公开(公告)号：US20160051473A1

公开(公告)日：2016-02-25

申请号：US14779156

申请日：2014-03-26

申请人： VECTURA LIMITED

发明人： David Farrow ,  Katie Coggins

IPC分类号： A61K9/16 ,  A61K45/06 ,  A61K31/40 ,  A61K9/00 ,  A61K31/185

CPC分类号： A61K9/1617 ,  A61K9/0075 ,  A61K9/008 ,  A61K9/1682 ,  A61K31/137 ,  A61K31/138 ,  A61K31/167 ,  A61K31/185 ,  A61K31/40 ,  A61K31/439 ,  A61K31/4704 ,  A61K31/58 ,  A61K45/06 ,  C07C303/42 ,  C07C309/14 ,  A61K2300/00

摘要： The invention discloses spray-dried compositions for inhalation and methods for preparing such powder compositions. The compositions of the invention are produced by spray-drying taurine under conditions that (i) retain the physical and chemical stability of the composition during spray drying and upon storage, (ii) protect the powder composition from aggregation and (iii) provide particles suitable for aerosolisation.

摘要翻译： 本发明公开了用于吸入的喷雾干燥组合物和制备这种粉末组合物的方法。 本发明的组合物通过在（i）在喷雾干燥和储存期间保持组合物的物理和化学稳定性的条件下，将牛磺酸喷雾干燥而制备，（ii）保护粉末组合物免受聚集，和（iii）提供适合的颗粒 用于雾化。

公开(公告)号：US09145359B2

公开(公告)日：2015-09-29

申请号：US13998958

申请日：2013-12-30

申请人： Songzhou Hu

发明人： Songzhou Hu

IPC分类号： C07C303/02 ,  C07C303/42 ,  C07C303/24

CPC分类号： C07C303/02 ,  C07C303/24 ,  C07C303/42 ,  C07C309/14 ,  C07C305/06

摘要： A method is disclosed for the production of taurine in high yield by a cyclic process of reacting monoethanolamine, sulfuric acid, and ammonium sulfite in the presence of additives to inhibit the hydrolysis of 2-aminoethyl hydrogen sulfate intermediate. The cyclic process is economical and little waste is generated.

公开(公告)号：US6133215A

公开(公告)日：2000-10-17

申请号：US140234

申请日：1998-08-26

申请人： Josef Zelger ,  Andreas Burkhard ,  Serge Schroeder ,  Bernard Schultz

发明人： Josef Zelger ,  Andreas Burkhard ,  Serge Schroeder ,  Bernard Schultz

IPC分类号： C11D3/395 ,  C07C303/42 ,  C07C309/32 ,  C07C315/06 ,  C07C317/14 ,  C09B57/00 ,  C09B67/48 ,  C11D3/42 ,  D06M13/02 ,  D06M13/148 ,  D06M13/224 ,  D06M13/228 ,  D06M13/248 ,  D06M13/256 ,  C11D9/44

CPC分类号： C07C309/32 ,  C07C303/42 ,  C11D3/42

摘要： There is provided a white crystal form of the compound having the formula: ##STR1## whose crystal form is characterised by an X-ray diffraction diagram which is essentially as shown in Table I, II or III. Also provided is a formulation comprising from 10 to 85% by weight of the white crystal form of compound having the formula (1) and from 90 to 15% by weight of a polyhydroxy compound, preferably glycerine.

摘要翻译： 提供具有下式的化合物的白色结晶形式：其结晶形式的特征在于基本上如表I，II或III所示的X射线衍射图。 还提供了包含10至85重量％的具有式（1）的化合物的白色结晶形式和90至15重量％的多羟基化合物，优选甘油的制剂。

公开(公告)号：US6087529A

公开(公告)日：2000-07-11

申请号：US142192

申请日：1998-09-01

申请人： Edouard Mathieu ,  Dominique Moulin ,  Jean Michel Legac ,  Olivier Letailleur

发明人： Edouard Mathieu ,  Dominique Moulin ,  Jean Michel Legac ,  Olivier Letailleur

IPC分类号： C07C303/42 ,  C07C309/31 ,  C10M135/10 ,  C10M159/24 ,  C07C309/00

CPC分类号： C10M135/10 ,  C07C303/42 ,  C10M159/24

摘要： To improve color and odor characteristics of sulfonic acids and their derivatives while maintaining sludge and sulfuric acid reduction and good thermal stability, they are treated with at least one unsaturated hydrocarbon, each having at most 36 carbon atoms and having defined substitution characteristics.

