公开(公告)号：US5840811A

公开(公告)日：1998-11-24

申请号：US786253

申请日：1997-01-22

申请人： Yoji Hori ,  Tohru Kobayashi ,  Hideyuki Hongo ,  Akio Yamaguchi ,  Yoko Takahashi ,  Takashi Imai ,  Toshimitsu Hagiwara

发明人： Yoji Hori ,  Tohru Kobayashi ,  Hideyuki Hongo ,  Akio Yamaguchi ,  Yoko Takahashi ,  Takashi Imai ,  Toshimitsu Hagiwara

IPC分类号： C08G63/06 ,  C08G63/08 ,  C08G63/82 ,  C08L101/16 ,  C08G63/85

CPC分类号： C08G63/823 ,  C08G63/08

摘要： An optically active block polyester copolymer formed of structural units represented by the following general formulas (I) and (II): ##STR1## wherein represents for an asymmetric carbon atom and m and n each represents a natural number in the range of from 300 to 5000 is obtained by subjecting an optically active butyrolactone and a species of lactone other than the optically active butyrolactone to sequential ringopening copolymerization in the presence of a catalyst. This optically active block polyester copolymer possesses a high molecular weight and a high melting point (not less than 130.degree. C.) and forms a biodegradable and hydrolyzable material of high strength capable of tolerating the impacts of actual use.

摘要翻译： 由以下通式（I）和（II）表示的结构单元形成的光学活性嵌段聚酯共聚物：式（I）公制碳原子，m和n各自表示300-5000的自然数 是通过使光学活性丁内酯和除光学活性丁内酯以外的其他种类的内酯在催化剂存在下进行顺序环环化共聚获得的。 该光学活性嵌段聚酯共聚物具有高分子量和高熔点（不低于130℃），并形成能够耐受实际影响的高强度的可生物降解和可水解的材料。

公开(公告)号：US5824751A

公开(公告)日：1998-10-20

申请号：US592518

申请日：1996-01-26

申请人： Yoji Hori ,  Yoko Takahashi ,  Hideyuki Hongo ,  Akio Yamaguchi ,  Toshimitsu Hagiwara

发明人： Yoji Hori ,  Yoko Takahashi ,  Hideyuki Hongo ,  Akio Yamaguchi ,  Toshimitsu Hagiwara

IPC分类号： C08G63/06 ,  C08G63/08 ,  C08G63/64

CPC分类号： C08G63/08 ,  C08G63/06 ,  C08G63/64

摘要： The biodegradable composition comprises at least poly(beta-hydroxybutyric acid) or a biodegradable copolymer thereof and a stereospecifically regular block copolymer having the structure units of formula (I): ##STR1## where R1 is a hydrocarbon group having 1 to 14 carbon atoms, optionally including double bonds, oxygen atoms or both of them; and m and n are respectively an integer ranging from 300 to 5,000, or having the structure units of formula (II): ##STR2## where R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are either a hydrogen atom or a methyl group; and m and n are respectively an integer ranging from 300 to 5,000.

摘要翻译： 可生物降解组合物至少包含聚（β-羟基丁酸）或其可生物降解的共聚物和具有式（I）结构单元的立体专一规则嵌段共聚物：其中R 1为具有1至14个碳原子的烃基 碳原子，任选地包括双键，氧原子或它们两者; m和n分别为300-5000的整数，或具有式（II）的结构单元：其中R 2，R 3，R 4和R 5为氢原子或甲基; m和n分别为300-5000的整数。

公开(公告)号：US5631344A

公开(公告)日：1997-05-20

申请号：US549544

申请日：1995-10-27

申请人： Hideyuki Hongo ,  Akio Yamaguchi ,  Yoji Hori ,  Toshimitsu Hagiwara ,  Yoko Takahashi

发明人： Hideyuki Hongo ,  Akio Yamaguchi ,  Yoji Hori ,  Toshimitsu Hagiwara ,  Yoko Takahashi

IPC分类号： C08G63/64 ,  C08G63/85 ,  C08G64/18 ,  C08L101/16 ,  C08G63/78

CPC分类号： C08G63/64 ,  C08G64/18

摘要： The block copolymer of polyesters and polycarbonates comprises at least one of each of the constituting units of (I) and (II) having the general formulae: ##STR1## where the sign * indicates an asymmetric carbon atom; R.sub.1, R.sup.2, R.sup.3 and R.sup.4 are either a hydrogen atom or a methyl group; m and n are respective a natural numbers ranging from 300 to 5000: The block copolymer is obtained by successive ring-opening and copolymerization of optically active .beta.-butyrolactones and cyclic carbonates in the presence of a catalyst.The block polymer obtained has high molecular weight and high melting temperature, and can thus be used as a high strength material for practical use and which has bio-degradable and hydrolyzable nature.

