公开(公告)号：US06819438B2

公开(公告)日：2004-11-16

申请号：US10137662

申请日：2002-05-03

申请人： Richard A. Neily ,  William McCreath ,  David Parker

发明人： Richard A. Neily ,  William McCreath ,  David Parker

IPC分类号： G01B1106

CPC分类号： G01B11/0625

摘要： To determine the uniformity of an optical component, a light beam is directed to impinge on a surface of an optical component at each of multiple points. A characteristic of the light beam impinging on the optical component surface at each of the multiple points is modified so as to have multiple different values. Light from the impinging light beam that passes through the optical component at each of the multiple points, with the light beam characteristic at each of the multiple different values, is detected. The non-uniformity of the optical component is determined based on the detected passing light.

摘要翻译： 为了确定光学部件的均匀性，在多个点处指向光束以撞击在光学部件的表面上。 在多个点处的每一个处照射在光学部件表面上的光束的特性被修改为具有多个不同的值。 检测在多个不同点处的每一个上通过光学部件的入射光束的光，其中在多个不同值的每一个处具有光束特性。 基于检测到的通过光来确定光学部件的不均匀性。

公开(公告)号：US06774228B1

公开(公告)日：2004-08-10

申请号：US07577072

申请日：1990-08-31

申请人： David Parker ,  Thomas Andrew Millican

发明人： David Parker ,  Thomas Andrew Millican

IPC分类号： C07D25702

CPC分类号： C07D401/12 ,  A61K47/6887 ,  A61K49/0002 ,  C07D257/02

摘要： 1,4,7,10-Tetrazacyclododecanes carrying a side chain terminating in a group capable of reacting with an antibody, and their complexes with a di- or tripositive metal having a coordination number of 6 or more can be used to prepare imaging agents. Typical metals are indium, copper, lead, bismuth, yttrium, terbium, gadolinium, and scandium. The compounds can be reacted with a monoclonal or polyclonal antibody or antibody fragment to target the metal to a specific type of tissue.

摘要翻译： 可以使用携带终止于能够与抗体反应的基团的侧链的1,4,7,10-四氮杂十二烷及其与配位数为6以上的二价或三价金属的配合物来制备显影剂。 典型的金属是铟，铜，铅，铋，钇，铽，钆和钪。 化合物可以与单克隆或多克隆抗体或抗体片段反应以将金属靶向特定类型的组织。

公开(公告)号：US06313660B1

公开(公告)日：2001-11-06

申请号：US09419921

申请日：1999-10-18

申请人： Gerald Edward Sobelman ,  David Parker

发明人： Gerald Edward Sobelman ,  David Parker

IPC分类号： G06F738

CPC分类号： H03K19/1735

摘要： A programmable gate array is disclosed for implementing asynchronous logic. In one embodiment, the array includes a set of cells, at least one of which includes a threshold gate having a plurality of inputs, an output, and a threshold value. Signals may assume an ASSERTED state having a logic meaning and a NULL state that has no logic meaning. The gate output switches to NULL when all inputs are NULL, and switches to the ASSERTED state when the number of ASSERTED inputs exceeds the threshold value. In the preferred embodiment, the gate exhibits hysteresis such that the output remains ASSERTED while the number of ASSERTED inputs remains greater than zero, less than the threshold value. In an alternate embodiment, an array of simplified threshold elements is used to form more complex threshold gates.

摘要翻译： 公开了一种用于实现异步逻辑的可编程门阵列。 在一个实施例中，阵列包括一组单元，其中至少一个包括具有多个输入，输出和阈值的阈值门。 信号可以假设具有逻辑含义的ASSERTED状态和没有逻辑含义的NULL状态。 当所有输入为NULL时，门输出切换到NULL，当ASSERTED输入的数量超过阈值时，切换到ASSERTED状态。 在优选实施例中，门显示滞后，使得输出保持为ASSERTED，而ASSERTED输入的数量保持大于零，小于阈值。 在替代实施例中，使用简化阈值元素的阵列来形成更复杂的阈值门。

公开(公告)号：US06186641B1

公开(公告)日：2001-02-13

申请号：US09345187

申请日：1999-06-30

申请人： David Parker

发明人： David Parker

IPC分类号： F21L1300

CPC分类号： F21L4/085 ,  F21V23/0414

摘要： A flashlight includes a rechargeable battery and is loaded from the front. The contacts are on an intermediate portion between the barrel extended and made with contacts of a recharging device. There is a helical spring member between the switching device above the barrel and the top of the battery and a helical spring member on the base of the barrel at the bottom of the battery. An enlarged head is located above the barrel and there is the intermediate portion between the head and the barrel. The intermediate portion receives the switching device.

