公开(公告)号：US20070299492A1

公开(公告)日：2007-12-27

申请号：US11895808

申请日：2007-08-28

申请人： Yongxing Zhang ,  James Gilkerson ,  Paul Zarembo

发明人： Yongxing Zhang ,  James Gilkerson ,  Paul Zarembo

IPC分类号： A61N1/05

CPC分类号： A61N1/056 ,  A61N1/057 ,  A61N2001/0585

摘要： A lead body includes an electrode coupled to an intermediate portion of the lead body. A distal end of the lead includes a pre-formed, biased shape adapted to passively fixate the distal end of the lead within a pulmonary artery with the electrode positioned in the right ventricle or ventricular outflow tract. The lead body can include a pre-formed J-shape, with the electrode coupled to the intermediate portion of the lead body and located distally from a bottom of the pre-formed J-shape. The lead body can include a section of the intermediate portion of the lead body being less stiff than adjacent sections of the lead body with the electrode coupled to the intermediate portion of the lead body and located distally from the less stiff section.

摘要翻译： 引线体包括连接到引线主体的中间部分的电极。 引线的远端包括预先形成的偏压形状，其适于被动地固定在肺动脉内的引线的远端，其中电极定位在右心室或心室流出道中。 引线体可以包括预形成的J形，电极耦合到引线本体的中间部分并且位于远离预成形的J形的底部。 引线主体可以包括引线主体的中间部分的一部分比引线主体的相邻部分刚性差，其中电极耦合到引线主体的中间部分并且位于较硬的部分的远侧。

公开(公告)号：US20070050003A1

公开(公告)日：2007-03-01

申请号：US11215786

申请日：2005-08-30

申请人： Paul Zarembo ,  Yongxing Zhang ,  Matthew Finlay ,  Jeffrey Bodner

发明人： Paul Zarembo ,  Yongxing Zhang ,  Matthew Finlay ,  Jeffrey Bodner

IPC分类号： A61N1/00

CPC分类号： A61N1/057 ,  A61N2001/0578 ,  A61N2001/0585

摘要： This document discusses, among other things, a lead body extending longitudinally along a lead axis, a driver axially displaceable relative to the lead body, and a driven member coupled to the lead body and displaceable away from the lead axis. The driven member at least partially defines an expandable passage having at least one internal dimension. The driver is displaceable into the expandable passage and has at least one outer dimension that is larger than the at least one internal dimension of the expandable passage. An example method includes disposing a first member having a first cross-section in a lead assembly having a lead axis, an expandable passage, and a displaceable member proximate the expandable passage. The method further includes urging the first member into the expandable passage in the lead assembly, and urging the displaceable member away from the lead axis to expand the expandable passage.

摘要翻译： 本文件尤其讨论了沿着引线轴线纵向延伸的引线本体，相对于引线主体轴向移位的驱动器以及耦合到引线主体并且可远离引导轴线移位的从动元件。 从动构件至少部分地限定具有至少一个内部尺寸的可扩张通道。 驾驶员可移动到可扩张通道中并且具有比可扩张通道的至少一个内部尺寸大的至少一个外部尺寸。 示例性方法包括将具有第一横截面的第一构件布置在具有引导轴线的引导组件中，可扩展通道和靠近可扩展通道的可移位构件。 所述方法还包括将所述第一构件推入所述引导组件中的所述可膨胀通道中，并且将所述可移位构件推离所述引导轴线以使所述可扩张通道膨胀。

公开(公告)号：US20050096719A1

公开(公告)日：2005-05-05

申请号：US10698843

申请日：2003-10-31

申请人： Eric Hammill ,  Yongxing Zhang ,  Jeffrey Bodner ,  Paul Zarembo ,  Mohan Krishnan

发明人： Eric Hammill ,  Yongxing Zhang ,  Jeffrey Bodner ,  Paul Zarembo ,  Mohan Krishnan

IPC分类号： A61N1/05 ,  A61N1/08

CPC分类号： A61N1/056 ,  A61N1/08 ,  A61N2001/083

摘要： An implantable lead assembly includes a lead body extending from a proximal end to a distal end having an intermediate portion therebetween, where the lead body includes an insulating layer. A conductor is disposed within the insulating layer and the insulating layer surrounds the conductor. An electrode is coupled to the lead body, and the electrode is in electrical communication with the conductor. At least one conductive sleeve is disposed within the insulating layer. The at least one conductive sleeve surrounds the conductor and is electrically isolated from the electrode. The at least one conductive sleeve has a first impedance value in a first condition.

