公开(公告)号：US08358408B2

公开(公告)日：2013-01-22

申请号：US12771824

申请日：2010-04-30

Applicant: Wei Wu ,  Min Hu ,  Fung Suong Ou ,  Zhiyong Li

Inventor： Wei Wu ,  Min Hu ,  Fung Suong Ou ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00

Abstract: An apparatus for performing Surface Enhanced Raman Spectroscopy (SERS) includes a reflective layer positioned above the substrate, a plurality of tapered nanowires disposed above the reflective layer, each of the plurality of tapered nanowires having a tapered end directed away from the reflective layer.

Abstract translation: 用于进行表面增强拉曼光谱（SERS）的设备包括位于衬底上方的反射层，设置在反射层上方的多个锥形纳米线，多个锥形纳米线中的每一个具有远离反射层的锥形端。

公开(公告)号：US20120281729A1

公开(公告)日：2012-11-08

申请号：US13387075

申请日：2010-01-29

Applicant: Fung Suong Ou ,  Zhiyong Li ,  Huei Pei Kuo ,  Min Hu

Inventor： Fung Suong Ou ,  Zhiyong Li ,  Huei Pei Kuo ,  Min Hu

IPC: G01K5/48 ,  B44C1/22

CPC classification number: B82Y15/00 ,  G01N21/658 ,  H01L29/0665

Abstract: An environment sensitive device is disclosed. The device includes a substrate, a three-dimensional structure established on the substrate, a first coating established on a first portion of the three-dimensional structure, and a second coating established on a second portion of the three-dimensional structure. The first and second coatings contain different materials that are configured to respond differently when exposed to a predetermined external stimulus.

Abstract translation: 公开了一种环境敏感设备。 该装置包括衬底，在衬底上建立的三维结构，在三维结构的第一部分上建立的第一涂层和建立在三维结构的第二部分上的第二涂层。 第一和第二涂层包含不同的材料，其被配置成当暴露于预定的外部刺激时不同地响应。

公开(公告)号：US20120188539A1

公开(公告)日：2012-07-26

申请号：US13014683

申请日：2011-01-26

Applicant: Michael J. Stuke ,  Shih-Yuan (SY) Wang ,  Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Huei Pei Kuo

Inventor： Michael J. Stuke ,  Shih-Yuan (SY) Wang ,  Zhiyong Li ,  Min Hu ,  Fung Suong Ou ,  Huei Pei Kuo

IPC: G01J3/44 ,  B82Y20/00

CPC classification number: B82Y20/00 ,  G01N21/658

Abstract: A nanorod surface enhanced Raman spectroscopy (SERS) apparatus, system and method of SERS using nanorods that are activated with a key. The nanorod SERS apparatus includes a plurality of nanorods, an activator to move the nanorods from an inactive to an active configuration and the key to trigger the activator. The nanorod SERS system further includes a Raman signal detector and an illumination source. The method of SERS using nanorods includes activating a plurality of nanorods with the key, illuminating the activated plurality of nanorods, and detecting a Raman scattering signal when the nanorods are in the active configuration.

Abstract translation: 纳米棒表面增强拉曼光谱（SERS）装置，使用由键激活的纳米棒的SERS的系统和方法。 纳米棒SERS装置包括多个纳米棒，激活剂将纳米棒从非活性构型移动到活性构型，以及触发激活剂的键。 纳米棒SERS系统还包括拉曼信号检测器和照明源。 使用纳米棒的SERS的方法包括用键激活多个纳米棒，照亮激活的多个纳米棒，以及当纳米棒处于活动配置时检测拉曼散射信号。

公开(公告)号：US20120119315A1

公开(公告)日：2012-05-17

申请号：US13384950

申请日：2010-01-29

Applicant: Fung Suong Ou ,  Huei Pei Kuo ,  Zhiyong Li ,  Min Hu

Inventor： Fung Suong Ou ,  Huei Pei Kuo ,  Zhiyong Li ,  Min Hu

IPC: H01L23/48 ,  H01L21/28 ,  H01L31/0224

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/44 ,  G01N27/12

Abstract: A sensing device (10, 10′) includes a substrate (14), and first and second electrodes (EIC, EICS, EO) established on the substrate (14). The first electrode (EIC, EICS) has a three-dimensional shape, and the second electrode (EO) is electrically isolated from and surrounds a perimeter of the first electrode (EIC, EICS).

