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51.发明授权Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds 失效用于制备氨基甾醇，维生素D类似物和其他化合物的24-羟化化合物的立体选择性合成公开(公告)号：US06262283B1
公开(公告)日：2001-07-17
申请号：US08985876
申请日：1997-12-05
Applicant: William A. Kinney , Steven Jones , Xuehai Zhang , Meena N. Rao , Michel Bulliard , Harold Meckler , Nancy Lee
Inventor： William A. Kinney , Steven Jones , Xuehai Zhang , Meena N. Rao , Michel Bulliard , Harold Meckler , Nancy Lee
IPC: C07J4100
CPC classification number: C07J31/006 , C07J9/00 , C07J41/0005
Abstract: A method is described for stereoselectively reducing an unsaturated alkyl ketone substituent attached to a fused ring base. In this method, the unsaturated alkyl ketone reacts with a chiral oxazaborolidine reagent. This reaction stereoselectively reduces the unsaturated alkyl ketone to an unsaturated alkyl alcohol. The unsaturated alkyl alcohol can be further reduced, if desired, to produce a saturated alkyl alcohol. The fused ring base can be, for example, a steroid ring base or a base of a vitamin D analog. The process in accordance with the invention can be used with an alkeneone substituent (e.g., a 22-ene-24-one substituent) or an alkyneone substituent (e.g., a 22-yne-24-one substituent) on a steroid ring base to make squalamine or other useful aminosterol compounds and intermediates for making aminosterol compounds.
Abstract translation: 描述了立体选择性还原与稠环基团连接的不饱和烷基酮取代基的方法。 在该方法中，不饱和烷基酮与手性恶唑硼烷试剂反应。 该反应立体选择性地将不饱和烷基酮还原成不饱和烷基醇。 如果需要，可以进一步还原不饱和烷基醇以制备饱和烷基醇。 稠环基可以是例如类固醇环基或维生素D类似物的碱。 根据本发明的方法可以与类固醇环基上的烯酮取代基（例如，22-烯-24一取代基）或炔炔酮取代基（例如，22-炔-24-取代基）一起使用 制备角质胺或其他有用的氨基甾醇化合物和制备氨基甾醇化合物的中间体。
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公开(公告)号：US09766029B2
公开(公告)日：2017-09-19
申请号：US13548154
申请日：2012-07-12
Applicant: Serge Dextraze , Steven Jones
Inventor： Serge Dextraze , Steven Jones
Abstract: A detachable chassis base for a tactical rifle is presented. The lower chassis receiver assembly can have a detachable chassis base that substantially selectively attaches to the chassis receiver interface. The detachable chassis base can be completely removable, or it can be hingedly attached to provide access without completely removing the chassis base, or a combination thereof. Multiple combinations of parts included in the detachable chassis base are possible. Several variations and combinations are illustrated herein, although others are contemplated.
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公开(公告)号：US08549823B2
公开(公告)日：2013-10-08
申请号：US13016463
申请日：2011-01-28
Applicant: Jerry Wayne Pipes , Mark Shane Hatcher , Wesley Steven Jones
Inventor： Jerry Wayne Pipes , Mark Shane Hatcher , Wesley Steven Jones
IPC: B65B53/02
CPC classification number: B65B51/10 , B31B50/26 , B31B2100/00 , B65B19/02 , B65B19/025 , B65B53/02 , B65B2220/16
Abstract: Methods and machines are provided for forming a five-sided carton of packages of smoking articles. A piece of film material is applied to a plurality of packages of smoking articles such that five sides of the plurality of packages are at least partially covered by the film material, but the sixth side remains uncovered. The film material is applied such that the group of packages is sufficiently tightly bound so that none of the packages may slip free from the carton. The sixth side of the plurality of packages in the carton remains exposed so that tax stamps may be easily applied. The film of material may be applied so that a gap is formed relative to the sixth side.