摘要翻译： 手电筒包括可充电电池，并从前面装载。 触点位于延伸并由充电装置的触点制成的筒之间的中间部分上。 在筒体之间的开关装置和电池的顶部之间存在螺旋弹簧构件，并且在电池底部的筒的底部上具有螺旋弹簧构件。 一个放大的头部位于镜筒上方，头部和镜筒之间有中间部分。 中间部分接收切换装置。

公开(公告)号：US5684135A

公开(公告)日：1997-11-04

申请号：US451306

申请日：1995-05-26

申请人： David Parker ,  Nigel Robert Arnold Beeley ,  Thomas Andrew Millican

发明人： David Parker ,  Nigel Robert Arnold Beeley ,  Thomas Andrew Millican

IPC分类号： A61K49/06 ,  C07D257/02 ,  C07F9/6524 ,  C07K17/06

CPC分类号： A61K49/06 ,  C07D257/02 ,  C07F9/6524

摘要： ##STR1## Conjugate compounds are described comprising a compound of formula (1), wherein A is a group --Alk
3 -- or --Alk
3 N(R
4 )Alk
1 --, Alk
2 , Alk
3 and Alk
4 which may be the same or different is each a C
1-4 alkylene chain optionally substituted by one or more C
1-6 alkyl groups; and R
1 , R
2 , R
3 and R
4 , which may be the same or different, is each a hydrogen atom or a group--AlkR
5 where Alk is an optionally substituted straight or branched C
1-6 alkyl group and R
5 is a hydrogen atom or a --CO
2 H, --CONR
6 R
7 (where R
6 and R
7 , which may be the same or different is each a hydrogen atom or an alkyl group) or --P(X
1 )(X
2 R
8 )L group where X
1 and X
2 is each an oxygen or sulphur atom. R
8 is a hydrogen atom or an alkyl group and L is an aliphatic, aromatic, or heteroaromatic group or a linker group with the proviso that at least one of R
1 , R
2 , R
3 and R
4 is a group AlkP(X
1 )(X
2 R
8 )L where L is a linker group; and a metal complexes and/or salts thereof, coupled to a protein, peptide or carbohydrate. The conjugates are useful for imaging and in the treatment of abnormal cell disorders, such as in the treatment of tumours.

摘要翻译： （1）描述了包含式（1）化合物的共轭化合物，其中A是可以相同或不同的基团-Alk3-或-Alk3N（R4）Alk1，Alk2，Alk3和Alk4，各自可以相同或不同 任选被一个或多个C 1-6烷基取代的C 1-4亚烷基链; 并且可以相同或不同的R 1，R 2，R 3和R 4各自为氢原子或AlkR 5基团，其中Alk为任选取代的直链或支链C 1-6烷基，R 5为氢原子或 - CO 2 H，-CONR 6 R 7（其中R 6和R 7可以相同或不同，各自为氢原子或烷基）或-P（X1）（X2R8）L基团，其中X1和X2各自为氧或硫原子。 R8是氢原子或烷基，L是脂族，芳族或杂芳族基团或连接基团，条件是R1，R2，R3和R4中的至少一个是AlkP（X1）（X2R8）L 其中L是连接基团; 和与蛋白质，肽或碳水化合物偶联的金属络合物和/或其盐。 缀合物可用于成像和治疗异常细胞疾病，例如治疗肿瘤。

公开(公告)号：US5653960A

公开(公告)日：1997-08-05

申请号：US311721

申请日：1994-09-23

申请人： David Parker ,  Nigel Robert Arnold Beeley

发明人： David Parker ,  Nigel Robert Arnold Beeley

IPC分类号： A61K49/00 ,  A61K49/06 ,  C07D257/02 ,  C07F20060101 ,  C07F9/30 ,  C07F9/32 ,  C07F9/6524 ,  A61B5/055 ,  C07D255/00 ,  C07D255/02

CPC分类号： A61K49/06 ,  C07D257/02 ,  C07F9/6524 ,  Y10S514/836

摘要： ##STR1## Metal complex of tetra-aza macrocycles of formula (1) wherein Alk
1 , Alk
2 , Alk
3 and Alk
4 , which may be the same or different, is each a C
1-4 alkylene chain optionally substituted by one or more optionally substituted C
1-6 alkyl groups; and R
1 , R
2 , R
3 and R
4 which may be the same or different is each a hydrogen atom or a group AlkR
5 where Alk is an optionally substituted straight or branched C
1-6 alkyl group and R
5 is a hydrogen atom or a --CO
2 H,--CONR
6 R
7 [where R
6 and R
7 , which may be the same or different, is each a hydrogen atom or a C
1-6 alkyl group] or --P(X
1 )(X
2 R
8 )R
9 group where X
1 and X
2 , which may be the same or different is each an oxygen or sulphur atom, R
8 is a hydrogen atom or an alkyl group and R
9 is an aliphatic, aromatic or heteroaromatic group, with the proviso that at least two of R
1 , R
2 , R
3 and R
4 is a group -AlkP(X
1 )(X
2 R
8 )R
9 or one or R
1 , R
2 , R
3 and R
4 is a group -AlkP(X
1 )(X
2 R
8 )R
9 and at least one of the remaining groups R
1 , R
2 , R
3 and R
4 is a group -AlkCO
2 H or -AlkCONR
6 R
7 , or a salt thereof, for use as contrast agents in nuclear magnetic resonance imaging are described.

