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41.发明申请Compositions of low molecular weight heparin produced with modified heparinase III 审中-公开用改良的肝素酶III生产的低分子量肝素的组合物公开(公告)号：US20060183713A1
公开(公告)日：2006-08-17
申请号：US11406215
申请日：2006-04-18
申请人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
发明人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
IPC分类号： A61K31/727 , C12P19/28
CPC分类号： C12P19/26 , A61K31/726 , A61K38/51 , C08B37/0075 , C12N9/88 , C12Q1/527 , G01N2333/988 , G01N2500/02 , Y10S530/811 , A61K31/00 , A61K2300/00
摘要： The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
摘要翻译： 本发明涉及肝素酶III及其突变体。 根据本发明已经发现具有降低的酶活性的修饰形式的肝素酶III可用于各种目的，包括肝素样糖胺聚糖（HLGAG）的测序，从溶液中除去活性硫酸乙酰肝素，血管生成抑制等 。 本发明在其它方面涉及使用肝素酶III或通过HLGAG的肝素酶III的酶切割产生的产物来治疗癌症并抑制肿瘤细胞生长和/或转移的方法。
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公开(公告)号：US20050214276A9
公开(公告)日：2005-09-29
申请号：US10429921
申请日：2003-05-05
CPC分类号： C12Y302/01056 , A61K38/00 , C07H21/04 , C12N9/2402 , C12Q1/34 , C12Y302/01166 , Y02A50/481
摘要： The invention relates to Δ4,5 glycuronidase, related compositions, and methods of use thereof.
摘要翻译： 本发明涉及Delta4,5糖醛酸糖苷酶，相关组合物及其使用方法。
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公开(公告)号：US07270815B2
公开(公告)日：2007-09-18
申请号：US10753761
申请日：2004-01-07
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。
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44.发明申请公开(公告)号：US20070066769A1
公开(公告)日：2007-03-22
申请号：US11518394
申请日：2006-09-08
IPC分类号： C08G85/00
CPC分类号： C07K1/00 , G16B50/00 , G16C20/20 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
摘要翻译： 本发明涉及确定和表征聚合物性质以提供关于聚合物的信息的方法，例如聚合物的电荷，聚合物单元的数量，类型或特性以及聚合物的顺序。 本发明还涉及聚合物如核酸，多肽和多糖的测序方法以及鉴定多糖 - 蛋白质相互作用的方法。
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公开(公告)号：US20060292130A1
公开(公告)日：2006-12-28
申请号：US11433224
申请日：2006-05-11
CPC分类号： C12N9/16 , A61K38/00 , C12P19/04 , G01N33/5041 , G01N2400/40
摘要： The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGs) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.
摘要翻译： 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAG）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。
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公开(公告)号：US20060067928A1
公开(公告)日：2006-03-30
申请号：US11187571
申请日：2005-07-22
申请人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
发明人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
CPC分类号： C12P19/26 , A61K31/726 , A61K38/51 , C08B37/0075 , C12N9/88 , C12Q1/527 , G01N2333/988 , G01N2500/02 , Y10S530/811 , A61K31/00 , A61K2300/00
摘要： The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis , etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
摘要翻译： 本发明涉及肝素酶III及其突变体。 根据本发明已经发现具有降低的酶活性的修饰形式的肝素酶III可用于各种目的，包括肝素样糖胺聚糖（HLGAG）的测序，从溶液中除去活性硫酸乙酰肝素，血管生成抑制等 。 本发明在其它方面涉及使用肝素酶III或通过HLGAG的肝素酶III的酶切割产生的产物来治疗癌症并抑制肿瘤细胞生长和/或转移的方法。
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公开(公告)号：US20050233402A1
公开(公告)日：2005-10-20
申请号：US10967067
申请日：2004-10-14
申请人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
发明人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
IPC分类号： C12N15/09 , A61K31/726 , A61K38/00 , A61K38/51 , A61K45/00 , A61K47/48 , A61K48/00 , A61P9/00 , A61P17/06 , A61P27/02 , A61P35/00 , A61P35/04 , C08B37/00 , C08B37/10 , C12N9/24 , C12N9/88 , C12N15/60 , C12P19/26 , C12P19/28 , C12Q1/34 , C12Q1/527
CPC分类号： C12P19/26 , A61K31/726 , A61K38/51 , C08B37/0075 , C12N9/88 , C12Q1/527 , G01N2333/988 , G01N2500/02 , Y10S530/811 , A61K31/00 , A61K2300/00
摘要： The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
摘要翻译： 本发明涉及肝素酶III及其突变体。 根据本发明已经发现具有降低的酶活性的修饰形式的肝素酶III可用于各种目的，包括肝素样糖胺聚糖（HLGAG）的测序，从溶液中除去活性硫酸乙酰肝素，血管生成抑制等 。 本发明在其它方面涉及使用肝素酶III或通过HLGAG的肝素酶III的酶切割产生的产物来治疗癌症并抑制肿瘤细胞生长和/或转移的方法。
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公开(公告)号：US08338088B2
公开(公告)日：2012-12-25
申请号：US12595902
申请日：2008-04-15
申请人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
发明人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
IPC分类号： C12Q1/00
CPC分类号： G01N33/5308 , G01N2400/00
摘要： The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
摘要翻译： 本公开提供了通过分析细胞上的细胞表面聚糖来评估由细胞产生的目标糖蛋白的糖基化的方法。 因此，本发明公开了细胞表面蛋白的糖基化可以作为其他蛋白质糖基化的代用物。
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公开(公告)号：US07939292B2
公开(公告)日：2011-05-10
申请号：US12261004
申请日：2008-10-29
申请人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
发明人： Dongfang Liu , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
IPC分类号： C12P1/00
CPC分类号： C12P19/26 , A61K31/726 , A61K38/51 , C08B37/0075 , C12N9/88 , C12Q1/527 , G01N2333/988 , G01N2500/02 , Y10S530/811 , A61K31/00 , A61K2300/00
摘要： The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
摘要翻译： 本发明涉及肝素酶III及其突变体。 根据本发明已经发现具有降低的酶活性的修饰形式的肝素酶III可用于各种目的，包括肝素样糖胺聚糖（HLGAG）的测序，从溶液中除去活性硫酸乙酰肝素，血管生成抑制等 。 本发明在其它方面涉及使用肝素酶III或通过HLGAG的肝素酶III的酶切割产生的产物来治疗癌症并抑制肿瘤细胞生长和/或转移的方法。
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公开(公告)号：US20100196940A1
公开(公告)日：2010-08-05
申请号：US12595902
申请日：2008-04-15
申请人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
发明人： Brian Edward Collins , Carlos J. Bosques , Xiangping Zhu , Dorota A. Bulik , Lakshmanan Thiruneelakantapillai , Ian Christopher Parsons , Zachary Shriver , Rajeev Chillakuru , Ganesh Venkataraman
CPC分类号： G01N33/5308 , G01N2400/00
摘要： The present disclosure provides methods for assessing the glycosylation of a target glycoprotein produced by a cell through analysis of cell-surface glycans on the cell. The present disclosure therefore teaches that glycosylation of cell surface proteins can serve as a proxy for glycosylation of other proteins.
摘要翻译： 本公开提供了通过分析细胞上的细胞表面聚糖来评估由细胞产生的目标糖蛋白的糖基化的方法。 因此，本发明公开了细胞表面蛋白的糖基化可以作为其他蛋白质糖基化的代用物。
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