公开(公告)号：US20250137059A1

公开(公告)日：2025-05-01

申请号：US18722756

申请日：2022-12-20

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  HUMANSCAPE INC.

Inventor： Beom Hee LEE ,  Min Hoo CHANG ,  Sun Hee HEO ,  Hyo Sang DO ,  Min Ji KANG

IPC: C12Q1/6886 ,  A61K31/4245 ,  A61P35/00 ,  C12Q1/48 ,  G01N33/574 ,  G01N33/68

Abstract: A biomarker composition for predicting susceptibility to a therapeutic agent for neurofibromatosis by using Ras activity; and a pharmaceutical composition for preventing or treating neurofibromatosis, including a Ras activity inhibitor. The biomarker composition can accurately diagnose susceptibility to a therapeutic agent for neurofibromatosis by measuring the expression levels of a GTP-bound and activated Ras (Ras-GTP) protein and an activated p-ERK protein or a gene encoding the same in a biological sample of an individual. The pharmaceutical composition inhibits the activity of Ras proteins, and thus can be effectively used for the prevention or treatment of neurofibromatosis in which the activity of the Ras proteins is increased.

公开(公告)号：US20250127678A1

公开(公告)日：2025-04-24

申请号：US19001153

申请日：2024-12-24

Applicant: THE ASAN FOUNDATION ,  NUNAPS INC. ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Dong Wha KANG ,  Hyun Taek LIM ,  Byung Joo LEE ,  Rak Kyeun HONG ,  Yong Hwan KIM

IPC: A61H5/00 ,  A61B3/113 ,  G06F3/01 ,  G06T7/00 ,  G06T7/20 ,  G06T7/70 ,  G06T19/00

Abstract: The present invention relates to an apparatus and method for providing virtual reality-based eye movement exercise and visual perception training, wherein a dichoptic presentation is provided in consideration of the deviation of a user's eyeball so as to prevent additional damage to stereoscopic vision due to suppression, and is provided by adjusting the degree of difficulty by changing the locations of visual stimuli on the basis of the level of deviation and training capability of the user, thus making it possible for the user to not only receive training suitable for the user's condition, but also simultaneously undergo visual perception training including eye exercise (movement) training and stereoscopic perception recognition.

公开(公告)号：US20250118441A1

公开(公告)日：2025-04-10

申请号：US18730634

申请日：2023-01-20

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sook Ryun PARK ,  Jung Kyoon CHOI ,  Jinhyeon AN ,  Changhwan SUNG

IPC: G16H50/30 ,  G16B20/20 ,  G16B40/20 ,  G16H10/40

Abstract: A SNP-based model for predicting the occurrence of irAEs induced by immunotherapy. The dbSNP database rs541169 and a single nucleotide polymorphism (SNP) site in the TMEM162 (FAM187B) gene are closely correlated with the occurrence of irAEs. The rs541169 can be advantageously used as a biomarker for predicting the occurrence of irAEs induced by immunotherapy or predicting responsiveness to immunotherapy.

公开(公告)号：US20250109523A1

公开(公告)日：2025-04-03

申请号：US18684120

申请日：2022-03-08

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Tae Heon KIM ,  Chang Won AHN ,  Muhammad SHEERAZ

IPC: C30B23/02 ,  C30B29/22

Abstract: The present invention provides a method for manufacturing a free-standing single-crystal membrane having a perovskite structure, the method comprising: applying an oxygen-deficient perovskite sacrificial layer having an ACuO2 structure (where A is at least one selected from the group consisting of calcium (Ca), strontium (Sr), and barium (Ba)) on a substrate; epitaxially growing a single-crystal membrane having a perovskite structure on the sacrificial layer; and selectively removing the sacrificial layer using an etchant, and provides a method for transferring a free-standing single-crystal membrane having a perovskite structure by using the method for manufacturing a free-standing single-crystal membrane having a perovskite structure.

公开(公告)号：US20250101516A1

公开(公告)日：2025-03-27

申请号：US18730595

申请日：2023-01-20

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sook Ryun PARK ,  Jung Kyoon CHOI ,  Jinhyeon AN ,  Changhwan SUNG

IPC: C12Q1/6881

Abstract: A method for predicting the occurrence of immune-related adverse events (irAEs) induced by an HLA type-based cancer immunotherapy agent. The method involves determining copy number variations (CNVs) of the HLA gene, such as HLA-B exon 2 deficiency, or HLA alleles such as HLA-B*35:01, HLA-B*40:02, HLA-B*54:01, or detecting an allele of an HLA gene selected from HLA-B*35:01, HLA-B*40:02, and HLA-B*54:01, in a biological sample isolated from a subject, and treating the cancer immunotherapy-induced irAE in the subject by administering to the subject a corticosteroid or immunosuppressant.

