公开(公告)号：US10805292B2

公开(公告)日：2020-10-13

申请号：US15898686

申请日：2018-02-19

申请人： FMR LLC

发明人： Rohith Ashok ,  Stein Eriksen

IPC分类号： H04L29/06 ,  H04W12/06 ,  H04W12/08 ,  H04L12/26 ,  H04L12/24 ,  H04L29/08

摘要： Methods and apparatuses are described for secure authentication and network access management for mobile computing devices. A server establishes a communications session with a mobile device. The server receives a network access request from the mobile device, the network access request including user access class data based upon authentication credentials provided by a user. The server determines a level of network access to provide to the mobile device based upon the user access class data. The server generates network configurations based upon the determined level of network access. The server applies the network configurations to the communications session with the mobile device. The server transmits an acknowledgment of the network access request to the mobile device. The mobile device routes network traffic originating from the mobile device to external network devices according to the applied network configurations.

公开(公告)号：US10802451B2

公开(公告)日：2020-10-13

申请号：US15499663

申请日：2017-04-27

申请人： Hypertherm, Inc.

发明人： Dana Labrecque ,  Christopher S. Passage

IPC分类号： B23K10/00 ,  G05B19/042 ,  H04W4/00 ,  H04L12/24 ,  H04L29/08

摘要： A material processing system includes a power supply in electrical communication with a cutting head. The power supply includes a control processor and a wireless communications control circuit configured to establish a web server for wirelessly communicating with a client device via a first communications interface. The wireless communications control circuit is configured to receive a request from the client device for a first web resource. The wireless communications control circuit is configured to request, via a second communications interface, a set of material processing system parameters from the control processor. The set of material processing system parameters is based on content of the request. The wireless communications control circuit is configured to serve, via the web server over the first communications interface, the first web resource to the client device. The first web resource includes web page formatting information and the set of material processing system parameters.

公开(公告)号：US10786557B2

公开(公告)日：2020-09-29

申请号：US16293134

申请日：2019-03-05

申请人： SHIRE VIROPHARMA LLC

发明人： Colin Broom ,  Jeffrey Dayno

IPC分类号： A61K38/57 ,  A61K38/55 ,  A61K45/06 ,  A61K35/16 ,  A61K39/395 ,  C07K16/18 ,  C07K16/28

摘要： Compositions and methods useful for the treatment of neuromyelitis optica (NMO) or neuromyelitis optica spectrum disorder (NMOSD) are disclosed.

公开(公告)号：US10729681B2

公开(公告)日：2020-08-04

申请号：US16119146

申请日：2018-08-31

申请人： Akebia Therapeutics, Inc.

发明人： Richard Masaru Kawamoto ,  Shengde Wu ,  Artem G. Evdokimov ,  Kenneth D. Greis ,  Angelique Sun Boyer ,  Namal C. Warshakoon

IPC分类号： A61K31/4418 ,  C07C235/60 ,  C07C237/42 ,  C07C255/57 ,  C07D213/81 ,  C07D213/65 ,  C07D405/10 ,  C07D405/04 ,  C07D295/192 ,  C07D401/04 ,  C07D401/10 ,  C07D417/04 ,  A61K31/4433

摘要： The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.

公开(公告)号：US10715516B1

公开(公告)日：2020-07-14

申请号：US16556834

申请日：2019-08-30

申请人： FMR LLC

发明人： Edward Colletta ,  Mrinal Vala

IPC分类号： G06F12/14 ,  H04L9/32 ,  G06F16/25 ,  H04L29/06 ,  G06F16/953

摘要： Methods and apparatuses are described for time-series database user authentication and access control. A server computing device receives a request from a remote computing device to access a time-series database coupled to the server computing device, wherein the request includes one or more authentication credentials associated with the remote computing device. The server computing device validates the one or more authentication credentials associated with the remote computing device. The server computing device connects to an access control layer associated with the time-series database. The access control layer authorizes the remote computing device to access data in the time-series database based upon an access profile associated with the validated authentication credentials. The server computing device retrieves data from the time-series database in response to the request.

公开(公告)号：US10713435B1

公开(公告)日：2020-07-14

申请号：US16412177

申请日：2019-05-14

申请人： FMR LLC

发明人： Romy Sreedharan ,  Celeste Dupuis

IPC分类号： G06F9/44 ,  G06F40/205 ,  G06F8/41 ,  G06K9/62 ,  G06F40/279

摘要： Methods and apparatuses are described for automated analysis, categorization, and behavior prediction of computer scripts using rules-based pattern matching. A server receives from a client device, a request for analysis of a process flow decision. The server identifies computer scripts that execute to generate the process flow decision. For each identified computer script: the server identifies text patterns in the computer script and categorizes the computer script based upon the identified patterns; the server converts the computer script into an expression tree data structure; the server traverses the expression tree to determine logical expressions that return a true result; the server parses each logical expression that returns a true result to identify parameters that contribute to the true result; the server generates a response to the request for analysis of the process flow decision and transmits the response to the request to the client computing device.

