公开(公告)号：US06482146B1

公开(公告)日：2002-11-19

申请号：US09593251

申请日：2000-06-13

申请人： Clifton A. Alferness ,  Donald G. Rohrbaugh ,  J. Edward Shapland ,  Michael J. Girard ,  Donald F. Palme, II ,  James E. Cox

发明人： Clifton A. Alferness ,  Donald G. Rohrbaugh ,  J. Edward Shapland ,  Michael J. Girard ,  Donald F. Palme, II ,  James E. Cox

IPC分类号： A61F200

CPC分类号： A61F2/2481 ,  Y10S623/904

摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.

摘要翻译： 生物相容材料的护套具有尺寸设计用于心脏顶点的内部容积，以将其插入体积中并使护套滑过心脏。 护套具有在上下端之间的纵向尺寸，足以使护套围绕心脏的下部围绕心脏的瓣膜环并且进一步围绕下部以至少覆盖心脏的心室下端 。 护套适于固定在心脏上，护套至少围绕瓣膜环和心室下肢。 护套在心脏上是可调节的，以贴合地符合心脏的外部几何形状，并假设护套的最大调节体积以约束舒张期心脏超过最大调节体积的周向扩张，并允许心脏收缩期间不受阻碍的收缩 。

公开(公告)号：US06375608B1

公开(公告)日：2002-04-23

申请号：US09696651

申请日：2000-10-25

申请人： Clifton A. Alferness

发明人： Clifton A. Alferness

IPC分类号： A61B1900

CPC分类号： A61F2/2481 ,  A61F2002/2484 ,  A61F2250/0003 ,  A61M1/1008 ,  A61M1/106 ,  A61M1/1068 ,  A61M1/12

摘要： The present disclosure is directed to a cardiac reinforcement device (CRD) and method for the treatment of cardiomyopathy. The CRD provides for reinforcement of the walls of the heart by constraining cardiac expansion, beyond a predetermined limit, during diastolic expansion of the heart. A CRD of the invention can be applied to the epicardium of the heart to locally constrain expansion of the cardiac wall or to circumferentially constrain the cardiac wall during cardiac expansion.

公开(公告)号：US06258100B1

公开(公告)日：2001-07-10

申请号：US09686204

申请日：2000-10-10

申请人： Clifton A. Alferness ,  Richard Y. Lin ,  Wilfred E. Jaeger

发明人： Clifton A. Alferness ,  Richard Y. Lin ,  Wilfred E. Jaeger

IPC分类号： A61F1100

CPC分类号： A61F2/04 ,  A61B17/12104 ,  A61B17/12172 ,  A61F2/24 ,  A61F2002/043

摘要： A device, system, and method provides for lung size reduction by permanently collapsing at least a portion of a lung. The lung portion may be collapsed by obstructing the air passageway which communicates the lung portion to be collapsed. The air passageway may be obstructed by an obstructing member which precludes airflow in either direction or with a one-way valve which permits air to be exhaled from the lung portion while precluding air from being inhaled into the lung portion. In addition, a vacuum may be pulled within the lung portion to be collapsed for collapsing the lung portion and while the lung portion is collapsed the obstructing member may be placed in the air passageway to maintain the lung portion in a permanently collapsed state.

摘要翻译： 装置，系统和方法通过永久地塌缩至少一部分肺而提供肺尺寸减小。 肺部分可以通过阻塞连通待收缩的肺部分的空气通道而折叠。 空气通道可能被妨碍任何一个方向气流的阻塞构件阻塞，或者阻止空气被吸入肺部的单向阀，从而允许空气从肺部呼出。 此外，真空可以在肺部分内被拉动以被塌缩以塌陷肺部，而当肺部收缩时，阻塞构件可以放置在空气通道中，以保持肺部分处于永久塌陷状态。

公开(公告)号：US06241654B1

公开(公告)日：2001-06-05

申请号：US09348697

申请日：1999-07-07

申请人： Clifton A. Alferness

发明人： Clifton A. Alferness

IPC分类号： A61F200

CPC分类号： A61F2/2481

摘要： The present disclosure is directed to materials, devices, and methods for treatment of cardiac conditions including, for example, cardiomyopathy and valvular insufficiency. The devices and methods are directed to constraining expansion of the heart during diastole to a predetermined limit. In one embodiment, a material of the invention is a weave material that can be applied to the heart as a wrap of a two-dimensional sheet or shaped into a jacket. A cardiac reinforcement device of the invention can be applied to the heart to constrain cardiac expansion to a predetermined limit.

