公开(公告)号：US06855728B2

公开(公告)日：2005-02-15

申请号：US10456326

申请日：2003-06-06

申请人： Sivaram Pillarisetti ,  Itzhak D. Goldberg

发明人： Sivaram Pillarisetti ,  Itzhak D. Goldberg

IPC分类号： A61K31/415 ,  A61K31/42

CPC分类号： A61K31/42 ,  A61K31/415

摘要： The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

摘要翻译： 本发明涉及具有模拟或激动肝细胞生长因子/分散因子（HGF / SF）活性或抑制或拮抗HGF / SF活性的能力的小有机分子，前者可用于促进例如组织的血管形成或 用于促进伤口或组织愈合的器官，或增加或恢复心肌梗死后心脏缺血组织的血流量。 抑制细胞生长或增殖在治疗例如炎性关节和皮肤疾病等炎性疾病以及诸如癌症的增生性增生性疾病中是有益的。

公开(公告)号：US06656699B2

公开(公告)日：2003-12-02

申请号：US09952648

申请日：2001-09-14

申请人： Sivaram Pillarisetti ,  Uday Saxena ,  Dongyan Wang

发明人： Sivaram Pillarisetti ,  Uday Saxena ,  Dongyan Wang

IPC分类号： C12Q134

CPC分类号： G01N33/573 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/924

摘要： The present invention is directed to compositions and methods for measuring enzymatic activity, particularly glycosidase activity. Methods of the present invention include assays for quantitatively determining the amount of glycosidase activity in a sample. The present invention also provides methods for the diagnosis of metastatic and inflammatory processes in vitro and in vivo. The present invention further provides compositions and methods for high throughput assays for identifying compounds that effect glycosidase activity.

公开(公告)号：US07335770B2

公开(公告)日：2008-02-26

申请号：US10808210

申请日：2004-03-24

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Sridevi Alluri ,  Velagala Venkata Rama Murali Krishna Reddy ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Koteswar Rao Yeleswarapu ,  Gaddam Om Reddy ,  Potlapally Rajender Kumar

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Sesha Sridevi Alluri ,  Velagala Venkata Rama Murali Krishna Reddy ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Koteswar Rao Yeleswarapu ,  Gaddam Om Reddy ,  Potlapally Rajender Kumar

IPC分类号： C07D251/54 ,  C07D251/48 ,  C07D251/18 ,  C07D251/42 ,  A61K31/53 ,  A61P35/00

CPC分类号： C07D251/46

摘要： The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells, inhibiting smooth muscle proliferation, treating vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis, and the like.

摘要翻译： 本发明涉及三嗪化合物及其类似物和衍生物，以及包含这些化合物的方法和组合物。 本发明的化合物和组合物尤其可用于治疗由炎症反应引起的病理生理学病症，抑制或阻断糖基化蛋白产生内皮细胞中信号传导相关炎症反应的诱导，抑制平滑肌增生，治疗血管闭塞症状 其特征在于平滑肌增生如再狭窄和动脉粥样硬化等。

公开(公告)号：US07169785B2

公开(公告)日：2007-01-30

申请号：US10400169

申请日：2003-03-26

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishma Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishma Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

IPC分类号： C07D251/42 ,  C07D251/48 ,  C07D251/54 ,  C07D239/24 ,  C07D213/02 ,  A61K31/53 ,  A61K31/506 ,  A61K35/00 ,  A61K31/424 ,  A61K31/427 ,  A61K31/4427

CPC分类号： A61K31/53 ,  C04B35/632 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/54 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

公开(公告)号：US07132423B2

公开(公告)日：2006-11-07

申请号：US10400140

申请日：2003-03-26

申请人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

发明人： Richard T. Timmer ,  Christopher W. Alexander ,  Sivaram Pillarisetti ,  Uday Saxena ,  Koteswar Rao Yeleswarapu ,  Manojit Pal ,  Jangalgar Tirupathy Reddy ,  Velagala Venkata Rama Murali Krishna Reddy ,  Sesha Sridevi Alluri ,  Potlapally Rajender Kumar ,  Gaddam Om Reddy

IPC分类号： C07D251/70 ,  C07D251/48 ,  A61K31/53 ,  A61P35/00

CPC分类号： A61K31/53 ,  C07D251/30 ,  C07D251/44 ,  C07D251/46 ,  C07D251/48 ,  C07D251/50 ,  C07D251/52 ,  C07D251/66 ,  C07D251/70 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07F9/6521 ,  C07F9/65583

摘要： The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.

公开(公告)号：US06610726B2

公开(公告)日：2003-08-26

申请号：US10026672

申请日：2001-12-19

申请人： Sivaram Pillarisetti ,  Itzhak D. Goldberg

发明人： Sivaram Pillarisetti ,  Itzhak D. Goldberg

IPC分类号： A61K31415

CPC分类号： A61K31/415 ,  A61K31/42

摘要： The invention is directed to pharmaceutical compositions containing small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction.

摘要翻译： 本发明涉及含有具有模拟或激动肝细胞生长因子/分散因子（HGF / SF）活性的能力的小有机分子的药物组合物，其可用于促进例如用于促进伤口或组织愈合的组织或器官的血管化， 或增加或恢复血液流向缺血组织，如心肌梗塞后的心脏。