利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

342 条记录 (耗时 0.015 秒)

    Method of synthesizing fatty acid esters of ascorbic acid
    41.
    发明授权
    Method of synthesizing fatty acid esters of ascorbic acid 失效
    合成抗坏血酸脂肪酸酯的方法

    公开(公告)号：US4151178A

    公开(公告)日：1979-04-24

    申请号：US872994

    申请日：1978-01-27

    申请人： Paul A. Seib ,  Raymond C. Cousins ,  Russell C. Hoseney

    发明人： Paul A. Seib ,  Raymond C. Cousins ,  Russell C. Hoseney

    IPC分类号： C07D307/62

    CPC分类号： C07D307/62

    摘要： A high-yield process of producing essentially pure fatty acid esters of ascorbic acid is disclosed which gives significantly increased yields of esters using a simple reaction scheme and an excess of relatively inexpensive, recoverable fatty acids, as opposed to use of an excess of ascorbic acid. The process hereof comprises reacting an ascorbic acid isomer and a saturated fatty acid in concentrated sulfuric acid at ambient or relatively low temperatures, followed by ester recovery. Surprisingly, enchanced yields are obtained by using a molar excess of fatty acid relative to the ascorbic acid, 98-99% concentrated sulfuric acid as opposed to 95% sulfuric acid, and/or a molar ratio of the sum of the fatty acid and ascorbic acid to sulfuric acid of from about 0.1 to 0.3.

    摘要翻译： 公开了生产基本上纯的抗坏血酸脂肪酸酯的高产量方法，其使用简单的反应方案和过量的相对便宜的可回收脂肪酸显着提高酯的产率，而不是使用过量的抗坏血酸 。 其方法包括在环境温度或较低温度下使抗坏血酸异构体和饱和脂肪酸在浓硫酸中反应，随后进行酯回收。 令人惊奇的是，通过使用相对于抗坏血酸的摩尔过量的脂肪酸，与95％硫酸相反的98-99％的浓硫酸和/或脂肪酸和抗坏血酸的总和的摩尔比来获得增强的产量 酸至硫酸为约0.1至0.3。

    Preparation of l-ascorbate 2-sulfate from l-ascorbic acid
    42.
    发明授权
    Preparation of l-ascorbate 2-sulfate from l-ascorbic acid 失效
    从1-抗坏血酸制备1-抗坏血酸2-硫酸盐

    公开(公告)号：US3954809A

    公开(公告)日：1976-05-04

    申请号：US325652

    申请日：1973-01-22

    申请人： Charles W. Deyoe ,  Paul A. Seib ,  R. Carl Hoseney

    发明人： Charles W. Deyoe ,  Paul A. Seib ,  R. Carl Hoseney

    IPC分类号： C07D307/62

    CPC分类号： C07D307/62

    摘要： A method is provided for the synthesis of L-ascorbate 2-sulfate compounds and salts thereof which comprises reacting L-ascorbic acid or the salts thereof of the formula ##EQU1## WHERE Z represents hydrogen or a cation capable of bonding with L-ascorbic acid, and n.sub.1 is the valence of Z, with a base-sulfur trioxide complex of the formula ##EQU2## where A represents a tertiary amine, tertiary amide, ether or thioether, the reaction being carried out in a compatible solvent and in the presence of sufficient base to render the C.sub.2 hydroxyl of the L-ascorbic acid more ionized than the C.sub.5 and C.sub.6 hydroxyls thereof. The process effects quantitative conversion of L-ascorbic acid to L-ascorbate 2-sulfate, and pure compounds of the latter are isolated in good yields. Such compounds have been found to act as stable vitamin C sources in food systems or the like.

    摘要翻译： 提供了用于合成L-抗坏血酸盐2-硫酸盐化合物及其盐的方法，其包括使L-抗坏血酸或其式为H 2 -C-OH | HC-OH | O || HC | ANGLE C = O | C = C || Z-OOH n1其中Z表示氢或能与L-抗坏血酸键合的阳离子，n1是Z的化合价，其中式O的碱式 - 三氧化硫复合物是平行A： S = O PARALLEL O其中A表示叔胺，叔酰胺，醚或硫醚，反应在相容的溶剂中并在足够的碱存在下进行，使L-抗坏血酸的C2羟基比 其C5和C6羟基。 该过程影响L-抗坏血酸定量转化为L-抗坏血酸2-硫酸酯，后者的纯化合物以良好的产率分离。 已经发现这些化合物在食品系统等中起着稳定的维生素C来源的作用。

    Stabilized particulate vitamin c composition
    43.
    发明授权
    Stabilized particulate vitamin c composition 失效
    稳定颗粒维生素C组成

    公开(公告)号：US3873713A

    公开(公告)日：1975-03-25

    申请号：US37555973

    申请日：1973-07-02

    申请人： HOFFMANN LA ROCHE

    发明人： HAAS WALTER ,  ZELLER HANS-GUNTHER

    IPC分类号： A61K9/20 ,  A61K9/50 ,  A61K31/375 ,  C07D307/62 ,  C08G77/06 ,  A61K27/00

    CPC分类号： C08G77/06 ,  A61K9/2081 ,  A61K9/5031 ,  A61K31/375 ,  C07D307/62

    摘要： A stable particulate vitamin C composition is described which comprises ascorbic acid, isoascorbic acid, or a salt or ester of either in the form of discrete particles, each particle of which is substantially uniformly coated with an organic polysiloxane. The polysiloxane coating, which does not substantially alter the size or shape of the particles, gives said particles excellent flow properties and stability and facilitates compression of such particles into tablets.

    摘要翻译： 描述了稳定的颗粒状维生素C组合物，其包含抗坏血酸，异抗坏血酸或以分散颗粒形式的盐或酯，其各自的颗粒基本上均匀地涂覆有机聚硅氧烷。 基本上不改变颗粒尺寸或形状的聚硅氧烷涂层使所述颗粒具有优异的流动性能和稳定性，有利于将这种颗粒压缩成片剂。