Abstract translation: 感测装置（10,10'）包括衬底（14）以及在衬底（14）上建立的第一和第二电极（EIC，EICS，EO）。 第一电极（EIC，EICS）具有三维形状，并且第二电极（EO）与第一电极（EIC，EICS）的周边电隔离并围绕第一电极的周边。

公开(公告)号：US20120113420A1

公开(公告)日：2012-05-10

申请号：US13384456

申请日：2009-09-17

Applicant: Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexander M. Bratkovski

Inventor： Huei Pei Kuo ,  Shih-Yuan Wang ,  Min Hu ,  Zhiyong Li ,  Alexander M. Bratkovski

IPC: G01J3/44

CPC classification number: G01N21/658 ,  B82Y15/00 ,  B82Y30/00

Abstract: An electrically driven device (10) for surface enhanced Raman spectroscopy includes a first electrode (16), a substrate (12) positioned proximate to the first electrode (16), a plurality of cone shaped protrusions (12′) formed integrally with or on a substrate surface (S), a Raman signal-enhancing material (14) coated on each protrusion (12′), and a second electrode (18) positioned relative to the first electrode (16) at a predetermined distance, D. Each of the protrusions (12′) has a tip (22) with a radius of curvature, r, ranging from about 0.1 nm to about 100 nm. The second electrode (18) is positioned relative to the first electrode (16) such that the electrodes (16, 18) together produce an electric field (EF) when a voltage bias is applied therebetween. The electric field (EF) has a field distribution that creates a stronger field gradient at a region proximate to the tips (22) than at other portions of the substrate (12).

Abstract translation: 用于表面增强拉曼光谱的电驱动装置（10）包括第一电极（16），靠近第一电极（16）定位的基板（12），与该第一电极（16）一体形成的多个锥形突起 涂覆在每个突起（12'）上的衬底表面（S），拉曼信号增强材料（14）和相对于第一电极（16）以预定距离D定位的第二电极（D）。 突起（12'）具有从约0.1nm至约100nm范围内的具有曲率半径r的尖端（22）。 第二电极（18）相对于第一电极（16）定位，使得当施加电压时，电极（16,18）一起产生电场（EF）。 电场（EF）具有在靠近尖端（22）的区域处比在衬底（12）的其它部分处产生更强的场梯度的场分布。

公开(公告)号：US20120107569A1

公开(公告)日：2012-05-03

申请号：US12916239

申请日：2010-10-29

Applicant: Michael Josef Stuke ,  Zhiyong Li ,  Shih-Yuan Wang ,  Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Lars Helge Thylen

Inventor： Michael Josef Stuke ,  Zhiyong Li ,  Shih-Yuan Wang ,  Fung Suong Ou ,  Min Hu ,  Wei Wu ,  Lars Helge Thylen

IPC: B32B3/30 ,  B05D3/06 ,  B05D3/02 ,  B05D1/36 ,  B05D3/00

CPC classification number: G01N21/658 ,  B81B3/0005 ,  Y10T428/24355 ,  Y10T428/24612

Abstract: A device for Surface Enhanced Raman Scattering (SERS). The device includes a plurality of nanostructures protruding from a surface of a substrate, a SERS active metal disposed on a portion of said plurality of nanostructures, and a low friction film disposed over the plurality of nanostructures and the SERS active metal. The low friction film is to prevent adhesion between the plurality of nanostructures.

