公开(公告)号：US20220193075A1

公开(公告)日：2022-06-23

申请号：US17606394

申请日：2020-04-24

Applicant: SUMITOMO DAINIPPON PHARMA CO., LTD.

Inventor： Mitsumasa Kurita ,  Yuki Ikeda ,  Mitsuhiro Nakato

IPC: A61K31/506 ,  A61K31/198 ,  A61P25/16 ,  A61K9/00 ,  A61K9/70 ,  A61K31/4015 ,  A61K31/496

Abstract: The present invention provides a therapeutic drug that is useful for levodopa induced dyskinesia in Parkinson's disease. In particular, the present invention provides a composition and method for treating, improving, suppressing the progression, or preventing motor complications associated with levodopa therapy for Parkinson's disease, especially levodopa induced dyskinesia (PD-LID), comprising tandospirone or a pharmaceutically acceptable salt or prodrug thereof, wherein the tandospirone or a pharmaceutically acceptable salt or prodrug thereof is parenterally administered.

公开(公告)号：US20220133712A1

公开(公告)日：2022-05-05

申请号：US17573693

申请日：2022-01-12

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

IPC: A61K31/495 ,  A61K31/415 ,  A61K47/54 ,  A61K45/06 ,  A61N5/10 ,  C07D207/26 ,  C07D231/12 ,  C07D487/04 ,  A61K31/4188 ,  A61K31/045 ,  A61K31/4015 ,  C07B59/00 ,  C07C33/14 ,  A61K9/00

Abstract: The present invention provides for a derivative of monoterpene or sesquiterpene, such as a perillyl alcohol derivative. For example, the perillyl alcohol derivative may be a perillyl alcohol carbamate. The perillyl alcohol derivative may be perillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The present invention also provides for a method of treating a disease such as cancer, comprising the step of delivering to a patient a therapeutically effective amount of a derivative of monoterpene (or sesquiterpene). The route of administration may vary, and can include, inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.

公开(公告)号：US20220105244A1

公开(公告)日：2022-04-07

申请号：US17499636

申请日：2021-10-12

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Giovanni Ferrari ,  Antonio Frasca

IPC: A61L27/36 ,  A61K31/4015 ,  A61K31/4164

Abstract: Compositions and methods for protecting BHV from SVD mechanisms, including non-calcific SVD mechanisms, are provided.

公开(公告)号：US11291653B2

公开(公告)日：2022-04-05

申请号：US16864014

申请日：2020-04-30

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Scott C. Baraban

IPC: A61K31/4184 ,  A61K31/137 ,  A61K31/20 ,  A61K31/27 ,  A61K31/473 ,  A61K31/551 ,  A61K31/7048 ,  A61K31/19 ,  A61K31/195 ,  A61K31/197 ,  A61K31/357 ,  A61K31/36 ,  A61K31/4015 ,  A61K31/4166 ,  A61K31/433 ,  A61K31/55 ,  A61K31/5513 ,  A61K33/00 ,  A61K45/06

Abstract: Provided, inter alia, are methods for treating an epilepsy disorder using clemizole, a clemizole analog, or pharmaceutical salts thereof.

公开(公告)号：US11230548B2

公开(公告)日：2022-01-25

申请号：US16987581

申请日：2020-08-07

Applicant: Alkermes Pharma Ireland Limited

Inventor： Tarek A. Zeidan ,  Scott Duncan ,  Christopher P. Hencken ,  Thomas Andrew Wynn ,  Carlos N. Sanrame

IPC: C07C229/12 ,  C07C317/18 ,  C07C317/28 ,  C07D491/113 ,  A61K31/4015 ,  C07D207/40 ,  C07D207/12 ,  C07C229/18 ,  C07D207/408 ,  C07D211/92 ,  C07D295/088

Abstract: The present invention provides compounds of formula (I), wherein: R1 is unsubstituted C1-C6 alkyl; La is substituted or unsubstituted C1-C6 alkyl linker, substituted or unsubstituted C3-C10 carbocycle, substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S, or substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S; and R2 and R3 are each, independently, H, substituted or unsubstituted C1-C6 alkyl, or substituted or unsubstituted C6-C10 aryl; or alternatively, R2 and R3, together with the nitrogen atom to which they are attached, form a substituted or unsubstituted heteroaryl comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S or a substituted or unsubstituted heterocycle comprising one or two 5- or 6-member rings and 1-4 heteroatoms selected from N, O and S. The invention also provides pharmaceutical compositions and methods for treating neurological diseases, such as multiple sclerosis.

