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公开(公告)号：US12128428B2
公开(公告)日：2024-10-29
申请号：US17296776
申请日：2019-12-09
发明人： Kasper Höglund , Peter Thorwid
摘要： A centrifugal separator for separation of a cell culture mixture includes a stationary frame, a rotatable assembly and a drive unit for rotating the rotatable assembly relative the frame around a vertical axis of rotation. The rotatable assembly includes a rotor casing enclosing a separation space in which a stack of separation discs is arranged to rotate around an axis of rotation. The rotor casing includes a mechanically hermetically sealed inlet and first and second mechanically hermetically sealed liquid outlets. The second mechanically hermetically sealed outlet is arranged at an axial end of the rotor casing opposite and arranged so that a separated cell phase is discharged at the rotational axis. The rotatable assembly includes an exchangeable separation insert and a rotatable member.
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公开(公告)号：US20240261754A1
公开(公告)日：2024-08-08
申请号：US18420145
申请日：2024-01-23
发明人： Karl Pflanz , Florian Hebenstreit , Andreas Pickl
CPC分类号： B01J20/14 , A61L2/081 , B01D37/02 , B01J20/28004 , B01J20/28016 , B01J20/2805 , B01J20/3028 , B65B55/02 , B65D65/40 , C12M47/02 , C12M47/10 , A61L2202/21
摘要： The present invention relates to a diatomaceous earth composition with a low endotoxin content, comprising an agglomerated mixture of calcined diatomaceous earth particles and water, wherein the mass ratio of calcined diatomaceous earth particles and water is in the range of 1:1.0 to 1:2.0, and wherein the endotoxin content of the diatomaceous earth composition is equal to or less than 0.5 EU/mL. In a further aspect, the present invention relates to a method for producing the diatomaceous earth composition with a low endotoxin content. In another aspect, the present invention relates to the use of the diatomaceous earth composition with a low endotoxin content as a precoat agent for the precoat filtration in biopharmaceutical applications.
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公开(公告)号：US12006495B2
公开(公告)日：2024-06-11
申请号：US16891112
申请日：2020-06-03
发明人： Patrick L. Hanks , Everett J. O'Neal , Sarah E. Feicht , Mark A. Deimund , Vinit Choudhary , Louis R. Brown
IPC分类号： C12M1/00 , A01G33/00 , C11B3/00 , C12M1/02 , C12M1/26 , C12M1/42 , C12N1/06 , F24S23/71 , F24S70/00 , F24S90/00 , F24S80/00
CPC分类号： C12M41/20 , A01G33/00 , C11B3/00 , C12M29/00 , C12M31/04 , C12M33/10 , C12M33/12 , C12M35/04 , C12M43/08 , C12M47/02 , C12M47/06 , C12M47/10 , C12M47/20 , C12N1/06 , F24S23/71 , F24S70/00 , F24S90/00 , F24S2080/017
摘要： A system includes an algae bioreactor that contains an algae slurry, a heat exchanger in fluid communication with the algae bioreactor to receive the algae slurry from the algae bioreactor and heat and increase a pressure of the algae slurry, and one or more valves and a flash vessel in fluid communication with a discharge of the heat exchanger to flash the algae slurry and create steam and algae biomass. A separator receives the algae biomass from the flash vessel and separates oils from the algae biomass to generate a biofuel.
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公开(公告)号：US11957998B2
公开(公告)日：2024-04-16
申请号：US17203025
申请日：2021-03-16
发明人： Stephen B. Kessler , T. David Marro
CPC分类号： B01D21/262 , B04B5/0442 , B04B7/08 , C12M47/02 , B01D2221/10 , B04B2005/045 , B04B2005/0464
摘要： An apparatus for separating cell suspension material into centrate and concentrate, includes a single use structure (178, 240, 250, 370, 414) releasably positioned in a cavity in a solid wall rotatable centrifuge bowl (172). The bowl and portions of single use structure rotate about an axis (174, 428). A stationary inlet feed tube (184, 430), a centrate discharge tube (212, 436) and a concentrate discharge tube (230,448) extend along the axis of the rotating single use structure. A centrate centripetal pump (208, 438) is in fluid connection with the centrate discharge tube. A concentrate centripetal pump (216, 450) is in fluid connection with the concentrate discharge tube. At least one concentrate channel (380, 454) and a concentrate centripetal pump chamber (376,452) have configurations in the structure that facilitate the flow of cell concentrate.
