公开(公告)号：US11905509B2

公开(公告)日：2024-02-20

申请号：US17512558

申请日：2021-10-27

Applicant: Koligo Therapeutics, Inc

Inventor： Rolf Wolters ,  Jules Valenti ,  Tom Gurski

IPC: C12M1/00 ,  A61K35/12 ,  B04B1/02 ,  C12M1/26 ,  B04B1/00

CPC classification number: C12M47/04 ,  A61K35/12 ,  B04B1/00 ,  B04B1/02 ,  C12M33/10 ,  C12M45/05 ,  C12M45/06 ,  C12M45/09

Abstract: Cell separation systems and methods of separating cells are disclosed. In an embodiment, a cell separation system is described that comprises a non-transitory storage device that executes a centrifugation program to separate cell volume from biologic material volume; a heating mechanism; a containment mechanism; and an assembly comprised of a single-walled centrifugation bowl. In an embodiment, methods of separating cells are disclosed whereby cells are separated by agitating a volume of biologic material and a volume digestion media to form a digested volume of biologic material; centrifuging the digested volume of biologic material; removing a portion of a resulting waste via at least one fluid outlet; isolating a different portion of the waste, and removing the concentrated cell volumes from the reservoir.

公开(公告)号：US20230415170A1

公开(公告)日：2023-12-28

申请号：US18248833

申请日：2021-11-02

Applicant: Bruno PREGENZER

Inventor： Bruno PREGENZER

IPC: B04B7/04 ,  B04B11/06 ,  B04B1/02

CPC classification number: B04B7/04 ,  B04B11/06 ,  B04B1/02 ,  A61C19/00

Abstract: The invention relates to a separator for separating solids from a water mixture, the separator comprising: a housing having a lid; and a centrifuge basket which is rotatably mounted in a centrifuge chamber of the housing and can be driven in rotation. The housing has a mixture inlet for the waste water mixture to be separated, which inlet opens into the centrifuge chamber, and a liquid outlet for liquid separated from the waste water mixture. An overflow opening is formed between the upper side of the centrifuge basket and the housing such that, during the centrifugal process, liquid can flow from the centrifuge basket into an outlet chamber which is connected to the liquid outlet. According to the invention, the centrifuge basket is designed such that, after the centrifugal process, solids which sink under the effect of gravity remain in the centrifuge basket.

公开(公告)号：US11717769B2

公开(公告)日：2023-08-08

申请号：US16985894

申请日：2020-08-05

Applicant: BATTELLE SAVANNAH RIVER ALLIANCE, LLC

Inventor： Michael L. Restivo ,  Michael R. Poirier ,  Fernando F. Fondeur ,  Samuel D. Fink

IPC: B01D11/04 ,  B04B1/02 ,  G01H9/00

CPC classification number: B01D11/048 ,  B01D11/0434 ,  B01D11/0461 ,  B01D11/0484 ,  B04B1/02 ,  G01H9/004

Abstract: Centrifugal contactors that can be used for mixing or separating materials are described. The contactors include a sensing system including a communications fiber within the shaft of the contactors and access ports providing access from the communications fiber to the mixing/separating zone of the contactor. The sensing system can be utilized during operation of the contactor and can provide for detailed and accurate on-line characterization of a protocol, as well as process control and system modification as necessary during operation.

公开(公告)号：US11433404B2

公开(公告)日：2022-09-06

申请号：US16471664

申请日：2016-12-22

Applicant: SHIMADZU CORPORATION

Inventor： Kengo Aoki ,  Ryutaro Oda

IPC: B04B1/02 ,  B03B5/32 ,  B04B11/02

Abstract: A centrifugal field-flow fractionation device includes an annular rotor, an arc-shaped channel member, a rotation drive unit, and a restriction unit. A channel member 16 is provided along an inner peripheral surface of the rotor, has therein a channel 161 for a liquid sample by laminating a plurality of layers, and has an inlet for the liquid sample to the channel 161 and an outlet for the liquid sample from the channel 161. By rotating the rotor, particles in the liquid sample in the channel 161 are classified by centrifugal force. A restriction spacer 64 restricts the channel 161 from being compressed to a height less than a certain height when the channel member 16 is compressed and deformed in a laminating direction.