摘要翻译： 聚酯和聚碳酸酯的嵌段共聚物包含具有以下通式的（I）和（II）的每个构成单元中的至少一个：符号*表示不对称碳 原子; R1，R2，R3和R4是氢原子或甲基; m和n分别为300至5000的自然数：嵌段共聚物通过在催化剂存在下连续的开环和共聚光学活性的β-丁内酯和环状碳酸酯而获得。 所得到的嵌段聚合物具有高分子量和高熔点温度，因此可用作实际使用的高强度材料，其具有生物降解性和水解性。

公开(公告)号：US5516883A

公开(公告)日：1996-05-14

申请号：US164697

申请日：1993-12-09

申请人： Yoji Hori ,  Akio Yamaguchi

发明人： Yoji Hori ,  Akio Yamaguchi

IPC分类号： C08G63/08 ,  C08G63/664 ,  C08G63/78 ,  C08G63/82 ,  C08G63/85 ,  C08L101/16

CPC分类号： C08G63/823 ,  C08G63/08 ,  C08G63/664

摘要： A biodegradable, optically active copolymer is disclosed. The copolymer is represented by general formula (I): ##STR1## wherein R.sup.1 represents a group selected from the group consisting of methyldimethylene, 1,2-dimethyldimethylene, 1,1-dimethyldimethylene, methyltrimethylene, tetramethylene, methyltetramethylene, pentamethylene, 1,4-dimethyl-2-oxo-3-oxytetramethylene, 2-oxo-3-oxytetramethylene, and 2-methyl-3-oxypentamethylene, and m and n each represents a natural number of from 10 to 15,000. According to the present invention, useful polymers which are a new type of functional materials characterized as having optical activity, biodegradability (enzymatic degradability), and hydrolyzability can be easily produced in an industrially advantageous manner by the ring-opening copolymerization of optically active .beta.-butyrolactone with various lactones.

摘要翻译： 公开了一种可生物降解的光学活性共聚物。 共聚物由通式（I）表示：其中R 1表示选自甲基亚甲基，1,2-二甲基亚甲基，1,1-二甲基二亚甲基，甲基三亚甲基，四亚甲基，甲基四亚甲基，五亚甲基， 1,4-二甲基-2-氧代-3-氧四亚甲基，2-氧代-3-氧四亚甲基和2-甲基-3-氧代亚戊基，m和n各自表示10〜15,000的自然数。 根据本发明，通过开环共聚光学活性β型聚合物，可以以工业上有利的方式容易地制备作为特征为具有光学活性，生物降解性（酶促降解性）和水解性的新型功能材料的有用聚合物， 丁内酯与各种内酯。

公开(公告)号：US5461139A

公开(公告)日：1995-10-24

申请号：US287916

申请日：1994-08-09

申请人： Yoshiharu Gonda ,  Yoji Hori ,  Akio Yamaguchi ,  Takao Nishishita

发明人： Yoshiharu Gonda ,  Yoji Hori ,  Akio Yamaguchi ,  Takao Nishishita

IPC分类号： C08G63/64 ,  C08G63/82 ,  C08G63/85 ,  C08L101/16 ,  C08G63/06 ,  C08G63/08

CPC分类号： C08G63/823 ,  C08G63/64

摘要： A biodegradable optically active copolymer is disclosed, which is represented by the general formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each represents a hydrogen atom or a methyl group; m and n each represents a natural number wherein the sum thereof gives 10 to 5,000; and C* represents an asymmetric carbon atom, and a process for producing the copolymer by ring-opening copolymerization of optically active .beta.-butyrolactone with a cyclic carbonate in the presence of catalyst. The biodegradable optically active copolymer of the present invention provides excellent biodegradability (enzyme degradability) and hydrolyzability.

