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公开(公告)号:US08338412B2
公开(公告)日:2012-12-25
申请号:US13107802
申请日:2011-05-13
申请人: Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人: Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号: C07D487/04 , A61K31/5025
CPC分类号: C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译: 本发明涉及p38的抑制剂,哺乳动物蛋白激酶涉及细胞增殖,细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号:US07951809B2
公开(公告)日:2011-05-31
申请号:US12062495
申请日:2008-04-03
申请人: Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
发明人: Guy W. Bemis , Francesco G. Salituro , John P. Duffy , John E. Cochran , Edmund M. Harrington , Mark A. Murcko , Keith P. Wilson , Michael Su , Vincent P. Galullo
IPC分类号: C07D239/70 , A61K31/519
CPC分类号: C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
摘要翻译: 本发明涉及p38的抑制剂,哺乳动物蛋白激酶涉及细胞增殖,细胞死亡和对细胞外刺激的反应。 本发明还涉及生产这些抑制剂的方法。 本发明还提供包含本发明抑制剂的药物组合物和利用这些组合物治疗和预防各种疾病的方法。
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公开(公告)号:US07205305B2
公开(公告)日:2007-04-17
申请号:US10622320
申请日:2003-07-17
申请人: Guy W Bemis , Francesco G Salituro , John P Duffy , John E Cochran , Edmund M Harrington , Mark A Murcko , Keith P Wilson , Michael Su , Vincent P Galullo
发明人: Guy W Bemis , Francesco G Salituro , John P Duffy , John E Cochran , Edmund M Harrington , Mark A Murcko , Keith P Wilson , Michael Su , Vincent P Galullo
IPC分类号: C07D213/02 , C07D213/89 , A61K31/44
CPC分类号: C07D213/70 , C07D213/56 , C07D213/75 , C07D237/18 , C07D241/12 , C07D241/20 , C07D401/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D471/04 , C07D487/04 , C07F9/6561
摘要: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
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公开(公告)号:US20180325898A1
公开(公告)日:2018-11-15
申请号:US16042206
申请日:2018-07-23
申请人: Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
发明人: Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号: A61K31/506 , A61K9/48 , C07D417/10 , A61K41/00 , C07D521/00 , C07D495/04 , C07D491/056 , C07D491/048 , C07D471/04 , C07D417/14 , C07D417/04 , C07D413/10 , C07D413/04 , C07D409/14 , C07D409/04 , C07D239/42 , C07D403/10 , C07D403/04 , C07D401/04 , C07D413/14 , C07D405/14 , C07D401/14 , A61K47/55 , A61K31/53 , A61K47/54 , A61K31/5377 , A61K9/20
CPC分类号: C07D401/14 , A61K9/20 , A61K9/48 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要: The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号:US20210040092A1
公开(公告)日:2021-02-11
申请号:US17083569
申请日:2020-10-29
申请人: Paul S. Charifson , Michael P. Clark , Upal K. Bandarage , Randy S. Bethiel , Michael J. Boyd , Ioana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brain Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
发明人: Paul S. Charifson , Michael P. Clark , Upal K. Bandarage , Randy S. Bethiel , Michael J. Boyd , Ioana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brain Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
IPC分类号: C07D471/04 , A61K31/506 , A61K45/06 , C07F9/6561 , A61K31/215 , A61K31/351 , A61K31/444 , A61K31/497
摘要: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
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公开(公告)号:US20160355512A1
公开(公告)日:2016-12-08
申请号:US15177546
申请日:2016-06-09
申请人: Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , Michael J. Boyd , loana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brian Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
发明人: Paul S. Charifson , Michael P. Clark , Upul K. Bandarage , Randy S. Bethiel , Michael J. Boyd , loana Davies , Hongbo Deng , John P. Duffy , Luc J. Farmer , Huai Gao , Wenxin Gu , Joseph M. Kennedy , Brian Ledford , Mark W. Ledeboer , Francois Maltais , Emanuele Perola , Tiansheng Wang