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公开(公告)号：US20240069049A1
公开(公告)日：2024-02-29
申请号：US18488369
申请日：2023-10-17
发明人： Aleksandar Vacic , Nathan Purmort , Eric Stern , Anna Passernig , Paul Otten , Randy Tragni , Ronan Hayes , Andriy Tsupryk , Bruce Richardson
CPC分类号： G01N35/02 , B01J20/041 , C12Q1/18 , G01N21/01 , G01N35/00 , G01N35/00029 , G01N35/0099 , G01N35/028 , G01N35/1065 , C12M47/02
摘要： In some aspects, automated rapid antimicrobial susceptibility testing systems for performing a multi-assay testing sequence can include an automated incubation assembly having a nest assembly adapted to house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, the incubation assembly facilitating incubation of one or more test panels in order to undergo the multi-assay testing sequence; a robotic handling assembly configured to accept one or more incoming test panels and move them to and from the incubation assembly for incubation between each assay of the multi-assay testing sequence; an automated liquid handling assembly configured to exchange one or more fluids in the plurality of wells of the test panels; and an optical assembly for interrogation and readout of each assay of the multi-assay testing sequence being performed in the plurality of wells.
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公开(公告)号：US11890557B2
公开(公告)日：2024-02-06
申请号：US17740710
申请日：2022-05-10
发明人： Charles R. Rhodes
IPC分类号： B01D29/27 , C12M1/12 , C12M1/00 , C12M1/26 , B01D35/027
CPC分类号： B01D29/27 , C12M23/14 , C12M23/28 , C12M25/16 , C12M29/04 , C12M33/14 , C12M47/02 , B01D35/027
摘要： A filter bag assembly includes: a flexible first sheet; a flexible second sheet overlying and secured to the first sheet so that a compartment is formed therebetween; a porous filter sheet disposed between the first sheet and the second sheet so as to divide the compartment into a first compartment and a second compartment; a first port secured to the second sheet so as to communicate directly with the first compartment; and a second port secured to the second sheet so as to communicate directly with the second compartment, the second port being spaced apart from the first port. The porous filter sheet is disposed so that fluid entering the first compartment through the first port must pass through the filter sheet before entering the second compartment or exiting through the second port.
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公开(公告)号：US20240026265A1
公开(公告)日：2024-01-25
申请号：US18216230
申请日：2023-06-29
CPC分类号： C12M23/12 , C12M47/02 , C12M47/04 , C12M25/04 , C12N1/02 , C12N5/0068 , C12M25/16 , B01J19/0046 , C12M23/20 , C12M23/22 , C12N2509/10 , B01J2219/00452 , B01J2219/00743
摘要： An apparatus for collecting or culturing cells or cell colonies includes: a common substrate formed from a flexible resilient polymeric material and having a plurality of wells formed therein; and a plurality of rigid cell carriers releasably connected to said common substrate, with said carriers arranged in the form of an array, and with each of the carriers resiliently received in one of the wells. A method of collecting or culturing cells or cell colonies with such an apparatus is carried out by depositing a liquid media carrying cells on the apparatus so that said cells settle on or adhere to said the carriers; and then (c) releasing at least one selected carrier having said cells thereon by gradual application of release energy to each carrier from the cavity in which it is received (e.g., by pushing with a probe).
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公开(公告)号：US11873474B2
公开(公告)日：2024-01-16
申请号：US17477019
申请日：2021-09-16
发明人： Daniel P. Welch , John R. Wilson
摘要： Novel methods and apparatus are disclosed for cell culture and cell recovery. The methods and apparatus simplify the process of cell separation from media, minimize potential damage to gas permeable devices during fluid handling, and allow closed system automated cell culture and cell recovery from gas permeable devices.
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公开(公告)号：US20240002778A1
公开(公告)日：2024-01-04
申请号：US18368281
申请日：2023-09-14
申请人： CORNING INCORPORATED
CPC分类号： C12M47/02 , C12M33/14 , C12N5/0075
摘要： A cell separation device configured for separating cells from microcarriers or spheroids in a liquid is provided. The cell separation device includes a vessel comprising a first port, a second port, and a cavity; and a porous mesh disposed within the cavity to divide the cavity into a first compartment and a second compartment, wherein the first port is in communication with the first compartment of the cavity, the first port located to a first side of the porous mesh, wherein the second port is in communication with the second compartment of the cavity, the second port located to a second side of the porous mesh, and wherein the porous mesh is positioned within the cavity to have a substantially vertical orientation or an inclined orientation with respect to a flow of liquid through the porous mesh.
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公开(公告)号：US20240002770A1
公开(公告)日：2024-01-04
申请号：US18344589
申请日：2023-06-29
摘要： Embodiments described herein generally relate to assemblies, systems, and methods for cell culture and production of biologics. Disclosed herein are multi-purpose assemblies that facilitate combination of perfusion processes and harvest processes. The multi-purpose assemblies and systems comprising the same simplify and streamline the biomanufacturing process, at least by improving automation capabilities, reducing physical footprint, reducing risk of contamination, and reducing consumable use rates. Also disclosed herein are methods of using the aforementioned assemblies and systems.
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