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51.发明授权Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡啶公开(公告)号：US06828338B2
公开(公告)日：2004-12-07
申请号：US10465125
申请日：2003-06-19
申请人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
发明人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
IPC分类号： A61K3144
CPC分类号： C07D213/74 , C07D213/89
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
摘要翻译： 本发明涉及化合物及其前药，可用于预防和治疗哺乳动物血栓形成病症的组合物和方法。 本发明的化合物及其前药选择性地抑制凝血级联的某些蛋白酶。
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52.发明授权Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基嘧啶酮公开(公告)号：US06653316B1
公开(公告)日：2003-11-25
申请号：US09716951
申请日：2000-11-20
申请人： Michael S. South , Ashton T. Hamme, II , William L. Neumann , Darin E. Jones , Melvin L. Rueppel
发明人： Michael S. South , Ashton T. Hamme, II , William L. Neumann , Darin E. Jones , Melvin L. Rueppel
IPC分类号： C07D23948
CPC分类号： C07D239/47 , C07D253/07 , C07D401/04 , C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyrimidinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及可用作凝血级联丝氨酸蛋白酶抑制剂的取代多环芳基和杂芳基嘧啶酮化合物，以及用于治疗和预防各种血栓形成疾病（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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公开(公告)号：US06624180B2
公开(公告)日：2003-09-23
申请号：US09989634
申请日：2001-11-20
申请人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
发明人： Michael J. South , Brenda Case , Danny J. Garland , Michael J. Hayes , Horng-Chih Huang , Wei Huang , Darin E. Jones , William L. Neumann , John J. Parlow , David B. Reitz , Melvin L. Rueppel , Rondald K. Webber
IPC分类号： C07D21306
CPC分类号： C07D213/74 , C07D213/89
摘要： The present invention relates to compounds, and prodrugs thereof, composition and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and prodrugs thereof, selectively inhibit certain proteases of the coagulation cascade.
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公开(公告)号：US5948937A
公开(公告)日：1999-09-07
申请号：US926263
申请日：1997-09-05
CPC分类号： C07F9/3813
摘要： This invention relates to a process for the preparation of N-phosphonomethylglycine and its salts. More particularly, this invention is directed to a method for preparing N-phosphonomethylglycine involving the reaction of AMPA, an alkali metal cyanide or hydrogen cyanide, and formaldehyde and hydrolyzing the product of that reaction to form N-phosphonomethylglycine and its salts.
摘要翻译： 本发明涉及N-膦酰甲基甘氨酸及其盐的制备方法。 更具体地说，本发明涉及一种制备涉及AMPA，碱金属氰化物或氰化氢与甲醛反应并生成N-膦酰基甲基甘氨酸及其盐的产物的N-膦酰基甲基甘氨酸的方法。
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公开(公告)号：US4227888A
公开(公告)日：1980-10-14
申请号：US970689
申请日：1978-12-18
CPC分类号： G01N33/182 , G01N31/00 , G01N31/224 , Y10T436/172307
摘要： A method for quantitatively determining the cyanide content of aqueous solution containing aldehydes and/or ketones as a measure of the sum of the free cyanide and cyanohydrin content. The method comprises converting cyanohydrin to free cyanide and then determining the free cyanide content of the solution.
摘要翻译： 用于定量测定含有醛和/或酮的水溶液的氰化物含量的方法，作为游离氰化物和氰醇含量之和的量度。 该方法包括将氰醇转化为游离氰化物，然后测定溶液中的游离氰化物含量。
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公开(公告)号：US07015230B1
公开(公告)日：2006-03-21
申请号：US09717051
申请日：2000-11-20
IPC分类号： C07D239/54 , A61K31/505
CPC分类号： C07D417/12 , C07D239/545 , C07D253/075
摘要： The invention relates to substituted polycyclic aryl and heteroaryl uracil compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
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57.发明授权Substitituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade 失效用于选择性抑制凝血级联的取代的多环芳基和杂芳基吡啶酮公开(公告)号：US06870056B1
公开(公告)日：2005-03-22
申请号：US09716962
申请日：2000-11-20
IPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D215/38 , C07D401/12 , C07D417/12 , C07D521/00 , A61K31/47 , C07D215/16 , C07D215/20 , C07D251/00
CPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D215/38 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
摘要翻译： 本发明涉及用于凝血级联丝氨酸蛋白酶的取代多环芳基和杂芳基吡啶酮化合物的抑制剂及其用于治疗和预防各种血栓形成疾病（包括冠状动脉和脑血管疾病）的抗凝血治疗的化合物，组合物和方法。
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公开(公告)号：US06867217B1
公开(公告)日：2005-03-15
申请号：US09574740
申请日：2000-05-18
IPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D215/38 , C07D401/12 , C07D417/12 , C07D521/00 , A61K31/535 , A61K31/517 , C07D401/00 , C07D417/00 , C07D453/02
CPC分类号： C07D213/74 , C07D213/75 , C07D213/77 , C07D215/38 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D417/12
摘要： The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.
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公开(公告)号：US4454043A
公开(公告)日：1984-06-12
申请号：US207539
申请日：1980-11-17
CPC分类号： G01N30/461 , G01N30/468
摘要： A method for increasing the capacity of a chromatographic system useful for the quantitative determination of at least one component of interest at a trace level concentration in a multi-component composition.
摘要翻译： 一种用于增加色谱系统的能力的方法，其用于在多组分组合物中以痕量浓度定量测定至少一种感兴趣组分。
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60.发明授权N-(perfluoroacyl)-N-phosphonomethyl glycine compounds, method of preparing same 失效N-（全氟酰基）-N-膦酰基甲基甘氨酸化合物及其制备方法
公开(公告)号：US4035176A
公开(公告)日：1977-07-12
申请号：US682244
申请日：1976-05-03
申请人： Melvin L. Rueppel
发明人： Melvin L. Rueppel
CPC分类号： C07F9/4093 , C07F9/3808 , C07F9/4006
摘要： N-(perfluoroacyl)-N-phosphonomethyl glycine compounds are prepared by the reaction of N-phosphonomethyl glycine with perfluoroacyl anhydrides employing an excess of the perfluoroalkanoic acid as the solvent. The N-(perfluoroacyl)-N-phosphonomethyl glycine compounds are useful as post-emergent herbicides and as sugar cane ripeners.
摘要翻译： N-（全氟酰基）-N-膦酰基甲基甘氨酸化合物通过使用过量的全氟链烷酸作为溶剂的N-膦酰基甲基甘氨酸与全氟酰基酸酐的反应来制备。 N-（全氟酰基）-N-膦酰基甲基甘氨酸化合物可用作芽后除草剂和甘蔗成熟剂。
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