公开(公告)号：US20130331927A1

公开(公告)日：2013-12-12

申请号：US13897302

申请日：2013-05-17

Applicant: Elixir Medical Corporation

Inventor： Xiaoxia Zheng ,  John Yan ,  Vinayak Bhat

IPC: A61F2/82

CPC classification number: A61F2/915 ,  A61F2/82 ,  A61F2/90 ,  A61F2/91 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0019 ,  A61F2230/0013 ,  A61F2230/0069 ,  A61F2240/001 ,  A61F2250/0073 ,  A61L31/048 ,  A61L31/06 ,  A61L31/14 ,  A61L31/148 ,  B33Y80/00 ,  C08L67/04

Abstract: The disclosure provides biodegradable implantable devices such as a stent comprising a biodegradable polymeric wherein the polymeric material is treated to control crystallinity and/or Tg. The stent is capable to expand at body temperature in a body lumen from a crimped configuration to a deployed diameter and have sufficient strength to support a body lumen.

Abstract translation: 本公开提供了可生物降解的可植入装置，例如包括可生物降解聚合物的支架，其中处理聚合物材料以控制结晶度和/或Tg。 支架能够在体腔中的体温从卷曲构型扩展到展开的直径，并且具有足够的强度来支撑体腔。

公开(公告)号：US20250073052A1

公开(公告)日：2025-03-06

申请号：US18629632

申请日：2024-04-08

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  John Yan ,  Vinayak Bhat ,  Joseph Paraschac ,  Brett Cryer ,  Benjamyn Serna

IPC: A61F2/89 ,  A61F2/07 ,  A61F2/24 ,  A61F2/82 ,  A61F2/90 ,  A61F2/915

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.

公开(公告)号：US12076504B2

公开(公告)日：2024-09-03

申请号：US18482711

申请日：2023-10-06

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  Benjamyn Serna ,  Kim Nguyen ,  John Yan ,  Matthew Tyler Surber

IPC: A61F2/01 ,  A61M25/00

CPC classification number: A61M25/0052 ,  A61M25/0074 ,  A61M2202/0014

Abstract: An aspiration catheter includes a catheter body having a proximal end, a distal end, and an aspiration lumen therebetween. A distal segment comprising an expandable distal tip of the aspiration catheter comprises a membrane and an expandable supporting structure, such as a scaffold, configured to radially expand the expandable distal tip. The expandable supporting structure may include supporting elements and other features which increase resistance to collapse of the expandable membrane under vacuum or negative pressure applied to aspirate clot through the aspiration lumen in the expanded configuration.

公开(公告)号：US20240225864A1

公开(公告)日：2024-07-11

申请号：US18451373

申请日：2023-08-17

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Vinayak Bhat

IPC: A61F2/89 ,  A61F2/915

CPC classification number: A61F2/89 ,  A61F2/915 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2230/0004 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/0069 ,  A61F2240/001 ,  A61F2250/0036 ,  A61F2250/0067

Abstract: A biodegradable stent prosthesis formed from a degradable material, having a plurality of luminal, abluminal, and side surface regions, wherein a surface portion extending between the abluminal and luminal surface region of at least some structural elements is convex.

公开(公告)号：US20230165874A1

公开(公告)日：2023-06-01

申请号：US18160519

申请日：2023-01-27

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat ,  Motasim Sirhan ,  Blaine Bueche

IPC: A61K31/5377 ,  A61K31/4709 ,  A61K45/06 ,  A61K31/4545 ,  A61K47/26 ,  A61K9/00 ,  A61K31/55 ,  A61K31/4706 ,  A61K47/40 ,  A61K47/12 ,  A61K31/496 ,  A61K31/4412 ,  A61K31/155 ,  A61K31/436 ,  A61K31/702

CPC classification number: A61K31/5377 ,  A61K31/4709 ,  A61K45/06 ,  A61K31/4545 ,  A61K47/26 ,  A61K9/0075 ,  A61K9/0078 ,  A61K31/55 ,  A61K31/4706 ,  A61K47/40 ,  A61K47/12 ,  A61K31/496 ,  A61K31/4412 ,  A61K31/155 ,  A61K31/436 ,  A61K31/702

Abstract: Devices, compositions, and methods are provided for inhibiting an inflammatory, fibrotic, and/or clot formation for pulmonary disease or condition in a patient. A therapeutic composition comprising a direct factor Xa inhibitor and/or a direct factor IIa inhibitor is provided. A therapeutically effective dose of the therapeutic composition is delivered to a site of the inflammatory, fibrotic, and/or clot formation pulmonary disease or condition in the patient's lung(s). The therapeutic composition may be formulated for delivery to the patient by inhalation, ventilation, instillation, ultrasound, vibration, injection, or the like. The therapeutic composition may include one or more additional therapeutically active substances and/or one or more additional pharmaceutical agents. The one or more additional therapeutically active substances and/or one or more additional pharmaceutical agents may be delivered together with the direct factor Xa inhibitor and/or direct factor IIa inhibitor or separately from the direct factor Xa inhibitor and/or factor IIa inhibitor.