摘要翻译： 本公开涉及用于治疗心脏病症的材料，装置和方法，包括例如心肌病和瓣膜功能不全。 装置和方法旨在将心脏舒张期的扩张约束到预定极限。 在一个实施方案中，本发明的材料是可以作为二维片的包裹物或成形为外套的心脏施加的编织材料。 本发明的心脏增强装置可以应用于心脏以将心脏扩张限制到预定极限。

公开(公告)号：US5350404A

公开(公告)日：1994-09-27

申请号：US130308

申请日：1993-10-01

申请人： John M. Adams ,  Clifton A. Alferness ,  Paul E. Kreyenhagen

发明人： John M. Adams ,  Clifton A. Alferness ,  Paul E. Kreyenhagen

IPC分类号： A61N1/05 ,  A61N1/372 ,  A61N1/39

CPC分类号： A61N1/3918 ,  A61N1/056 ,  A61N1/0563 ,  A61N1/3956 ,  A61N1/3962 ,  A61N1/395 ,  A61N1/3987 ,  A61N2001/0585

摘要： An implantable atrial defibrillator provides a pulse of defibrillating electrical energy to the atria of the heart in synchronism with sensed R waves in response to non-coincident sensing of an R wave at first and second areas of the heart. The defibrillating pulse is provided after a predetermined number of consecutive R waves are non-coincidently sensed to assure reliable synchronization. The atrial defibrillator is also operational in a marker mode wherein a number of synchronization marker pulses are delivered to the heart for detection on an externally generated electrocardiogram. The atrial fibrillation detector of the defibrillator is normally disabled and is activated when the sensed ventricular activity indicates a probability of atrial fibrillation to conserve a depletable power source. A plurality of lead systems are also described for use with the atrial defibrillator which reduce the quantity of electrical energy required to defibrillate the heart and ensure that the delivered atrial defibrillating electrical energy is substantially confined to the atria of the heart.

摘要翻译： 可植入心房除颤器响应于在心脏的第一和第二区域处的R波的不一致的感测，与感测到的R波同步地向心脏的心房提供除颤电脉冲。 在不一致地感测到预定数量的连续R波之后提供除颤脉冲，以确保可靠的同步。 心房除颤器还可以在标记模式中操作，其中多个同步标记脉冲被传送到心脏以便在外部产生的心电图上进行检测。 除颤器的心房颤动检测器通常被禁用，并且当感测到的心室活动指示心房颤动的概率以节省可消耗的电源时被激活。 还描述了与心房除颤器一起使用的多个引导系统，其减少了除颤心脏所需的电能的量，并确保输送的心房除颤电能基本上限于心脏的心房。

公开(公告)号：US5332400A

公开(公告)日：1994-07-26

申请号：US996656

申请日：1992-12-24

申请人： Clifton A. Alferness

发明人： Clifton A. Alferness

IPC分类号： A61N1/39 ,  A61B5/04

CPC分类号： A61N1/3925 ,  A61N1/395

摘要： An implantable atrial defibrillator provides cardioverting electrical energy to the atria of a patient's heart in need of cardioversion and a precardioversion warning to the patient. The atrial defibrillator includes a detector for detecting atrial activity of the patient's heart, and an atrial fibrillation detector responsive to the atrial activity detector for determining when the atria of the patient's heart are in need of cardioversion. A cardioverter responsive to the atrial fibrillation detector, applies warning electrical energy to the atria of the patient's heart when the atria are in need of cardioversion and thereafter applies cardioverting electrical energy to the atria. The warning electrical energy is of insufficient quantity to intentionally cardiovert the atria but of sufficient quantity so as to be discernable by the patient.

摘要翻译： 可植入心房除颤器为需要心脏复律的患者心脏的心房提供心脏转复电能，并向患者提供预防心律失常警告。 心房除颤器包括用于检测患者心脏的心房活动的检测器，以及响应于心房活动检测器的心房颤动检测器，用于确定患者心脏的心房何时需要心脏复律。 响应于心房颤动检测器的心律转复器在心房需要心脏复律时向患者心脏的心房施加警告电能，然后将心电转移电能施加到心房。 预警电能数量不足以故意心跳心房但足够数量，以便患者辨别。

公开(公告)号：US5269298A

公开(公告)日：1993-12-14

申请号：US965168

申请日：1992-10-23

申请人： John M. Adams ,  Clifton A. Alferness ,  Kenneth R. Infinger ,  Yixuan Jin

发明人： John M. Adams ,  Clifton A. Alferness ,  Kenneth R. Infinger ,  Yixuan Jin

IPC分类号： A61N1/39

CPC分类号： A61N1/3956 ,  A61N1/395 ,  A61N1/3987

摘要： An implantable atrial defibrillator provides cardioverting electrical energy to the atria of a human heart in need of cardioversion. The atrial defibrillator includes a first detector for detecting ventricular activations of the heart, a second detector for detecting atrial activity of the heart, and an atrial fibrillation detector responsive to the second detector for determining when the atria of the heart are in need of cardioversion. The atrial defibrillator further includes a cardioverter for applying the cardioverting electrical energy to the atria of the heart when the atria of the heart are in need of cardioversion, and a timer delay stage responsive to the first detector for causing the cardioverter to apply the cardioverting electrical energy to the atria of the heart a predetermined delay time after the first detector detects one of the ventricular activations and before the T wave of the heart immediately following the one of the ventricular activations.

