公开(公告)号：US20070191920A1

公开(公告)日：2007-08-16

申请号：US11737936

申请日：2007-04-20

申请人： Gregory Ley ,  Yongxing Zhang

发明人： Gregory Ley ,  Yongxing Zhang

IPC分类号： A61N1/00

CPC分类号： A61N1/05 ,  A61N1/056 ,  A61N2001/0578

摘要： An apparatus includes an elongated tube and an elongated rod having a holding member on one end, the holding member is adapted to hold an end of a lead such that the end of the lead can be pulled through the elongated tube resulting in minimal forces on the lead.

摘要翻译： 一种装置包括细长管和在一端具有保持构件的细长杆，所述保持构件适于保持引线的端部，使得引线的端部可以被拉动穿过细长管，导致在最小的力 铅。

公开(公告)号：US20070050003A1

公开(公告)日：2007-03-01

申请号：US11215786

申请日：2005-08-30

申请人： Paul Zarembo ,  Yongxing Zhang ,  Matthew Finlay ,  Jeffrey Bodner

发明人： Paul Zarembo ,  Yongxing Zhang ,  Matthew Finlay ,  Jeffrey Bodner

IPC分类号： A61N1/00

CPC分类号： A61N1/057 ,  A61N2001/0578 ,  A61N2001/0585

摘要： This document discusses, among other things, a lead body extending longitudinally along a lead axis, a driver axially displaceable relative to the lead body, and a driven member coupled to the lead body and displaceable away from the lead axis. The driven member at least partially defines an expandable passage having at least one internal dimension. The driver is displaceable into the expandable passage and has at least one outer dimension that is larger than the at least one internal dimension of the expandable passage. An example method includes disposing a first member having a first cross-section in a lead assembly having a lead axis, an expandable passage, and a displaceable member proximate the expandable passage. The method further includes urging the first member into the expandable passage in the lead assembly, and urging the displaceable member away from the lead axis to expand the expandable passage.

摘要翻译： 本文件尤其讨论了沿着引线轴线纵向延伸的引线本体，相对于引线主体轴向移位的驱动器以及耦合到引线主体并且可远离引导轴线移位的从动元件。 从动构件至少部分地限定具有至少一个内部尺寸的可扩张通道。 驾驶员可移动到可扩张通道中并且具有比可扩张通道的至少一个内部尺寸大的至少一个外部尺寸。 示例性方法包括将具有第一横截面的第一构件布置在具有引导轴线的引导组件中，可扩展通道和靠近可扩展通道的可移位构件。 所述方法还包括将所述第一构件推入所述引导组件中的所述可膨胀通道中，并且将所述可移位构件推离所述引导轴线以使所述可扩张通道膨胀。

公开(公告)号：US08715279B2

公开(公告)日：2014-05-06

申请号：US13532164

申请日：2012-06-25

申请人： Alan de la Rama ,  Kirk Kochin Wu ,  Yongxing Zhang

发明人： Alan de la Rama ,  Kirk Kochin Wu ,  Yongxing Zhang

IPC分类号： A61B18/18 ,  A61B19/00

CPC分类号： A61B18/1492 ,  A61B34/73 ,  A61B2018/00577 ,  A61B2218/002 ,  A61M25/0127

摘要： A catheter includes a flexible tubing having a proximal end and a distal end. The catheter also includes an electrode assembly attached to the distal end of the flexible tubing and having a first magnet therein. The electrode assembly further includes an electrically conductive tip electrode and an electrically nonconductive coupler which is connected between the tip electrode and the distal end of the flexible tubing. The coupler and the tip electrode are coupled by an interlocking connection. The catheter also includes a second magnet spaced from the electrode assembly along a longitudinal axis of the tubing. The first magnet and the second magnet are responsive to an external magnetic field to selectively position and guide the electrode assembly within a body of a patient.

摘要翻译： 导管包括具有近端和远端的柔性管。 导管还包括附接到柔性管的远端并且其中具有第一磁体的电极组件。 电极组件还包括导电尖端电极和连接在尖端电极和柔性管的远端之间的非导电耦合器。 耦合器和尖端电极通过互锁连接耦合。 导管还包括沿着管道的纵向轴线与电极组件间隔开的第二磁体。 第一磁体和第二磁体响应于外部磁场来选择性地将电极组件定位并引导到患者体内。

公开(公告)号：US20140107639A1

公开(公告)日：2014-04-17

申请号：US14124419

申请日：2012-06-06

申请人： Yongxing Zhang ,  Cary Hata ,  Alan De La Rama

发明人： Yongxing Zhang ,  Cary Hata ,  Alan De La Rama

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B18/24 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00982 ,  A61B2018/0212 ,  A61B2218/002 ,  A61N7/022

摘要： A method for denervation comprises introducing a distal portion of a catheter through an interior of a vessel of a patient to a location at or proximate one of a renal pelvis or a calyx. The catheter includes an elongated catheter body extending longitudinally between a proximal end and a distal end. The catheter body includes the distal portion at the distal end and a catheter lumen from the proximal end to the distal end. Energy is delivered from the distal portion to cause renal denervation, for example, by denervating at least some tissue proximate at least one of the renal pelvis or a renal vessel from a location at or proximate the renal pelvis or the calyx from a location at or proximate the calyx.