公开(公告)号：US10918505B2

公开(公告)日：2021-02-16

申请号：US17017544

申请日：2020-09-10

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  John Yan ,  Vinayak Bhat ,  Joseph Paraschac ,  Brett Cryer ,  Benjamyn Serna

IPC: A61F2/915 ,  A61F2/89 ,  A61F2/90 ,  A61F2/07 ,  A61F2/82 ,  A61F2/24

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provide high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold is typically formed from non-degradable material and will be modified to expand and/or uncage after deployment.

公开(公告)号：US20210007867A1

公开(公告)日：2021-01-14

申请号：US16775764

申请日：2020-01-29

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Vinayak Bhat

IPC: A61F2/89 ,  A61F2/915

Abstract: A biodegradable stent prosthesis formed from a degradable material, having a plurality of luminal, abluminal, and side surface regions, wherein a surface portion extending between the abluminal and luminal surface region of at least some structural elements is convex.

公开(公告)号：US10695327B2

公开(公告)日：2020-06-30

申请号：US16154501

申请日：2018-10-08

Applicant: Elixir Medical Corporation

Inventor： John Yan ,  Xiaoxia Zheng ,  Vinayak D. Bhat

IPC: A61K45/06 ,  A61K9/00 ,  A61K31/436 ,  A61K31/439 ,  A61K31/4525

Abstract: A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of the formula: wherein R1, R2, R3, R5, R6, R8, M1, M2, M3, M4, M5, M6 and M7 are each independently a member selected from the group consisting of H, C1-6 alkyl, OH and C1-6 hydroxyalkyl; R4, R7 and R9 are each independently selected from the group consisting of C1-6 alkoxy and OH; R10 is a member selected from the group consisting of H, —OH, —OP(O)Me2, —O—(CH2)n—OH and —O—(CH2)m—O—(CH2)o—CH3, wherein subscripts n and m are each independently from 2 to 8 and subscript o is from 1 to 6; each of L1 and L4 are independently selected from the group consisting of: wherein each M8 is independently a member selected from the group consisting of C1-6 alkyl, OH and C1-6 hydroxyalkyl; each of L2 and L3 are independently selected from the group consisting of: and salts, isomers, or N-oxides thereof.

公开(公告)号：US20190231564A1

公开(公告)日：2019-08-01

申请号：US16356933

申请日：2019-03-18

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  John Yan ,  Vinayak Bhat ,  Joseph Paraschac ,  Brett Cryer ,  Benjamyn Serna

IPC: A61F2/89 ,  A61F2/90 ,  A61F2/915

CPC classification number: A61F2/89 ,  A61F2/2442 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/825 ,  A61F2002/91558 ,  A61F2002/91566 ,  A61F2002/91575 ,  A61F2002/91591 ,  A61F2210/0004 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2220/0033 ,  A61F2220/0091 ,  A61F2230/0006 ,  A61F2230/0008 ,  A61F2230/001 ,  A61F2230/0069 ,  A61F2250/0031 ,  A61F2250/0036 ,  A61F2250/0048 ,  A61F2250/0067 ,  A61F2250/0071

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.

公开(公告)号：US10271976B2

公开(公告)日：2019-04-30

申请号：US16039194

申请日：2018-07-18

Applicant: Elixir Medical Corporation

Inventor： Motasim Sirhan ,  John Yan ,  Vinayak Bhat ,  Joseph Paraschac ,  Brett Cryer ,  Benjamyn Serna

IPC: A61F2/89 ,  A61F2/915 ,  A61F2/90 ,  A61F2/07 ,  A61F2/24 ,  A61F2/82

Abstract: A stent (scaffold) or other luminal prosthesis comprising circumferential structural elements which provides high strength after deployment and allows for scaffold to uncage, and/or allow for scaffold or luminal expansion thereafter. The circumferential scaffold may be formed from degradable material, or may be formed from non-degradable material and will be modified to expand and/or uncage after deployment.