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公开(公告)号：US20200324301A1
公开(公告)日：2020-10-15
申请号：US16842205
申请日：2020-04-07
Applicant: Terumo BCT, Inc.
Abstract: A frustro-conical chamber for separating particles in a fluidized bed for blood component or cell separation. The chamber is characterized by injection-directing means for directing inflowing fluid along a frustro-conical wall of the chamber. A dam adjacent the cell-injection port may be circumferentially disposed within the chamber and may have its maximum height adjacent an injection port, and the height may diminish away from the injection port. The injection directing means may comprise a shelf extending into the interior of the chamber from the injection port, thereby impeding fluid flow in the direction of an outlet port.
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公开(公告)号：US20200216809A1
公开(公告)日：2020-07-09
申请号：US16648551
申请日：2018-09-19
Applicant: MEGAKARYON CORPORATION
Inventor： Hiroya TAKAHARA , Junko TOMIZUKA
Abstract: Provided is a method for producing platelets, in which damage to platelets is suppressed compared with a method in which platelets are separated using a filter from a megakaryocyte culture, and then the platelets are concentrated using a hollow fiber membrane and are further washed using the hollow fiber membrane, and purified platelets can be produced in a shorter period of time compared with the time that is taken to perform the above-described method so as to reduce damage to platelets. The method for producing purified platelets of the present invention includes a concentrating step of concentrating a megakaryocyte culture, and a centrifuging step of centrifuging platelets from an obtained concentrate.
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43.发明授权Washing of separated solids in solid bowl and screen bowl decanting centrifuges 有权在固体碗和筛碗滗析离心机中洗涤分离的固体公开(公告)号：US07448992B2
公开(公告)日：2008-11-11
申请号：US11049627
申请日：2005-02-01
Applicant: Geoffrey Clive Grimwood , John Wright
Inventor： Geoffrey Clive Grimwood , John Wright
Abstract: A solid or screen bowl decanting-type centrifuge comprising:a rotatable bowl; a helical scroll conveyor which rotates coaxially within the bowl at a different rotational speed, the helical scroll comprising a hub carrying a plurality of flights whose radially outer edges lie close to an inner wall of the bowl such that, in use, solids are scrolled by the conveyer to solids discharge ports at one end of the bowl, with separated liquid being discharged from liquids discharge ports at the opposite end of the bowl. The conveyor hub carries a plurality of nozzles in a wash zone for supplying wash fluid to solids being scrolled by the conveyer towards the solids discharge ports. The conveyor hub also carries a blade in the region of the nozzles and intermediate adjacent flights of the conveyor for directing fluid droplets from the nozzles over said solids.
Abstract translation: 一种固体或筛碗倾析式离心机，包括：可旋转的碗; 螺旋形涡旋传送器，其以不同的转速在碗内同轴旋转，螺旋形涡卷包括承载多个飞行的轮毂，其径向外边缘靠近碗的内壁，使得在使用中，固体被滚动 输送机到碗的一端处的固体排出口，分离的液体从碗的另一端的液体排出口排出。 输送轮毂在洗涤区域中承载多个喷嘴，用于将洗涤流体供给由输送机向固体排出口滚动的固体。 输送轮毂还在喷嘴的区域中和在输送机的相邻的中间部分之间承载有叶片，用于将来自喷嘴的流体液滴引导到所述固体上。
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44.发明申请Washing of separated solids in solid bowl and screen bowl decanting centrifuges 有权在固体碗和筛碗滗析离心机中洗涤分离的固体公开(公告)号：US20050192173A1
公开(公告)日：2005-09-01
申请号：US11049627
申请日：2005-02-01
Applicant: Geoffrey Grimwood , John Wright
Inventor： Geoffrey Grimwood , John Wright
Abstract: A solid or screen bowl decanting-type centrifuge comprising: a rotatable bowl; a helical scroll conveyor which rotates coaxially within the bowl at a different rotational speed, the helical scroll comprising a hub carrying a plurality of flights whose radially outer edges lie close to an inner wall of the bowl such that, in use, solids are scrolled by the conveyer to solids discharge ports at one end of the bowl, with separated liquid being discharged from liquids discharge ports at the opposite end of the bowl. The conveyor hub carries a plurality of nozzles in a wash zone for supplying wash fluid to solids being scrolled by the conveyer towards the solids discharge ports. The conveyor hub also carries a blade in the region of the nozzles and intermediate adjacent flights of the conveyor for directing fluid droplets from the nozzles over said solids.