摘要翻译： （1）式（1）的四氮杂大环的金属络合物，其中Alk1，Alk2，Alk3和Alk4可以相同或不同，各自为任选被一个或多个任选取代的C 1-4亚烷基链 C 1-6烷基; 可以相同或不同的R 1，R 2，R 3和R 4各自为氢原子或AlkR 5基团，其中Alk为任选取代的直链或支链C 1-6烷基，R 5为氢原子或-CO 2 H，-CONR 6 R 7 [其中R6和R7可以相同或不同，各自为氢原子或C1-6烷基]或-P（X1）（X2R8）R9基团，其中X1和X2可以相同或不同 每个为氧或硫原子，R8为氢原子或烷基，R9为脂族，芳族或杂芳族基团，条件是R1，R2，R3和R4中的至少两个为基团-AlkP（X1） （X2R8）R9或一个或R1，R2，R3和R4是基团-AlkP（X1）（X2R8）R9，并且其余基团R1，R2，R3和R4中的至少一个是基团-AlkCO2H或-AlkCONR6R7， 或其盐，用作核磁共振成像中的造影剂。

公开(公告)号：US5583254A

公开(公告)日：1996-12-10

申请号：US343419

申请日：1995-01-13

申请人： John A. Turner ,  Eric Hindmarsh ,  David Parker ,  Ian P. Milne

发明人： John A. Turner ,  Eric Hindmarsh ,  David Parker ,  Ian P. Milne

IPC分类号： C07C51/43 ,  C07C63/26

CPC分类号： C07C51/43

摘要： Purified terephthalic acid is prepared by subjecting an aqueous solution of crude terephthalic acid to hydrogenation to reduce impurities, crystallizing this solution to produce a slurry of purified terephthalic acid in an aqueous liquor, and carrying out an integrated separation and washing process. The integrated separation is performed by exchanging the acidic reaction medium with water to produce a water containing cake of terephthalic acid.

摘要翻译： PCT No.PCT / GB93 / 01019 Sec。 371日期1995年1月13日 102（e）日期1995年1月13日PCT提交1993年5月19日PCT公布。 公开号WO93 / 24440 日期1993年12月9日通过使粗对苯二甲酸的水溶液进行氢化以减少杂质，使该溶液结晶，从而在含水液体中产生纯化的对苯二甲酸的浆液，并进行一体的分离和洗涤过程 。 通过将酸性反应介质与水交换以产生对苯二甲酸的含水饼来进行整体分离。

公开(公告)号：US5271927A

公开(公告)日：1993-12-21

申请号：US33461

申请日：1993-03-18

申请人： David Parker ,  Thomas A. Millican

发明人： David Parker ,  Thomas A. Millican

IPC分类号： A61K51/10 ,  C07D257/02 ,  C07D257/10 ,  C07D273/00 ,  C07D401/12 ,  C07D403/12 ,  A61K39/395 ,  A61K47/06 ,  A61K47/16 ,  A61K47/22

CPC分类号： C07D273/00 ,  A61K51/1093 ,  C07D257/02 ,  C07D257/10 ,  C07D401/12 ,  C07D403/12 ,  A61K2123/00

摘要： The conjugation of antibodies to a macrocyclic conjugate compound wherein the conjugate compound has the structure (I), wherein R.sup.1 is --(CH.sub.2).sub.p --R.sup.6 --CH.sub.2).sub.q -- where p and q are the same or different and are 0, 1 or 2, and --R.sup.6 -- is --((CH.sub.2).sub.n --, where n is 0 or 1, --NH--, --O--, --S-- or (II), R.sup.1 optionally being alkyl substituted, provided that neither p nor q is 0 unless R.sup.6 is --CH.sub.2 --; R.sup.2 are --CH.sub.2 CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH.sub.2 --, optionally alkyl, alkoxyalkyl or hydroxyalkyl substituted; R.sup.3 are the same or different and are --H, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, carboxyalkyl ester, phosphate, sulphonate or phosphonate; R.sup.4 is one of the compounds of formula (III) optionally alkyl substituted, wherein R.sup.7 is --H, alkyl, hydroxyalkyl, or alkoxyalkyl provided that when R.sup.4 is (III d), R.sup.3 is not carboxyalkyl, R.sup.5 is a linker, and Ab is an antibody. The conjugate compound provides for complexes of metals such as Tc, Co, Re, Cu, Au and Ag which are useful reagents for in vivo imaging and therapy.

