公开(公告)号：US20210038540A1

公开(公告)日：2021-02-11

申请号：US16992742

申请日：2020-08-13

申请人： The United States of America as represented by the Secretary, Department of Health and Human Service

发明人： Irving W. Wainer ,  Michel Bernier ,  Rajib K. Paul

IPC分类号： A61K31/137 ,  A61K45/06 ,  A61K31/05

摘要： This disclosure concerns the discovery of the use of fenoterol analogues for regulating cannabinoid (CB) receptor activity-related disorders and disease, such as dysregulated CB receptors, including treating a disorder or disease, such as a glioblastoma, hepatocellular carcinoma, liver cancer, colon cancer, and/or lung cancer, which is associated with altered cannabinoid receptor activity. In one example, the method includes administering to a subject having or at risk of developing a disorder or disease regulated by CB receptor activity an effective amount of a fenoterol analogue to reduce one or more symptoms associated with the disorder or disease regulated by CB receptor activity.

公开(公告)号：US20200325223A1

公开(公告)日：2020-10-15

申请号：US16912291

申请日：2020-06-25

申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE

发明人： Michel Sadelain ,  Reuben Benjamin ,  Dimiter S. Dimitrov ,  Yang Feng

IPC分类号： C07K16/28 ,  C07K14/725 ,  C07K16/30 ,  A61P35/00 ,  A61K35/17 ,  C07K14/705

摘要： The presently disclosed subject matter provides for methods and compositions for treating cancer (e.g., multiple myeloma). It relates to anti-CD56 antibodies, chimeric antigen receptors (CARs) that specifically target human CD56, and immunoresponsive cells comprising such CARs. The presently disclosed CD56-specific CARs have enhanced immune-activating properties, including anti-tumor activity.

公开(公告)号：US20200233099A1

公开(公告)日：2020-07-23

申请号：US16644441

申请日：2018-09-04

申请人： THE UNITED STATES OF AMERICA,as Represented by the Secretary, Department of Health and Human Service

发明人： Stephen S. Adler

IPC分类号： G01T1/167 ,  G01T1/202 ,  G01T7/00 ,  G01T1/20

摘要： Methods and apparatus for calibrating radioactive sources are described. An array of scintillation detectors forms a receptacle within which a sample or sample container can be retained by a holder. The scintillation detectors are coupled via light transducers such as photomultiplier tubes (PMTs) to independent electronic counters. Coincidence processing of time-tagged events yields a correlated event rate. One or more corrections can be applied as needed, for background counts, deadtime, or random coincidences. Voltage tuning of PMTs yields improved reproducibility. Accuracy of 1% has been demonstrated over a range of 10 kBq -3 MBq.

公开(公告)号：US20200184647A1

公开(公告)日：2020-06-11

申请号：US16620464

申请日：2018-06-08

申请人： The United States of America, as represented by the Secretary Department of Health and Human Service

发明人： Adam Patrick Harrison ,  Ziyue Xu ,  Le Lu ,  Ronald M. Summers ,  Daniel Joseph Mollura

IPC分类号： G06T7/00 ,  G06N3/04 ,  G06N3/08 ,  G16H30/40 ,  G16H50/50 ,  G06T7/174 ,  A61B6/00 ,  A61B6/03 ,  A61B5/00

摘要： Methods include processing image data through a plurality of network stages of a progressively holistically nested convolutional neural network, wherein the processing the image data includes producing a side output from a network stage m, of the network stages, where m>1, based on a progressive combination of an activation output from the network stage m and an activation output from a preceding stage m−1. Image segmentations are produced. Systems include a 3D imaging system operable to obtain 3D imaging data for a patient including a target anatomical body, and a computing system comprising a processor, memory, and software, the computing system operable to process the 3D imaging data through a plurality of progressively holistically nested convolutional neural network stages of a convolutional neural network.

公开(公告)号：US20200181280A1

公开(公告)日：2020-06-11

申请号：US16429829

申请日：2019-06-03

申请人： The United States of America, as represented by the Secretary,Department of Health and Human Service ,  Hoffmann-La Roche Inc.

发明人： Ira H. Pastan ,  Ronit Mazor ,  Masanori Onda ,  Byungkook Lee ,  Gerhard Niederfellner ,  Sabine Imhof-Jung ,  Ulrich Brinkmann ,  Werner Scheuer ,  Guy Georges

IPC分类号： C07K16/30 ,  C07K14/21 ,  C07K16/12 ,  C07K16/40 ,  A61K31/337 ,  A61K47/68 ,  A61K39/395

摘要： The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The invention further provides related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions. Methods of treating or preventing cancer in a mammal, methods of inhibiting the growth of a target cell, methods of producing the PE, and methods of producing the chimeric molecule are further provided by the invention.

