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公开(公告)号：US4200747A
公开(公告)日：1980-04-29
申请号：US947541
申请日：1978-10-02
IPC分类号： C07D501/36
CPC分类号： C07D501/36 , C07D501/24
摘要： New indole derivatives of cephalosporin compounds have been prepared which are useful as antibiotics.
摘要翻译： 已经制备了可用作抗生素的头孢菌素化合物的新吲哚衍生物。
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52.发明授权7-[(Substituted-thiomethyl)phenyl]acetamidocephalosporin derivatives 失效7- {8（取代的硫代甲基）苯基{9乙酰氨基头孢菌素衍生物
公开(公告)号：US4172942A
公开(公告)日：1979-10-30
申请号：US924939
申请日：1978-07-17
IPC分类号： C07D501/20 , C07D501/36
CPC分类号： C07D501/36 , C07D501/20
摘要： Novel compounds of the formula ##STR1## are useful as antibiotics.
摘要翻译： 新颖的式（IMAGE）化合物可用作抗生素。
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53.发明授权7-[(SUBSTITUTED-THIOMETHYL)PHENYL] ACETAMIDOCEPHALOSPORIN DERIVATIVES 失效7- {8（取代的 - 甲硫基）苯基{9 {0]乙酰氨基辛酸衍生物
公开(公告)号：US4124761A
公开(公告)日：1978-11-07
申请号：US853154
申请日：1977-11-21
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/04 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/28 , C07D501/34 , C07D501/36
CPC分类号： C07D501/36 , C07D501/20
摘要： Novel compounds of the formula ##STR1## are useful as antibiotics.
摘要翻译： 新颖的式（IMAGE）化合物可用作抗生素。
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公开(公告)号：US08722923B2
公开(公告)日：2014-05-13
申请号：US13531673
申请日：2012-06-25
申请人： Gideon Stein , Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman
发明人： Gideon Stein , Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman
IPC分类号： C07C261/00 , C07C229/00 , A01N37/12
CPC分类号： C07C237/12 , C07C229/36
摘要： A conjugate comprising L-DOPA covalently linked to at least one γ-aminobutyric acid (GABA) moiety, an ester and/or an addition salt thereof are disclosed, as well as uses thereof for treating a neurodegenerative disease or disorder.
摘要翻译： 公开了包含与至少一种γ-氨基丁酸（GABA）部分共价连接的L-DOPA，其酯和/或加成盐的缀合物，以及其用于治疗神经变性疾病或病症的用途。
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55.发明授权Conjugates comprising a psychotropic drug or a GABA agonist and an organic acid and their use in treating pain and other CNS disorders 失效包含精神药物或GABA激动剂和有机酸的缀合物及其在治疗疼痛和其它中枢神经系统疾病中的用途公开(公告)号：US08377990B2
公开(公告)日：2013-02-19
申请号：US12309361
申请日：2007-07-17
申请人： Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman
发明人： Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman
IPC分类号： A01N37/18 , A61K31/16 , C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00
摘要： A novel use of conjugates of psychotropic drugs (e.g., antidepressants or anti-epileptic drugs) and organic acids such as GABA in the treatment of pain is disclosed. A novel GABA conjugate and uses thereof is also disclosed.
摘要翻译： 公开了一种在治疗疼痛中使用精神药物（例如抗抑郁药或抗癫痫药物）和有机酸（例如GABA）的新型用途。 还公开了一种新型的GABA缀合物及其用途。
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56.发明授权Crystalline forms of the tri-mesylate salt of perphenazine-GABA and process of producing the same 有权奋乃静-GABA三甲磺酸盐的结晶形式及其制备方法公开(公告)号：US08377929B2
公开(公告)日：2013-02-19
申请号：US13034453
申请日：2011-02-24
申请人： Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman , Mazal Shaul , Efrat Halbfinger
发明人： Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman , Mazal Shaul , Efrat Halbfinger
IPC分类号： A61K31/5415 , C07D417/06 , A61P25/28 , A61P25/00 , A61P25/18 , B32B5/16 , B65D79/00
CPC分类号： C07D417/06 , C07D279/28 , Y10T428/2982
摘要： Novel crystalline form of perphenazine 4-aminobutyrate trimesylate and a process of producing the same are disclosed. The novel crystalline form is characterized by a unique XRPD pattern and a DSC that exhibits an endothermic peak at a relatively high temperature (e.g., higher than 209° C.). Also disclosed are a process of preparing perphenazine 4-aminobutyrate trimesylate by in situ deprotection and salification, in a single-step synthesis, and a highly pure perphenazine 4-aminobutyrate trimesylate obtained thereby. Uses of any of the described perphenazine 4-aminobutyrate trimesylate are also disclosed.