公开(公告)号：US09072534B2

公开(公告)日：2015-07-07

申请号：US13465264

申请日：2012-05-07

申请人： John M. Adams ,  Clifton A. Alferness ,  Daniel Hawkins

发明人： John M. Adams ,  Clifton A. Alferness ,  Daniel Hawkins

IPC分类号： A61B17/225 ,  A61B17/22 ,  A61B17/3207

CPC分类号： A61B17/2202 ,  A61B17/22022 ,  A61B17/2251 ,  A61B17/320725 ,  A61B2017/22024 ,  A61B2017/22025

摘要： An angioplasty catheter includes an elongated carrier, and an angioplasty balloon about the carrier in sealed relation thereto. The balloon is arranged to receive a fluid therein that inflates the balloon. The catheter further includes a shock wave generator within the balloon that forms a rapidly expanding and collapsing bubble within the balloon to form mechanical shock waves within the balloon. The expanding bubble forms a first shock and the collapsing balloon forms a second shock wave. The shock wave generator is arranged such that the energy of the first shock wave is greater than the energy of the second shock wave.

摘要翻译： 血管成形术导管包括细长的载体和与其密封的关于载体的血管成形术球囊。 气囊被布置成接收其中使气囊膨胀的流体。 导管还包括气囊内的冲击波发生器，其在球囊内形成快速膨胀和塌陷的气泡，以在球囊内形成机械冲击波。 膨胀的气泡形成第一次冲击，并且塌缩的气球形成第二冲击波。 冲击波发生器被布置成使得第一冲击波的能量大于第二冲击波的能量。

公开(公告)号：US08414655B2

公开(公告)日：2013-04-09

申请号：US12828629

申请日：2010-07-01

申请人： Clifton A. Alferness ,  Hugo X. Gonzalez ,  David H. Dillard

发明人： Clifton A. Alferness ,  Hugo X. Gonzalez ,  David H. Dillard

IPC分类号： A61F2/04

CPC分类号： A61B17/12104 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12172 ,  A61B2017/1205 ,  A61B2017/12054 ,  A61F2002/043 ,  A61M16/0404

摘要： An air passageway obstruction device includes a frame structure and a flexible membrane overlying the frame structure. The frame structure is collapsible upon advancement of the device into the air passageway, expandable into a rigid structure upon deploying in the air passageway and recollapsible upon removal from the air passageway. The flexible membrane obstructs inhaled air flow into a lung portion communicating with the air passageway. The device may be removed after deployment in an air passageway by recollapsing the device and pulling the device proximally through a catheter.

公开(公告)号：US20120215175A1

公开(公告)日：2012-08-23

申请号：US13360485

申请日：2012-01-27

申请人： Clifton A. Alferness ,  John M. Adams

发明人： Clifton A. Alferness ,  John M. Adams

IPC分类号： A61M5/142

CPC分类号： A61M5/1424 ,  A61M5/1454 ,  A61M2005/1405

摘要： A fully manually powered infusion device provides both basal and bolus delivery of a liquid medicament to a patient. In some embodiments, the device includes a main reservoir that supplies the liquid medicament, an outlet port that delivers the liquid medicament to the patient, a basal dispenser that delivers a substantially constant flow of the liquid medicament to the outlet port, and a manually actuated bolus pump that delivers a bolus dose of the liquid medicament from the main reservoir to the outlet when actuated. The basal medicament supply delivers a volume of the liquid medicament from the main reservoir to the basal dispenser consonant with each actuation of the bolus pump.

摘要翻译： 完全手动输液装置提供液体药物到患者的基础和推注。 在一些实施例中，该装置包括供给液体药物的主储存器，将液体药物输送给患者的出口端口，将液体药物的基本上恒定的流量输送到出口的基础分配器，以及手动致动 推动泵，其在致动时将液体药物从主容器输送到出口。 基础药物供应器通过每次推动推注泵将一定体积的液体药物从主储存器输送到基础分配器辅助器。