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公开(公告)号：US20150067900A1
公开(公告)日：2015-03-05
申请号：US14384957
申请日：2013-03-15
Applicant: CELLECTIS, S.A.
Inventor： Philippe Duchateau , Alexandre Juillerat , Claudia Bertonati
IPC: A01K67/027 , C12N15/82 , C12N15/10
CPC classification number: A01K67/0275 , C12N15/10 , C12N15/63 , C12N15/82 , C12N15/8213 , C12Q1/6834 , C12Q2522/101
Abstract: The present invention relates to polypeptides and more particularly to Transcription Activator-Like Effector derived proteins that allow to efficiently target and/or process nucleic acids. The present invention also concerns methods to use these proteins. The present invention also relates to vectors, compositions and kits in which RVD domains and Transcription Activator-Like Effector (TALE) proteins of the present invention are used.
Abstract translation: 本发明涉及多肽，更具体地涉及允许有效靶向和/或加工核酸的转录激活子样效应物衍生蛋白。 本发明还涉及使用这些蛋白质的方法。 本发明还涉及使用本发明的RVD结构域和转录激活子效应（TALE）蛋白质的载体，组合物和试剂盒。
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52.发明申请METHOD TO OVERCOME DNA CHEMICAL MODIFICATIONS SENSITIVITY OF ENGINEERED TALE DNA BINDING DOMAINS 审中-公开扩增DNA结合域的DNA化学修饰的灵敏度的方法公开(公告)号：US20150037809A1
公开(公告)日：2015-02-05
申请号：US14387162
申请日：2013-03-15
Applicant: CELLECTIS, S.A.
Inventor： Philippe Duchateau , Julien Valton
CPC classification number: G01N33/5308 , C07K14/47 , C07K2319/61 , C07K2319/80 , C12N9/22 , C12N15/102
Abstract: The present invention relates to polypeptides and more particularly to Transcription Activator-Like Effector derived proteins that allow to efficiently target and/or process nucleic acids. Particularly, the present invention reports the characterization of TALE derived proteins that can efficiently target methylated DNA. The present invention more specifically relates to TALE derived proteins that allow activation of methylated promoters responsible for gene silencing.
Abstract translation: 本发明涉及多肽，更具体地涉及允许有效靶向和/或加工核酸的转录激活子样效应物衍生蛋白。 特别地，本发明报道了可有效靶向甲基化DNA的TALE衍生蛋白质的表征。 本发明更具体地涉及允许活化负责基因沉默的甲基化启动子的TALE衍生的蛋白质。
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