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41.发明申请公开(公告)号：US20060099692A1
公开(公告)日：2006-05-11
申请号：US10520210
申请日：2002-07-03
申请人： R Yocum , Thomas Patterson , Janice Pero , Theron Hermann
发明人： R Yocum , Thomas Patterson , Janice Pero , Theron Hermann
CPC分类号： C07H21/04 , C12N9/0006 , C12N9/1003 , C12N9/1014 , C12N15/52 , C12P13/02
摘要： The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme activities. In particular, the invention features methods for enhancing production of desired products by increasing levels of a key intermediate, ketopantoate, by increasing enzymes or substrates that contribute directly or indirectly to its synthesis. Recombinant microorganisms and conditions for culturing same are also featured. Also featured are compositions produced by such microorganisms.
摘要翻译： 本发明的特征在于利用具有改良的泛酸生物合成酶活性并具有改性的亚甲基四氢叶酸（MTF）生物合成酶活性的微生物增强生产泛酸盐和泛酸盐的改进方法。 特别地，本发明的特征在于通过增加对其合成直接或间接有贡献的酶或底物来增加关键中间体酮托品酸的水平来增强所需产物的产生的方法。 还具有重组微生物和培养条件。 还有这些微生物产生的组合物。
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42.发明授权公开(公告)号：US06436410B1
公开(公告)日：2002-08-20
申请号：US09203895
申请日：1998-12-02
IPC分类号： A61K39002
CPC分类号： C12N9/003 , A61K39/00 , A61K2039/51 , C07K14/44 , C12N9/1003 , Y02A50/489
摘要： The present invention provides isolated polynucleotide molecules comprising a nucleotide sequence encoding the DHFR-TS protein of Neospora which polynucleotide molecules are useful in preparing modified live vaccines against neosporosis, and as diagnostic reagents. The present invention further provides cloning and expression vectors, transformed host cells, substantially purified DHFR-TS proteins and peptide fragments, genetic constructs useful for targeted gene deletion, and vaccine compositions.
摘要翻译： 本发明提供了分离的多核苷酸分子，其包含编码新孢子虫的DHFR-TS蛋白的核苷酸序列，该多核苷酸分子可用于制备针对新孢子虫病的修饰的活疫苗以及作为诊断试剂。 本发明还提供克隆和表达载体，转化的宿主细胞，基本上纯化的DHFR-TS蛋白和肽片段，用于靶向基因缺失的遗传构建体和疫苗组合物。
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