摘要翻译： 公开了4-氨基丁酸三苯甲磺隆的奋乃静化新型结晶形式及其生产方法。 新型结晶形式的特征在于独特的XRPD图案和DSC，其在相对较高的温度（例如高于209℃）下显示出吸热峰。 还公开了通过在单步合成中原位去保护和成盐，以及由此得到的高纯度的奋乃静4-氨基丁酸三苯甲磺酸盐，制备4-氨基丁酸三苯甲基奋乃静化物的方法。 还公开了所述所述的所述4-氨基丁酸三苯甲磺酸激素的用途。
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公开(公告)号：US20120309748A1
公开(公告)日：2012-12-06
申请号：US13586913
申请日：2012-08-16
申请人： Abraham Nudelman , Ada Rephaeli , Irit Gil-ad , Abraham Weizman
发明人： Abraham Nudelman , Ada Rephaeli , Irit Gil-ad , Abraham Weizman
IPC分类号： C07D417/06 , A61P25/18 , A61P25/00 , A61P25/24 , A61P35/04 , A61P25/16 , A61P25/28 , A61P25/08 , A61P35/00 , A61K31/5415 , A61P25/22
CPC分类号： C07D279/28 , A61K31/16 , A61K31/4172 , A61K31/5415 , A61K47/54 , A61K47/542 , A61K47/55
摘要： Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
摘要翻译： 公开了精神药物和有机酸的新型化学共轭物，其用于治疗精神病和/或增殖性疾病和疾病以及作为化学增敏剂的用途及其合成。 选择有机酸以减少由精神药物引起的副作用和/或发挥抗增殖活性。
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公开(公告)号：US20110034553A1
公开(公告)日：2011-02-10
申请号：US12867055
申请日：2009-02-11
申请人： Gideon Stein , Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman
发明人： Gideon Stein , Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman
IPC分类号： A61K31/24 , C07C57/34 , C07C229/34 , A61K31/195 , A61P25/28
CPC分类号： C07C237/12 , C07C229/36
摘要： A conjugate comprising L-DOPA covalently linked to at least one y-aminobutyric acid (GABA) moiety, an ester and/or an addition salt thereof are disclosed, as well as uses thereof for treating a neurodegenerative disease or disorder.
摘要翻译： 公开了包含与至少一种γ-氨基丁酸（GABA）部分共价连接的L-DOPA，其酯和/或加成盐的缀合物及其用于治疗神经变性疾病或病症的用途。
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59.发明申请NOVEL DERIVATIVES OF PURINIC AND PYRIMIDINIC ANTIVIRAL AGENTS AND USE THEREOF AS POTENT ANTICANCER AGENTS 审中-公开胭脂红抗菌药物的新型衍生物及其作为抗原剂的用途公开(公告)号：US20110028497A1
公开(公告)日：2011-02-03
申请号：US12450477
申请日：2008-03-30
申请人： Abraham Nudelman , Ada Rephaeli
发明人： Abraham Nudelman , Ada Rephaeli
IPC分类号： A61K31/522 , C07D473/18 , A61P35/00
CPC分类号： C07D473/18
摘要： Novel N-acylated, O-acylated and (bis or tris)-N,O-acylated derivatives of purinic and pyrimidinic nucleoside analogs, pharmaceutical compositions containing same, and uses thereof for treating proliferative diseases or disorders are disclosed.
摘要翻译： 公开了嘌呤和嘧啶核苷类似物的新型N-酰化，O-酰化和（双或三）-N，O-酰化衍生物，含有它们的药物组合物及其用于治疗增殖性疾病或病症的用途。
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公开(公告)号：US20100120755A1
公开(公告)日：2010-05-13
申请号：US12656048
申请日：2010-01-14
申请人： Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman
发明人： Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman
IPC分类号： A61K31/5415 , C07D513/00 , C07C229/08 , A61K31/225 , A61P25/18 , A61P35/00 , A61P35/04
CPC分类号： C07D279/28 , A61K31/16 , A61K31/4172 , A61K31/5415 , A61K47/54 , A61K47/542 , A61K47/55
摘要： Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side effects induced by the psychotropic drugs and/or to exert an anti-proliferative activity.
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