公开(公告)号：US20250090415A1

公开(公告)日：2025-03-20

申请号：US18961944

申请日：2024-11-27

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Jae Yong JEON ,  Sang Ah KIM ,  Hwayeong CHEON

IPC: A61H23/02

Abstract: The present disclosure relates to a medical vibratory stimulation device comprising: a wearable part that is worn on a target site of the body; a plurality of vibration elements which are arranged in the wearable part to apply vibratory stimuli to the target site of the body; and a control unit which individually controls the plurality of vibration elements so that the plurality of vibration elements sequentially apply vibratory stimuli from the distal portion to the proximal portion of the target site of the body.

公开(公告)号：US20250057616A1

公开(公告)日：2025-02-20

申请号：US18723273

申请日：2023-03-03

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  LN ROBOTICS INC.

Inventor： Jaesoon CHOI ,  Young-Hak KIM ,  Sunghan BAE ,  Young Jin MOON

IPC: A61B34/37 ,  A61B17/22 ,  A61B34/30

Abstract: A medical procedure tool control apparatus, according to one embodiment, has: a main housing; a medical procedure tool control assembly installed in the main housing so as to control at least one medical procedure tool; and a guide catheter control assembly positioned at the front end side of the main housing so as to control a guide catheter for guiding a path of the at least one medical procedure tool. The guide catheter control assembly includes a frame positioned at the front end of the main housing; and a first roller module and a second roller module installed on the frame, wherein the second roller module may move horizontally toward the first roller module so as to enable the guide catheter to be held between the first roller module and the second roller module.

公开(公告)号：US20250009879A1

公开(公告)日：2025-01-09

申请号：US18712346

申请日：2022-11-14

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Hun Sik KIM ,  Hyo Jin PARK ,  Eunbi YI

IPC: A61K39/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C12N5/0783

Abstract: A chimeric antigen receptor (CAR), including an antigen-binding domain, a CD8 or CD28 hinge domain, a DAP10 cytoplasmic domain, a 2B4 cytoplasmic domain, and a CD3z cytoplasmic domain, where the CAR is expressed in natural killer (NK) cells. A method for treating cancer, including administering a therapeutically effective amount of a composition containing a NK cell that expresses the CAR, or a therapeutically effective amount of a cellular therapeutic agent containing a NK cell that expresses the CAR, to a subject in need thereof.

公开(公告)号：US20240368509A1

公开(公告)日：2024-11-07

申请号：US18686154

申请日：2022-08-23

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Gi Seok JEONG

IPC: C12M1/32 ,  C12M1/00 ,  C12M1/12

Abstract: The present disclosure relates to a cell culture device.
An aspect of the present disclosure may include a culture medium supply unit including a base, a first reservoir disposed on the base and having an accommodation space, which accommodates the culture medium and has one surface in which a through hole through which the culture medium is discharged is formed, and a culture medium control member disposed to pass through the through hole and configured to control a flow of the culture medium discharged from the first reservoir.

公开(公告)号：US20240342504A1

公开(公告)日：2024-10-17

申请号：US18556360

申请日：2022-03-29

Applicant: THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Do Hyun PARK ,  Jin Hee KWON

IPC: A61N5/067 ,  A61B1/00 ,  A61B18/00 ,  A61N5/06

CPC classification number: A61N5/067 ,  A61B1/00137 ,  A61B2018/00494 ,  A61N2005/0609 ,  A61N2005/0653

Abstract: The present disclosure relates to a low-level laser therapy device using a light-emitting diode (LED) endoscope cap.
One aspect of the present disclosure may include a catheter formed to extend so as to be inserted into a body of a patient and including an air insufflation part for stretching the mucosal folds of the duodenum of the patient, an endoscope cap having a through hole therein to allow the catheter to be inserted therethrough, a hood disposed in one region outside the endoscope cap and disposed such that at least one region thereof protrudes forward from the endoscope cap, and one or more LEDs disposed on each of the endoscope cap and the hood.