公开(公告)号：US11167292B2

公开(公告)日：2021-11-09

申请号：US16833743

申请日：2020-03-30

Applicant: DSM IP Assets B.V.

Inventor： John E. Nash ,  William T. Fisher ,  Douglas G. Evans

IPC: B04B11/04 ,  B01D21/26 ,  B01D21/34 ,  B04B1/02 ,  B04B5/04 ,  B04B7/08 ,  A61M1/36 ,  B04B1/18 ,  B04B1/14

Abstract: Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (PRP) and or platelet poor plasma (PPP) can be obtained rapidly and is ready for immediate injection into the host. Embodiments may include valves, operated manually or automatically, to open ports that discharge the excess red blood cells and the excess plasma into separate receivers while retaining the platelets and other factors in the centrifuge chamber. High speeds used allow simple and small embodiments to be used at the patient's side during surgical procedures. The embodiments can also be used for the separation of liquids or slurries in other fields such as, for example, the separation of pigments or lubricants.

公开(公告)号：US20210039116A1

公开(公告)日：2021-02-11

申请号：US17040603

申请日：2019-03-26

Applicant: GM INNOVATIONS LIMITED

Inventor： Gerard MELLING ,  Alan SUTTIE ,  Brian LOUDON ,  John ELLIOT

IPC: B04B11/02 ,  B04B5/12 ,  B04B5/10 ,  B01D17/02 ,  C02F1/38 ,  B04B1/02

Abstract: The invention provides an apparatus for separating components of a fluid stream comprising a first centrifugal separator and a further separator; the first centrifugal separator comprising: a support structure and a centrifugal separator unit rotatably mounted on the support structure so as to be rotatable about a rotational axis extending through the centrifugal separator unit; a drive element for driving rotation of the centrifugal separator unit; wherein the centrifugal separator unit comprises a centrifugal separation chamber having an inlet which is connected or connectable to a source of fluid requiring separation, a first outlet for collecting a higher density component of the fluid stream, and a second outlet for collecting a lower density component of the fluid stream; the first outlet being connected or connectable to a first collector for collecting the higher density component and the second outlet being connected or connectable to a second collector for collecting the lower density component.

公开(公告)号：US10420876B2

公开(公告)日：2019-09-24

申请号：US15269237

申请日：2016-09-19

Applicant: FUJIFILM Corporation

Inventor： Tomonori Nishio ,  Kazuteru Nishijima

IPC: A61M1/36 ,  B04B1/02 ,  B04B7/08 ,  B04B9/14 ,  B04B5/04 ,  B01D17/02 ,  A61J1/05 ,  B04B1/08 ,  B04B11/04

Abstract: A storage portion forming a storage space 10, includes an inclined inner wall portion 20 that is connected to a base portion so that the diameter of the inclined inner wall portion gradually decreases; a concave portion 22 is formed at a part of the inclined inner wall portion; and the concave portion 22 includes a concave portion side surface 22b that is connected to a concave portion bottom surface 22a. The concave portion 22 is formed at a position, where the concave portion crosses an interface S between the specimen centrifuged during rotation and air, in a radial direction with respect to the central axis; and the maximum width of the concave portion 22 in a circumferential direction around the central axis is included in a range of 2 mm to a length of 20% of the whole circumference.

公开(公告)号：US20190060914A1

公开(公告)日：2019-02-28

申请号：US16079899

申请日：2017-02-24

Applicant: SEPRO MINERAL SYSTEMS CORP.

