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    Regulation of gene expression by protein methylation
    2.
    发明授权
    Regulation of gene expression by protein methylation 失效
    通过蛋白质甲基化调节基因表达

    公开(公告)号：US08247168B2

    公开(公告)日：2012-08-21

    申请号：US12573066

    申请日：2009-10-02

    申请人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

    发明人： Michael R. Stallcup ,  Dagang Chen ,  Heng Hong ,  Dana W. Aswad

    IPC分类号： C12Q1/48 ,  C12Q1/68 ,  C12N9/10

    CPC分类号： C07K16/40 ,  C12N9/1003

    摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

    摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

    Regulation of Gene Expression by Protein Methylation
    3.
    发明申请
    Regulation of Gene Expression by Protein Methylation 失效
    通过蛋白质甲基化调节基因表达

    公开(公告)号：US20100092982A1

    公开(公告)日：2010-04-15

    申请号：US12573066

    申请日：2009-10-02

    申请人： MICHAEL R. STALLCUP ,  DAGANG CHEN ,  HENG HONG ,  DANA W. ASWAD

    发明人： MICHAEL R. STALLCUP ,  DAGANG CHEN ,  HENG HONG ,  DANA W. ASWAD

    IPC分类号： C12Q1/68

    CPC分类号： C07K16/40 ,  C12N9/1003

    摘要： The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine residues of histones, synthetic peptides, and other proteins. A method to use CARM1 to screen for drugs that inhibit its methyltransferase activity is also described, as is a method to screen for drugs that modulate CARM1's interactions with other proteins.

    摘要翻译： 本发明涉及Coactivator Associated精氨酸（R）甲基转移酶蛋白CARM1的cDNA和推导的氨基酸序列。 描述了一种使用CARM1调节体内基因表达的方法。 CARM1也用于甲基化组蛋白，合成肽和其他蛋白质的精氨酸残基。 还描述了使用CARM1筛选抑制其甲基转移酶活性的药物的方法，也是筛选调节CARM1与其他蛋白质相互作用的药物的方法。

    Tetrahydrofolate synthetase gene
    4.
    发明授权
    Tetrahydrofolate synthetase gene 有权
    四氢叶酸合成酶基因

    公开(公告)号：US07534562B2

    公开(公告)日：2009-05-19

    申请号：US10573969

    申请日：2004-09-30

    申请人： Takeyuki Sugiura

    发明人： Takeyuki Sugiura

    IPC分类号： C12Q1/68

    CPC分类号： C12N9/93 ,  A61K31/00 ,  C12N9/1003 ,  C12Q1/527 ,  G01N33/57407

    摘要： By finding a novel tetrahydrofolate synthetase gene and a protein encoded by said gene, a method for identifying a compound which inhibits cell growth accelerating activity of said protein is provided, and a judging method, a preventing method and a treating method of colon cancer are provided. A DNA comprising a nucleotide sequence of from the 94th to 2934th positions of the nucleotide sequence of SEQ ID NO:1 of the SEQUENCE LISTING; a polynucleotide which specifically hybridizes with said DNA; a protein encoded by said DNA; a recombinant vector comprising said DNA; a transformant comprising said recombinant vector; an antibody for said protein; a method for producing said protein; a method for identifying a compound which inhibits cell growth accelerating activity possessed by said protein; a method for judging colon cancer, characterizing in that expressed amount of said DNA is measured; a kit for judging colon cancer; a preventive agent and/or therapeutic agent for colon cancer.

    摘要翻译： 提供一种新型四氢叶酸合成酶基因和由所述基因编码的蛋白质，提供了鉴定抑制所述蛋白质的细胞生长促进活性的化合物的方法，提供了判定方法，预防方法和结肠癌的治疗方法 。 包含SEQ ID NO：1的核苷酸序列的第94位至第2934位的核苷酸序列的DNA; 与所述DNA特异性杂交的多核苷酸; 由所述DNA编码的蛋白质; 包含所述DNA的重组载体; 包含所述重组载体的转化体; 所述蛋白质的抗体; 一种生产所述蛋白质的方法; 用于鉴定抑制所述蛋白质具有的细胞生长促进活性的化合物的方法; 测定结肠癌的方法，其特征在于测定表达量的所述DNA; 用于判断结肠癌的试剂盒; 用于结肠癌的预防剂和/或治疗剂。

    Chimeric isoprenoid synthases and uses thereof
    6.
    发明申请
    Chimeric isoprenoid synthases and uses thereof 有权
    嵌合类异戊二烯合酶及其用途

    公开(公告)号：US20040078840A1

    公开(公告)日：2004-04-22

    申请号：US10717500

    申请日：2003-11-21

    发明人： Joseph Chappell ,  Kyoungwhan Beck

    IPC分类号： A01H001/00 ,  C12N015/82 ,  C07H021/04 ,  C12N009/10 ,  C12N005/04

    CPC分类号： C12P5/007 ,  C07K2319/00 ,  C12N9/00 ,  C12N9/1003 ,  C12N9/88 ,  C12N15/8243

    摘要： Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.

