公开(公告)号：US4404410A

公开(公告)日：1983-09-13

申请号：US272229

申请日：1981-06-10

Applicant: Boy Cornils ,  Jurgen Weber ,  Wolfgang Bernhagen ,  Helmut Springer

Inventor： Boy Cornils ,  Jurgen Weber ,  Wolfgang Bernhagen ,  Helmut Springer

IPC: B01J31/00 ,  C07B61/00 ,  C07C27/00 ,  C07C29/03 ,  C07C31/20 ,  C07C67/00

CPC classification number: C07C29/03 ,  A24F2700/03

Abstract: An improved process for the preparation of 2,3-dimethyl-2,3-butanediol is disclosed wherein hydrogen peroxide and 2,3-dimethylbutene are reacted with formic acid at 50.degree. to 70.degree. C. while stirring, the 2,3-dimethylbutene and hydrogen peroxide being introduced into the formic acid simultaneously but separately. The diol can be obtained by hydrolysis of the pinacol monoformate formed.

Abstract translation: 公开了一种制备2,3-二甲基-2,3-丁二醇的改进方法，其中过氧化氢和2,3-二甲基丁烯在50℃至70℃下与甲酸反应同时搅拌， 二甲基丁烯和过氧化氢同时引入甲酸，但分开。 二醇可以通过水解形成的频哪醇单甲酸酯来获得。

公开(公告)号：US4317945A

公开(公告)日：1982-03-02

申请号：US178396

申请日：1980-08-15

Applicant: Wolfgang Bernhagen ,  Jurgen Weber ,  Helmut Bahrmann ,  Helmut Springer

Inventor： Wolfgang Bernhagen ,  Jurgen Weber ,  Helmut Bahrmann ,  Helmut Springer

IPC: B01J23/00 ,  C07B61/00 ,  C07C27/00 ,  C07C29/38 ,  C07C31/20 ,  C07C45/50 ,  C07C45/62 ,  C07C45/75 ,  C07C47/02 ,  C07C67/00 ,  C07C29/14

CPC classification number: C07C47/02 ,  C07C29/38 ,  C07C45/50 ,  C07C45/62 ,  C07C45/75

Abstract: A process for the preparation of 2-methyl-2-sec.butyl-1,3-propanediol comprising hydroformylating 2-methyl-1-butene with carbon monoxide and hydrogen in the presence of a first catalyst to form the substance 3-methyl-pentanal, condensing said substance with formaldehyde, or a compound which forms formaldehyde under the conditions of condensation in a basic medium to form alpha-sec.butyl-acrolein, partially hydrogenating said acrolein in the presence of a second catalyst to form the material 2,3-dimethyl pentanal, and converting said material into said diol by treatment with formaldehyde, or a compound which forms formaldehyde under the conditions of conversion, in the presence of a strong base as a third catalyst.The compound of the present invention is useful as an intermediate in the production of pharmaceuticals and drugs; in particular, the production of carbamates which are useful as tranquilizers and blood pressure lowering agents.

Abstract translation: 一种制备2-甲基-2-仲丁基-1,3-丙二醇的方法，包括在第一催化剂存在下，将2-甲基-1-丁烯与一氧化碳和氢气进行甲酰化，形成3-甲基-2- 戊醛，用甲醛缩合所述物质，或在碱性介质中在冷凝条件下形成甲醛以形成α-仲丁基丙烯醛的化合物，在第二催化剂存在下部分氢化所述丙烯醛以形成材料2， 并通过用甲醛处理或在转化条件下形成甲醛的化合物在作为第三催化剂的强碱存在下将所述物质转化成所述二醇。 本发明化合物可用作药物和药物生产中的中间体; 特别是生产可用作镇定剂和降血压剂的氨基甲酸酯。

