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1.发明申请公开(公告)号：US20070066769A1
公开(公告)日：2007-03-22
申请号：US11518394
申请日：2006-09-08
IPC分类号： C08G85/00
CPC分类号： C07K1/00 , G16B50/00 , G16C20/20 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
摘要翻译： 本发明涉及确定和表征聚合物性质以提供关于聚合物的信息的方法，例如聚合物的电荷，聚合物单元的数量，类型或特性以及聚合物的顺序。 本发明还涉及聚合物如核酸，多肽和多糖的测序方法以及鉴定多糖 - 蛋白质相互作用的方法。
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2.发明申请公开(公告)号：US20090119027A1
公开(公告)日：2009-05-07
申请号：US12260992
申请日：2008-10-29
IPC分类号： G06F19/00
CPC分类号： C07K1/00 , G16B50/00 , G16C20/20 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
摘要翻译： 本发明涉及确定和表征聚合物性质以提供关于聚合物的信息的方法，例如聚合物的电荷，聚合物单元的数量，类型或特性以及聚合物的顺序。 本发明还涉及聚合物如核酸，多肽和多糖的测序方法以及鉴定多糖 - 蛋白质相互作用的方法。
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公开(公告)号：US07139666B2
公开(公告)日：2006-11-21
申请号：US10356349
申请日：2003-01-31
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
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公开(公告)号：US06947849B2
公开(公告)日：2005-09-20
申请号：US10356349
申请日：2003-01-31
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
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公开(公告)号：US07412332B1
公开(公告)日：2008-08-12
申请号：US09557997
申请日：2000-04-24
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. Also disclosed is a computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, and the polymer is represented by a second data structure, each are tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence and polymer, respectively. The invention also involves a notational system referred to as Property Encoded Nomenclature.
摘要翻译： 公开了一种有形地体现在表示化学单元的聚合物的计算机可读介质中的数据结构。 数据结构包括标识符，其包括用于存储与聚合物的性质对应的值的多个场。 聚合物可以是例如多糖，化学单元可以是糖。 还公开了一种用于确定化学单元的查询序列的属性是否与化学单元的聚合物的性质匹配的计算机实现的方法。 查询序列由第一数据结构表示，并且聚合物由第二数据结构表示，每个数据结构都有形地体现在计算机可读介质中，包括包括多个位字段的标识符，用于存储对应于 查询序列和聚合物。 本发明还涉及称为属性编码术语的符号系统。
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公开(公告)号：US07110889B2
公开(公告)日：2006-09-19
申请号：US10760133
申请日：2004-01-16
IPC分类号： G06F19/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
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7.发明申请DATA STRUCTURES REPRESENTING POLYSACCHARIDES AND DATABASES AND METHODS RELATED THERETO 审中-公开代表多糖和数据库的数据结构及其相关方法公开(公告)号：US20080301178A1
公开(公告)日：2008-12-04
申请号：US12133334
申请日：2008-06-04
IPC分类号： G06F17/30
CPC分类号： C07K1/00 , G16B50/00 , G16C20/20 , Y10S707/99936 , Y10S707/99943
摘要： A data structure, tangibly embodied in a computer-readable medium, representing a polymer of chemical units is disclosed. The data structure includes an identifier including a plurality of fields for storing values corresponding to properties of the polymer. The polymer may, for example, be a polysaccharide and the chemical units may be saccharides. Also disclosed is a computer-implemented method for determining whether properties of a query sequence of chemical units match properties of a polymer of chemical units. The query sequence is represented by a first data structure, and the polymer is represented by a second data structure, each are tangibly embodied in a computer-readable medium, including an identifier including a plurality of bit fields for storing values corresponding to properties of the query sequence and polymer, respectively. The invention also involves a notational system referred to as Property Encoded Nomenclature.
摘要翻译： 公开了一种有形地体现在表示化学单元的聚合物的计算机可读介质中的数据结构。 数据结构包括标识符，其包括用于存储与聚合物的性质对应的值的多个场。 聚合物可以是例如多糖，化学单元可以是糖。 还公开了一种用于确定化学单元的查询序列的属性是否与化学单元的聚合物的性质匹配的计算机实现的方法。 查询序列由第一数据结构表示，并且聚合物由第二数据结构表示，每个数据结构都有形地体现在计算机可读介质中，包括包括多个位字段的标识符，用于存储对应于 查询序列和聚合物。 本发明还涉及称为属性编码术语的符号系统。
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公开(公告)号：US07117100B2
公开(公告)日：2006-10-03
申请号：US10759520
申请日：2004-01-16
IPC分类号： G06F17/00
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
摘要翻译： 本发明涉及确定和表征聚合物性质以提供关于聚合物的信息的方法，例如聚合物的电荷，聚合物单元的数量，类型或特性以及聚合物的顺序。 本发明还涉及聚合物如核酸，多肽和多糖的测序方法以及鉴定多糖 - 蛋白质相互作用的方法。
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公开(公告)号：US06597996B1
公开(公告)日：2003-07-22
申请号：US09558137
申请日：2000-04-24
IPC分类号： G06F1900
CPC分类号： G06F19/703 , C07K1/00 , G06F19/28 , Y10S707/99936 , Y10S707/99943
摘要： The invention relates to methods of identifying and characterizing properties of polymers to provide information about the polymer such as the charge of the polymer, the number and types or characteristics of units of the polymer and the sequence of the polymers. The invention also relates to methods of sequencing polymers such as nucleic acids, polypeptides and polysaccharides and methods for identifying a polysaccharide-protein interaction.
摘要翻译： 本发明涉及确定和表征聚合物性质以提供关于聚合物的信息的方法，例如聚合物的电荷，聚合物单元的数量，类型或特性以及聚合物的顺序。 本发明还涉及聚合物如核酸，多肽和多糖的测序方法以及鉴定多糖 - 蛋白质相互作用的方法。
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10.发明申请公开(公告)号：US20100144553A1
公开(公告)日：2010-06-10
申请号：US12623070
申请日：2009-11-20
申请人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
发明人： Carlos Bosques , Nishla Keiser , Aravind Srinivasan , Rahul Raman , Karthik Viswanathan , Ram Sasisekharan , Pankaj Gandhe , Sasi Raguram
IPC分类号： C40B40/12
CPC分类号： G01N33/6851 , G01N33/66 , G01N33/68 , G01N33/6842 , G01N33/6848 , G01N2400/10 , G06F19/703
摘要： The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation.
摘要翻译： 本发明部分涉及碳水化合物的改进分析。 特别地，本发明涉及碳水化合物的分析，例如在蛋白质上发现的N-聚糖和O-聚糖以及与脂质连接的糖。 因此，还提供了改进的方法，用于研究细胞，组织和体液上的糖基化模式。 来自聚糖分析的信息，例如细胞，组织和体液中的糖基化模式，可用于诊断和治疗方法以及促进糖基化/改变糖基化作用的研究。 还提供了这样的方法。 进一步提供方法以评估生产过程，以评估含有糖缀合物的样品的纯度，并选择具有所需糖基化的糖缀合物。
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