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70 条记录 (耗时 0.028 秒)

    Oral osmotic device for delivery of nystatin with hydrogel driving member
    52.
    发明授权
    Oral osmotic device for delivery of nystatin with hydrogel driving member 失效
    口服渗透装置用于用水凝胶驱动构件递送制霉菌素

    公开(公告)号：US5776493A

    公开(公告)日：1998-07-07

    申请号：US171875

    申请日：1993-12-22

    申请人： Brian L. Barclay ,  Jerry D. Childers ,  Jeri Wright ,  Virgil A. Place ,  Patrick S.-L. Wong

    发明人： Brian L. Barclay ,  Jerry D. Childers ,  Jeri Wright ,  Virgil A. Place ,  Patrick S.-L. Wong

    IPC分类号： A61K9/00 ,  A61K9/52 ,  A61K9/24

    CPC分类号： A61K9/0004

    摘要： An osmotic device (10) for delivering a beneficial drug, such as an anti-fungal, into the mouth of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a wall (12) surrounding a compartment (13) housing a layer of an agent (14) that is insoluble to very soluble in aqueous biological fluids, e.g., saliva, and a layer (16) of a fluid swellable, hydrophilic polymer. A passageway (17) in the wall (12) connects the agent (14) with the exterior of the device (10). The wall (12) is permeable to the passage of aqueous biological fluid but substantially impermeable to the passage of the hydrophilic polymer (16). In one embodiment the beneficial agent (14) has a different color than the hydrophilic polymer (16). The wall (12) is sufficiently translucent to permit the patient to see the amount of drug/beneficial agent (14) remaining to be delivered. Marking lines (19) may be provided on the wall (12) indicating the amount of drug/agent (14) which has been delivered and/or the amount remaining to be delivered.

    摘要翻译： 公开了一种用于将有益药物（例如抗真菌）递送到人类患者的口中的渗透装置（10）。 装置（10）具有适应其舒适地保持在口中长时间的尺寸和形状。 装置（10）包括围绕隔室（13）的壁（12），该隔室（13）容纳不溶于非常可溶于水生物流体（例如唾液）的试剂（14）层，以及流体层 可溶胀的亲水性聚合物。 壁（12）中的通道（17）将试剂（14）与装置（10）的外部连接。 所述壁（12）对于水性生物流体的通道是可渗透的，但是对于亲水性聚合物（16）的通过基本上是不透水的。 在一个实施方案中，有益剂（14）具有与亲水性聚合物（16）不同的颜色。 壁（12）是足够半透明的，以允许患者看到待传送的药物/有益剂（14）的量。 标记线（19）可以设置在壁（12）上，指示已经被输送的药物/试剂（14）的量和/或剩余的待传送量。

    Osmotic device with delayed activation of drug delivery
    54.
    发明授权
    Osmotic device with delayed activation of drug delivery 失效
    渗透装置延迟激活药物递送

    公开(公告)号：US5312390A

    公开(公告)日：1994-05-17

    申请号：US4340

    申请日：1993-01-14

    申请人： Patrick S.-L. Wong

    发明人： Patrick S.-L. Wong

    IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation being of a predetermined length of time. The delivery of the agent formulation from the dispensing device, once begun, is continued over a predetermined prolonged period of time.

    摘要翻译： 本发明涉及一种流体吸收药物递送装置，其可用于将活性剂制剂初始延迟递送至使用的流体环境，起始或启动的初始延迟时间为预定时间长度。 一旦开始，药剂制剂从分配装置的输送在预定的较长时间内继续进行。

    Osmotic device for delayed delivery of agent
    55.
    发明授权
    Osmotic device for delayed delivery of agent 失效
    用于延迟递送药剂的渗透装置

    公开(公告)号：US5312388A

    公开(公告)日：1994-05-17

    申请号：US830160

    申请日：1992-01-31

    申请人： Patrick S.-L. Wong ,  Felix Theeuwes ,  Steven D. Larsen

    发明人： Patrick S.-L. Wong ,  Felix Theeuwes ,  Steven D. Larsen

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/48

    CPC分类号： A61K9/0004 ,  A61K9/4808

    摘要： The present invention is directed to a fluid-imbibing dispensing device for the immediate or almost immediate and extended delivery of an active agent over a prolonged period of time together with the initially delayed pulse delivery of an active agent to a fluid environment of use. The dispenser comprises a housing having a first wall section and a second wall section in slidably telescoping arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; a first active agent delivery chamber within a portion of the compartment defined by the first wall section, the first delivery chamber including at least one active agent formulation, an exit means for providing communication between the active agent formulation and the environment, and a first expansion means for dispensing the first active agent formulation through the exit means to the environment immediately and over a prolonged period of time; a second active agent delivery chamber within a portion of the compartment defined by the first wall section and adjacent the open end of the first wall section, the second delivery chamber including at least one active agent formulation; and an expansion chamber within a portion of the compartment defined by the second wall section, for separating apart the first and second wall sections of the housing after exposure to the environment of use for dispensing the second active agent formulation to the environment in a pulse after an initially delayed period of time, the expansion chamber including a second expansion means and a partition layer or push plate.

    摘要翻译： 本发明涉及一种流体吸入分配装置，用于在延长的时间段内立即或几乎立即和延长地递送活性剂，同时将活性剂的初始延迟脉冲输送到使用的流体环境。 分配器包括具有彼此可滑动地伸缩布置的第一壁部分和第二壁部分的壳体，该壳体在使用环境中保持其完整性; 由壳体包围和限定的内部隔室; 第一活性剂递送室，位于由第一壁部限定的隔室的一部分内，第一递送室包括至少一种活性剂制剂，用于提供活性剂配方与环境之间的连通的出口装置，以及第一膨胀 用于通过出口装置将第一活性剂制剂直接和长时间地分配到环境的装置; 第二活性剂递送室，其在由第一壁部分限定并且邻近第一壁部分的开口端限定的隔室的一部分内，第二递送室包括至少一种活性剂制剂; 以及在由所述第二壁部限定的所述隔室的一部分内的膨胀室，用于在暴露于使用环境之后分离所述壳体的所述第一和第二壁部分，以在所述第二活性剂配方的环境中以脉冲分配所述环境 最初延迟的时间段，膨胀室包括第二膨胀装置和分隔层或推板。

    Oral delivery of discrete units
    59.
    发明授权
    Oral delivery of discrete units 有权
    口服离散单位

    公开(公告)号：US06333050B2

    公开(公告)日：2001-12-25

    申请号：US09764074

    申请日：2001-01-19

    申请人： Patrick S.-L. Wong ,  Howard B. Rosen ,  Nathan Roth ,  Phyllis I. Gardner

    发明人： Patrick S.-L. Wong ,  Howard B. Rosen ,  Nathan Roth ,  Phyllis I. Gardner

    IPC分类号： A61K914

    CPC分类号： A61K9/0092 ,  A47G21/183 ,  A61J7/0038

    摘要： The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent formulation to a patient. An active agent formulation chamber containing the active agent formulation and having a fluid passing active agent formulation retainer is placed at a first end into a fluid and at a second end into a patient's mouth. The active agent is delivered when the patient sips on the second end of the chamber.

    摘要翻译： 本发明涉及一种用于将活性剂制剂的离散单元递送至患者的口服活性剂递送系统和方法。 含有活性剂制剂并具有流体通过的活性剂制剂保持剂的活性剂制剂室在第一端置于流体中，并在第二端置于患者口中。 当患者在房间的第二端上浸泡时，递送活性剂。