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公开(公告)号：US20100130589A1
公开(公告)日：2010-05-27
申请号：US12550479
申请日：2009-08-31
申请人： Susan M. Freier , Kenneth Dobie , Eric G. Marcusson , Eric E. Swayze , Balkrishen Bhat , Jeremy Richard Graff , Bruce William Konicek
发明人： Susan M. Freier , Kenneth Dobie , Eric G. Marcusson , Eric E. Swayze , Balkrishen Bhat , Jeremy Richard Graff , Bruce William Konicek
IPC分类号： A61K31/7088 , C07H21/00 , A61P35/00
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US20120283312A1
公开(公告)日：2012-11-08
申请号：US13548784
申请日：2012-07-13
IPC分类号： A61K31/7115 , A61P35/00 , A61K31/712 , C07H21/04 , A61K31/7125
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US20090192106A1
公开(公告)日：2009-07-30
申请号：US12184379
申请日：2008-08-01
IPC分类号： A61K31/7088 , C07H21/04
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US07601700B2
公开(公告)日：2009-10-13
申请号：US12184379
申请日：2008-08-01
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US07425544B2
公开(公告)日：2008-09-16
申请号：US10571339
申请日：2004-09-17
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
摘要翻译： 提供低分子化合物，组合物和方法用于调节eIF4E的表达。 反义化合物可以是单链或双链的，并且靶向编码eIF4E的核酸。 提供了使用这些化合物调节eIF4E表达和用于诊断和治疗与eIF4E表达相关的疾病和病症的方法。
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公开(公告)号：US08410074B2
公开(公告)日：2013-04-02
申请号：US13548784
申请日：2012-07-13
CPC分类号： C07H21/00 , A61K38/00 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/3181 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/53 , C12N2310/3525 , C12N2310/3521 , C12N2310/3533
摘要： Oligomeric compounds, compositions and methods are provided for modulating the expression of eIF4E. The antisense compounds may be single- or double-stranded and are targeted to nucleic acid encoding eIF4E. Methods of using these compounds for modulation of eIF4E expression and for diagnosis and treatment of diseases and conditions associated with expression of eIF4E are provided.
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公开(公告)号：US20110280963A1
公开(公告)日：2011-11-17
申请号：US13130038
申请日：2009-11-17
申请人： Jeremy Richard Graff
发明人： Jeremy Richard Graff
CPC分类号： A61K31/282 , A61K31/7088 , A61K31/7125 , A61K2300/00
摘要： The present invention provides methods of sensitizing lung cancer cells to cisplatin and inhibiting the growth of lung cancer tumors by employing a modified eIF-4E antisense oligonucleotide and cisplatin in combination.
摘要翻译： 本发明提供了通过使用修饰的eIF-4E反义寡核苷酸和顺铂组合使肺癌细胞对顺铂敏感并抑制肺癌肿瘤生长的方法。
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公开(公告)号：US08268797B2
公开(公告)日：2012-09-18
申请号：US13130038
申请日：2009-11-17
申请人： Jeremy Richard Graff
发明人： Jeremy Richard Graff
CPC分类号： A61K31/282 , A61K31/7088 , A61K31/7125 , A61K2300/00
摘要： The present invention provides methods of sensitizing lung cancer cells to cisplatin and inhibiting the growth of lung cancer tumors by employing a modified eIF-4E antisense oligonucleotide and cisplatin in combination.
摘要翻译： 本发明提供了通过使用修饰的eIF-4E反义寡核苷酸和顺铂组合使肺癌细胞对顺铂敏感并抑制肺癌肿瘤生长的方法。
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公开(公告)号：US20110301222A1
公开(公告)日：2011-12-08
申请号：US13130039
申请日：2009-11-17
申请人： Jeremy Richard Graff
发明人： Jeremy Richard Graff
IPC分类号： A61K31/7125 , A61P35/00
CPC分类号： A61K45/06 , A61K31/337 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K2300/00
摘要： The present invention provides methods of sensitizing cancer cells to docetaxel and inhibiting the growth of various tumors by employing a modified eIF-4E antisense oligonucleotide and docetaxel in combination.
摘要翻译： 本发明提供通过使用修饰的eIF-4E反义寡核苷酸和多西紫杉醇组合使癌细胞对多西紫杉醇敏感并抑制各种肿瘤的生长的方法。
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公开(公告)号：US20140323543A1
公开(公告)日：2014-10-30
申请号：US13870823
申请日：2013-04-25
申请人： Jeremy Richard Graff
发明人： Jeremy Richard Graff
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2320/31 , C12N2320/35 , C12N2310/321 , C12N2310/3525
摘要： The present invention provides methods of sensitizing cancer cells to docetaxel and inhibiting the growth of various tumors by employing a modified eIF-4E antisense oligonucleotide and docetaxel in combination.
摘要翻译： 本发明提供通过使用修饰的eIF-4E反义寡核苷酸和多西紫杉醇组合使癌细胞对多西紫杉醇敏感并抑制各种肿瘤的生长的方法。
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