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公开(公告)号：US20100144834A1
公开(公告)日：2010-06-10
申请号：US12516457
申请日：2007-11-27
申请人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina Lemonidis Tarbet , Sanjay Bhanot , Diane Tribble , Andrew T. Watts
发明人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina Lemonidis Tarbet , Sanjay Bhanot , Diane Tribble , Andrew T. Watts
IPC分类号： A61K31/7088 , C07H21/04
CPC分类号： C12N15/1137 , A01K2227/105 , A01K2267/0375 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
摘要翻译： 本文公开了用于降低具有升高的LDL-C的个体中的LDL-C的反义化合物和方法。 另外公开了用于治疗高胆固醇血症或替代地治疗或预防动脉粥样硬化的反义化合物和方法。 进一步公开的是用于降低冠心病风险的反义化合物和方法。 这样的方法包括向需要治疗的个体施用靶向PCSK9核酸的反义化合物。 施用的反义化合物包括gapmer反义寡核苷酸。
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公开(公告)号：US07723508B2
公开(公告)日：2010-05-25
申请号：US10559647
申请日：2004-06-02
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and treatment of disease associated with expression of apolipoprotein(a) are provided.
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白（a）的表达。 组合物包含靶向编码载脂蛋白（a）的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白（a）表达和用于诊断和治疗与载脂蛋白（a）表达相关的疾病的方法。
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公开(公告)号：US07491815B2
公开(公告)日：2009-02-17
申请号：US11211803
申请日：2005-08-25
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含靶向编码C反应蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节C反应蛋白表达和治疗与C反应蛋白表达相关的疾病的方法。
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公开(公告)号：US07425545B2
公开(公告)日：2008-09-16
申请号：US10858500
申请日：2004-06-01
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
摘要翻译： 提供化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含针对编码C反应蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节C-反应蛋白表达和用于诊断和治疗与C-反应蛋白表达相关的疾病的方法。
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公开(公告)号：US07132529B2
公开(公告)日：2006-11-07
申请号：US09918187
申请日：2001-07-30
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/1137 , A61K38/00 , C12N9/0083 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
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公开(公告)号：US20120270929A1
公开(公告)日：2012-10-25
申请号：US13498055
申请日：2010-09-24
申请人： Rosanne M. Crooke , Mark Graham , Thomas A. Bell
发明人： Rosanne M. Crooke , Mark Graham , Thomas A. Bell
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods, compounds, and compositions for reducing expression of a TTC39 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL and/or decreasing PCSK9 in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate cardiovascular disease, or a symptom thereof.
摘要翻译： 本文提供了用于减少动物中TTC39mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供用于增加动物体内HDL和/或降低PCSK9的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或其症状。
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公开(公告)号：US20090326040A1
公开(公告)日：2009-12-31
申请号：US11573537
申请日：2005-08-10
IPC分类号： A61K31/7088
CPC分类号： C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Methods for the rapid and long-term lowering of lipid levels in human subjects and for the treatment of conditions associated with elevated LDL-cholesterol and elevated apolipoprotein B are provided.
摘要翻译： 提供了快速和长期降低人类受试者脂质水平和治疗与升高的LDL-胆固醇和升高的载脂蛋白B相关的病症的方法。
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公开(公告)号：US20120115926A1
公开(公告)日：2012-05-10
申请号：US13214135
申请日：2011-08-19
IPC分类号： A61K31/7088 , A61P3/06
CPC分类号： C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Methods for the rapid and long-term lowering of lipid levels in human subjects and for the treatment of conditions associated with elevated LDL-cholesterol and elevated apolipoprotein B are provided.
摘要翻译： 提供了快速和长期降低人类受试者脂质水平和治疗与升高的LDL-胆固醇和升高的载脂蛋白B相关的病症的方法。
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