Abstract translation: 用于表面增强拉曼散射（SERS）的器件。 该装置包括从衬底表面突出的多个纳米结构，设置在所述多个纳米结构的一部分上的SERS活性金属，以及设置在多个纳米结构和SERS活性金属上的低摩擦膜。 低摩擦膜是为了防止多个纳米结构之间的粘附。

公开(公告)号：US20110267606A1

公开(公告)日：2011-11-03

申请号：US12771440

申请日：2010-04-30

Applicant: Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

Inventor： Fung Suong Ou ,  Zhiyong Li ,  Min Hu ,  Wei Wu

IPC: G01J3/44 ,  G02B1/12

CPC classification number: G02B1/12 ,  G01N21/658

Abstract: A surface-enhanced Raman spectroscopy device includes a substrate, and an ultraviolet cured resist disposed on the substrate. The ultraviolet cured resist has a pattern of cone-shaped protrusions, where each cone-shaped protrusion has a tip with a radius of curvature equal to or less than 10 nm. The ultraviolet cured resist is formed of a predetermined ratio of a photoinitiator, a cross-linking agent, and a siloxane based backbone chain. A Raman signal-enhancing material is disposed on each of the cone-shaped protrusions.

Abstract translation: 表面增强拉曼光谱装置包括基板和设置在基板上的紫外线固化抗蚀剂。 紫外线固化抗蚀剂具有锥形突起的图案，其中每个锥形突起具有等于或小于10nm的曲率半径的尖端。 紫外线固化的抗蚀剂由光引发剂，交联剂和基于硅氧烷的主链以预定比例形成。 拉曼信号增强材料设置在每个锥形突起上。

公开(公告)号：US10520440B2

公开(公告)日：2019-12-31

申请号：US14377524

申请日：2012-02-08

Applicant: Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

Inventor： Devin Alexander Mourey ,  James William Stasiak ,  James Elmer Abbott, Jr. ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

Abstract: Molecule sensing apparatus. The apparatus has first and second chambers, an input port extending into the first chamber, a fluid channel extending from the first chamber to the second chamber, and a surface-enhanced substrate in the second chamber.

公开(公告)号：US09592001B2

公开(公告)日：2017-03-14

申请号：US14406601

申请日：2012-07-29

Applicant: Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

Inventor： Steven Barcelo ,  Zhiyong Li ,  Ansoon Kim ,  Gary Gibson

IPC: G01J3/44 ,  A61B5/1459 ,  G01N21/65 ,  A61B5/00

CPC classification number: A61B5/1459 ,  A61B5/0075 ,  A61B5/6862 ,  G01N21/658

Abstract: An implantable nanosensor includes a stent to be implanted inside a fluid conduit. The stent has a well in a surface of the stent. The implantable nanosensor further includes a nanoscale-patterned sensing substrate disposed in the well. The nanoscale-patterned sensing substrate is to produce an optical scattering response signal indicative of a presence of an analyte in a fluid carried by the fluid conduit when interrogated by an optical stimulus signal.

Abstract translation: 可植入纳米传感器包括待植入流体导管内的支架。 支架在支架表面有一个井。 可植入纳米传感器还包括设置在井中的纳米级图案感测基片。 纳米级图案化感测衬底将产生光学散射响应信号，该信号指示由光学刺激信号询问时由流体导管携带的流体中分析物的存在。

公开(公告)号：US09310306B2

公开(公告)日：2016-04-12

申请号：US14006436

申请日：2011-03-24

Applicant: Zhiyong Li ,  Ivan Naumov ,  Farzad Parvaresh

Inventor： Zhiyong Li ,  Ivan Naumov ,  Farzad Parvaresh

IPC: G01J3/44 ,  G01N21/65 ,  B05D3/00

CPC classification number: G01N21/65 ,  B05D3/007 ,  G01N21/658

Abstract: An apparatus for use in sensing applications includes a substrate and a plurality of clusters arranged in an aperiodic configuration on the substrate, wherein each of the plurality of clusters is formed of a plurality of Raman-active material nano-particles, and wherein each of the Raman-active material nano-particles is positioned in a substantially ordered configuration with respect to each other in each of the respective plurality of clusters.

Abstract translation: 用于感测应用的装置包括基板和在基板上以非周期配置布置的多个簇，其中多个簇中的每一个由多个拉曼活性材料纳米颗粒形成，并且其中 拉曼活性材料纳米颗粒在相应的多个簇中的每一个中相对于彼此定位成基本排列的构型。