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48 条记录 (耗时 0.01 秒)

    N-oxide of poly i:poly c
    41.
    发明授权
    N-oxide of poly i:poly c 失效
    聚氧化烯I：聚C

    公开(公告)号：US3775399A

    公开(公告)日：1973-11-27

    申请号：US3775399D

    申请日：1971-04-29

    申请人： BEECHAM GROUP LTD

    发明人： HARNDEN M

    IPC分类号： C07H21/00 ,  C07D51/50

    CPC分类号： C07H21/00

    摘要： N-OXIDES AND SALTS OF POLY I:POLY C WHICH ARE THEMSELVES DOUBLE-STRANDED, METHODS OF MAKING SUCH N-OXIDES AND SALTS AND PHARMACEUTICAL COMPOSITIONS THEREOF ARE DESCRIBED. THE NEW POLYI:POLY C DERIVATIVES HAVE REDUCED TOXICITY AND ARE CHARACTERIZED BY BROAD ANTIVIRAL ACTIVITY. THE METHODS COMPRISE OXIDATION WITH HYDROGEN PERIOXIDE OR A PERACID WHICH IS CONTROLLED TO AVOID SEPARATION OF THE DOUBLE-STRANDED MATERIAL INTO SINGE-STRANDED MATERIAL.

    N-oxide of double stranded rna
    42.
    发明授权
    N-oxide of double stranded rna 失效
    双链RNA的N-氧化物

    公开(公告)号：US3775398A

    公开(公告)日：1973-11-27

    申请号：US3775398D

    申请日：1971-04-15

    申请人： BEECHAM GROUP LTD

    发明人： HARNDEN M

    IPC分类号： C07H21/00 ,  C07D51/50

    CPC分类号： C07H21/00

    摘要： N-OXIDES OF NATURAL DOUBLE-STANDED RIBONUCLIEC ACIDS AND SALTS THEREOF, WHICH ARE THEMSELVES DOUBLE-STRANDED, PREPARED BY REACTING DOUBLE-STRANDED RIBONUCLEIC ACIDS WITH HYDROGEN PERIOXIDE OR A PERACID, ARE DESCRIBED. THE NEW RNA DERIVATIVES ARE INTERFERON INDUCERS AND/OR HAVE ANTIVIRAL ACTIVITY AND ARE LESS TOXIC THAN THE PRENT RNA''S. NATURAL RNA''S HAVE EDENINE, CYTOSINE, URACIL AND GUANINE BASES LINKED TO REPEATING RIBOSE/PHOSPHATE BACKBONE UNITS AND DIFFERENT DEGREES OF OXIDATION OF THE BASES CAN BE CARRIED TO PRODUCE A VARIETY OF NEW N-OXIDE DERIVATIVES. THE CONVERSION TO SINGLE-STRANDED MATERIAL IS AVOIDED BY LIMITING THE EXTENT OF OXIDATION AND LEAVING SOME UNOXIDIZED BASE SITES. FORMULATION INTO AEROSOLS, INJECTIBLES AND TOPICALS IS DESCRIBED.

    Imidazole derivatives inhibiting nf sarcoma
    43.
    发明授权
    Imidazole derivatives inhibiting nf sarcoma 失效
    咪唑衍生物抑制NF SARCOMA

    公开(公告)号：US3678030A

    公开(公告)日：1972-07-18

    申请号：US3678030D

    申请日：1970-02-27

    申请人： AJINOMOTO KK

    发明人： YAMAZAKI AKIHIRO ,  FURUKAWA TERUO ,  KUMASHIRO IZUMI

    IPC分类号： C07H19/052 ,  C07D51/50

    CPC分类号： C07H19/052

    摘要： Imidazole derivatives of the formula (I)

    wherein R1 is lower alkanoyl, and R2 and R3 are each lower alkanoyl or jointly lower alkylidene are readily prepared by reaction of formic acid with corresponding starting compounds having an amino group in position 5 of the imidazole ring, and hydrogen or lower alkanoyl groups instead of each of R1, R2, R3 or alkylidene in R2 and R3. They inhibit the growth of NF sarcoma in mice.

    摘要翻译： 式（I）的咪唑衍生物，其中R 1是低级烷酰基，R 2和R 3各自是低级烷酰基或共同低级亚烷基，通过甲酸与相应的咪唑环位置5上的氨基起始化合物的反应， 和R 2和R 3中的R 1，R 2，R 3或亚烷基中的每一个代替氢或低级烷酰基。 它们抑制小鼠中NF肉瘤的生长。