摘要翻译： 去神经支配的方法包括将导管的远端部分通过患者血管的内部引入到肾盂或萼片之一处或其附近的位置。 导管包括在近端和远端之间纵向延伸的细长导管体。 导管主体包括远端的远端部分和从近端到远端的导管腔。 从远端部分输送能量以引起肾去神经支配，例如，通过从肾盂或肾盂中的至少一个处的至少一些组织从肾盂或萼骨处的位置或从其位置处的 靠近花萼

公开(公告)号：US07392094B2

公开(公告)日：2008-06-24

申请号：US10325433

申请日：2002-12-19

申请人： Yongxing Zhang ,  James O. Gilkerson ,  Paul E. Zarembo

发明人： Yongxing Zhang ,  James O. Gilkerson ,  Paul E. Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/056 ,  A61N2001/0585

摘要： A pacing lead having a lead body configured into a pre-formed J-shape. The lead includes a pacing electrode coupled to an intermediate portion of the lead body and located distally from a bottom of the pre-formed J-shape. The lead is adapted to be placed within a heart in a J-shaped configuration with the electrode positioned proximate a ventricular septum or a right ventricular outflow tract such that at least a portion of the distal end of the lead body is located within a pulmonary artery. In one embodiment, the distal end of the lead is configured to be passively fixated within the pulmonary artery. Another aspect includes a lead body wherein a section of the intermediate portion of the lead body is less stiff than adjacent sections of the lead body. The lead includes a pacing electrode coupled to the intermediate portion of the lead body and located distally from the less stiff section. The lead is adapted to be placed within a heart in a J-shaped configuration with the less stiff section near a bottom of the J-shape such that the electrode is positioned proximate a ventricular septum or a right ventricular outflow tract and at least a portion of the distal end of the lead body is fixated within a pulmonary artery.

摘要翻译： 具有构造成预成形的J形的引线主体的起搏引线。 引线包括连接到引线主体的中间部分并且位于远离预成形的J形的底部的起搏电极。 引线适于放置在J形构型的心脏内，其中电极位于心室隔膜或右心室流出道附近，使得引线体的远端的至少一部分位于肺动脉内 。 在一个实施例中，引线的远端构造成被动地固定在肺动脉内。 另一方面包括引线体，其中引线主体的中间部分的部分比引线本体的相邻部分刚性差。 引线包括连接到引线主体的中间部分并位于较不硬的部分的远侧的起搏电极。 引线适于放置在心脏内的J形构型中，具有靠近J形底部的较硬的部分，使得电极位于靠近心室隔膜或右心室流出道和至少一部分 引导体的远端固定在肺动脉内。

公开(公告)号：US20070299492A1

公开(公告)日：2007-12-27

申请号：US11895808

申请日：2007-08-28

申请人： Yongxing Zhang ,  James Gilkerson ,  Paul Zarembo

发明人： Yongxing Zhang ,  James Gilkerson ,  Paul Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0585

摘要： A lead body includes an electrode coupled to an intermediate portion of the lead body. A distal end of the lead includes a pre-formed, biased shape adapted to passively fixate the distal end of the lead within a pulmonary artery with the electrode positioned in the right ventricle or ventricular outflow tract. The lead body can include a pre-formed J-shape, with the electrode coupled to the intermediate portion of the lead body and located distally from a bottom of the pre-formed J-shape. The lead body can include a section of the intermediate portion of the lead body being less stiff than adjacent sections of the lead body with the electrode coupled to the intermediate portion of the lead body and located distally from the less stiff section.

摘要翻译： 引线体包括连接到引线主体的中间部分的电极。 引线的远端包括预先形成的偏压形状，其适于被动地固定在肺动脉内的引线的远端，其中电极定位在右心室或心室流出道中。 引线体可以包括预形成的J形，电极耦合到引线本体的中间部分并且位于远离预成形的J形的底部。 引线主体可以包括引线主体的中间部分的一部分比引线主体的相邻部分刚性差，其中电极耦合到引线主体的中间部分并且位于较硬的部分的远侧。

公开(公告)号：US06944505B2

公开(公告)日：2005-09-13

申请号：US10455984

申请日：2003-06-06

申请人： Yongxing Zhang ,  Mohan Krishnan

发明人： Yongxing Zhang ,  Mohan Krishnan

IPC分类号： A61N1/05 ,  A61N1/18

CPC分类号： A61N1/0573 ,  A61N1/056

摘要： A lead has a flexible lead body which extends from a proximal end to a distal end. The lead body has a conductor coupled with an electrode. At least a portion of the conductor includes a layer of echogenic material encapsulated by the lead body. Alternatively, the echogenic material includes a coating of material. Optionally, the layer of echogenic material is disposed on at least a portion of the conductor or on one or more portions of the conductor.

