公开(公告)号：US20230348481A1

公开(公告)日：2023-11-02

申请号：US18329986

申请日：2023-06-06

Applicant: AbbVie Inc.

Inventor： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC: C07D487/14 ,  A61K47/38 ,  A61K9/00 ,  A61K47/12 ,  A61K31/4985

CPC classification number: C07D487/14 ,  A61K47/38 ,  A61K9/0053 ,  A61K47/12 ,  A61K31/4985 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230331735A1

公开(公告)日：2023-10-19

申请号：US18329980

申请日：2023-06-06

Applicant: AbbVie Inc.

Inventor： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew M. Mulhern ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC: C07D487/14 ,  A61K47/38 ,  A61K9/00 ,  A61K47/12 ,  A61K31/4985

CPC classification number: C07D487/14 ,  A61K47/38 ,  A61K9/0053 ,  A61K47/12 ,  A61K31/4985 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230203051A1

公开(公告)日：2023-06-29

申请号：US18176848

申请日：2023-03-01

Applicant: AbbVie Inc.

Inventor： Ayman Allian ,  Jayanthy Jayanth ,  Mohamed-Eslam F. Mohamed ,  Mathew Mulhem ,  Fredrik Lars Nordstrom ,  Ahmed A. Othman ,  Michael J. Rozema ,  Lakshmi Bhagavatula ,  Patrick J. Marroum ,  Peter T. Mayer ,  Ahmad Y. Sheikh ,  Thomas B. Borchardt ,  Ben Klünder

IPC: C07D487/14 ,  A61K9/00 ,  A61K47/12 ,  A61K47/38 ,  A61K31/4985

CPC classification number: C07D487/14 ,  A61K9/0053 ,  A61K47/12 ,  A61K47/38 ,  A61K31/4985 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and various spondyloarthritic conditions, including types of axial spondyloarthritis (axSpA)), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating active non-radiographic axSpA (nr-axSpA) and methods for treating active ankylosing spondylitis (AS).

公开(公告)号：US10519164B2

公开(公告)日：2019-12-31

申请号：US16453684

申请日：2019-06-26

Applicant: AbbVie Inc.

Inventor： Ayman Allian ,  Jayanthy Jayanth ,  Ben Klünder ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Patrick J. Marroum ,  Peter T. Mayer

IPC: C07D487/14 ,  A61K31/4985 ,  A61K47/38 ,  A61K47/12 ,  A61K9/00

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US10344036B2

公开(公告)日：2019-07-09

申请号：US15908347

申请日：2018-02-28

Applicant: AbbVie Inc.

Inventor： Jayanthy Jayanth ,  Patrick J. Marroum ,  Peter T. Mayer ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder ,  Ayman Allian

IPC: C07D487/14 ,  A61K9/00 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US10174061B2

公开(公告)日：2019-01-08

申请号：US15715245

申请日：2017-09-26

Applicant: AbbVie Inc.

Inventor： Benoit Cardinal-David ,  Vincent S. Chan ,  Brian P. Enright ,  Ye Huang ,  Alexander D. Huters ,  Russell C. Klix ,  Scott W. Krabbe ,  Philip R. Kym ,  Yanbin Lao ,  Xiaochun Lou ,  Sean E. Mackey ,  Mark A. Matulenko ,  Peter T. Mayer ,  Christopher P. Miller ,  James Stambuli ,  Eric A. Voight ,  Zhi Wang ,  Geoff G. Zhang ,  Valentino J. Stella

IPC: C07F9/09 ,  A61K31/661 ,  C07F9/06 ,  A61K31/6615 ,  C07C281/02 ,  C07C309/24 ,  C07C47/277 ,  A61K45/06

Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

公开(公告)号：US20180079762A1

公开(公告)日：2018-03-22

申请号：US15715245

申请日：2017-09-26

Applicant: AbbVie Inc.

Inventor： Benoit Cardinal-David ,  Vincent S. Chan ,  Kassibla Dempah ,  Brian P. Enright ,  Rodger F. Henry ,  Raimundo Ho ,  Ye Huang ,  Alexander D. Huters ,  Russell C. Klix ,  Scott W. Krabbe ,  Philip R. Kym ,  Yanbin Lao ,  Xiaochun Lou ,  Sean E. Mackey ,  Mark A. Matulenko ,  Peter T. Mayer ,  Christopher P. Miller ,  James Stambuli ,  Eric A. Voight ,  Zhi Wang ,  Geoff G. Zhang ,  Valentino J. Stella

IPC: C07F9/09 ,  A61K31/661 ,  C07F9/06 ,  A61K45/06 ,  C07C47/277 ,  C07C309/24 ,  C07C281/02 ,  A61K31/6615

CPC classification number: C07F9/094 ,  A61K31/661 ,  A61K31/6615 ,  A61K45/06 ,  C07B2200/13 ,  C07C47/277 ,  C07C281/02 ,  C07C309/24 ,  C07F9/06 ,  A61K2300/00

Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

公开(公告)号：US09446059B2

公开(公告)日：2016-09-20

申请号：US14919418

申请日：2015-10-21

Applicant: AbbVie Inc.

Inventor： Benoit Cardinal-David ,  Vincent S. Chan ,  Kassibla E. Dempah ,  Brian P. Enright ,  Rodger F. Henry ,  Raimundo Ho ,  Ye Huang ,  Alexander D. Huters ,  Russell C. Klix ,  Scott W. Krabbe ,  Philip R. Kym ,  Yanbin Lao ,  Xiaochun Lou ,  Sean E. Mackey ,  Mark A. Matulenko ,  Peter T. Mayer ,  Christopher P. Miller ,  James Stambuli ,  Eric A. Voight ,  Zhi Wang ,  Geoff G. Zhang ,  Valentino J. Stella

IPC: A61K31/661 ,  C07F9/06 ,  A61K31/6615

CPC classification number: C07F9/094 ,  A61K31/661 ,  A61K31/6615 ,  A61K45/06 ,  C07B2200/13 ,  C07C47/277 ,  C07C281/02 ,  C07C309/24 ,  C07F9/06 ,  A61K2300/00

Abstract: The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.

Abstract translation: 本公开内容涉及（a）卡比多巴前药，（b）药物组合和包含卡比多巴前药和/或左旋多巴前药的组合物，和（c）治疗帕金森病和相关病症的方法，包括施用卡比多巴前药和 左旋多巴前药与帕金森病患者。