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公开(公告)号：US20120077866A1
公开(公告)日：2012-03-29
申请号：US13309835
申请日：2011-12-02
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
IPC分类号： A61K31/7088 , C12N5/07 , A61P31/00 , A61P9/10 , A61P35/00 , A61P9/00 , A61P13/12 , A61P19/02 , A61P3/04 , A61P29/00 , C07H21/00 , A61P17/02
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含靶向编码C反应蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节C反应蛋白表达和治疗与C反应蛋白表达相关的疾病的方法。
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公开(公告)号：US07803930B2
公开(公告)日：2010-09-28
申请号：US10920612
申请日：2004-08-17
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/13 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节载脂蛋白B的表达。组合物包含靶向编码载脂蛋白B的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节载脂蛋白B表达和治疗疾病的方法 与载脂蛋白B的表达相关。
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公开(公告)号：US07741305B2
公开(公告)日：2010-06-22
申请号：US11830734
申请日：2007-07-30
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for diagnosis and treatment of disease associated with expression of apolipoprotein(a) are provided.
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白（a）的表达。 组合物包含靶向编码载脂蛋白（a）的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白（a）表达和用于诊断和治疗与载脂蛋白（a）表达相关的疾病的方法。
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公开(公告)号：US20090275133A1
公开(公告)日：2009-11-05
申请号：US12352572
申请日：2009-01-12
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
IPC分类号： C12N5/02
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含靶向编码C反应蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节C反应蛋白表达和治疗与C反应蛋白表达相关的疾病的方法。
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公开(公告)号：US20090170799A1
公开(公告)日：2009-07-02
申请号：US11969208
申请日：2008-01-03
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
摘要翻译： 提供化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含针对编码C反应蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节C-反应蛋白表达和用于诊断和治疗与C-反应蛋白表达相关的疾病的方法。
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公开(公告)号：US07227014B2
公开(公告)日：2007-06-05
申请号：US09923515
申请日：2001-08-07
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein(a). Methods of using these compounds for modulation of apolipoprotein(a) expression and for treatment of diseases associated with expression of apolipoprotein(a) are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节载脂蛋白（a）的表达。 组合物包含靶向编码载脂蛋白（a）的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节载脂蛋白（a）表达和治疗与载脂蛋白（a）表达相关的疾病的方法。
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7.发明授权公开(公告)号：US07202357B2
公开(公告)日：2007-04-10
申请号：US10484441
申请日：2002-07-15
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y203/01026 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节酰基辅酶A胆固醇酰基转移酶-2的表达。 组合物包含靶向编码酰基辅酶A胆固醇酰基转移酶-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节酰基辅酶A胆固醇酰基转移酶-2表达和治疗与酰基辅酶A胆固醇酰基转移酶-2表达相关疾病的方法。
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公开(公告)号：US06964950B2
公开(公告)日：2005-11-15
申请号：US09912724
申请日：2001-07-25
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
IPC分类号： C12N15/09 , A61K31/7088 , A61K38/00 , A61K48/00 , A61P9/00 , A61P9/10 , C12N15/113 , C07H21/04 , C12N15/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for treatment of diseases associated with expression of C-reactive protein are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含靶向编码C反应蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节C-反应蛋白表达和治疗与C反应蛋白表达相关的疾病的方法。
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公开(公告)号：US08735364B2
公开(公告)日：2014-05-27
申请号：US11969096
申请日：2008-01-03
申请人： Rosanne M. Crooke , Mark J. Graham
发明人： Rosanne M. Crooke , Mark J. Graham
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节载脂蛋白B的表达。组合物包含靶向编码载脂蛋白B的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节载脂蛋白B表达和治疗疾病的方法 与载脂蛋白B的表达相关。
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10.发明申请公开(公告)号：US20140128453A1
公开(公告)日：2014-05-08
申请号：US14114187
申请日：2012-04-27
申请人： Adam Mullick , Rosanne M. Crooke , Mark J. Graham , Kenneth W. Dobie , Thomas A. Bell, III , Richard Lee
发明人： Adam Mullick , Rosanne M. Crooke , Mark J. Graham , Kenneth W. Dobie , Thomas A. Bell, III , Richard Lee
IPC分类号： C12N15/113 , A61K31/713
CPC分类号： C12N15/113 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , C12N2310/346 , C12N2310/351 , A61K2300/00
摘要： Provided herein are methods, compounds, and compositions for reducing expression of ApoCIII mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for increasing HDL levels and/or improving the ratio of TG to HDL and reducing plasma lipids and plasma glucose in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disorder, or a symptom thereof.
摘要翻译： 本文提供了用于在动物中降低ApoCIII mRNA和蛋白质表达的方法，化合物和组合物。 本文还提供了用于增加HDL水平和/或改善动物体内TG与HDL的比例以及降低血浆脂质和血浆葡萄糖的方法，化合物和组合物。 这些方法，化合物和组合物可用于治疗，预防，延迟或改善心血管疾病或代谢紊乱或其症状中的任何一种或多种。
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