Abstract translation: 一种固体或筛碗倾析式离心机，包括：可旋转的碗; 螺旋形涡旋传送器，其以不同的转速在碗内同轴旋转，螺旋形涡卷包括承载多个飞行的轮毂，其径向外边缘靠近碗的内壁，使得在使用中，固体被滚动 输送机到碗的一端的固体排出口，分离的液体从碗的另一端的液体排出口排出。 输送轮毂在洗涤区域中承载多个喷嘴，用于将洗涤流体供给由输送机向固体排出口滚动的固体。 输送轮毂还在喷嘴的区域中和在输送机的相邻的中间部分之间承载有叶片，用于将来自喷嘴的流体液滴引导到所述固体上。
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公开(公告)号：US06846281B2
公开(公告)日：2005-01-25
申请号：US10386426
申请日：2003-03-13
Applicant: Kazuhiko Murayama , Kenji Yamada , Daijiro Shiraishi
Inventor： Kazuhiko Murayama , Kenji Yamada , Daijiro Shiraishi
IPC: G01N33/48 , B04B5/02 , B04B5/04 , B04B7/02 , B04B7/18 , B04B11/05 , B04B15/06 , B04B15/12 , B04B7/04
CPC classification number: B04B15/12 , B04B5/0421 , B04B7/02 , B04B15/06
Abstract: A bio cell cleaning centrifuge having a detachable inner chamber body. The centrifuge includes a rotor detachable from a drive mechanism. Test tube holders are pivotally movably supported on the rotor for holding test tubes. A cleaning liquid distributor is detachably disposed on the rotor for supplying cleaning liquid to the respective test tubes. A bowl detachable from the drive mechanism is disposed below the test tube holders. The inner chamber body is disposed below the bowl for receiving therein supernatant liquid discharged out of the test tubes during rotation of the rotor. The inner chamber body is detachably mounted on a main case. The inner chamber body is detached after the distributor, the rotor, and the bowl are detached.
Abstract translation: 具有可拆卸内腔体的生物细胞清洗离心机。 离心机包括可从驱动机构拆卸的转子。 试管支架可转动地支撑在转子上用于保持试管。 清洁液分配器可拆卸地设置在转子上，用于向各个试管供应清洗液。 从驱动机构可拆卸的碗设置在试管支架下方。 内室主体设置在碗的下方，用于接收其中转子旋转期间从试管排出的上清液。 内室主体可拆卸地安装在主壳体上。 在分配器，转子和碗被分离之后，内室主体被分离。
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Patent Agency Ranking
公开(公告)号：US6159360A
公开(公告)日：2000-12-12
申请号：US301407
申请日：1999-04-28
Applicant: Hans Gerteis , Gerd Mayer
Inventor： Hans Gerteis , Gerd Mayer
CPC classification number: B04B15/12 , B04B13/00 , B04B3/025 , B04B2005/105
Abstract: A solids dryer is post-connected to an invertible filter centrifuge, wherein a dehumidification and drying of the solids takes place in the invertible filter centrifuge by means of centrifugation, pressure gas compression and/or heat convection and in the solids dryer by means of heat contact and/or heat convection. The invertible filter centrifuge and the solids dryer are connected to one another to form a unit via a closure device. Sensors serve to measure the respectively prevailing degree of dehumidification and drying as well as to determine additional operating parameters. The sensors actuate a common control device which regulates the operating parameters. The control device carries out the regulation of the operating parameters automatically in such a manner that the operating times for the dehumidification and drying in the invertible filter centrifuge and in the solids dryer are coordinated with one another and at the same time the mechanical centrifugal energy and the thermal energies in invertible filter centrifuge and solids dryer are distributed in an optimum manner.
Abstract translation: 固体干燥器后连接到可逆过滤离心机，其中通过离心，压力气体压缩和/或热对流在固体干燥器中通过热量在可逆过滤离心机中进行固体的除湿和干燥 接触和/或热对流。 可逆过滤离心机和固体干燥器通过封闭装置相互连接形成一个单元。 传感器用于测量相应的主要的除湿和干燥程度以及确定额外的操作参数。 传感器启动调节操作参数的公共控制装置。 控制装置自动执行操作参数的调节，使得可逆过滤离心机和固体干燥器中的除湿和干燥的操作时间彼此协调，同时机械离心能和 可逆过滤离心机和固体干燥机中的热能以最佳方式分布。
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47.发明授权
公开(公告)号：US5509882A
公开(公告)日：1996-04-23
申请号：US304073
申请日：1994-09-12
Applicant: John W. Caldwell
Inventor： John W. Caldwell
CPC classification number: B04B15/12 , B04B1/20 , B04B2001/205
Abstract: A liquid-solids separator, or centrifuge, of the type having a screw conveyor is provided with a series of offset conveyor flights. A spacer is positioned within the offset of the conveyor flights to form a channel therein. Rinse liquid is introduced into the channel through the central hub of the conveyor. The channel directs the rinse liquid into the heavy phase cake. An opening may be provided at various radial distances for varying the position of introduction of the rinse liquid from the channel. The amount of rinse liquid introduced through various channels formed by the series of offset conveyor flights may also be varied.