摘要翻译： 导线具有从近端延伸到远端的柔性引线体。 引线体具有与电极耦合的导体。 导体的至少一部分包括由引线体封装的回声材料层。 或者，回声材料包括材料涂层。 可选地，回声材料层设置在导体的至少一部分上或导体的一个或多个部分上。

公开(公告)号：US06592553B2

公开(公告)日：2003-07-15

申请号：US09800265

申请日：2001-03-06

申请人： Yongxing Zhang ,  Martin Tze

发明人： Yongxing Zhang ,  Martin Tze

IPC分类号： A61M5178

CPC分类号： A61M25/00 ,  A61M25/02 ,  A61M2025/0059 ,  A61M2025/028 ,  A61M2025/0286

摘要： An assembly includes an introducing assembly having an elongate tubular sheath which has an external diameter. The sheath, which extends from a distal end to a proximal end, has a bore including an internal diameter sized to receive a dilator therethrough. The sheath includes a movable suture sleeve thereon. A method includes inserting an introducing assembly into a living body, and sliding a protector over a portion of the instrument and into a costoclavicular space.

公开(公告)号：US06544270B1

公开(公告)日：2003-04-08

申请号：US09661928

申请日：2000-09-14

申请人： Yongxing Zhang

发明人： Yongxing Zhang

IPC分类号： A61N105

CPC分类号： A61N1/056 ,  A61N2001/0578 ,  A61N2001/0585

摘要： A system which includes a catheter and at least a first and second lead, where the catheter includes an elongate catheter body having at least two lumens through which the first and second leads pass. In one embodiment, the leads are reduced diameter leads having a complete, partial or no stylet lumen. The elongate catheter body further includes a first section and a second section, where there is a transition (e.g., a tapered portion) between the first section and the second section. A first lumen extends through the first section and the second section between a first inlet at the proximal end to a first outlet at the distal end. A second lumen extends through the first section between a second inlet at the proximal end to a second outlet at a point in the first section. In one embodiment, the second outlet is located approximately at the transition between the first section and the second section.

摘要翻译： 一种包括导管和至少第一和第二引线的系统，其中所述导管包括具有至少两个流明的第一和第二引线通过的细长导管体。 在一个实施例中，引线是具有完全，部分或无针刺管腔的直径减小的引线。 细长导管主体还包括第一部分和第二部分，其中在第一部分和第二部分之间存在过渡部分（例如锥形部分）。 第一腔延伸穿过第一部分，第二部分在近端的第一入口与远端的第一出口之间延伸。 第二腔在第一部分的点处在第一部分延伸穿过近端处的第二入口到第二出口。 在一个实施例中，第二出口大致位于第一部分和第二部分之间的过渡处。

公开(公告)号：US08239039B2

公开(公告)日：2012-08-07

申请号：US11215786

申请日：2005-08-30

申请人： Paul E. Zarembo ,  Yongxing Zhang ,  Matthew Finlay ,  Jeffrey P. Bodner

发明人： Paul E. Zarembo ,  Yongxing Zhang ,  Matthew Finlay ,  Jeffrey P. Bodner

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N2001/0578 ,  A61N2001/0585

摘要： This document discusses, among other things, a lead body extending longitudinally along a lead axis, a driver axially displaceable relative to the lead body, and a driven member coupled to the lead body and displaceable away from the lead axis. The driven member at least partially defines an expandable passage having at least one internal dimension. The driver is displaceable into the expandable passage and has at least one outer dimension that is larger than the at least one internal dimension of the expandable passage. An example method includes disposing a first member having a first cross-section in a lead assembly having a lead axis, an expandable passage, and a displaceable member proximate the expandable passage. The method further includes urging the first member into the expandable passage in the lead assembly, and urging the displaceable member away from the lead axis to expand the expandable passage.

摘要翻译： 本文件尤其讨论了沿着引线轴线纵向延伸的引线本体，相对于引线主体轴向移位的驱动器以及耦合到引线主体并且可远离引导轴线移位的从动元件。 从动构件至少部分地限定具有至少一个内部尺寸的可扩张通道。 驾驶员可移动到可扩张通道中并且具有比可扩张通道的至少一个内部尺寸大的至少一个外部尺寸。 示例性方法包括将具有第一横截面的第一构件布置在具有引导轴线的引导组件中，可扩展通道和靠近可扩展通道的可移位构件。 所述方法还包括将所述第一构件推入所述引导组件中的所述可膨胀通道中，并且将所述可移位构件推离所述引导轴线以使所述可扩张通道膨胀。