公开(公告)号：US4307252A

公开(公告)日：1981-12-22

申请号：US173792

申请日：1980-07-30

Applicant: Jurgen Weber ,  Wolfgang Bernhagen ,  Helmut Springer

Inventor： Jurgen Weber ,  Wolfgang Bernhagen ,  Helmut Springer

IPC: A61K8/33 ,  A61Q13/00 ,  C07C41/28 ,  C07C43/15 ,  C07C45/00 ,  C07C45/51 ,  C07C47/21 ,  C07C67/00 ,  C11B9/00

CPC classification number: C11B9/0015 ,  C07C41/28 ,  C07C45/513 ,  C07C45/515 ,  C07C47/21 ,  Y02P20/582

Abstract: 2-Propyl-pent-4-en-1-al of the formula ##STR1## and a process for its preparation.

公开(公告)号：US4288643A

公开(公告)日：1981-09-08

申请号：US146830

申请日：1980-05-05

Applicant: Jurgen Weber ,  Wolfgang Bernhagen ,  Helmut Springer

Inventor： Jurgen Weber ,  Wolfgang Bernhagen ,  Helmut Springer

IPC: C07C1/00 ,  C07C1/24 ,  C07C5/25 ,  C07C11/107 ,  C07C27/00 ,  C07C29/14 ,  C07C29/141 ,  C07C29/17 ,  C07C31/125 ,  C07C45/00 ,  C07C45/68 ,  C07C45/75 ,  C07C67/00 ,  C07C1/253

CPC classification number: C07C5/2531 ,  C07C1/24 ,  C07C11/107 ,  C07C29/175 ,  C07C45/75 ,  C07C2521/04 ,  C07C2527/054

Abstract: A process for the preparation of 2,3-dimethylbutene-2 is disclosed, which comprises the steps of converting isovaleraldehyde to isopropylacrolein, hydrogenating .alpha.-isopropylacrolein to form 2,3-dimethylbutanol, dehydrating 2,3-dimethylbutanol to form an olefin mixture comprising 2,3-dimethylbutene-1 and 2,3-dimethylbutene-2, and isomerizing the 2,3-dimethylbutene-1 contained in the mixture into 2,3-dimethylbutene-2. The present process is technically simple and inexpensive to utilize, and results in high yields of the desired product.

Abstract translation: 公开了制备2,3-二甲基丁烯-2的方法，其包括将异戊醛转化为异丙基丙烯醛，氢化α-异丙基丙烯醛形成2,3-二甲基丁醇，脱水2,3-二甲基丁醇以形成烯烃混合物的步骤，该烯烃混合物包含 2,3-二甲基丁烯-1和2,3-二甲基丁烯-2，并将混合物中所含的2,3-二甲基丁烯-1异构化为2,3-二甲基丁烯-2。 本发明的方法在技术上是简单且便宜的，并且导致所需产物的高产率。

公开(公告)号：US4172091A

公开(公告)日：1979-10-23

申请号：US883757

申请日：1978-03-06

Applicant: Jurgen Weber ,  Helmut Springer ,  Boy Cornils ,  Hans Feichtinger ,  Wolfgang Payer

Inventor： Jurgen Weber ,  Helmut Springer ,  Boy Cornils ,  Hans Feichtinger ,  Wolfgang Payer

IPC: C07C255/24 ,  C07C20060101 ,  C07C67/00 ,  C07C253/00 ,  C08F20060101 ,  C11D20060101 ,  C07C120/00 ,  C07C121/43

CPC classification number: C07C253/30

Abstract: An improvement in a process for the manufacture of .beta.-(dimethylamino)-propionitrile by contacting acrylonitrile with dimethylamine, the improvement residing in passing the reactants in countercurrent with respect to one another in a bubble column reactor and reacting them therein at a temperature between 25.degree. and 80.degree. C., preferably 40.degree. to 60.degree. C.

Abstract translation: 通过使丙烯腈与二甲胺接触制备β-（二甲基氨基） - 丙腈的方法的改进，其改进在气泡塔型反应器中使反应物相对于彼此逆流通过，并使其在25℃ DEG和80℃，优选40℃至60℃。