公开(公告)号：US20240352480A1

公开(公告)日：2024-10-24

申请号：US18628578

申请日：2024-04-05

Applicant: Monsanto Technology LLC

Inventor： David J. Bowen ,  Catherine A. Chay ,  Todd A. Ciche ,  Stanislaw Flasinski ,  Arlene R. Howe ,  Krishnakumar Sridharan

IPC: C12N15/82 ,  A01N37/46 ,  A01N63/50 ,  C07K14/195 ,  C07K14/32

CPC classification number: C12N15/8286 ,  A01N37/46 ,  A01N63/50 ,  C07K14/195 ,  C07K14/32 ,  C07K2319/00

Abstract: A pesticidal protein class exhibiting toxic activity against Coleopteran and Lepidopteran pest species is disclosed, and includes, but is not limited to, TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389. DNA constructs are provided which contain a recombinant nucleic acid sequence encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Coleopteran and Lepidopteran infestation are provided which contain recombinant nucleic acid sequences encoding the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins of the present invention. Methods for detecting the presence of the recombinant nucleic acid sequences or the proteins of the present invention in a biological sample, and methods of controlling Coleopteran and Lepidopteran species pests using the TIC7040, TIC7042, TIC7381, TIC7382, TIC7383, TIC7386, TIC7388, and TIC7389 pesticidal proteins are also provided.

公开(公告)号：US20240336661A1

公开(公告)日：2024-10-10

申请号：US18564398

申请日：2022-06-02

Applicant: University of Copenhagen

Inventor： Oluf Pedersen ,  Yong Fan

IPC: C07K14/195 ,  A61K38/00 ,  A61P3/04 ,  A61P3/10 ,  A61P19/00

CPC classification number: C07K14/195 ,  A61P3/04 ,  A61P3/10 ,  A61P19/00 ,  A61K38/00

Abstract: The present invention relates to polypeptides derived from Ruminococcus torques, and polypeptide fragments and variants thereof useful for treatment and/or prevention of metabolic disorders, muscle disorders and injuries, and bone disorders, and host cells comprising said polypeptides, polypeptide fragments or variants thereof for use as a probiotic or as a Live Biopharmaceutical Product (LBP).

公开(公告)号：US12098173B2

公开(公告)日：2024-09-24

申请号：US17057418

申请日：2019-05-22

Applicant: The Governors of the University of Alberta

Inventor： Holger Wille ,  Jiarui Fang ,  José Miguel Flores-Fernández ,  Vineet Rathod ,  Xinli Tang

IPC: C07K14/47 ,  A61K39/00 ,  A61K39/385 ,  A61P25/16 ,  A61P25/28 ,  A61P37/04 ,  C07K14/195 ,  C07K14/285 ,  C07K14/37 ,  C07K14/705 ,  C07K16/12 ,  C07K16/14 ,  C07K16/18 ,  C07K16/28 ,  C12N9/88

CPC classification number: C07K14/47 ,  A61K39/0007 ,  A61K39/385 ,  A61P25/16 ,  A61P25/28 ,  A61P37/04 ,  C07K14/195 ,  C07K14/285 ,  C07K14/37 ,  C07K14/70596 ,  C07K16/1203 ,  C07K16/1242 ,  C07K16/14 ,  C07K16/18 ,  C07K16/2872 ,  C12N9/88 ,  C12Y402/02002 ,  A61K2039/6031 ,  A61K2039/6068 ,  C07K2319/33

Abstract: The present disclosure relates generally to polypeptides, which may be used of the treatment of neurological diseases or disorders.

公开(公告)号：US12091652B2

公开(公告)日：2024-09-17

申请号：US17101871

申请日：2020-11-23

Applicant: AOBIOME LLC

Inventor： David R. Whitlock ,  Spiros Jamas ,  Larry Weiss ,  Ioannis Gryllos

IPC: C12N1/20 ,  A61K8/99 ,  A61K9/00 ,  A61K35/74 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K48/00 ,  A61L15/36 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07K14/195 ,  C12N1/00 ,  C12Q1/02 ,  C12Q1/689 ,  A61Q19/02 ,  A61Q19/04 ,  C12R1/01

CPC classification number: C12N1/20 ,  A61K8/99 ,  A61K9/0014 ,  A61K35/74 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K48/00 ,  A61L15/36 ,  A61Q15/00 ,  A61Q17/04 ,  A61Q19/00 ,  C07K14/195 ,  C12N1/00 ,  C12N1/205 ,  C12Q1/02 ,  C12Q1/689 ,  A61Q19/02 ,  A61Q19/04 ,  C12R2001/01

Abstract: This disclosure provides, inter alia, an optimized strain of Nitrosomonas eutropha (N. eutropha) designated D23, D23-100, or AOB D23-100. N. eutropha bacteria disclosed in this application have desirable properties, e.g., optimized properties, such as the ability to suppress growth of pathogenic bacteria, and an enhanced ability to produce nitric oxide and nitric oxide precursors. The N. eutropha herein may be used, for instance, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria.

公开(公告)号：US20240301009A1

公开(公告)日：2024-09-12

申请号：US18578302

申请日：2022-07-19

Applicant: The Penn State Research Foundation

Inventor： Joseph Alfred COTRUVO, Jr. ,  Emily Rowland FEATHERSTON ,  Joseph A. MATTOCKS

IPC: C07K14/195 ,  G01N33/18 ,  G01N33/24

CPC classification number: C07K14/195 ,  G01N33/1813 ,  G01N33/24 ,  C07K2319/20

Abstract: The present disclosure provides proteins that bind lanthanides and actinides. Disclosed are proteins based on lanmodulin (LanM) that comprised one or more sensitizers. Various residues in LanM may be substituted with a sensitizer, such as, for example, tryptophan. The proteins may be used to detect and quantify lanthanides and actinides. Also provided are kits and devices.

