公开(公告)号：US20080280327A1

公开(公告)日：2008-11-13

申请号：US12167680

申请日：2008-07-03

Applicant: Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

Inventor： Glenn R. Larsen ,  Dianne S. Sako ,  Xiao-Jia Chang ,  Geertruida M. Veldman ,  Dale Cumming ,  Ravindra Kumar ,  Gray Shaw

IPC: C12P21/00 ,  C07H21/04 ,  C12N5/06

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4703 ,  C07K14/51 ,  C07K14/52 ,  C07K14/5431 ,  C07K14/705 ,  C07K16/2851 ,  C07K16/2854 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/24 ,  C12N9/10 ,  C12N9/1051 ,  C12N9/6454 ,  C12N2770/36222

Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.

Abstract translation: 公开了一种新型P-选择素配体糖蛋白，其包含SEQ ID NO：2所示的氨基酸序列或SEQ ID NO：4所示的氨基酸序列。 还公开了编码P-选择素配体蛋白的DNA序列，以及载体，宿主细胞和制备P-选择蛋白配体蛋白的方法。 还公开了含有P-选择素配体蛋白质的药物组合物和治疗由P-选择蛋白和E-选择素介导的细胞间粘附特征的炎性疾病状态的方法。

公开(公告)号：US20050089888A1

公开(公告)日：2005-04-28

申请号：US10868371

申请日：2004-06-14

Applicant: Gray Shaw ,  Dianne Sako ,  Ravindra Kumar ,  Jin Xu

Inventor： Gray Shaw ,  Dianne Sako ,  Ravindra Kumar ,  Jin Xu

IPC: A61K38/00 ,  A61K38/36 ,  C07K14/705 ,  C07K14/745 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04 ,  C12N9/22

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K2319/00

Abstract: The present invention provides compositions and methods for treating or preventing vascular-associated disorders.

Abstract translation: 本发明提供了用于治疗或预防血管相关疾病的组合物和方法。

公开(公告)号：US5869307A

公开(公告)日：1999-02-09

申请号：US984246

申请日：1997-12-03

Applicant: Francis Sullivan ,  Ronald Kriz ,  Ravindra Kumar

Inventor： Francis Sullivan ,  Ronald Kriz ,  Ravindra Kumar

IPC: A61P29/00 ,  C12N1/21 ,  C12N9/88 ,  C12N15/60 ,  C12N9/06

CPC classification number: C12N9/88

Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.

Abstract translation: 本发明提供了一种新的GDP-甘露糖4,6-脱水酶。

公开(公告)号：US5728568A

公开(公告)日：1998-03-17

申请号：US753233

申请日：1996-11-22

Applicant: Francis Sullivan ,  Ronald Kriz ,  Ravindra Kumar

Inventor： Francis Sullivan ,  Ronald Kriz ,  Ravindra Kumar

IPC: A61P29/00 ,  C12N1/21 ,  C12N9/88 ,  C12N15/60 ,  C12N15/63

CPC classification number: C12N9/88

Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.

公开(公告)号：US20230017924A1

公开(公告)日：2023-01-19

申请号：US17787422

申请日：2020-12-21

Applicant: Urvi CHAUHAN ,  Rudra Pratap Singh CHAUHAN ,  Jagdeep Ravindra KUMAR

Inventor： Urvi CHAUHAN ,  Rudra Pratap Singh CHAUHAN ,  Jagdeep Ravindra KUMAR

IPC: F24H15/223 ,  F24D17/00 ,  F24D19/10 ,  F24H15/156 ,  F24H15/248 ,  F24H15/305

Abstract: Disclosed are system 100 and method of energy efficient hot and cold water management. The system 100 comprises: a control unit 101 for dynamically controlling the functioning of the system 100; at least a water storage tank 102 with at least one of a water level sensor, at least a heating element 1021, at least a temperature sensor 1022 or any combination thereof; at least an auxiliary water storage tank 103 with at least one of a water level sensor, at least a temperature sensor 1032; at least a water mixer unit 105 having at least a temperature sensor 1051; a user interface unit 1012 for controlling and monitoring different parameters including temperature, water level, opening and closing of valves 108 and 109; and a power supply with power backup unit 104 for providing basic power for proper functioning of the system 100.

公开(公告)号：US10059756B2

公开(公告)日：2018-08-28

申请号：US13447091

申请日：2012-04-13

Applicant: Asya Grinberg ,  John Knopf ,  Robert S. Pearsall ,  Ravindra Kumar ,  Jasbir Seehra ,  Kristian Pietras

Inventor： Asya Grinberg ,  John Knopf ,  Robert S. Pearsall ,  Ravindra Kumar ,  Jasbir Seehra ,  Kristian Pietras

IPC: A61K38/16 ,  C07K14/71

CPC classification number: C07K14/71 ,  C07K2319/30 ,  C07K2319/32

Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.