摘要翻译： PCT No.PCT / EP97 / 01263 Sec。 371日期：1998年9月1日 102（e）1998年9月1日PCT PCT 1997年3月10日PCT公布。 出版物WO97 / 33864 日期1997年9月18日为了改善磺酸及其衍生物的颜色和气味特征，同时保持污泥和硫酸还原性以及良好的热稳定性，它们用至少一种不饱和烃进行处理，每个不饱和碳原子数最多为36个碳原子并具有定义的取代基 特点

公开(公告)号：US4874552A

公开(公告)日：1989-10-17

申请号：US62736

申请日：1987-06-15

申请人： Hans-Joachim Richtler ,  Udo Kreutzer ,  Franz-Josef Carduck ,  Klaus Koester ,  Hubert Harth

发明人： Hans-Joachim Richtler ,  Udo Kreutzer ,  Franz-Josef Carduck ,  Klaus Koester ,  Hubert Harth

IPC分类号： C11D1/28 ,  C07C67/00 ,  C07C301/00 ,  C07C303/32 ,  C07C303/42 ,  C07C309/17 ,  C11D13/06 ,  C11D17/06

CPC分类号： C07C303/42

摘要： For the production of solid, substantially anhydrous alkali metal salts of .alpha.-sulfofatty acid alkyl esters containing from 8 to 22 carbon atoms in the fatty acid chain and from 1 to 6 carbon atoms in the ester alkyl radical, solid or molten .alpha.-sulfofatty acid alkyl esters are simltaneously mixed with an aqueous solution of hydrogen peroxide or an H.sub.2 O.sub.2 -yielding compound and with solid alkali metal carbonate at a temperature of from 20.degree. to 80.degree. C. optionally in the presence of aqueous alkali metal hydroxide, the ratio by weight of ester of H.sub.2 O.sub.2 being from 1:0.01 to 1:0.06 and the molar ratio of ester to alkali metal carbonate being in the range of from 1:0.5 to 1:0.75, the foam formed through the release of CO.sub.2 is mechanically destroyed under a pressure of from 0.2 to 1.0 bar and at a temperature of from 50.degree. to 70.degree. C., and the product formed is residually degassed and residually dehydrated under a pressure of from 15 to 50 mbar and a temperature of from 50.degree. to 80.degree. C.

摘要翻译： 用于生产在脂肪酸链中含有8-22个碳原子和在酯烷基中含有1-6个碳原子的α-磺基脂肪酸烷基酯的固体，基本上无水的碱金属盐，固体或熔融的α-磺基脂肪酸 将烷基酯与过氧化氢水溶液或产生H 2 O 2的化合物和固体碱金属碳酸盐在20至80℃的温度下任意地在碱金属氢氧化物水溶液的存在下与其混合，重量比 的H 2 O 2酯为1:0.01至1:0.06，酯与碱金属碳酸盐的摩尔比为1:0.5至1:0.75，通过释放二氧化碳形成的泡沫体在 压力为0.2至1.0巴，温度为50至70℃，所形成的产品在15至50毫巴的压力和50至80埃的温度下进行残留脱气和残留脱水 GC。

公开(公告)号：US4690785A

公开(公告)日：1987-09-01

申请号：US882290

申请日：1986-07-07

申请人： Marvin L. Mausner ,  Siegfried Meinstein

发明人： Marvin L. Mausner ,  Siegfried Meinstein

IPC分类号： C07C303/42 ,  C07C309/31 ,  C07C143/24

CPC分类号： C07C303/42

摘要： An improved low water neutralization energy-saving process for the preparation of an alkaryl sulfonate by combining an alkaryl sulfonic acid with a salt-forming base, and utilizing the heat generated during the neutralization reaction to drive off the water present in the reaction mixture.

摘要翻译： 通过将烷芳基磺酸与成盐碱组合而制备烷芳基磺酸盐的改进的低水中和节能方法，以及利用在中和反应过程中产生的热量来驱除反应混合物中存在的水。

公开(公告)号：US4671900A

公开(公告)日：1987-06-09

申请号：US288769

申请日：1981-07-31

申请人： Karl Schmid ,  Werner Stein ,  Horst Baumann

发明人： Karl Schmid ,  Werner Stein ,  Horst Baumann

IPC分类号： C07C67/00 ,  C07C301/00 ,  C07C303/06 ,  C07C303/42 ,  C07C303/44 ,  C07C309/09 ,  C07C309/17 ,  C07C309/58 ,  C07C309/62 ,  C11C3/00 ,  C11D1/28 ,  C07C143/90

CPC分类号： C07C303/42 ,  C11C3/00 ,  C11D1/28

摘要： This invention is directed to the preparation of .alpha.-sulfofatty acid esters. More particularly, this invention is directed to a process for the simplified preparation of light-colored, wash-active esters of .alpha.-sulfofatty acids with monovalent C.sub.1 to C.sub.8 alcohols or their salts from fats and oils of vegetable and/or animal origin comprising re-esterification with the monovalent alcohols or saponification and esterification with the monovalent alcohols, separation of the fatty acid ester formed, hydrogenation of the fatty acid ester, sulfonation, and bleaching, wherein a fatty acid ester fraction from which accompanying fatty acid glycerides have been removed to the extent of about 1 percent by weight or less, based upon the weight of the material to be sulfonated, is introduced into the sulfonation stage.

