates to a pharmaceutical composition for use in the treatment or prevention of diseases where the inhibition of autophosphorylation of Flt3 therapeutically or prophylactically effective, which comprises a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, OH, or optionally substituted alkoxy; R4 represents H; R5, R6, R7, and R8 represent H, Hal, alkyl or the like; and R9 represents, e.g., alkyl substituted by t-butyl or the like.

摘要翻译： 本发明的目的是提供可用于治疗FMS样酪氨酸激酶3（Flt3）的自磷酸化抑制是治疗有效的疾病的化合物和药物。 本发明涉及用于治疗或预防治疗或预防有效的Flt3的自磷酸化的疾病的药物组合物，其包含由式（I）表示的化合物或其药学上可接受的盐或溶剂合物：其中X 表示CH或N; Z表示O或S; R 1，R 2，R 3和R 3代表H，OH或任选取代的烷氧基; R 4表示H; R 5，R 6，R 7和R 8代表H，Hal，烷基等; R 9表示例如被叔丁基等取代的烷基。

公开(公告)号：US20080048138A1

公开(公告)日：2008-02-28

申请号：US11833497

申请日：2007-08-03

申请人： Atsushi Miwa

发明人： Atsushi Miwa

IPC分类号： G01N21/86

CPC分类号： B41J13/0018 ,  B41J11/0095 ,  G03G15/6558 ,  G03G2215/00616 ,  G03G2215/00721

摘要： An image forming apparatus that forms an image on a recording medium includes a sensor including a light emitting element configured to emit light and a light receiving element configured to receive light emitted from the light emitting element. A sensor actuator is configured to cause a transition between a first state where the light emitted from the light emitting element is received at the light receiving element and a second state where the light emitted from the light emitting element is not received at the light receiving element in response to a recording medium being detected. A light shield is coupled to the sensor actuator and configured to cover at least a part of the sensor and to prevent light other than light emitted from the light emitting element from entering the light receiving element in the second state.

摘要翻译： 在记录介质上形成图像的图像形成装置包括：传感器，包括被配置为发光的发光元件和被配置为接收从发光元件发射的光的光接收元件。 传感器致动器被配置为使得在从光发射元件发射的光在光接收元件处被接收的第一状态和从发光元件发射的光未被接收在光接收元件的第二状态之间的转变 响应于检测到的记录介质。 光屏蔽耦合到传感器致动器并且构造成覆盖传感器的至少一部分并且防止除了从发光元件发射的光以外的光在第二状态下进入光接收元件。

公开(公告)号：US20060211717A1

公开(公告)日：2006-09-21

申请号：US11432407

申请日：2006-05-12

申请人： Teruyuki Sakai ,  Terufumi Senga ,  Takayuki Furuta ,  Atsushi Miwa

发明人： Teruyuki Sakai ,  Terufumi Senga ,  Takayuki Furuta ,  Atsushi Miwa

IPC分类号： A61K31/517 ,  C07D403/02

CPC分类号： C07D215/233 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/505 ,  A61K31/517 ,  A61K31/5377 ,  C07D231/12 ,  C07D233/56 ,  C07D233/88 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically acceptable salts or solvates thereof: wherein R1 and R2 represent hydrogen, alkyl or the like; R3, R4, R5, and R6 represent hydrogen, halogen, alkyl, alkoxy or the like; R11 and R12 represent hydrogen, alkyl, alkylcarbonyl or the like; and A represents any one of formulae (i) to (x), provided that compounds wherein R3, R4, R5 and R6 represent hydrogen and A represents group (v) wherein u is 0 (zero) and R19 represents phenyl optionally substituted by halogen, alkyl, or alkoxy are excluded.

摘要翻译： 提供的化合物可用于治疗由PDGF受体的自磷酸化介导的疾病，特别是可抑制新内膜形成肥大的化合物。 化合物是由式（I）表示的化合物或其药学上可接受的盐或溶剂化物：其中R 1和R 2代表氢，烷基等; R 3，R 4，R 5和R 6代表氢，卤素，烷基，烷氧基或 喜欢; R 11和R 12代表氢，烷基，烷基羰基等; 并且A表示式（i）至（x）中的任何一个，条件是其中R 3，R 4，R 5和R 5的化合物 代表氢，A代表其中u为0（零）且R 19表示任选被卤素，烷基或烷氧基取代的苯基的基团（ⅴ）。