Inventor： Steven Alexander MCALISTER ,  Jonas Hendrik BOEHNKE

IPC: B04B3/06 ,  B04B1/02 ,  B01D21/26 ,  B01D21/28

Abstract: A rotor bowl for use in a centrifugal concentrator for separating particulate material of higher specific gravity from a liquid slurry comprising a liquid and particulate material of different specific gravities, wherein the inner surface of the rotor bowl has an outwardly inclined migration surface and a capture zone above the migration surface, wherein the capture zone has a generally vertical annular wall located radially outwardly of the migration zone, and the generally vertical annular wall has a vibratory surface adapted to be selectively vibrated to thereby stratify particulate material or slurry located in contact with or adjacent to the vibratory surface within the capture zone to thereby permit the heavier concentrate to accumulate in the area closest to the wall of the capture zone. The vibratory surface may be the continuous inner liner of the capture zone, or separate vibrating surfaces may be provided on the surface of the inner liner in the capture zone.The vibratory motion may be provided by one or more vibrators mounted radially outwardly of each vibratory surface. The rotor bowl may also comprise a plurality of springs mounted on the outer periphery of the vibrators and which are each biased to bear against the outer surface of a vibrator to offset centrifugal force so that each vibrator is kept in contact with the vibrating surface during rotation of the hollow bowl.

公开(公告)号：US20160144382A1

公开(公告)日：2016-05-26

申请号：US14907068

申请日：2014-07-23

Applicant: RIERA NADEU,S.A.

Inventor： Marc Riera-Domenech

IPC: B04B11/08 ,  B01D21/26 ,  B04B11/05 ,  B04B15/06 ,  B04B1/02

CPC classification number: B04B11/08 ,  B01D21/262 ,  B04B1/02 ,  B04B11/05 ,  B04B15/06 ,  B04B2005/0485

Abstract: A supercentrifuge with a non-intrusive device for the extraction of solids, the supercentrifuge comprising a chamber or rotor (1) for the clarification of liquids and a piston (4) located within the chamber passing through it in order to discharge the solids, the piston (4) being driven in its outward travel along the chamber (1) by the injection of a pressurised fluid which pushes the piston, in which the supercentrifuge has means for the generation of vacuum to bring about return movement of the piston along the chamber.

Abstract translation: 一种具有用于提取固体的非侵入式装置的超级离心机，该超级离心机包括用于澄清液体的室或转子（1）和位于通过其的室内的活塞（4）以便排出固体， 活塞（4）通过注射推动活塞的加压流体而沿着腔室（1）向外移动，其中超级离心机具有用于产生真空的装置，以使活塞沿着腔室返回运动 。

公开(公告)号：US20160107173A1

公开(公告)日：2016-04-21

申请号：US14892351

申请日：2013-06-14

Applicant: TOMOE ENGINEERING CO., LTD.

Inventor： Qun Ce FENG ,  Kensuke OZAWA

IPC: B04B11/05 ,  B04B1/02

CPC classification number: B04B11/05 ,  B04B1/02 ,  B04B11/08 ,  B04B15/06 ,  B04B2011/086

Abstract: A centrifuge has a bowl, an opening at the center of the lower part of the bowl for supplying liquid to be treated and for discharging a centrifugally separated solids cake, and a tapered section configured so that the radius of the inner peripheral surface of the tapered section reduces downward toward the opening. Protrusions are provided at circumferential locations on the inner peripheral surface of the tapered section and protrude from the inner peripheral surface. A wing rotates within the bowl about the vertical axis and transports the separated solids cake toward the opening when rotating relative to the bowl. A drive mechanism moves the wing to a first height position and rotates the bowl and the wing together, or moves the wing to a second height position lower than the first height position and rotates the wing relative to the bowl.

Abstract translation: 离心机具有碗，碗的下部中心的开口，用于提供待处理液体和排出离心分离的固体饼;以及锥形部分，其被构造成使锥形部分的内周面的半径 部分朝向开口向下减小。 突出部设置在锥形部的内周面的周向位置，从内周面突出。 机翼围绕垂直轴在碗内旋转，并且当相对于碗转动时将分离的固体饼移向开口。 驱动机构将翼移动到第一高度位置并将碗和翼旋转在一起，或者将翼移动到低于第一高度位置的第二高度位置，并使翼相对于碗旋转。