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公开(公告)号:US20120270929A1
公开(公告)日:2012-10-25
申请号:US13498055
申请日:2010-09-24
申请人: Rosanne M. Crooke , Mark Graham , Thomas A. Bell
发明人: Rosanne M. Crooke , Mark Graham , Thomas A. Bell
CPC分类号: C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要: Provided herein are methods, compounds, and compositions for reducing expression of a TTC39 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL and/or decreasing PCSK9 in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate cardiovascular disease, or a symptom thereof.
摘要翻译: 本文提供了用于减少动物中TTC39mRNA和蛋白质表达的方法,化合物和组合物。 本文还提供用于增加动物体内HDL和/或降低PCSK9的方法,化合物和组合物。 这些方法,化合物和组合物可用于治疗,预防,延迟或改善心血管疾病或其症状。
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公开(公告)号:US08944590B2
公开(公告)日:2015-02-03
申请号:US13298997
申请日:2011-11-17
摘要: Embodiments may provide a first device that comprises eyeglasses, where the eyeglasses may further include a lens housing, a first temple and a second temple coupled to the lens housing, and a first and a second lens supported by the lens housing. The first device may further include a façade that covers the lens housing. The first device may further comprise an electronic component and at least one conductive path may be provided from the electronic component to the first lens having a portion that runs through the lens housing.
摘要翻译: 实施例可以提供包括眼镜的第一装置,其中眼镜还可以包括透镜壳体,耦合到透镜壳体的第一镜腿和第二镜腿以及由透镜壳体支撑的第一和第二透镜。 第一装置还可以包括覆盖透镜壳体的外墙。 第一装置还可以包括电子部件,并且可以从电子部件到具有穿过透镜壳体的部分的第一透镜提供至少一个导电路径。
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公开(公告)号:US20130070198A1
公开(公告)日:2013-03-21
申请号:US13587645
申请日:2012-08-16
申请人: Charles Willey , Joshua Haddock , Mark Graham , Claudio Dalla Longa , Ronald Blum , William Kokonaski
发明人: Charles Willey , Joshua Haddock , Mark Graham , Claudio Dalla Longa , Ronald Blum , William Kokonaski
CPC分类号: G02C11/10 , G02B27/017 , G02B2027/0178 , G02C7/083 , G02C7/101 , G02C13/001 , H01R13/2414 , H01R35/04
摘要: Eyewear including an optical functional member, control electronics, and a sealed electrical connective element connecting the electronics to the optical functional member. The connective element can directly connect the electronics to the optical functional member, or can connect through an intermediate contact, e.g., a plug-and-receptacle. The connective element can be routed from the electronics, around a rimlock of the eyewear to the optical functional member. The connective element can be a conductive compressible member, such as conductive rubber. In some embodiments, the connective element can be a multiconductor cable.
摘要翻译: 眼镜包括光学功能元件,控制电子元件以及将电子元件连接到光学功能元件的密封电连接元件。 连接元件可以将电子器件直接连接到光学功能元件,或者可以通过诸如插头和插座的中间触点连接。 连接元件可以从电子设备,眼镜框架周围路由到光学功能部件。 连接元件可以是导电可压缩构件,例如导电橡胶。 在一些实施例中,连接元件可以是多导体电缆。
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公开(公告)号:US07603917B2
公开(公告)日:2009-10-20
申请号:US11573322
申请日:2005-08-08
申请人: Mark Graham , Chris Lussey
发明人: Mark Graham , Chris Lussey
IPC分类号: G01D7/00
CPC分类号: G01L5/223 , G01L5/16 , G05G9/04737 , G05G2009/04707 , G05G2009/04729 , G05G2009/04762
摘要: A sensor (100) for detecting input force and/or torque with six degrees of freedom for use as a computer input device is provided. The sensor has a technically simple detection mechanism which obviates the need for complex and fragile securing components. A user-manipulable core (106) is enclosed in a casing (109). Electrodes (114) in the casing (109) are separated from the core (106) by a layer of elastically deformable conductive polymer (108). Electric current flows between the core (106) and the electrodes (114). The polymer (108) has variable resistivity depending on the stress it experiences. Manipulation of the core (106) causes deformation of the polymer (108); the type of deformation, and hence the type of force/torque applied to core (106), is determinable from the currents flowing through the electrodes (114).