摘要翻译： 可植入引线组件包括引线本体，该引线体从近端延伸至具有中间部分的远端，其中引线主体包括绝缘层。 导体设置在绝缘层内，绝缘层包围导体。 电极耦合到引线体，并且电极与导体电连通。 至少一个导电套管设置在绝缘层内。 所述至少一个导电套管围绕所述导体并且与所述电极电隔离。 所述至少一个导电套筒在第一状态下具有第一阻抗值。

公开(公告)号：US20080114258A1

公开(公告)日：2008-05-15

申请号：US12016843

申请日：2008-01-18

申请人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

IPC分类号： A61B5/0452

CPC分类号： A61N1/3622 ,  A61B5/0452 ,  A61B5/7264 ,  A61N1/3956

摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.

摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。

公开(公告)号：US20060116594A1

公开(公告)日：2006-06-01

申请号：US11000133

申请日：2004-11-30

申请人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

发明人： Yunlong Zhang ,  Julie Thompson ,  James Gilkerson ,  Yongxing Zhang

IPC分类号： A61B5/04

CPC分类号： A61N1/3622 ,  A61B5/0452 ,  A61B5/7264 ,  A61N1/3956

摘要： An implantable medical device senses a plurality of electrograms from substantially different atrial locations, detects regional depolarizations from the electrograms, and analyzes timing relationships among the regional depolarizations. The timing relationships provide a basis for effective therapy control and/or prognosis of certain cardiac disorders. In one embodiment, an atrial activation sequence is mapped to show the order of occurrences of the regional depolarizations during an atrial depolarization for classifying a detected tachyarrhythmia by its origin. In another embodiment, conduction time between two atrial locations is measured for monitoring the development of an abnormal atrial conditions and/or the effect of a therapy.

摘要翻译： 植入式医疗装置感测来自实质上不同的心房位置的多个电描记图，检测来自电描记图的区域去极化，并且分析区域去极化之间的时间关系。 时间关系为某些心脏疾病的有效治疗控制和/或预后提供了依据。 在一个实施方案中，映射心房激活序列以显示在心房去极化期间区域去极化的发生顺序，以将检测到的快速性心律失常归因于其来源。 在另一个实施例中，测量两个心房位置之间的传导时间，以监测异常心房状况的发展和/或治疗的效果。

公开(公告)号：US20070129765A1

公开(公告)日：2007-06-07

申请号：US11296732

申请日：2005-12-07

申请人： James Gilkerson ,  Yongxing Zhang ,  Yunlong Zhang ,  Sophia Wang

发明人： James Gilkerson ,  Yongxing Zhang ,  Yunlong Zhang ,  Sophia Wang

IPC分类号： A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3962

摘要： An implantable medical device for generating a cardiac pressure-volume loop, the implantable medical device comprising a pulse generator including control circuitry, a first cardiac lead including a proximal end and a distal end and coupled to the pulse generator at the proximal end, a first electrode located at the distal end of the cardiac lead and operatively coupled to the control circuitry, a sound sensor operatively coupled to the control circuitry, and a pressure sensor operatively coupled to the control circuitry, wherein the implantable medical device is adapted for measuring intracardiac impedance. A method of using the implantable medical device to optimize therapy delivered to the heart.

摘要翻译： 一种用于产生心脏压力 - 体积回路的可植入医疗装置，所述可植入医疗装置包括脉冲发生器，所述脉冲发生器包括控制电路，包括近端和远端的第一心脏引线，并且在近端处耦合到所述脉冲发生器， 电极，位于心脏引线的远端并且可操作地耦合到控制电路，操作地耦合到控制电路的声音传感器和可操作地耦合到控制电路的压力传感器，其中可植入医疗装置适于测量心内阻抗 。 一种使用可植入医疗装置来优化递送至心脏的治疗的方法。

公开(公告)号：US20070043394A1

公开(公告)日：2007-02-22

申请号：US11208922

申请日：2005-08-22

申请人： Yunlong Zhang ,  James Gilkerson ,  Yongxing Zhang ,  Boyce Moon

发明人： Yunlong Zhang ,  James Gilkerson ,  Yongxing Zhang ,  Boyce Moon

IPC分类号： A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3925

摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.