IPC分类号: C07D471/04 , A61K31/351 , A61K31/215 , A61K31/497 , A61K31/506 , A61K31/444
CPC分类号: C07D471/04 , A61K31/215 , A61K31/351 , A61K31/444 , A61K31/497 , A61K31/506 , A61K45/06 , C07F9/6561
摘要: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译: 或其药学上可接受的盐,其中结构式(I)的值如本文所述。 化合物由结构式(I)表示或其药学上可接受的盐,其中结构式(I)的值如本文所述。 药物组合物包含有效量的这种化合物或其药学上可接受的盐,以及药学上可接受的载体,佐剂或媒介物。
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公开(公告)号:US07592340B2
公开(公告)日:2009-09-22
申请号:US11004657
申请日:2004-12-03
申请人: Guy W. Bernis , John P. Duffy
发明人: Guy W. Bernis , John P. Duffy
IPC分类号: C07D241/42 , C07D241/44 , A61K31/498 , A61P35/04 , A61P37/02 , A61P25/28
CPC分类号: C07D241/26 , C07D241/44 , C07D401/12 , C07D403/12 , C07D417/12
摘要: The present invention relates to compounds of formula I useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的式I化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US6162790A
公开(公告)日:2000-12-19
申请号:US24537
申请日:1998-02-17
申请人: Guy W. Bemis , John P. Duffy , Wolf Herman Fridman , Julian M. C. Golec , David J. Livingston , Michael D. Mullican , Mark A. Murcko , Robert E. Zelle
发明人: Guy W. Bemis , John P. Duffy , Wolf Herman Fridman , Julian M. C. Golec , David J. Livingston , Michael D. Mullican , Mark A. Murcko , Robert E. Zelle
IPC分类号: A61K38/00 , A61K38/55 , A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P5/14 , A61P7/00 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/02 , A61P19/08 , A61P19/10 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P37/02 , A61P43/00 , C07K5/00 , C07K5/02 , C07K5/08 , C07K5/083
CPC分类号: C07K5/0205 , A61K38/00 , C07K5/0202 , Y02A50/475
摘要: The present invention relates to novel classes of compounds which are inhibitors of interleukin-1 .beta. converting enzyme. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting ICE activity and consequently, may be advantageously used as agents against interleukin-1 and apoptosis-mediated diseases, including inflammatory diseases, autoimmune diseases, proliferative, infectious, and degenerative diseases. This invention also relates to methods for inhibiting ICE activity and methods for treating interleukin-1 mediated diseases using the compounds and compositions of this invention.
摘要翻译: 本发明涉及作为白细胞介素-1β转换酶抑制剂的新型化合物。 本发明还涉及包含这些化合物的药物组合物。 本发明的化合物和药物组合物特别适用于抑制ICE活性,因此可有利地用作抗白介素-1和细胞凋亡介导的疾病(包括炎性疾病,自身免疫性疾病,增殖性,感染性和退行性疾病)的药物。 本发明还涉及使用本发明的化合物和组合物来抑制ICE活性的方法和用于治疗白细胞介素-1介导的疾病的方法。
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公开(公告)号:US20100081657A1
公开(公告)日:2010-04-01
申请号:US12540516
申请日:2009-08-13
申请人: Guy W. Bemis , John P. Duffy
发明人: Guy W. Bemis , John P. Duffy
IPC分类号: A61K31/498 , C07D241/44 , C07D413/12 , A61K31/5377 , A61P25/28 , A61P25/16 , A61P25/22 , A61P3/10 , A61P11/06 , A61P27/00
CPC分类号: C07D241/26 , C07D241/44 , C07D401/12 , C07D403/12 , C07D417/12
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US4504654A
公开(公告)日:1985-03-12
申请号:US418629
申请日:1982-09-16
申请人: John P. Duffy
发明人: John P. Duffy
CPC分类号: C08F6/12
摘要: An improved process is provided for the recovery of a polymer from a solution thereof in an organic solvent by contact with steam and water wherein economics in the use of energy are achieved by controlling the contact of said solution with steam and water to provide a predetermined amount of residual solvent in the polymer, said contact being under conditions of controlled temperature and pressure. Such a process may be used for the recovery, for example, of polybutadiene from a solution in a benzene-butene-1 mixture.
摘要翻译: 提供了一种改进的方法,用于通过与蒸汽和水接触从有机溶剂中的溶液中回收聚合物,其中使用能量的经济性通过控制所述溶液与蒸汽和水的接触来提供预定量 的聚合物中的残留溶剂,所述接触在受控的温度和压力的条件下。 这种方法可以用于从苯 - 丁烯-1混合物中的溶液中回收例如聚丁二烯。
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