Abstract translation: 提供了用于形成吸烟制品包装的五面纸箱的方法和机器。 将一片薄膜材料施加到多个发烟制品包装，使得多个包装的五个面至少部分被薄膜材料覆盖，但是第六面保持未被覆盖。 应用薄膜材料使得包装组具有足够的紧密结合，使得包装物中的任何一个都不会脱离纸箱。 纸箱中的多个包装的第六面保持暴露，使得可以容易地应用税券。 可以施加材料膜，使得相对于第六面形成间隙。
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公开(公告)号：USD687300S1
公开(公告)日：2013-08-06
申请号：US29429241
申请日：2012-08-08
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公开(公告)号：USD685522S1
公开(公告)日：2013-07-02
申请号：US29432110
申请日：2012-09-13
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Patent Agency Ranking
公开(公告)号：USD677163S1
公开(公告)日：2013-03-05
申请号：US29429244
申请日：2012-08-08
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公开(公告)号：USD667304S1
公开(公告)日：2012-09-18
申请号：US29386800
申请日：2011-03-04
Applicant: Wesley Steven Jones , Jerry Wayne Pipes
Designer： Wesley Steven Jones , Jerry Wayne Pipes
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公开(公告)号：USD667301S1
公开(公告)日：2012-09-18
申请号：US29386792
申请日：2011-03-04
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公开(公告)号：US20120171245A1
公开(公告)日：2012-07-05
申请号：US13327206
申请日：2011-12-15
Applicant: Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , John J. Court , Hongbo Deng , Ioana Davies , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Dylan H. Jacobs , Joseph M. Kennedy , Mark W. Ledeboer , Brian Ledford , Francois Maltais , Emanuele Perola , Tiansheng Wang , M. Woods Wannamaker , Randal Byrn , Yi Zhou , Chao Lin , Min Jiang , Steven Jones , Ursula A. Germann
Inventor： Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , John J. Court , Hongbo Deng , Ioana Davies , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Dylan H. Jacobs , Joseph M. Kennedy , Mark W. Ledeboer , Brian Ledford , Francois Maltais , Emanuele Perola , Tiansheng Wang , M. Woods Wannamaker , Randal Byrn , Yi Zhou , Chao Lin , Min Jiang , Steven Jones , Ursula A. Germann
IPC: A61K39/145 , A61K31/506 , A61K31/5377 , A61K31/551 , A61K31/553 , A01P1/00 , A01N43/90 , C07D491/08 , C07D491/107 , A61P31/16 , A61P37/04 , C07D471/04 , A61K31/55
CPC classification number: A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D239/30 , C07D401/04 , C07D401/10 , C07D471/04
Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A compound is represented by Structural Formula (IA) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (IA) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
Abstract translation: 抑制生物样品或患者中流感病毒复制，减少生物样品或患者中的流感病毒数量和治疗患者流感的方法包括向所述生物样本或患者施用有效量的 由结构式（I）表示的化合物或其药学上可接受的盐，其中结构式（IA）的值如本文所述。 化合物由结构式（IA）或其药学上可接受的盐表示，其中结构式（IA）的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐，以及药学上可接受的载体，佐剂或媒介物。
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60.发明申请SYSTEM, METHOD, AND COMPUTER-READABLE MEDIUM FOR DELIVERING RELEVANT MEDICAL INFORMATION 审中-公开用于递送相关医学信息的系统，方法和计算机可读介质公开(公告)号：US20120130745A1
公开(公告)日：2012-05-24
申请号：US13304595
申请日：2011-11-25
Applicant: Steven Jones
Inventor： Steven Jones
IPC: G06Q50/24
Abstract: A system, method, and computer-readable medium for delivering relevant medical information are disclosed. Such a method for delivering relevant medical information includes determining that a medical order has been scheduled or completed for a patient, identifying the patient that is the subject of the medical order, finding prior medical records of the patient, automatically determining relevant medical records from the prior medical records of the patient based upon the medical order, and delivering the relevant medical records to one or more remote computers.
Abstract translation: 公开了用于递送相关医疗信息的系统，方法和计算机可读介质。 用于递送相关医疗信息的这种方法包括确定已经为患者安排或完成了医疗订单，识别作为医疗命令的主体的患者，找到患者的先前病历，自动确定患者的相关医疗记录 基于医疗订单的患者的先前病历，以及将相关医疗记录递送到一个或多个远程计算机。
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