摘要翻译： 公开了一种可生物降解的光学活性共聚物，其由通式（I）表示：其中R 1，R 2，R 3和R 4各自表示氢原子或甲基; m和n各自表示其总和为10至5,000的自然数; C *表示不对称碳原子，以及在催化剂存在下通过光学活性β-丁内酯与环状碳酸酯开环共聚制备共聚物的方法。 本发明的生物降解性光学活性共聚物提供优异的生物降解性（酶降解性）和水解性。

公开(公告)号：US5430125A

公开(公告)日：1995-07-04

申请号：US202131

申请日：1994-02-25

申请人： Yoji Hori ,  Takao Nishishita ,  Akio Yamaguchi

发明人： Yoji Hori ,  Takao Nishishita ,  Akio Yamaguchi

IPC分类号： C08G63/08 ,  C08G63/82 ,  C08G63/85

CPC分类号： C08G63/823

摘要： A process for producing poly(3-hydroxybutyric acid) comprising ring-opening polymerization of .beta.-butyrolactone is disclosed, wherein the ring-opening polymerization is carried out in the presence of at least one tin compound selected from the group consisting of a distannoxane derivative (e.g., 1-chloro-3-ethoxy-1,1,3,3-tetrabutyldistannoxane), a tin carboxylate compound (e.g., tin dioctanoate), and a di-lower alkyltin oxide (e.g., dibutyltin oxide). Poly(3-hydroxybutyric acid) can be produced in high yield at low cost through simple production steps. The resulting polymer has an increased molecular weight to a degree not heretofore attained.

摘要翻译： 公开了一种制备包含β-丁内酯的开环聚合的聚（3-羟基丁酸）的方法，其中开环聚合在至少一种锡化合物的存在下进行，所述锡化合物选自二锡氧烷衍生物 （例如1-氯-3-乙氧基-1,1,3,3-四丁基二锡氧烷），羧酸锡化合物（例如二辛酸锡）和二低级烷基锡氧化物（例如二丁基锡氧化物）。 聚（3-羟基丁酸）可以通过简单的生产步骤以低成本生产。 所得聚合物的分子量增加至迄今未达到的程度。

公开(公告)号：US5312939A

公开(公告)日：1994-05-17

申请号：US727709

申请日：1991-07-10

申请人： Yoji Hori ,  Hidenori Kumobayashi

发明人： Yoji Hori ,  Hidenori Kumobayashi

IPC分类号： B01J31/24 ,  C07B53/00 ,  C07B61/00 ,  C07C29/17 ,  C07D295/145 ,  C07F9/50 ,  C07F15/00 ,  C07F15/04 ,  C07F9/02

CPC分类号： C07D295/145 ,  C07C29/17 ,  C07F15/0013 ,  C07F15/0053 ,  C07F15/008 ,  C07F9/5027

摘要： Novel 2,2'-bis(dicyclopentylphosphino)-1,1'-binaphthyl represented by formula (I): ##STR1## and a transition metal complex using the same as a ligand, are disclosed. The transition metal complex is industrially excellent as a catalyst for various asymmetric synthesis reactions.

摘要翻译： 公开了由式（I）表示的新型2,2'-双（二环戊基膦基）-1,1'-联萘：（I）和使用其作为配体的过渡金属络合物。 作为各种不对称合成反应的催化剂，过渡金属络合物在工业上是优异的。

公开(公告)号：US5264547A

公开(公告)日：1993-11-23

申请号：US25059

申请日：1993-03-02

申请人： Akio Yamaguchi ,  Yoji Hori ,  Susumu Akutagawa

发明人： Akio Yamaguchi ,  Yoji Hori ,  Susumu Akutagawa

IPC分类号： C07D321/08 ,  C08G63/08

CPC分类号： C07D321/08

摘要： An optically active 7-substituted-1,4-dioxepan-5-one derivative represented by the general formula (I): ##STR1## wherein R represents an alkyl group having from 1 to 5 carbon atoms; and * means an asymmetric carbon atom, is disclosed. An optically active polymer represented by formula (II): ##STR2## wherein R and * are as defined above; and n is an integer of 25 or more, obtained by ring opening polymerization of the optically active 7-substituted-1,4-dioxepan-5-one derivative represented by formula (I) is also disclosed. A process for producing the optically active polymer represented by formula (II) is further disclosed, comprising subjecting an optically active 7-substituted-1,4-dioxepan-5-one derivative represented by formula (I) to ring opening polymerization in the presence of at least one catalyst selected from the group consisting of (i) an organotin compound, (ii) an organoaluminum compound and water, and (iii) an organozinc compound and water.