摘要翻译: 提供了用于以六自由度检测用作计算机输入装置的输入力和/或扭矩的传感器(100)。 传感器具有技术上简单的检测机制,可以避免对复杂和易碎的固定部件的需要。 用户可操纵的芯(106)被封装在壳体(109)中。 壳体(109)中的电极(114)通过一层可弹性变形的导电聚合物(108)与芯部(106)分离。 电流在芯(106)和电极(114)之间流动。 聚合物(108)具有取决于其经历的应力的可变电阻率。 芯部(106)的操纵导致聚合物(108)的变形; 变形的类型以及因此施加到芯(106)的力/扭矩的类型可以从流过电极(114)的电流确定。
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公开(公告)号:US20080021605A1
公开(公告)日:2008-01-24
申请号:US11618198
申请日:2006-12-29
IPC分类号: G06F19/00
CPC分类号: G07C5/008 , G06Q10/00 , G06Q10/06 , G06Q10/107 , G06Q30/02 , G06Q30/0278 , G06Q50/30 , G07C5/085 , Y10S370/908
摘要: A vehicle email notification system and method that accesses data from the vehicle as well as from one or more other sources and combines the information into an email that is then sent to the owner or other authorized subscriber. The email notifications are triggered by different events, some of which are independent of the vehicle (e.g., a monthly trigger), and others of which occur at the vehicle, such as a mileage or low oil life trigger. The notification system builds and sends to the subscriber an email message that contains the dynamic vehicle information and identifies any detected vehicle condition for which action is needed.
摘要翻译: 车辆电子邮件通知系统和方法,其从车辆以及来自一个或多个其他来源的数据访问并将该信息组合成电子邮件,然后发送给所有者或其他授权用户。 电子邮件通知由不同的事件触发,其中一些事件是独立于车辆(例如,每月触发器),其他事件发生在车辆上,例如里程或低油寿命触发。 通知系统构建并向用户发送包含动态车辆信息的电子邮件消息,并且识别需要动作的任何检测到的车辆状况。
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公开(公告)号:US20070251014A1
公开(公告)日:2007-11-01
申请号:US11770265
申请日:2007-06-28
IPC分类号: A47C31/00
CPC分类号: A61G7/1076 , A61G7/0503 , A61G7/1007 , A61G7/1019 , A61G7/1044 , A61G7/1051 , A61G7/1061 , A61G12/002 , A61G12/004 , A61G12/005 , A61G13/107 , A61G2200/32 , A61G2200/34 , A61G2203/80 , A61M5/1415 , F16M11/08 , F16M11/18 , F16M11/2014 , F16M11/2092 , F16M11/26 , F16M13/02 , F16M2200/065 , F16M2200/068 , G06F19/00 , Y10T137/6918
摘要: A system for supporting patient care equipment alongside a patient support is provided. In one embodiment, the system includes a plurality of arms supported by a support structure. The arms may be pivoted to either side of the patient support. The arms may be stored in a console. At least one of the arms may carry service conduits that provide medical air, oxygen, vacuum, nitrogen, nitrous oxide, or electricity.