摘要翻译： 测量心内阻抗的系统包括可植入电极和医疗装置。 电极感测受试者心脏的电信号。 医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。 心脏信号感测电路提供感测的心脏信号。 阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。 控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。

公开(公告)号：US08979837B2

公开(公告)日：2015-03-17

申请号：US12651074

申请日：2009-12-31

申请人： Alan de la Rama ,  Cary Hata ,  William Du ,  Yongxing Zhang

发明人： Alan de la Rama ,  Cary Hata ,  William Du ,  Yongxing Zhang

IPC分类号： A61B18/14 ,  A61M25/00 ,  A61B5/04 ,  A61B18/00 ,  A61M25/10

CPC分类号： A61M25/007 ,  A61B5/04 ,  A61B18/1492 ,  A61B2018/00011 ,  A61B2018/00101 ,  A61B2018/00577 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/1465 ,  A61B2218/002 ,  A61M25/0026 ,  A61M25/0074 ,  A61M25/008 ,  A61M25/0082 ,  A61M2025/1047

摘要： A lumen extension member is provided for a catheter having a catheter body and an elongate electrode coupled to the catheter body. The elongate electrode defines an electrode lumen extending therethrough. The lumen extension member is positioned within the electrode lumen and is coupled to the catheter body. The lumen extension member includes a tubular member including a sidewall and at least one opening that extends through the sidewall.

摘要翻译： 为具有导管主体和连接到导管主体的细长电极的导管提供管腔延伸构件。 细长电极限定延伸穿过其中的电极腔。 内腔延伸构件定位在电极内腔内并且联接到导管主体。 管腔延伸构件包括管状构件，其包括侧壁和延伸穿过侧壁的至少一个开口。

公开(公告)号：US08781604B2

公开(公告)日：2014-07-15

申请号：US12384139

申请日：2009-04-01

申请人： Yongxing Zhang ,  Yunlong Zhang

发明人： Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N1/0568 ,  A61N1/0573

摘要： A lead includes a lead body and an electrode disposed proximate a distal end of the lead body. A retaining member is disposed proximate the distal end of the lead and adapted to retain the electrode proximate an interatrial septum when the retaining member is located on a left atrial side of the interatrial septum.

摘要翻译： 引线包括引线体和靠近引线主体的远端设置的电极。 保持构件设置在引线的远端附近，并且当保持构件位于房间隔间隔的左心房侧时适于将电极保持靠近房间隔。

公开(公告)号：US08221323B2

公开(公告)日：2012-07-17

申请号：US11833502

申请日：2007-08-03

申请人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

发明人： Yunlong Zhang ,  Yongxing Zhang ,  Paul E. Zarembo

IPC分类号： A61B8/00

CPC分类号： A61B8/12 ,  A61B5/0031 ,  A61B5/08 ,  A61B5/4878 ,  A61B8/4472

摘要： Systems and methods for monitoring lung edema fluid status, such as monitoring the presence or absence of pulmonary edema, in a subject using information about responsive acoustic energy echoes from a lung are described. The system comprises, among other things, an implantable device including an acoustic transducer configured to emit acoustic energy to a lung and to receive one or more responsive acoustic energy echoes from a lung. In an example, the implantable device includes a cardiac function management device having an acoustic window in a body thereof. In another example, the implantable device includes one or more subcutaneous leads. An implantable or external processor circuit is configured to receive information about the acoustic energy echoes to compute and provide a lung edema fluid status indication; such information may include an increased number or special pattern of acoustic energy echoes received or a decreased time between successively received echoes.

摘要翻译： 描述了使用关于来自肺的响应性声能回波的信息来监测受试者肺水肿液体状态的系统和方法，例如监测受试者是否存在肺水肿。 除其他之外，该系统包括可植入装置，其包括被配置为向肺发出声能并且接收来自肺的一个或多个响应声能回波的声学换能器。 在一个示例中，可植入装置包括其身体中具有声窗口的心脏功能管理装置。 在另一示例中，可植入装置包括一个或多个皮下引线。 植入式或外部处理器电路被配置为接收关于声能回波的信息，以计算并提供肺水肿状态指示; 这样的信息可以包括接收的声能回波的增加的数量或特殊模式或连续接收的回波之间的减少的时间。