公开(公告)号：US10561673B2

公开(公告)日：2020-02-18

申请号：US16223793

申请日：2018-12-18

申请人： Wayne State University ,  The United States of America as Represented by the Secretary, Department of Health and Human Service

发明人： Kannan Rangaramanujam ,  Sujatha Kannan ,  Roberto Romero ,  Raghavendra S Navath ,  Hui Dai ,  Anupa R. Menjoge

IPC分类号： A61K9/00 ,  A61K31/65 ,  A61K47/64 ,  A61K47/59 ,  A61K47/60 ,  A61K38/10 ,  A61K31/198 ,  A61K31/405 ,  A61K31/43 ,  A61K31/57 ,  A61K31/573 ,  C08G83/00

摘要： A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAMAM dendrimer or multiarm PEG polymer using a disulfide bond, administering the PAMAM dendrimer or multiarm PEG polymer to a patient in need of treatment, localizing the dendrimer or multiarm PEG polymer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.

公开(公告)号：US20190285643A1

公开(公告)日：2019-09-19

申请号：US16387486

申请日：2019-04-17

申请人： Wayne State University ,  The United States of America as Represented by the Secretary, Department of Health and Human Service

发明人： Tinnakorn Chaiworapongsa ,  Roberto Romero ,  Sonia S. Hassan

IPC分类号： G01N33/68 ,  C12Q1/6883 ,  A61K31/22 ,  G16H50/30 ,  A61K31/616 ,  A61K31/727 ,  G16H20/10

摘要： Provided are systems and methods for assessing the presence or risk of obstetrical complications, particularly those related to an angiogenic and anti-angiogenic imbalance. Also provided are methods of treating an angiogenic and anti-angiogenic imbalance with water-soluble statins, such as pravastatin.

公开(公告)号：US20190091325A1

公开(公告)日：2019-03-28

申请号：US15765716

申请日：2016-09-28

申请人： THE UNITED STATES OF AMERICA,as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICE

发明人： Baoming Jiang ,  Yuhuan Wang

IPC分类号： A61K39/15 ,  C12N7/00 ,  A61K39/39 ,  A61K9/00 ,  A61P31/14

CPC分类号： A61K39/15 ,  A61K9/0053 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/55505 ,  A61P31/14 ,  C12N7/00 ,  C12N2720/12021 ,  C12N2720/12034 ,  C12N2720/12043

摘要： Attenuated G9P[6] rotavirus is disclosed herein. In some embodiments, pharmaceutical compositions are disclosed that include an attenuated G9P[6] rotavirus, or a component thereof. These compositions can be used to induce an immune response, such as a protective immune response, to a rotavirus. The compositions can be used as vaccines, such as for children (infants), for example in a prime boost strategy.

公开(公告)号：US20190085047A1

公开(公告)日：2019-03-21

申请号：US16205631

申请日：2018-11-30

申请人： The United States of America,as represented by the Secretary, Department of Health and Human Service

发明人： Christian S. Hinrichs ,  Steven A. Rosenberg

IPC分类号： C07K14/725 ,  C07K16/28 ,  A61K38/17 ,  G01N33/569 ,  G01N33/574 ,  A61K38/00

摘要： Disclosed is a synthetic T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E7, E711-19. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.

公开(公告)号：US20180003720A1

公开(公告)日：2018-01-04

申请号：US15545402

申请日：2016-02-01

申请人： The United States of America,as represented by the Secretary,Department of Health and Human Service

发明人： Christophe E. Redon ,  William M. Bonner ,  Yiping Zhang ,  Jiuping Ji

IPC分类号： G01N33/68 ,  C12Q1/68

CPC分类号： G01N33/6875 ,  C12Q1/6804 ,  C12Q2522/101 ,  C12Q2523/107

摘要： Disclosed are methods of measuring the amount of exposure of a host to a DNA double-stranded break (DSB)-causing agent by determining the ratio of the quantity of γ-H2AX to the quantity of total H2AX in a biological sample from the host as compared to the ratio of the quantity of γ-H2AX to the quantity of total H2AX in a positive control biological sample that has been exposed to a known amount of a DSB-causing agent. Related kits and methods of quantifying DSBs in a test biological sample are also disclosed.