摘要翻译： 本发明涉及α-磺基脂肪酸酯的制备。 更具体地，本发明涉及一种简单制备α-磺基脂肪酸的浅色洗涤活性酯与一价C1至C8醇或其植物和/或动物来源的脂肪和油的盐的方法，其包括re 用单价醇进行酯化反应或用单价醇皂化和酯化，形成脂肪酸酯的分离，脂肪酸酯的氢化，磺化和漂白，其中伴随的脂肪酸甘油酯已被除去的脂肪酸酯部分 基于待磺化材料的重量约1重量％或更少的程度引入磺化阶段。

公开(公告)号：US4411815A

公开(公告)日：1983-10-25

申请号：US276734

申请日：1981-06-24

申请人： Hideo Ando ,  Akira Hayashi ,  Kyozo Kitano

发明人： Hideo Ando ,  Akira Hayashi ,  Kyozo Kitano

IPC分类号： C11D1/29 ,  B01F17/02 ,  B01F17/04 ,  C07C67/00 ,  C07C301/00 ,  C07C303/42 ,  C07C305/06 ,  C07C305/10

CPC分类号： C07C303/42 ,  Y10S516/05

摘要： An odorless polyoxyethylene alkyl ether sulfate concentrate having a concentration of about 85 wt. % or more can be obtained by treating a polyoxyethylene alkyl ether sulfate aqueous solution having a concentration of about 60-80 wt. % under reduced pressure and at a temperature of 50.degree.-130.degree. C.

摘要翻译： 浓度为约85重量％的无臭聚氧乙烯烷基醚硫酸盐浓缩物 可以通过处理浓度为约60〜80重量％的聚氧乙烯烷基醚硫酸盐水溶液来获得％以上。 在减压下和在50℃-130℃的温度下

公开(公告)号：US4344889A

公开(公告)日：1982-08-17

申请号：US223750

申请日：1981-01-09

申请人： Nicolas Inchauspe

发明人： Nicolas Inchauspe

IPC分类号： C07C309/02 ,  C07C67/00 ,  C07C301/00 ,  C07C303/06 ,  C07C303/14 ,  C07C303/32 ,  C07C309/17 ,  C07C309/62 ,  C11D1/28 ,  C07C143/90

CPC分类号： C07C303/42 ,  C07C309/00

摘要： The starting material is subjected to the action of a sulfonating agent; the sulfonation product so obtained is degassed (2) and treated with slightly aqueous methanol in order to obtain, on the one hand, an ester phase containing the unsulfonated starting material which is returned to the sulfonation stage and, on the other hand, a methanol phase which contains the desired sulfonic acids and which is subjected to evaporation permitting the separation of the methanol from the said sulfonic acids.

摘要翻译： 起始材料经受磺化剂的作用; 将如此获得的磺化产物脱气（2）并用少量甲醇水溶液处理，以便一方面获得含有未磺化起始原料的酯相，其返回到磺化阶段，另一方面获得甲醇 相，其含有所需的磺酸，并进行蒸发，从而使甲醇与所述磺酸分离。

公开(公告)号：US4337215A

公开(公告)日：1982-06-29

申请号：US8114

申请日：1979-01-31

申请人： Shunichi Doi ,  Masatake Kamogawa

发明人： Shunichi Doi ,  Masatake Kamogawa

IPC分类号： C07C67/00 ,  C07C301/00 ,  C07C303/42 ,  C07C309/15 ,  C07C143/02

CPC分类号： C07C303/42 ,  C07C309/15

摘要： This disclosure relates to a process for the purification of 2-acrylamido-2-methylpropanesulfonic acid, which comprises dissolving said sulfonic acid in hydrous acetic acid of a water content of 3 to 80% by weight at 60.degree. to 110.degree. C. and subjecting the resulting solution to recrystallization. The purified product thus obtained is useful particularly as a starting material in preparing a high-molecular-weight polymer or copolymer.

摘要翻译： 本公开内容涉及2-丙烯酰氨基-2-甲基丙磺酸的纯化方法，其包括将所述磺酸溶解在含水量为3-80重量％的含水乙酸中，在60-110℃， 所得到的重结晶溶液。 由此获得的纯化产物特别用作制备高分子量聚合物或共聚物的原料。