    摘要翻译： 本发明公开了一种嵌合型类异戊二烯合酶，​​其包括第一种类型的类异戊二烯合酶的第一结构域，其与第二异源类异戊二烯合酶连接到第二结构域，由此嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物的产生 不存在第二种异源类异戊二烯合酶的第二结构域。 还公开了嵌合型类异戊二烯合酶多肽，其包括不对称定位的同源结构域，其中嵌合型类异戊二烯合酶能够催化产生类异戊二烯反应产物，当该结构域位于其在类异戊二烯合酶多肽的天然存在位点时不产生 。

    Chimeric isoprenoid synthases and uses thereof
    7.
    发明授权
    Chimeric isoprenoid synthases and uses thereof 有权
    嵌合类异戊二烯合酶及其用途

    公开(公告)号：US08354504B2

    公开(公告)日：2013-01-15

    申请号：US12927805

    申请日：2010-11-23

    申请人： Joseph Chappell ,  Kyoungwhan Back

    发明人： Joseph Chappell ,  Kyoungwhan Back

    IPC分类号： C07K14/415

    CPC分类号： C12P5/007 ,  C07K2319/00 ,  C12N9/00 ,  C12N9/1003 ,  C12N9/88 ,  C12N15/8243

    摘要： Provided is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous, isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous, isoprenoid synthase. Also provided is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned heterologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.

    摘要翻译： 本发明提供了一种嵌合型类异戊二烯合酶，​​其包含与第二种异戊二烯合成酶连接到第二结构域的第一种类型的类异戊二烯合酶的第一结构域，其中嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物 不存在第二种异源的类异戊二烯合酶的第二结构域。 还提供了嵌合型类异戊二烯合酶多肽，其包括不对称定位的异源结构域，由此嵌合型类异戊二烯合酶能够催化当该结构域位于类固醇合成酶多肽的天然存在位点时不产生的类异戊二烯反应产物的产生 。

    Tetrahydrofolate synthetase gene
    8.
    发明授权
    Tetrahydrofolate synthetase gene 有权
    四氢叶酸合成酶基因

    公开(公告)号：US08168392B2

    公开(公告)日：2012-05-01

    申请号：US12420702

    申请日：2009-04-08

    申请人： Takeyuki Sugiura

    发明人： Takeyuki Sugiura

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12N9/06 ,  C12N15/00 ,  C12P21/06 ,  C07H21/04

    CPC分类号： C12N9/93 ,  A61K31/00 ,  C12N9/1003 ,  C12Q1/527 ,  G01N33/57407

    摘要： By finding a novel tetrahydrofolate synthetase gene and a protein encoded by said gene, a method for identifying a compound which inhibits cell growth accelerating activity of said protein is provided, and a judging method, a preventing method and a treating method of colon cancer are provided. A DNA comprising a nucleotide sequence of from the 94th to 2934th positions of the nucleotide sequence of SEQ ID NO:1 of the SEQUENCE LISTING; a polynucleotide which specifically hybridizes with said DNA; a protein encoded by said DNA; a recombinant vector comprising said DNA; a transformant comprising said recombinant vector; an antibody for said protein; a method for producing said protein; a method for identifying a compound which inhibits cell growth accelerating activity possessed by said protein; a method for judging colon cancer, characterizing in that expressed amount of said DNA is measured; a kit for judging colon cancer; a preventive agent and/or therapeutic agent for colon cancer.

    摘要翻译： 提供一种新型四氢叶酸合成酶基因和由所述基因编码的蛋白质，提供了鉴定抑制所述蛋白质的细胞生长促进活性的化合物的方法，提供了判定方法，预防方法和结肠癌的治疗方法 。 包含SEQ ID NO：1的核苷酸序列的第94位至第2934位的核苷酸序列的DNA; 与所述DNA特异性杂交的多核苷酸; 由所述DNA编码的蛋白质; 包含所述DNA的重组载体; 包含所述重组载体的转化体; 所述蛋白质的抗体; 一种生产所述蛋白质的方法; 用于鉴定抑制所述蛋白质具有的细胞生长促进活性的化合物的方法; 测定结肠癌的方法，其特征在于测定表达量的所述DNA; 用于判断结肠癌的试剂盒; 用于结肠癌的预防剂和/或治疗剂。

    Chimeric isoprenoid synthases and uses thereof
    9.
    发明授权
    Chimeric isoprenoid synthases and uses thereof 有权
    嵌合类异戊二烯合酶及其用途

    公开(公告)号：US08106260B2

    公开(公告)日：2012-01-31

    申请号：US10717500

    申请日：2003-11-21

    申请人： Joseph Chappell ,  Kyoungwhan Back

    发明人： Joseph Chappell ,  Kyoungwhan Back

    IPC分类号： C12N15/29 ,  C12N15/52 ,  C12N15/82 ,  A01H5/00

    CPC分类号： C12P5/007 ,  C07K2319/00 ,  C12N9/00 ,  C12N9/1003 ,  C12N9/88 ,  C12N15/8243

    摘要： Disclosed is a chimeric isoprenoid synthase polypeptide including a first domain from a first isoprenoid synthase joined to a second domain from a second, heterologous isoprenoid synthase, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced in the absence of the second domain of the second, heterologous isoprenoid synthase. Also disclosed is a chimeric isoprenoid synthase polypeptide including an asymmetrically positioned homologous domain, whereby the chimeric isoprenoid synthase is capable of catalyzing the production of isoprenoid reaction products that are not produced when the domain is positioned at its naturally-occurring site in the isoprenoid synthase polypeptide.

    摘要翻译： 本发明公开了一种嵌合型类异戊二烯合酶，​​其包括第一种类型的类异戊二烯合酶的第一结构域，其与第二异源类异戊二烯合酶连接到第二结构域，由此嵌合型类异戊二烯合酶能够催化不产生的类异戊二烯反应产物的产生 不存在第二种异源类异戊二烯合酶的第二结构域。 还公开了嵌合型类异戊二烯合酶多肽，其包括不对称定位的同源结构域，其中嵌合型类异戊二烯合酶能够催化产生类异戊二烯反应产物，当该结构域位于其在类异戊二烯合酶多肽的天然存在位点时不产生 。