公开(公告)号：US20120315703A1

公开(公告)日：2012-12-13

申请号：US13394481

申请日：2010-09-07

申请人： Pentao Liu ,  Wei Wang ,  Jian Yang

发明人： Pentao Liu ,  Wei Wang ,  Jian Yang

IPC分类号： C12N5/071 ,  C12N5/10 ,  C07K14/47 ,  C12N15/85 ,  C12N15/12

CPC分类号： C12N5/0696 ,  C12N2501/235 ,  C12N2501/385 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/727 ,  C12N2510/00

摘要： Reprogrammed somatic cells, methods for reprogramming, reprogramming factors for somatic cells and uses of such factors and cells are described. Nuclear reprogramming factors [NRF] described comprise one or more of a gene product or a polynucleic acid encoding a gene product from a retinoic acid receptor (RAR/RXR) family member, or an agonist or antagonist thereof; a gene product from an Lrh1 family member; or an agonist thereof; retinoic acid or a gene product involved in synthesizing or metabolizing retinoic acid; or an agonist or antagonist thereof; or a gene product that is involved in transporting a retinoic acid family member.

摘要翻译： 描述了重编程体细胞，重编程方法，体细胞重编程因子以及这些因子和细胞的用途。 所述核重编程因子包括一种或多种编码来自视黄酸受体（RAR / RXR）家族成员或其激动剂或拮抗剂的基因产物的基因产物或多核酸; 来自Lrh1家族成员的基因产物; 或其激动剂; 视黄酸或涉及合成或代谢视黄酸的基因产物; 或其激动剂或拮抗剂; 或涉及运输视黄酸家族成员的基因产物。

公开(公告)号：US08224692B2

公开(公告)日：2012-07-17

申请号：US12263406

申请日：2008-10-31

申请人： Deepak K. Agarwal ,  John Anthony Tomlin ,  Jian Yang

发明人： Deepak K. Agarwal ,  John Anthony Tomlin ,  Jian Yang

IPC分类号： G06Q30/00

CPC分类号： G06Q30/0207 ,  G06Q30/02 ,  G06Q30/0277

摘要： An improved system and method for pricing of overlapping impression pools of online advertisement impressions for advertising demand is provided. An inventory of online advertisement impressions may be grouped in impression pools according to attributes of the advertisement impressions and advertisers' requests for impressions targeting specific attributes may be received. An optimal price may be computed for each of the impression pools of the inventory of online advertisement impressions using dual values of an optimization program. The values of a dual variable for prices of impression pools on the supply constraints of an objective function for allocating the impression pools may be extracted and iteratively increased on those impression pools which have a dual value greater than the book rate value.

摘要翻译： 提供了一种改进的用于定价广告需求的在线广告印象的重叠印象池的系统和方法。 可以根据广告展示的属性将在线广告展示的广告资源分组在展示池中，并且可以接收广告客户针对特定属性的展示的请求。 可以使用优化程序的双重值来计算在线广告展示广告资源的每个展示池的最优价格。 可以在具有大于书本率值的双重值的那些印象池上提取并迭代地增加用于分配展示池的目标函数的供应限制的压缩池价格的双变量的值。

公开(公告)号：US08189298B1

公开(公告)日：2012-05-29

申请号：US12163815

申请日：2008-06-27

申请人： Yu-Min Lee ,  Arman V. Golgolab ,  Jian Yang

发明人： Yu-Min Lee ,  Arman V. Golgolab ,  Jian Yang

IPC分类号： G11B5/55

CPC分类号： G11B5/5573

摘要： A C-shaped bobbin includes a bobbin base member adjacent and attached to a first lateral leg of an actuator coil. A bobbin recess, adjacent the bobbin base member, separates first and second bobbin wings. The first and second bobbin wings define first and second wing lengths measured parallel to first and second longitudinal legs of the coil, respectively, and also define first and second wing widths measured normal to the first and second longitudinal legs, respectively. The bobbin recess defines a recess depth measured normal to the first lateral leg, and defines a recess width measured parallel to the first lateral leg. Each of the first and second wing lengths is less than the length of the longitudinal legs. The recess depth is at least half a base member width. The recess width is at least twice the first wing width and/or the second wing width.

摘要翻译： C形绕线架包括与致动器线圈的第一侧腿相邻并附接的绕线筒基座。 与梭芯基部件相邻的绕线筒凹槽分离第一和第二线轴架。 第一和第二梭骨架分别限定平行于线圈的第一和第二纵向腿部测量的第一和第二翼长度，并且还分别限定垂直于第一和第二纵向腿部测量的第一和第二翼部宽度。 梭心凹槽限定了垂直于第一侧腿测量的凹陷深度，并且限定了平行于第一侧腿测量的凹陷宽度。 第一和第二翼长中的每一个都小于纵向腿的长度。 凹陷深度至少为基础构件宽度的一半。 凹槽宽度至少是第一机翼宽度和/或第二机翼宽度的两倍。

