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    DETECTION OF HEPATITIS B VIRUS IN BLOOD USING LAMP METHOD
    7.
    发明申请
    DETECTION OF HEPATITIS B VIRUS IN BLOOD USING LAMP METHOD 审中-公开
    使用灯泡方法检测血液中乙型肝炎病毒

    公开(公告)号：US20120202190A1

    公开(公告)日：2012-08-09

    申请号：US13370283

    申请日：2012-02-09

    申请人： Wei-Mei Ching ,  Chien-Chung Chao ,  Hua-Wei Chen

    发明人： Wei-Mei Ching ,  Chien-Chung Chao ,  Hua-Wei Chen

    IPC分类号： C12Q1/70

    CPC分类号： C12Q1/706

    摘要： A method for detection blood borne pathogen in whole blood, comprising collecting a blood sample from a subject, heating said sample for a period of time, adding said heated sample to a pre-mixed LAMP solution comprising one or more LAMP primer set, and Bst DNA polymerase to create a reaction mixture, incubating said reaction mixture for a period of time and determining the presence of blood born pathogen.

    摘要翻译： 一种全血检测血液传播病原体的方法，包括从受试者收集血液样品，加热所述样品一段时间，将所述加热的样品加入到包含一个或多个LAMP引物组和Bst的预混合LAMP溶液中 DNA聚合酶以产生反应混合物，将所述反应混合物温育一段时间并确定血液中的病原体的存在。

    Recombinant chimeric antigens for diagnosis and prevention of scrub typhus
    8.
    发明授权
    Recombinant chimeric antigens for diagnosis and prevention of scrub typhus 有权
    用于诊断和预防恙虫病的重组嵌合抗原

    公开(公告)号：US08029804B2

    公开(公告)日：2011-10-04

    申请号：US12467533

    申请日：2009-05-18

    申请人： Wei-Mei Ching ,  Chien-Chung Chao

    发明人： Wei-Mei Ching ,  Chien-Chung Chao

    IPC分类号： A61K39/02

    CPC分类号： G01N33/56911 ,  C07K14/195 ,  Y02A50/59

    摘要： Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as Karp, Kato (Ktr56), Gilliam (Gmr56), and TA763 (TAr56). The invention is useful for detecting prior exposure to a number of strains of scrub typhus, based on the strength of reaction toward the chimeric protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects against heterologous infections.

    摘要翻译： 重组嵌合抗原包括多重斑马疹病毒株，如Karp，Kato（Ktr56），Gillam（Gmr56）和TA763（TAr56）的重组56kDa蛋白的表达产物的未修饰和修饰的反应性多肽片段。 基于针对嵌合蛋白的反应强度以及作为疫苗制剂中的组分和免疫球蛋白的产生，本发明可用于检测先前暴露于许多恙虫病菌株的方法，用于针对异源感染的受试者的被动预防和免疫。

    Cloning and expression of the full length 110 KDa antigen of Orientia tsutsugamushi to be used as a vaccine component against scrub typhus
    9.
    发明申请
    Cloning and expression of the full length 110 KDa antigen of Orientia tsutsugamushi to be used as a vaccine component against scrub typhus 有权
    克隆和表达恙虫病东方全长110KDa抗原，用作疫苗组分，用于恙虫病

    公开(公告)号：US20050234005A1

    公开(公告)日：2005-10-20

    申请号：US11108867

    申请日：2005-04-19

    申请人： Wei-Mei Ching ,  Chien-Chung Chao

    发明人： Wei-Mei Ching ,  Chien-Chung Chao

    IPC分类号： A61K38/00 ,  A61K38/19 ,  A61K38/20 ,  A61K48/00 ,  C07K14/29 ,  C12N15/74

    CPC分类号： C07K14/29 ,  A61K38/00 ,  A61K48/00 ,  Y10S530/825

    摘要： The inventive subject matter relates to a recombinant 110 kDa protein from O. tsutsugamuchi, Karp, Kato and Gilliam strains and for a DNA expression system containing DNA encoding the 110 kDa protein of O. tsutsugamuchi. The invention also relates to the use of these recombinant contructs in a formulation for the induction of a protective immune response against O. tsutsugamuchi invection using. The inventive subject matter also relates to a recombinant 110 kDa O. tsutsugamuchi protein or 110 kDa fragments for the production of antigen for use in immunodiagnosistic asssays for scrub typhus.

    摘要翻译： 本发明涉及来自恙虫螨，Karp，Kato和Gilliam菌株的重组110kDa蛋白质，以及含有编码恙虫the the的110kDa蛋白质的DNA的DNA表达系统。 本发明还涉及这些重组构型在制剂中用于诱导针对恙虫病ts疮侵入的保护性免疫应答的用途。 本发明还涉及用于产生抗原的重组110kDa O. tsutsugamami蛋白或110kDa片段，用于免疫诊断性屁股用于恙虫病。

    RECOMBINANT CHIMERIC ANTIGENS FOR DIAGNOSIS AND PREVENTION OF SCRUB TYPHUS
    10.
    发明申请
    RECOMBINANT CHIMERIC ANTIGENS FOR DIAGNOSIS AND PREVENTION OF SCRUB TYPHUS 有权
    用于诊断和预防淋巴细胞的重组抗体

    公开(公告)号：US20120171237A1

    公开(公告)日：2012-07-05

    申请号：US13371578

    申请日：2012-02-13

    申请人： Wei-Mei Ching ,  Chien-Chung Chao

    发明人： Wei-Mei Ching ,  Chien-Chung Chao

    IPC分类号： A61K39/02 ,  A61P37/04 ,  G01N33/566 ,  C07K14/195 ,  A61P31/04

    CPC分类号： G01N33/56911 ,  C07K14/195 ,  Y02A50/59

    摘要： Recombinant chimeric antigens comprising unmodified and modified reactive polypeptide fragments of expressed product of the recombinant 56 kDa proteins of multiple strain of scrub typhus, such as Karp, Kato (Ktr56), Gilliam (Gmr56), and TA763 (TAr56). The invention is useful for detecting prior exposure to a number of strains of scrub typhus, based on the strength of reaction toward the chimeric protein and as a component in vaccine formulations and production of immune globulins for passive prophylaxis and immunity in subjects against heterologous infections.

    摘要翻译： 重组嵌合抗原包括多重斑马疹病毒株，如Karp，Kato（Ktr56），Gillam（Gmr56）和TA763（TAr56）的重组56kDa蛋白的表达产物的未修饰和修饰的反应性多肽片段。 基于针对嵌合蛋白的反应强度以及作为疫苗制剂中的组分和免疫球蛋白的产生，本发明可用于检测先前暴露于许多恙虫病菌株的方法，用于针对异源感染的受试者的被动预防和免疫。