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    MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-21 ACTIVITY
    54.
    发明申请
    MICRORNA COMPOUNDS AND METHODS FOR MODULATING MIR-21 ACTIVITY 审中-公开
    MICRORNA化合物和调节MIR-21活性的方法

    公开(公告)号：US20120270928A1

    公开(公告)日：2012-10-25

    申请号：US13455337

    申请日：2012-04-25

    申请人： Balkrishen Bhat

    发明人： Balkrishen Bhat

    IPC分类号： A61K31/7088 ,  C12N5/02 ,  A61P35/00 ,  C07H21/00

    CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/3231 ,  C12N2310/343 ,  C12N2310/35

    摘要： Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield potent inhibitors of miR-21 activity. The compositions may be used to inhibit miR-21, and also to treat diseases associated with abnormal expression of miR-21, such as fibrosis and cancer.

    摘要翻译： 本文描述了抑制miR-21活性的组合物和方法。 该组合物具有产生miR-21活性的有效抑制剂的某些核苷修饰模式。 该组合物可用于抑制miR-21，并且还可用于治疗与miR-21异常表达相关的疾病，如纤维化和癌症。

    5′-modified bicyclic nucleic acid analogs
    55.
    发明授权
    5′-modified bicyclic nucleic acid analogs 有权
    5'-修饰的双环核酸类似物

    公开(公告)号：US08268980B2

    公开(公告)日：2012-09-18

    申请号：US13243321

    申请日：2011-09-23

    申请人： Punit P. Seth ,  Eric E. Swayze ,  Balkrishen Bhat

    发明人： Punit P. Seth ,  Eric E. Swayze ,  Balkrishen Bhat

    IPC分类号： C07H21/00 ,  C07H21/04

    CPC分类号： C07H19/04 ,  C07H21/00

    摘要： The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.

    摘要翻译： 本发明提供了包含这些核苷类似物中的至少一种的5'-修饰的双环核苷类似物和寡聚化合物。 在优选的实施方案中，核苷类似物在5'-碳上具有（R）或（S） - 亲和性。 这些双环核苷类似物可用于增强低聚化合物的性质，包括例如增强的核酸酶抗性。

    Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
    57.
    发明授权
    Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation 有权
    用于基因调控的含多环糖替代物的寡聚化合物和组合物

    公开(公告)号：US08124745B2

    公开(公告)日：2012-02-28

    申请号：US12774566

    申请日：2010-05-05

    申请人： Charles Allerson ,  Balkrishen Bhat ,  Eric E. Swayze ,  Thazha P. Prakash

    发明人： Charles Allerson ,  Balkrishen Bhat ,  Eric E. Swayze ,  Thazha P. Prakash

    IPC分类号： C07H19/00 ,  C07H21/04

    CPC分类号： C07H21/00 ,  C07H21/04 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/323 ,  C12N2310/343 ,  C12N2310/3521 ,  C12N2310/3533 ,  C12N2320/51

    摘要： Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a polycyclic sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a polycyclic sugar surrogate modification.

    摘要翻译： 提供包含第一和第二寡聚体的组合物，其中至少一部分第一寡聚体能够与至少一部分第二寡聚物杂交，至少一部分第一寡聚体与选定的靶互补并能够与选定的靶 核酸，并且第一或第二寡聚体中的至少一种包括包含多环糖替代物的修饰物。 还提供寡聚物/蛋白质组合物，其包含与选定的靶核酸互补并且能够与选定的靶核酸杂交的寡聚体和至少一种包含至少一部分RNA诱导的沉默复合物（RISC）的蛋白质，其中至少一种核苷 低聚物具有多环糖替代物修饰。