公开(公告)号：US20070225221A1

公开(公告)日：2007-09-27

申请号：US11499892

申请日：2006-08-04

申请人： Jonathan Oliner ,  Hosung Min

发明人： Jonathan Oliner ,  Hosung Min

IPC分类号： A61K38/00

CPC分类号： A61K38/16 ,  A61K38/08 ,  A61K38/10 ,  A61K39/3955 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001 ,  C07K14/515 ,  C07K16/22 ,  C07K2317/52 ,  C07K2319/30 ,  A61K2300/00

摘要： Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.

公开(公告)号：US07259137B2

公开(公告)日：2007-08-21

申请号：US10145206

申请日：2002-05-13

申请人： Hosung Min ,  Hailing Hsu ,  Fei Xiong

发明人： Hosung Min ,  Hailing Hsu ,  Fei Xiong

IPC分类号： C07K7/00 ,  C07K14/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K38/10 ,  C07K1/047 ,  C07K14/001 ,  C07K14/4702 ,  C07K14/7151 ,  C07K16/241 ,  C07K2319/30 ,  C07K2319/74 ,  C12N15/1037 ,  C40B40/02

摘要： The present invention concerns therapeutic agents that modulate the activity of TALL-1. In accordance with the present invention, modulators of TALL-1 may comprise an amino acid sequence Dz2Lz4 wherein z2 is an amino acid residue and z4 is threonyl or isoleucyl. Exemplary molecules comprise a sequence of the formulae (SEQ. ID. NO: 100) a1a2a3CDa6La8a9a10Ca12a13a14, (SEQ. ID. NO: 104) b1b2b3Cb5b6Db8Lb10b11b12b13b14Cb16b17b18 (SEQ. ID. NO: 105) c1c2c3Cc5Dc7Lc9c10c11c12c13c14Cc16c17c18 (SEQ. ID. NO: 106) d1d2d3Cd5d6d7WDd10Ld13d14d15Cd16d17d18 (SEQ. ID. NO: 107) e1e2e3Ce5e6e7De9Le11Ke13Ce15e16e17e18 (SEQ. ID NO: 109) f1f2f3Kf5Df7Lf9f10Qf12f13f14 wherein the substituents are as defined in the specification. The invention further comprises compositions of matter of the formula (X1)a-V1-(X2)b wherein V1 is a vehicle that is covalently attached to one or more of the above TALL-1 modulating compositions of matter. The vehicle and the TALL-1 modulating composition of matter may be linked through the N- or C-terminus of the TALL-1 modulating portion. The preferred vehicle is an Fc domain, and the preferred Fc domain is an IgG Fc domain.

公开(公告)号：US20070072801A1

公开(公告)日：2007-03-29

申请号：US11499891

申请日：2006-08-04

申请人： Jonathan Oliner ,  Hosung Min

发明人： Jonathan Oliner ,  Hosung Min

IPC分类号： A61K38/16 ,  A61K38/10 ,  A61K38/08

CPC分类号： A61K38/16 ,  A61K38/08 ,  A61K38/10 ,  A61K39/3955 ,  C07K7/06 ,  C07K7/08 ,  C07K14/001 ,  C07K14/515 ,  C07K16/22 ,  C07K2317/52 ,  C07K2319/30 ,  A61K2300/00

摘要： Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.

摘要翻译： 公开了结合Ang-2的肽。 还公开了包含肽的肽类，制备这些肽和肽类的方法，以及使用这些肽和肽抗体的治疗方法。

公开(公告)号：US20050222035A1

公开(公告)日：2005-10-06

申请号：US11127702

申请日：2005-05-11

申请人： Thomas Boone ,  Kenneth Wild ,  Karen Sitney ,  Hosung Min ,  Bruce Kimmel

发明人： Thomas Boone ,  Kenneth Wild ,  Karen Sitney ,  Hosung Min ,  Bruce Kimmel

IPC分类号： A61K38/00 ,  C07H21/04 ,  C07K7/08 ,  C07K14/00 ,  A61K38/10

CPC分类号： C07K16/22 ,  A61K38/00 ,  C07H21/04 ,  C07K7/08 ,  C07K14/001

摘要： The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the causative agent. In one aspect of the present invention, pharmacologically active polypeptides comprising peptides linked to one or more Fc domains are provided.