公开(公告)号：US20120110526A1

公开(公告)日：2012-05-03

申请号：US13280853

申请日：2011-10-25

申请人： Liang Chen ,  Yufei Li ,  Yong Feng Pan ,  Jian Yang

发明人： Liang Chen ,  Yufei Li ,  Yong Feng Pan ,  Jian Yang

IPC分类号： G06F17/50

CPC分类号： G06F17/5027 ,  G06F17/5022 ,  G06F17/5081

摘要： A method and an apparatus for tracking uncertain signals in the simulation of chip design are provided. The method comprises: generating a directed graph which contains sequential logic devices and IO devices from the netlist of chip design, wherein the directed graph illustrates the signal association among the sequential logic devices and IO devices; obtaining the signals related with the sequential logic devices and IO devices from the simulation results, wherein the signals contain a plurality of uncertain signals; and back tracing at least a part of the plurality of uncertain signals along the directed graph to determine the device which firstly generates an uncertain signal. The corresponding apparatus is also provided. With the above method and apparatus, uncertain signals can be traced and their source can be determined, which improves the debugging efficiency.

摘要翻译： 提供了一种在芯片设计仿真中跟踪不确定信号的方法和装置。 该方法包括：从芯片设计的网表生成包含顺序逻辑器件和IO器件的有向图，其中有向图示出了顺序逻辑器件和IO器件之间的信号关联; 从仿真结果获得与顺序逻辑器件和IO器件相关的信号，其中信号包含多个不确定信号; 并且沿着有向图向后跟踪多个不确定信号的至少一部分，以确定首先产生不确定信号的装置。 还提供了相应的装置。 利用上述方法和装置，可以追踪不确定的信号并确定其来源，从而提高调试效率。

公开(公告)号：US08164905B2

公开(公告)日：2012-04-24

申请号：US12915009

申请日：2010-10-29

申请人： Jian Yang

发明人： Jian Yang

IPC分类号： H05K7/20 ,  F28F7/00 ,  H01L23/34

CPC分类号： H01L23/4093 ,  H01L23/3677 ,  H01L2924/0002 ,  H01L2924/00

摘要： An exemplary heat sink assembly includes a heat sink and a clip resiliently clamping the heat sink on a printed circuit board. The heat sink includes a base and a plurality of first fins and two central second fins extending upwardly from the base. The clip includes a locating portion fixed between the second fins of the heat sink, a pair of elastic portions extending outwardly from opposite ends of the locating portion and oriented towards substantially opposite directions, and two hooks extending outwardly from ends of the operating members, respectively. An acute included angle is formed between each elastic portion and the locating portion of the clip in an original relaxed position, and the acute included angles become approximately right angles when the clip is preassembled in the heat sink with the elastic portions abutting the second fins.

摘要翻译： 示例性散热器组件包括散热器和将散热器弹性地夹持在印刷电路板上的夹子。 散热器包括底座和多个第一翅片以及从基座向上延伸的两个中央第二鳍片。 夹具包括固定在散热片的第二散热片之间的定位部分，一对弹性部分，其从定位部分的相对端部向外延伸并朝向基本上相反的方向定位，以及分别从操作部件的端部向外延伸的两个钩子 。 在弹性部分和夹子的定位部分之间形成初始放松位置的锐角，并且当弹簧部分邻接第二散热片时，夹子预先组装在散热器中时，锐角包括的角度变成近似的直角。

公开(公告)号：US08085542B2

公开(公告)日：2011-12-27

申请号：US12770749

申请日：2010-04-30

申请人： Jian Yang

发明人： Jian Yang

IPC分类号： H05K7/20

CPC分类号： H01L23/427 ,  G06F1/20 ,  H01L23/4093 ,  H01L23/467 ,  H01L2924/0002 ,  H01L2924/00

摘要： A heat dissipation device for a first electronic component and a second electronic component mounted on a circuit board includes a first base mounted on the first electronic component and a second base mounted on the second electronic component. The second base is movably connected with the first base. An electronic system incorporating the heat dissipation device is also provided.

摘要翻译： 用于第一电子部件的散热装置和安装在电路板上的第二电子部件包括安装在第一电子部件上的第一基座和安装在第二电子部件上的第二基座。 第二基座与第一基座可移动地连接。 还提供了一种结合了散热装置的电子系统。

公开(公告)号：US20110229576A1

公开(公告)日：2011-09-22

申请号：US12673224

申请日：2008-08-13

申请人： William C. Trogler ,  Sadik C. Esener ,  Davorka Messmer ,  Johan Ulrik Lind ,  Kristina K.P. Mitchell ,  Jian Yang

发明人： William C. Trogler ,  Sadik C. Esener ,  Davorka Messmer ,  Johan Ulrik Lind ,  Kristina K.P. Mitchell ,  Jian Yang

IPC分类号： A61K9/14 ,  B32B5/16 ,  C08J9/26 ,  C12N5/071 ,  C12N15/87 ,  A61K31/7088 ,  A61K39/00 ,  A61P37/04 ,  A61P35/00

CPC分类号： A61K47/6923 ,  A61K9/0019 ,  A61K9/14 ,  A61K9/1611 ,  A61K9/2009 ,  A61K9/5115 ,  A61K9/5192 ,  A61K39/0011 ,  A61K47/59 ,  A61K47/6455 ,  A61K47/6925 ,  A61K48/0041 ,  A61K49/04 ,  A61K49/183 ,  A61K2039/53 ,  A61K2039/6093 ,  B82Y5/00 ,  C01B33/12 ,  C01B33/18 ,  C12N15/87 ,  Y10S977/773 ,  Y10T428/2982

摘要： The disclosure provide hollow nanospheres and methods of making and using the same. The methods and compositions of the disclosure are useful for drug delivery and gene transfer.