Abstract translation: 具有螺旋输送机的类型的液体 - 固体分离器或离心机设置有一系列偏移输送机飞行。 间隔件定位在输送机的偏移范围内以在其中形成通道。 冲洗液体通过输送机的中心毂引入通道。 通道将冲洗液引导到重质相饼中。 可以以各种径向距离提供开口，以改变从通道引入冲洗液体的位置。 通过由一系列胶印输送机形成的各种通道引入的冲洗液体的量也可以变化。
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公开(公告)号：US5227066A
公开(公告)日：1993-07-13
申请号：US722219
申请日：1991-06-27
Applicant: Masahiko Ishida , Ryoichi Haga , Harumi Matsuzaki
Inventor： Masahiko Ishida , Ryoichi Haga , Harumi Matsuzaki
CPC classification number: B04B5/00 , B04B15/12 , C12M47/02 , C12N1/02 , Y10T436/111666 , Y10T436/25375
Abstract: A centrifugal separation method for living cells is disclosed in which a cell containing solution is charged in a rotor chamber confined by a steam pressure-resistant wall. A rotor having septa is disposed in the rotor chamber. The septa are rotatable in the same direction at the same angular velocity as the rotor while at least part thereof is immersed in a solution in the rotor when cells are to be centrifuged from the cell-containing solution. After the cells are separated and adhered to the inner surface of the rotor, a supernatant in the rotor is discharged form the rotor. Then a fresh cultivating medium is introduced into the rotor, and the septa and the rotor are rotated at mutually different angular velocities while at least part of the septa is immersed in the fresh medium in the rotor. As a result, the cells are again suspended in the fresh medium.
Abstract translation: 公开了一种用于活细胞的离心分离方法，其中将含细胞的溶液装入由耐蒸汽压壁限制的转子室中。 具有隔片的转子设置在转子室中。 隔垫可以以与转子相同的角速度在相同的方向上旋转，而当细胞从含细胞溶液中离心时，其至少部分浸入到转子的溶液中。 在细胞分离并粘附到转子的内表面之后，转子中的上清液从转子排出。 然后将新鲜的培养介质引入转子中，并且隔片和转子以相互不同的角速度旋转，同时至少部分隔片浸入转子中的新鲜介质中。 结果，细胞再次悬浮在新鲜培养基中。
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公开(公告)号：US4654022A
公开(公告)日：1987-03-31
申请号：US824480
申请日：1986-01-31
Applicant: Leonard Shapiro
Inventor： Leonard Shapiro
IPC: B04B15/12
Abstract: Screw conveyor of solid bowl centrifuge has its flight member modified at the bowl dry beach area by welding sheet metal, for example, to trailing surfaces of the flight forming a chamber for rinse liquid driven thereinto. Leading or working surfaces of the flight are provided with a plurality of series of orifices per 360.degree. revolution thereof, each series comprising spaced orifices extending inwardly from a distal portion thereof and preferentially angled therethrough. Overflow passageways with cooperating baffles are provided. Thus, rinse liquid passes onto solids pile surfaces through orifices immediately inwardly thereof as well as through orifices submerged by the solids for passage of rinse liquid thereinto.
Abstract translation: 固体碗式离心机的螺旋输送机通过焊接金属板将其飞行构件改变为在碗干燥的海滩区域，例如，到飞行器的后表面，形成用于冲洗液体的腔室。 飞行器的前导或工作表面每360°旋转设置有多个孔系列，每个系列包括从其远端部分向内延伸并优先从其穿过的间隔开的孔。 提供具有配合挡板的溢流通道。 因此，冲洗液体通过其内部的孔口以及通过浸没在固体中的通孔的孔通过固体堆积表面，以便将漂洗液通过。
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公开(公告)号：US4187979A
公开(公告)日：1980-02-12
申请号：US944640
申请日：1978-09-21
Applicant: Herbert M. Cullis , Evelyn E. Dorsey , James H. De Vries
Inventor： Herbert M. Cullis , Evelyn E. Dorsey , James H. De Vries
CPC classification number: B04B5/0442 , A61M1/3603 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M2205/3306
Abstract: The method, and system for carrying out the steps of the method, are utilized in taking whole blood from a supply of blood withdrawn from a donor or from a previously banked supply of whole blood in a container, centrifuging the blood in a centrifuge device to separate the whole blood into its components, and then collecting the components, namely red blood cells, white blood cells, platelets and plasma. The fractionation of the whole blood in the centrifuge device takes place in first, second and third separation chambers. The first chamber has a square shape and is positioned in the centrifuge device in a diamond position. Each corner of the first separation chamber has an opening. Whole blood is pumped into one side corner opening and red blood cells are withdrawn from the other side corner opening and returned to the container for recirculation through the first chamber. White blood cells, platelets and plasma are withdrawn from the upper corner opening and passed through the second chamber wherein white blood cells are separated by centrifugal force. The plasma and platelets are then withdrawn from the second chamber and passed through the third chamber wherein the platelets are separated from the plasma by centrifugal force. The plasma exiting from the third separation chamber is passed back into the bottom corner of the first chamber to cause a flow of plasma across the flow of whole blood and red blood cells to elute white blood cells and plateletstherefrom and to wash the red blood cells. By appropriate operation of electromechanically controlled clamps associated with tubing carrying the various blood components, plasma can be siphoned off into a plasma collection receptacle located outside the centrifuge device. After the red blood cells have been recirculated several times through the first separation chamber, the red blood cells then can be directed to a red blood cell collection receptacle by operation of other electromechanically controlled clamps.
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