公开(公告)号：US10711246B2

公开(公告)日：2020-07-14

申请号：US14915992

申请日：2014-09-12

申请人： UNIVERSITY HEALTH NETWORK

发明人： Gordon Keller ,  Alec Drake Witty ,  Steven James Kattman

IPC分类号： C12N5/077 ,  C12Q1/6881 ,  G01N33/50

摘要： Provided are methods and products for obtaining cardiovascular lineage cells from hPSCs. The method for obtaining a cardiomyocyte lineage or an epicardial lineage cell population from human pluripotent stem cells (hPSCs) comprises one or more of the following steps: (a) contacting BMP component primed hPSCs with a cardiovascular mesoderm programming cocktail suitable for inducing the hPSCs to differentiate to a cardiovascular mesoderm cell population under conditions suitable for the programming cocktail to penetrate the hPSCs and culturing the contacted hPSCs for a period of time to generate a KDR+ and PDGFRalpha+ cardiovascular mesoderm cell population; (b) contacting the cardiovascular mesoderm cell population with a cardiovascular progenitor specification cocktail suitable to specify a NKX2-5+ or WT1+ cardiovascular progenitor cell population under conditions suitable for the specification cocktail to penetrate the cardiovascular mesoderm cell population and culturing the contacted cardiovascular mesoderm cell population for a period of time to generate a NKX2-5+ or WT1+ cardiovascular progenitor cell population; and (d) contacting the cardiovascular progenitor cell population with a maturation cocktail under conditions suitable for the maturation cocktail to penetrate the cardiovascular progenitor cell population and culturing the contacted cardiovascular progenitor population for a period of time to produce a cardiovascular population optionally cardiomyocyte lineage cells expressing cardiac troponin T (cTnT) and/or SIRPA and/or epicardial lineage cells expressing WT1.

公开(公告)号：US10702478B2

公开(公告)日：2020-07-07

申请号：US16452353

申请日：2019-06-25

申请人： Translate Bio, Inc.

发明人： Braydon Charles Guild ,  Michael Heartlein ,  Frank DeRosa ,  Jerry Chi Zhang

IPC分类号： A61K9/14 ,  A61K9/19 ,  C07D233/64 ,  A61K9/127 ,  C07C323/25 ,  C07C323/44 ,  C12N15/88 ,  A61K38/45 ,  A61K38/46 ,  A61K38/47 ,  A61K38/50 ,  A61K31/7088 ,  C07C323/27 ,  C07J41/00 ,  C07J43/00 ,  A61K9/51

摘要： Disclosed herein are novel compounds, pharmaceutical compositions comprising such compounds and related methods of their use. The compounds described herein are useful, e.g. as liposomal delivery vehicles to facilitate the delivery of encapsulated polynucleotides to target cells and subsequent transfection of said target cells, and in certain embodiments are characterized as having one or more properties that afford such compounds advantages relative to other similarly classified lipids.

公开(公告)号：US10693856B2

公开(公告)日：2020-06-23

申请号：US15672203

申请日：2017-08-08

申请人： FMR LLC

发明人： Richard Elliott Cox, Jr. ,  Robert S. Campbell ,  Ryan Hightower ,  Ramakrishnan Balachandran ,  Mena Gerges

IPC分类号： H04L29/06 ,  H04L29/08 ,  H04L12/58

摘要： Methods and apparatuses are described for automatic authentication switching in online chat sessions. A server receives a request to establish an online chat session from a first client device, including authentication credentials associated with the first client device. The server establishes an online chat session between the first client device and a second client device via a first authenticated communications channel. The server transmits one or more chat messages between the first client device and the second client device using the first authenticated communications channel. The first client device determines that the online chat session has lost authentication. The first client device automatically switches the online chat session to a second unauthenticated communications channel. The server maintains the established online chat session between the first client device and the second client device via the second unauthenticated communications channel.

公开(公告)号：USD879468S1

公开(公告)日：2020-03-31

申请号：US29609841

申请日：2017-07-06

申请人： JRSK, Inc.

设计人： Stephanie Korey ,  Jennifer Rubio ,  Bret Recor ,  Seth Murray ,  Charles Weber ,  Ahyoung Park