摘要翻译： 本发明提供中空纳米球及其制备和使用方法。 本公开的方法和组合物可用于药物递送和基因转移。

公开(公告)号：US07996540B2

公开(公告)日：2011-08-09

申请号：US11805547

申请日：2007-05-23

申请人： Jian Yang

发明人： Jian Yang

IPC分类号： G06F15/16

CPC分类号： H04L29/06027 ,  H04L65/4092 ,  H04L65/607 ,  H04N21/23424 ,  H04N21/2368 ,  H04N21/41407 ,  H04N21/4341 ,  H04N21/44016 ,  H04N21/4788

摘要： A method and a system for replacing media stream in a communication process of a terminal are disclosed. The method includes: a terminal issuing a request for replacing media stream to a communication server in a communication process; the communication server obtaining a corresponding replacing media source from a multimedia server according to a replacing media source identification carried in the request for replacing media stream, and replacing media stream sent by the terminal with the replacing media source. The system includes a multimedia server and a communication server. According to the embodiments of the present invention, a terminal participating in a communication process may replace its own voice and/or pictures with stored audio and/or video and/or data, so as to provide a new value-added service and bring new service revenue for operators.

摘要翻译： 公开了一种用于在终端的通信过程中替换媒体流的方法和系统。 该方法包括：终端在通信过程中向通信服务器发出替换媒体流的请求; 通信服务器根据在替换媒体流的请求中携带的替换媒体源标识从多媒体服务器获得相应的替换媒体源，以及用替换媒体源替换终端发送的媒体流。 该系统包括多媒体服务器和通信服务器。 根据本发明的实施例，参与通信过程的终端可以用存储的音频和/或视频和/或数据替换其自己的语音和/或图片，以便提供新的增值服务并带来新的 运营商的服务收入。

公开(公告)号：US07973062B2

公开(公告)日：2011-07-05

申请号：US12389759

申请日：2009-02-20

申请人： Ching-Shih Chen ,  Dasheng Wang ,  Jian Yang

发明人： Ching-Shih Chen ,  Dasheng Wang ,  Jian Yang

IPC分类号： A61K31/426 ,  C07D277/34

CPC分类号： C07D277/34 ,  C07D417/06 ,  C07D417/12

摘要： Compounds of the thiazolidinedione family are provided and shown to be effective androgen receptor ablative agents that can be used in methods of treating or preventing cancer or precancer, including prostate cancer. Also provided are methods of treating or preventing cancer by administering a therapeutically effective amount of one of the androgen receptor ablative agents to a subject in need of such treatment.

摘要翻译： 噻唑烷二酮家族的化合物被提供并显示为有效的雄激素受体消融剂，其可用于治疗或预防癌症或癌前病，包括前列腺癌的方法。 还提供了通过向需要这种治疗的受试者施用治疗有效量的一种雄激素受体消融剂来治疗或预防癌症的方法。

公开(公告)号：US20110140701A1

公开(公告)日：2011-06-16

申请号：US12639123

申请日：2009-12-16

申请人： EMMANUEL LEGENDRE ,  Jean Seydoux ,  Reza Taherian ,  Jian Yang ,  Qiming Li

发明人： EMMANUEL LEGENDRE ,  Jean Seydoux ,  Reza Taherian ,  Jian Yang ,  Qiming Li

IPC分类号： G01V3/18

CPC分类号： G01V3/28

摘要： A system and method to determine earth formation properties by positioning a logging tool within a wellbore in the earth formation, the logging tool having a tool rotation axis and a first, a second, and a third tilted transmitter coil, and a tilted receiver coil; rotating the logging tool about the tool rotation axis; energizing each transmitter coil; measuring a coupling signal between each transmitter coil and the receiver coil for a plurality of angles of rotation; determining a coupling tensor; and determining the earth formation properties using the coupling tensor.

摘要翻译： 一种用于通过将测井工具放置在地层中的井筒内，测井工具具有工具旋转轴和第一，第二和第三倾斜发射器线圈以及倾斜的接收器线圈来确定地球形成特性的系统和方法; 围绕刀具旋转轴旋转测井工具; 为每个发射器线圈通电; 测量多个旋转角度的每个发射器线圈和接收器线圈之间的耦合信号; 确定耦合张量; 并使用耦合张量来确定地层的形成特性。