公开(公告)号：US20240294582A1

公开(公告)日：2024-09-05

申请号：US18655708

申请日：2024-05-06

Applicant: Janssen Pharmaceuticals, Inc.

Inventor： Jan GRIJPSTRA ,  Marleen Eveline WEERDENBURG ,  Jeroen GEURTSEN ,  Cristhina Kellen FAE ,  Jakob Louris FEITSMA

IPC: C07K14/195 ,  A61K39/02 ,  A61K39/108 ,  C07K14/245 ,  C07K16/12

CPC classification number: C07K14/195 ,  A61K39/025 ,  A61K39/0258 ,  A61K39/0266 ,  C07K14/245 ,  C07K16/1232

Abstract: Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

公开(公告)号：US20240287539A1

公开(公告)日：2024-08-29

申请号：US18426976

申请日：2024-01-30

Applicant: Monsanto Technology LLC

Inventor： Gregory J. Bean ,  David J. Bowen ,  Catherine A. Chay ,  Arlene R. Howe ,  Jason S. Milligan ,  Yong Yin

IPC: C12N15/82 ,  A01N63/50 ,  C07K14/195

CPC classification number: C12N15/8286 ,  A01N63/50 ,  C07K14/195

Abstract: Insecticidal proteins exhibiting toxic activity against Coleopteran and Lepidopteran pest species are disclosed, and include, but are not limited to, TIC3668, TIC3669, TIC3670, TIC4076, TIC4078, TIC4260, TIC4346, TIC4826, TIC4861, TIC4862, TIC4863, TIC11239, TIC11243, TIC11256, TIC4544, TIC4545, TIC6871, TIC7429, TIC7497, TIC7511, TIC7513, TIC7518, TIC7524, TIC7526, TIC7528, TIC7535 and TIC-3668-type proteins. DNA molecules and constructs are provided which contain a polynucleotide sequence encoding one or more of the disclosed TIC3668-type proteins. Transgenic plants, plant cells, seed, and plant parts resistant to Lepidopteran and Coleopteran infestation are provided which contain polynucleotide sequences encoding the insecticidal proteins of the present invention. Methods for detecting the presence of the polynucleotides or the proteins of the present invention in a biological sample, and methods of controlling Coleopteran and Lepidopteran species pests using any of the TIC3668-type insecticidal proteins are also provided.

公开(公告)号：US20240287478A1

公开(公告)日：2024-08-29

申请号：US18681152

申请日：2022-08-06

Applicant: ISOBIONICS B.V.

Inventor： Martinus Julius BEEKWILDER ,  Matthew Quinn STYLES ,  Susan Eline BOUWMEESTER ,  Hendrik Jan BOSCH

IPC: C12N9/02 ,  C07K14/195 ,  C12N9/88 ,  C12N15/52 ,  C12P5/00

CPC classification number: C12N9/0095 ,  C07K14/195 ,  C12N9/0077 ,  C12N9/88 ,  C12N15/52 ,  C12P5/007

Abstract: An artificial alkane oxidation system comprising components: a. an oxidase enzyme; and b. one or more enzymes to provide one or more alkanes. The artificial alkane oxidation system optionally has c. an electron transfer compound suitable to transfer at least one electron to the oxidase enzyme; and further optionally has d. an electron transfer compound regeneration enzyme suitable to reduce the electron transfer compound of c. when it is in its oxidized state. The oxidase enzyme is an amino acid sequence with a sequence identity of at least 70% with any one of SEQ ID NO: 1, 10, 11, 23 to 43 or a fragment thereof or a variant thereof.

公开(公告)号：US20240284945A1

公开(公告)日：2024-08-29

申请号：US18572037

申请日：2022-06-27

Applicant: Cargill, Incorporated

Inventor： Hans H. LIAO ,  Catherine Bradshaw POOR

IPC: A23L5/43 ,  A23J3/16 ,  A23J3/18 ,  A23J3/22 ,  C07K14/195 ,  C09B61/00

CPC classification number: A23L5/43 ,  A23J3/16 ,  A23J3/18 ,  A23J3/227 ,  C07K14/195 ,  C09B61/00

Abstract: Disclosed herein are pigment compositions for meat substitutes and meat substitutes including such pigment compositions. The pigment compositions include a thermolabile AlacDFX variant polypeptide, e.g. a thermolabile DFX polypeptide including a sequence at least 80% identical to SEQ ID NO:1 and including a mutation at a position selected from the group consisting of I76, H68, E106, K58, E108, K90, I15, I16, I89, Q88, F102, Y80, Y7, and combinations thereof relative to SEQ ID NO:1. The pigment compositions provide a pink and/or red color to a meat substitute composition that transitions to a brown color after cooking.

公开(公告)号：US12071454B2

公开(公告)日：2024-08-27

申请号：US17061065

申请日：2020-10-01

Applicant: Sanofi

Inventor： Gary J. Nabel ,  Chih-Jen Wei ,  Kurt Swanson ,  Pradeep Dhal ,  Ram Dharanipragada ,  Magnus Besev

IPC: C07K14/195

CPC classification number: C07K14/195 ,  C07K2319/30

Abstract: Antigenic respiratory syncytial virus (RSV) polypeptides for use in eliciting antibodies against RSV are provided. Also provided are antigenic polypeptides comprising an RSV polypeptide and a ferritin protein.