公开(公告)号：US20210386739A1

公开(公告)日：2021-12-16

申请号：US17461015

申请日：2021-08-30

Applicant: SUMITOMO DAINIPPON PHARMA CO., LTD.

Inventor： Mitsumasa Kurita ,  Yuki Ikeda ,  Mitsuhiro Nakato

IPC: A61K31/506 ,  A61K31/198 ,  A61P25/16 ,  A61K9/00 ,  A61K9/70 ,  A61K31/4015 ,  A61K31/496

Abstract: The present invention provides a therapeutic drug that is useful for levodopa induced dyskinesia in Parkinson's disease. In particular, the present invention provides a composition and method for treating, improving, delaying the progression, or preventing motor complications associated with levodopa therapy for Parkinson's disease, especially levodopa induced dyskinesia (PD-LID), comprising tandospirone or a pharmaceutically acceptable salt or prodrug thereof, wherein the tandospirone or a pharmaceutically acceptable salt or prodrug thereof is parenterally administered.

公开(公告)号：US11174227B2

公开(公告)日：2021-11-16

申请号：US16587688

申请日：2019-09-30

Applicant: THE BOEING COMPANY

Inventor： Michael Monteiro ,  Jason W. Armstrong

IPC: C07D207/416 ,  A61K31/4188 ,  A61K31/4402 ,  A61K31/4015 ,  C08F293/00 ,  C08F299/00 ,  A61K31/795 ,  C08F220/54

Abstract: The present disclosure provides compounds and nanostructures having one or more quaternary ammonium salts, compositions including the compounds and nanostructures, and methods useful for treating conditions using the compounds, nanostructures, and compositions. In at least one aspect, a compound is represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein: Q is fluoro, chloro, bromo, or iodo; each of s, b, and n is independently an integer from about 10 to about 100; and each of v, j, p, z, q, x and m is independently an integer from 1 to about 20.

公开(公告)号：US11160787B2

公开(公告)日：2021-11-02

申请号：US16316910

申请日：2017-07-13

Applicant: Conopco, Inc.

Inventor： Neil James Parry ,  Paolo Pantalone ,  Paul Williams

IPC: A61K31/4015 ,  A61P31/04

Abstract: 4-(4-Chlorophenyl)-5-methylene-pyrrol-2-one and 5-methylene-4-(p-tolyl)pyrrol-2-one for use in the treatment of gram-negative bacterial infections, in particular infections in which Pseudomonas is implicated.

公开(公告)号：US11147809B2

公开(公告)日：2021-10-19

申请号：US16313388

申请日：2017-06-30

Applicant: NeOnc Technologies, Inc.

Inventor： Thomas Chen

IPC: A61K31/495 ,  C07D231/12 ,  A61K31/4188 ,  A61K47/54 ,  C07B59/00 ,  A61K31/4015 ,  A61K9/00 ,  A61K31/045 ,  A61K31/415 ,  C07D207/26 ,  C07C33/14 ,  C07D487/04 ,  A61K45/06 ,  A61N5/10 ,  A61K31/635 ,  A61K47/55 ,  A61K31/366

Abstract: The present methods treat neurofibromatosis by a administering to a subject perillyl alcohol or iso-perillyl alcohol. The present methods also treat neurofibromatosis by administering to a subject a carbamate of perillyl alcohol, or a carbamate of iso-perillyl alcohol. The perillyl alcohol carbamate may comprise perillyl alcohol conjugated with rolipram or temozolomide.

公开(公告)号：US20210275450A1

公开(公告)日：2021-09-09

申请号：US17249491

申请日：2021-03-03

Applicant: Gary S. Fialk

Inventor： Gary S. Fialk

IPC: A61K9/06 ,  A61B17/34 ,  A61K9/00 ,  A61K31/4015 ,  A61K31/167 ,  A61K47/02 ,  A61K47/10 ,  A61K47/24 ,  A61K47/38

Abstract: A combination gel lubricant composition for use in transrectal ultra-sound guided needle biopsy procedures comprising a 10% povidone iodine antiseptic gel and 2% lidocaine anesthetic gel to form the combination gel lubricant. The combination gel lubricant is used in a method of performing a transrectal ultra-sound guided needle biopsy.