公开(公告)号：US09348730B2

公开(公告)日：2016-05-24

申请号：US11669776

申请日：2007-01-31

Applicant: Andrew J. Odlivak ,  Ravindra Kumar ,  Warren R. Stearns ,  John Glen Rockford

Inventor： Andrew J. Odlivak ,  Ravindra Kumar ,  Warren R. Stearns ,  John Glen Rockford

IPC: G06F9/44 ,  G06F11/36

CPC classification number: G06F11/3644 ,  G06F11/3628 ,  G06F11/3648

Abstract: A system in which firmware residing in ROM may be upgraded without re-spinning silicon. A one-bit flag may be assigned for each patchable function representing a firmware upgrade. The first statement of each function may check its associated flag and determine if patch-code should be executed in place of the current function residing in ROM. If the flag is not set, the code may continue executing normally. If the flag is set, a function identifier may be placed into a global memory location, and an assembly language “jump” instruction may be executed, redirecting program control to a specified location in a volatile Scratch Read Only Memory (SROM) where the corresponding patched code may be stored. If more than one function is patched, the global identifier may be used to determine which patched function to execute. Using an assembly language “jump” instruction to redirect control results in the patched function's returning normally to its calling function once it has completed executing.

Abstract translation: 驻留在ROM中的固件可以升级而不需要重新硅芯片的系统。 可以为表示固件升级的每个可修补功能分配一位标志。 每个功能的第一个语句可以检查其关联的标志，并确定是否应该执行补丁代码来代替驻留在ROM中的当前功能。 如果未设置标志，则代码可能会继续正常执行。 如果标志被设置，则可以将功能标识符放置到全局存储器位置中，并且可以执行汇编语言“跳转”指令，将程序控制重定向到易失性的只读存储器（SROM）中的指定位置，其中相应的 可以存储修补代码。 如果修复了多个功能，则可以使用全局标识符来确定要执行的修补功能。 使用汇编语言“跳转”指令重定向控制结果，修补后的函数在完成执行后正常返回到调用函数。

公开(公告)号：US20130202594A1

公开(公告)日：2013-08-08

申请号：US13757672

申请日：2013-02-01

Applicant: Rupal S. BHATT ,  Ravindra Kumar ,  James W. Mier ,  Robert Pearsall ,  Matthew Sherman ,  Nicolas Solban

Inventor： Rupal S. BHATT ,  Ravindra Kumar ,  James W. Mier ,  Robert Pearsall ,  Matthew Sherman ,  Nicolas Solban

IPC: A61K38/45 ,  A61K31/404 ,  A61K31/44 ,  A61K31/436 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/517 ,  A61K39/395 ,  A61K31/506

CPC classification number: A61K38/45 ,  A61K31/404 ,  A61K31/436 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4709 ,  A61K31/506 ,  A61K31/517 ,  A61K45/06 ,  A61K47/68 ,  A61K47/6811 ,  C07K16/22 ,  C07K16/40 ,  C07K2319/30 ,  C12Y207/1103 ,  A61K2300/00

Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit tumor growth of renal cell carcinoma (RCC) in vivo. In additional aspects the disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of ALK1 dramatically increases the ability of a standard of care receptor tyrosine kinase inhibitor to inhibit RCC tumor growth in vivo.

Abstract translation: 在某些方面，本公开内容涉及包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可以用于抑制体内肾细胞癌（RCC）的肿瘤生长的认识 。 在另外的方面，本公开涉及以下认识：包含ALK1的细胞外结构域的配体结合部分的多肽显着增加了护理受体酪氨酸激酶抑制剂标准物在体内抑制RCC肿瘤生长的能力。

公开(公告)号：US08455428B2

公开(公告)日：2013-06-04

申请号：US11982738

申请日：2007-11-02

Applicant: Asya Grinberg ,  John Knopf ,  Robert S. Pearsall ,  Ravindra Kumar ,  Jasbir Seehra

Inventor： Asya Grinberg ,  John Knopf ,  Robert S. Pearsall ,  Ravindra Kumar ,  Jasbir Seehra

IPC: A61K38/00

CPC classification number: A61K39/39558 ,  A61K45/06 ,  C07K14/71 ,  C07K16/18 ,  C07K2317/52 ,  C07K2319/30

Abstract: In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and antibodies that inhibit receptor-ligand interaction.

Abstract translation: 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 该公开内容还鉴定了ALK1的配体，并证明这些配体具有促血管生成活性，以及​​抑制受体 - 配体相互作用的抗体。

公开(公告)号：US08361957B2

公开(公告)日：2013-01-29

申请号：US13247748

申请日：2011-09-28

Applicant: Jasbir Seehra ,  Robert Scott Pearsall ,  Ravindra Kumar

Inventor： Jasbir Seehra ,  Robert Scott Pearsall ,  Ravindra Kumar

IPC: A61K38/00

CPC classification number: C12N9/12 ,  A61K38/179 ,  A61K38/1796 ,  C07K14/47 ,  C07K14/475 ,  C07K2319/30 ,  C12Q1/6897 ,  C12Y207/1103

Abstract: In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

Abstract translation: 在某些方面，本发明提供用于增加脊椎动物（包括啮齿动物和灵长类动物，特别是人）中红细胞和/或血红蛋白水平的组合物和方法。