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公开(公告)号：US11674950B2
公开(公告)日：2023-06-13
申请号：US16756545
申请日：2018-10-30
发明人： Andrew Lane , Jon Aster
IPC分类号： A61K45/06 , G01N33/50 , G01N33/574
CPC分类号： G01N33/5011 , A61K45/06 , G01N33/57426
摘要： The present invention is based in part on the identification of DPH1 and other members of the diphthamide synthesis pathway as biomarkers of resistance to an ADP-ribosylating toxin in a cell, and methods for identification, assessment, and treatment of a condition that is resistant to an ADP-ribosylating toxin.
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公开(公告)号：US20230149460A1
公开(公告)日：2023-05-18
申请号：US17910776
申请日：2021-03-10
发明人： Jianzhu Chen , Jerome Ritz , Rizwan Romee , Han Dong , Guozhu Xie , James Dongjoo Ham
CPC分类号： A61K35/17 , A61P35/04 , C07K16/2818 , C07K16/3061
摘要： The present disclosure relates to cytokine-induced memory-like NK cells expressing a chimeric antigen receptor polypeptide that binds to a neoepitope of mutant nucleophosmin (NPM1c) in complex with, or presented by, a class I major histocompatibility complex (MHC class I) protein, or cells expressing such compounds, and their use in methods for treating, or ameliorating one or more symptoms of, cancer.
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公开(公告)号：US20230133538A1
公开(公告)日：2023-05-04
申请号：US17912272
申请日：2021-03-17
发明人： Fleur M. Ferguson , Nathanael S. Gray , Stephen J. Haggarty , Maria Catarina Telo Baptista Lima Da Silva
IPC分类号： C07D417/06 , C07D413/06 , C07D401/04 , C07D403/04 , C07D417/14 , C07D487/04
摘要： Disclosed are bispecific compounds (degraders) that target tau protein for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat neurodegenerative and neuropsychiatric diseases associated with aberrant tau.
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公开(公告)号：US20230132372A9
公开(公告)日：2023-04-27
申请号：US17387888
申请日：2021-07-28
发明人： Craig Braun , Wilhelm Haas , Steven P. Gygi , Gregory H. Bird , Loren D. Walensky , Martin Helmut Wuhr , Brian K. Erickson
IPC分类号： G01N33/58 , C07D207/46 , C07C237/22 , C07K1/13 , C07K5/02 , G01N33/68
摘要： In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.
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公开(公告)号：US20230115483A1
公开(公告)日：2023-04-13
申请号：US17978591
申请日：2022-11-01
发明人： Jun Qi , Anthony Varca , Li Chai
IPC分类号： C07D471/04 , C07D519/00 , C07D487/04
摘要： Provided herein are compounds that interrupt the function of SALL4. Also described are pharmaceutical compositions and medical uses of these compounds.
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公开(公告)号：US11624747B2
公开(公告)日：2023-04-11
申请号：US17015702
申请日：2020-09-09
申请人： ARIZONA BOARD OF REGENTS, a body corporate acting for and on behalf of Arizona State University , DANA-FARBER CANCER INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE
IPC分类号： G01N33/574 , C07K14/47 , C07K17/00 , C12Q1/6886 , C40B40/10
摘要： The present invention provides reagents and methods for breast cancer detection.
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公开(公告)号：US20230093238A1
公开(公告)日：2023-03-23
申请号：US17811282
申请日：2022-07-07
发明人： Alan D'Andrea , Kah Suan Lim
IPC分类号： A61K31/506 , A61P35/00 , A61K31/423 , A61K31/4439 , A61K31/454 , A61K31/713 , A61K38/17 , A61K38/45 , A61K39/395 , A61K45/06 , C07K16/40 , C12N15/113
摘要： The disclosure relates to methods for treating cancers (e.g., cancers having a BRCA1 and/or BRCA2 mutation(s)) by administering to the subject an effective amount of a ubiquitin-specific protease 1 (USP1) inhibitor.
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公开(公告)号：US11597934B2
公开(公告)日：2023-03-07
申请号：US17102787
申请日：2020-11-24
发明人： Kai W. Wucherpfennig , Glenn Dranoff , Penghui Zhou , Donald Shaffer , Nir Hacohen , Harvey I. Cantor , Diana Alvarez Arias
IPC分类号： C12N15/113 , A61K35/17 , C07K14/725 , C12N5/0783 , A61K39/00 , C07K16/32 , C12Q1/6886
摘要： The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.
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59.发明授权公开(公告)号：US11590213B2
公开(公告)日：2023-02-28
申请号：US16719814
申请日：2019-12-18
IPC分类号： A61K39/00 , A61K35/17 , C07K14/47 , C07K14/74 , C12N5/0783
摘要： Nanoparticles to treat autoimmune diseases and HIV infection are provided. The nanoparticles comprise a biocompatible polymer and a complex, wherein the complex is a major histocompatibility complex (MHC) class I antigen E (HLA-E) linked to a peptide, and wherein the HLA-E-peptide complex is linked to the surface of the nanoparticle. The present invention also relates to methods for treating autoimmune diseases and HIV infection.
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公开(公告)号：US11578075B2
公开(公告)日：2023-02-14
申请号：US17096026
申请日：2020-11-12
IPC分类号： C07D519/00 , C07D521/00 , A61K31/33 , A61P35/00 , A61P35/02 , C07D487/04 , A61K47/54 , C07D401/14 , C07D417/14 , C07D471/04 , C07D513/04 , C07D495/04 , A61K45/06 , C07D209/34
摘要： The present application provides bifunctional compounds of Formula (X): or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for protein kinases. The present application also relates to methods for the targeted degradation of one or more protein kinases through the use of the bifunctional compounds that link a ubiquitin ligase-binding moiety to a ligand that is capable of binding to one or more protein kinases which can be utilized in the treatment of disorders modulated by protein kinases.
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