摘要翻译： 抗体与大环结合化合物的缀合，其中偶联化合物具有结构（I），其中R 1是 - （CH 2）p -R 6 -CH 2）q-，其中p和q相同或不同，并且是0,1或 2，-R6-为（（CH2）n-，其中n为0或1，-NH-，-O - ， - S-或（II），R1任选为烷基取代基，条件是p和q 除非R6是-CH2-; R2是-CH2CH2-或-CH2CH2CH2-，任选地烷基，烷氧基烷基或羟烷基取代; R3相同或不同，是-H，烷基，羟基烷基，烷氧基烷基，羧基烷基，羧基烷基酯，磷酸酯 ，磺酸盐或膦酸盐; R4是任选被烷基取代的式（III）化合物之一，其中R 7是-H，烷基，羟基烷基或烷氧基烷基，条件是当R 4是（III d）时，R 3不是羧基烷基，R 5是 接头和Ab是抗体，偶联化合物提供了诸如Tc，Co，Re，Cu，Au和Ag的金属络合物，它们是用于体内成像和治疗的有用试剂。

公开(公告)号：US20220411346A1

公开(公告)日：2022-12-29

申请号：US17897133

申请日：2022-08-27

申请人： Gary David McKnight ,  Randall Linwood Rayborn ,  Wei Xu ,  Raymond Patrick Perkins ,  Zehui Yang ,  David Parker ,  Andrew Semple

发明人： Gary David McKnight ,  Randall Linwood Rayborn ,  Wei Xu ,  Raymond Patrick Perkins ,  Zehui Yang ,  David Parker ,  Andrew Semple

IPC分类号： C05G3/90 ,  C05C9/00 ,  C09K15/30 ,  C09K15/28 ,  C09K15/18 ,  C09K15/22

摘要： The present invention relates to increasing longevity of the nitrogen content of soil through improved liquid delivery formulations of nitrification inhibitors. The liquid formulation can also be comprised of nitrification inhibitors and optionally urease inhibitors that are blended solutions of each. The nitrification inhibitors are present in a mixture that comprises both a protic and an aprotic solvent system. The novel formulations are designed to be applied to fertilizers, especially urea and manure based fertilizers. The delivery formulations provide an environmentally sound and inherently safe solvating system that improves the storage stability of the urease inhibitors by utilizing liquid organic non-water containing solvents, maintains the nitrification inhibitors in solution to storage temperatures of at least 10° C., and provides improved application to fertilizer of nitrification inhibitors. These delivery formulations enable safe storage, transport and subsequent application or blending with urea-based or manure-based fertilizers that can be applied to soil in either a liquid or granular form to provide improved nitrogen retention in the soil for uptake for plant life.

公开(公告)号：US09650306B2

公开(公告)日：2017-05-16

申请号：US14689470

申请日：2015-04-17

申请人： Gary David McKnight ,  Randall Linwood Rayborn ,  Wei Xu ,  Raymond Patrick Perkins ,  Zehui Yang ,  David Parker ,  Andrew Semple

发明人： Gary David McKnight ,  Randall Linwood Rayborn ,  Wei Xu ,  Raymond Patrick Perkins ,  Zehui Yang ,  David Parker ,  Andrew Semple

IPC分类号： C05C9/00 ,  C05G3/08 ,  C09K15/28 ,  C09K15/30

CPC分类号： C05G3/08 ,  C05C9/00 ,  C09K15/18 ,  C09K15/22 ,  C09K15/28 ,  C09K15/30 ,  Y02P60/218

摘要： The present invention relates to increasing longevity of the nitrogen content of soil through improved liquid delivery formulations of nitrification inhibitors. The liquid formulation can also be comprised of nitrification inhibitors and optionally urease inhibitors that are blended solutions of each. The nitrification inhibitors are present in a mixture that comprises both a protic and an aprotic solvent system. The novel formulations are designed to be applied to fertilizers, especially urea and manure based fertilizers. The delivery formulations provide an environmentally sound and inherently safe solvating system that improves the storage stability of the urease inhibitors by utilizing liquid organic non-water containing solvents, maintains the nitrification inhibitors in solution to storage temperatures of at least 10° C., and provides improved application to fertilizer of nitrification inhibitors. These delivery formulations enable safe storage, transport and subsequent application or blending with urea-based or manure-based fertilizers that can be applied to soil in either a liquid or granular form to provide improved nitrogen retention in the soil for uptake for plant life.