摘要翻译: 提供了一种用于在患者支架旁边支撑病人护理设备的系统。 在一个实施例中,系统包括由支撑结构支撑的多个臂。 臂可以枢转到患者支架的任一侧。 手臂可以存储在控制台中。 至少一个臂可以携带提供医疗空气,氧气,真空,氮气,一氧化二氮或电力的服务管道。
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公开(公告)号:US20070187559A1
公开(公告)日:2007-08-16
申请号:US11737298
申请日:2007-04-19
申请人: David Newkirk , Mark Graham , Steven Schwartz , Michael Cerimele , John Ruehl
发明人: David Newkirk , Mark Graham , Steven Schwartz , Michael Cerimele , John Ruehl
IPC分类号: F16M11/00
CPC分类号: F16M11/42 , A61G7/012 , A61G7/0503 , A61G12/002 , A61G12/005 , A61G12/008 , A61G13/107 , A61G2203/80 , A61M5/1415 , A61M5/1417 , F16M11/18 , F16M11/2014 , F16M11/28 , F16M11/34 , F16M13/022 , F16M2200/063 , F16M2200/065 , G06F19/00
摘要: An equipment support system has a first telescoping arm and a second telescoping arm. The arms are pivotable relative to a room wall about a generally vertical axis and are extendable and retractable along respective generally horizontal axes. A first equipment support is coupled to the first telescoping arm and is configured to support patient care equipment thereon. A second equipment support is coupled to the second telescoping arm and is configured to support patient care equipment thereon.
摘要翻译: 设备支撑系统具有第一伸缩臂和第二伸缩臂。 臂相对于围绕大致垂直轴线的室壁可枢转,并且可沿着相应的大致水平轴线延伸和缩回。 第一设备支撑件联接到第一伸缩臂并且构造成在其上支撑病人护理设备。 第二设备支撑件联接到第二伸缩臂并且构造成在其上支撑病人护理设备。
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公开(公告)号:US20070069093A1
公开(公告)日:2007-03-29
申请号:US10575404
申请日:2004-10-12
申请人: Mark Graham , David Newkirk , Christian Reinke
发明人: Mark Graham , David Newkirk , Christian Reinke
CPC分类号: A61G7/0503 , A47B81/061 , A61G12/002 , A61G12/005 , A61G13/107 , A61G2203/723 , A61G2203/80 , A61M5/1415 , A61M5/1417 , F16M11/08 , F16M11/2085 , F16M13/02 , F16M2200/028
摘要: An apparatus includes a rail configured to be coupled to a support structure such as hospital bed, a carriage coupled to the rail for movement along the rail and a lock coupled to the carriage for selectively locking the carriage at one of a plurality of locations along the rail. The carriage is configured to support a patient care equipment rack such as an IV pole. The rail has a plurality of locking portions spaced therealong. The lock is movable between a locking position where a portion of the lock engages a selected one of the locking portions to block the carriage from moving along the rail and an unlocking position where the portion of the lock disengages from the selected one of the locking portions to allow the carriage to move along the rail.
摘要翻译: 一种装置包括:轨道,其构造成联接到诸如医院病床的支撑结构,联接到轨道的滑架,用于沿着轨道运动;以及锁定,其联接到滑架,用于沿着沿着轨道的多个位置中的一个位置选择性地锁定滑架 轨。 托架被配置为支撑诸如IV杆的病人护理设备架。 轨道具有多个沿其间隔开的锁定部分。 该锁可在锁定位置和锁定位置之间移动,锁定位置与锁定部分中的一个锁定部分接合,以阻止滑架沿着轨道移动;以及解锁位置,其中锁定部分与选定的一个锁定部分脱离 以允许滑架沿着轨道移动。
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公开(公告)号:US20060281698A1
公开(公告)日:2006-12-14
申请号:US10559647
申请日:2004-06-02
申请人: Rosanne Crooke , Mark Graham
发明人: Rosanne Crooke , Mark Graham
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3525
摘要: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and treatment of disease associated with expression of apolipoprotein(a) are provided.
摘要翻译: 提供化合物,组合物和方法用于调节载脂蛋白(a)的表达。 组合物包含靶向编码载脂蛋白(a)的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白(a)表达和用于诊断和治疗与载脂蛋白(a)表达相关的疾病的方法。
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公开(公告)号:US20060264395A1
公开(公告)日:2006-11-23
申请号:US10553722
申请日:2004-04-15
申请人: Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
发明人: Rosanne Crooke , Mark Graham , Kristina Tarbet , Kenneth Dobie
CPC分类号: C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
摘要翻译: 提供化合物,组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。
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