公开(公告)号：US07824909B2

公开(公告)日：2010-11-02

申请号：US12001598

申请日：2007-12-11

申请人： Wei-Mei Ching ,  Chien-Chung Chao ,  Xuan Li ,  Hua-Wei Chen

发明人： Wei-Mei Ching ,  Chien-Chung Chao ,  Xuan Li ,  Hua-Wei Chen

IPC分类号： C12N15/31

CPC分类号： G01N33/6854 ,  C07K14/195 ,  C07K2319/20 ,  C07K2319/21 ,  C12Q1/04 ,  G01N33/56966 ,  G01N2333/195

摘要： The invention relates to a method for the detection of prior exposure to Coxiella. burnetii infection by antibody-based assays using recombinant, immunodominant C. burnetii polypeptides. The invention also relates to the design of biotin or His-tagged C. burnetii proteins useful in the antibody-based assays as standardized antigen reagents.

摘要翻译： 本发明涉及一种用于检测先前暴露于考克氏杆菌的方法。 通过基于抗体的测定，使用重组，免疫显性大肠杆菌多核苷酸感染。 本发明还涉及可用于基于抗体的测定中用作标准化抗原试剂的生物素或His-标记的枯草芽孢杆菌蛋白的设计。

公开(公告)号：US20070184460A1

公开(公告)日：2007-08-09

申请号：US11357462

申请日：2006-02-09

申请人： Wei-Mei Ching ,  Xuan Li

发明人： Wei-Mei Ching ,  Xuan Li

IPC分类号： C12Q1/68 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： The inventive subject matter relates to a method for the diagnosis of Orientia tsutsugamushi infection by measuring the increased or decreased expression of specific human genes following infection by microarray or polymerase chain reaction analysis. The method employs the creation of gene modulation profiles in patients suspected to be infected with O. tsutsugamushi and comparing the profiles with a pre-determined profile of genes known to modulate in response to O. tsutsugamushi exposure and infection. The method permits the early detection of O. tsutsugamushi infection and diagnosis of scrub typhus earlier than currently available methods. The method also permits mid-course monitoring of disease progression with greater detail than currently available methods.

摘要翻译： 本发明主题涉及通过微阵列或聚合酶链反应分析测量感染后特异性人基因表达增加或降低来诊断恙虫病东方感染的方法。 该方法采用在怀疑感染恙虫病恙虫病的患者中产生基因调控谱，并比较该曲线与预先确定的响应于恙虫病暴露和感染的调控基因。 该方法允许早期检测恙虫病感染和诊断恙虫病早于现有的方法。 该方法还允许比目前可用的方法更详细地中期监测疾病进展。

公开(公告)号：US20050005707A1

公开(公告)日：2005-01-13

申请号：US10911474

申请日：2004-08-05

申请人： Xuan Li

发明人： Xuan Li

IPC分类号： G03F7/20 ,  H01L21/68 ,  G01N13/00

CPC分类号： H01J37/3174 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/7035 ,  G03F7/70775 ,  H01L21/682

摘要： A first stage and a second stage are disposed to face each other. A first object is fixed on the first stage. A first displacement sensor attached on the first stage is used to measure a distance extending from the first displacement sensor to a plane disposed in front of the first displacement sensor. A second object is fixed on the second stage. A second displacement sensor attached on the second stage is used to measure a distance extending from the second displacement sensor to a plane disposed in front of the second displacement sensor. A moving mechanism is provided to move one of the first stage and the second stage, with the movement of one stage being relative to the other stage.